Indígena y abogado: el caso de José Domingo Choquehuanca de Azángaro

This essay focuses on the political thought of José Domingo Choquehuanca, a member of a family of indigenous nobles that, from the colonial period and the first Republican century, occupied administrative, judicial, and political posts in their regional power center. Thus, José Domingo found himself in a key transitional period between the Spanish colonial system and the formation of the republic; a member of a group of intellectuals who laid a liberal juridical foundation for the newly-born nation. This study suggests that Choquehuanca preserved symbols of his seigneurial authority while following the constant changes of a politically and socially tumultuous Peru, which informed the development of his political thought in a new context of meritocracy and equality.Este ensayo tiene como tema el pensamiento político de José Domingo Choquehuanca, miembro de una familia de nobles indígenas, quienes, desde la colonia y durante el primer siglo republicano, ocuparon cargos administrativos, judiciales y políticos desde su centro de poder regional. De este modo, José Domingo se ubicó en un periodo clave de transición entre el sistema colonial hispano y la formación de una república, siendo él parte del grupo de intelectuales que laboró una base jurídica liberal para la naciente nación. Sobre la base del estudio de su vida y publicaciones, se sugiere que Choquehuanca preservó símbolos de su autoridad señorial, pero moldeándose a los constantes cambios de un Perú convulso política y socialmente, lo que marcó el desarrollo de su pensamiento político en un contexto nuevo de meritocracia e igualdad

Dietary α-linolenic acid, marine ω-3 fatty acids, and mortality in a population with high fish consumption: Findings from the PREvención con DIeta MEDiterránea (PREDIMED) Study

12 Páginas.-- 6 Tablas.-- 1 FiguraBackground-Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results-We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable-adjusted Cox regressionmodels were fitted to estimate hazard ratios. ALA intake correlated towalnut consumption (r=0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios formeeting ALArecommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all-causemortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all-causemortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45-0.87]). Conclusions-In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids.This study was funded in part by Instituto de Salud Carlos III (ISCIII) (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/01292, the Spanish Ministry of Science and Innovation (MICINN) AGL2010‐22319‐C03‐02 and AGL2009‐13906‐C02‐02, and an unrestricted grant from the California Walnut Commission. Sala‐Vila holds a Miguel Servet I fellowship from the Ministry of Economy and Competitiveness through the ISCIII

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present