Deep Neural Networks - A Brief History

Introduction to deep neural networks and their history.Comment: 14 pages, 14 figure

Less Minimal Flavour Violation

We consider the approximate U(2)^3 flavour symmetry exhibited by the quark sector of the Standard Model and all its possible breaking terms appearing in the quark Yukawa couplings. Taking an Effective Field Theory point of view, we determine the current bounds on these parameters, assumed to control the breaking of flavour in a generic extension of the Standard Model at a reference scale Lambda. In particular, a significant bound from epsilon'/epsilon is derived, which is relevant to Minimal Flavour Violation as well. In the up-quark sector, the recently observed CP violation in D -> pi+ pi-, K+ K- decays might be accounted for in this generic framework, consistently with any other constraint.Comment: 15 pages, 1 figur

CeRu4_4Sn6_6: a strongly correlated material with nontrivial topology

Topological insulators form a novel state of matter that provides new opportunities to create unique quantum phenomena. While the materials used so far are based on semiconductors, recent theoretical studies predict that also strongly correlated systems can show non-trivial topological properties, thereby allowing even the emergence of surface phenomena that are not possible with topological band insulators. From a practical point of view, it is also expected that strong correlations will reduce the disturbing impact of defects or impurities, and at the same increase the Fermi velocities of the topological surface states. The challenge is now to discover such correlated materials. Here, using advanced x-ray spectroscopies in combination with band structure calculations, we infer that CeRu$_4$Sn$_6$ is a strongly correlated material with non-trivial topology.Comment: 10 pages, 6 figures, submitted to Scientific Report

New smart functional fluorophores based on stable spirocyclic zwitterionic Meisenheimer compounds

Altres ajuts: Universitat Autònoma de Barcelona predoctoral PIF fellowshipMolecules and materials showing stimulus-induced modulation of their optical properties are of interest in a large variety of areas. In this paper, we focus on fluorescent switches based on stable spirocyclic zwitterionic Meisenheimer compounds (SZMC), which are composed of a 2,4,6-trisubstituted cyclohexadienyl anion chromophore fused with a triazene ring via a spiro carbon atom. By exploiting a facile one-pot synthetic strategy, new SZMC switches have been prepared with halo-, electro- and thermochromic properties. These properties can be controlled by modifying the substituents on their two constituting units. In particular, the optical properties, the sensitivity to different chemical stimuli, and the range of thermal response of these systems can be tailored by varying (a) the nature of the electron-withdrawing groups in their 2,4,6-trisubstituted cyclohexadienyl anion chromophore, and (b) the bulkiness of the pending chains in their triazene ring. In combination with their versatile optical switching behavior, this synthetic tunability makes SZMC switches very promising functional molecules for applications in chemistry, materials science, and biosciences

Effects of UV-B radiation on the structural and physiological diversity of bacterioneuston and bacterioplankton

The effects of UV radiation (UVR) on estuarine bacterioneuston and bacterioplankton were assessed in microcosm experiments. Bacterial abundance and DNA synthesis were more affected in bacterioplankton. Protein synthesis was more inhibited in bacterioneuston. Community analysis indicated that UVR has the potential to select resistant bacteria (e.g., Gammaproteobacteria), particularly abundant in bacterioneuston

Dense matrix computations on NUMA architectures with distance-aware work stealing

We employ the dynamic runtime system OmpSs to decrease the overhead of data motion in the now ubiquitous non-uniform memory access (NUMA) high concurrency environment of multicore processors. The dense numerical linear algebra algorithms of Cholesky factorization and symmetric matrix inversion are employed as representative benchmarks. Work stealing occurs within an innovative NUMA-aware scheduling policy to reduce data movement between NUMA nodes. The overall approach achieves separation of concerns by abstracting the complexity of the hardware from the end users so that high productivity can be achieved. Performance results on a large NUMA system outperform the state-of-the-art existing implementations up to a two fold speedup for the Cholesky factorization, as well as the symmetric matrix inversion, while the OmpSs-enabled code maintains strong similarity to its original sequential version.The authors would like to thank the National Institute for Computational Sciences for granting us access on the Nautilus system. The KAUST authors acknowledge support of the Extreme Computing Research Center. The BSC-affiliated authors thankfully acknowledges the support of the European Commission through the HiPEAC-3 Network of Excellence (FP7-ICT 287759), Intel-BSC Exascale Lab and IBM/BSC Exascale Initiative collaboration, Spanish Ministry of Education (FPU), Computación de Altas Prestaciones VI (TIN2012-34557), Generalitat de Catalunya (2014-SGR-1051) and the grant SEV-2011-00067 of the Severo Ochoa Program.Peer ReviewedPostprint (published version

MicroRNA-24 targets Notch and other vascular morphogens to regulates post-ischemic microvascular responses in limb muscles

MicroRNAs (miRs) regulate complex processes, including angiogenesis, by targeting multiple mRNAs. miR-24-3p-3p directly represses eNOS, GATA2, and PAK4 in endothelial cells (ECs), thus inhibiting angiogenesis during development and in the infarcted heart. miR-24-3p is widely expressed in cardiovascular cells, suggesting that it could additionally regulate angiogenesis by acting on vascular mural cells. Here, we have investigated: (1) new miR-24-3p targets; (2) the expression and the function of miR-24-3p in human vascular ECs; (3) the impact of miR-24-3p inhibition in the angiogenesis reparative response to limb ischemia in mice. Using bioinformatics target prediction platforms and 3′-UTR luciferase assays, we newly identified Notch1 and its Delta-like ligand 1 (Dll1) to be directly targeted by miR-24-3p. miR-24-3p was expressed in human ECs and pericytes cultured under normal conditions. Exposure to hypoxia increased miR-24-3p in ECs but not in pericytes. Transfection with a miR-24-3p precursor (pre-miR-24-3p) increased miR-24-3p expression in ECs, reducing the cell survival, proliferation, and angiogenic capacity. Opposite effects were caused by miR-24-3p inhibition. The anti-angiogenic action of miR-24-3p overexpression could be prevented by simultaneous adenovirus (Ad)-mediated delivery of constitutively active Notch intracellular domain (NICD) into cultured ECs. We next demonstrated that reduced Notch signalling contributes to the anti-angiogenic effect of miR-24-3p in vitro. In a mouse unilateral limb ischemia model, local miR-24-3p inhibition (by adenovirus-mediated miR-24-3p decoy delivery) restored endothelial Notch signalling and increased capillary density. However, the new vessels appeared disorganised and twisted, worsening post-ischemic blood perfusion recovery. To better understand the underpinning mechanisms, we widened the search for miR-24-3p target genes, identifying several contributors to vascular morphogenesis, such as several members of the Wingless (Wnt) signalling pathway, β-catenin signalling components, and VE-cadherin, which synergise to regulate angiogenesis, pericytes recruitment to neoformed capillaries, maturation, and stabilization of newly formed vessels. Among those, we next focussed on β-catenin to demonstrate that miR-24-3p inhibition reduces β-catenin expression in hypoxic ECs, which is accompanied by reduced adhesion of pericytes to ECs. In summary, miR-24-3p differentially targets several angiogenesis modulators and contributes to autonomous and non-autonomous EC crosstalk. In ischemic limbs, miR-24-3p inhibition increases the production of dysfunctional microvessels, impairing perfusion. Caution should be observed in therapeutic targeting of miR-24-3p

Exact Kohn-Sham exchange kernel for insulators and its long-wavelength behavior

We present an exact expression for the frequency-dependent Kohn-Sham exact-exchange (EXX) kernel for periodic insulators, which can be employed for the calculation of electronic response properties within time-dependent (TD) density-functional theory. It is shown that the EXX kernel has a long-wavelength divergence behavior of the exact full exchange-correlation kernel and thus rectifies one serious shortcoming of the adiabatic local-density approximation and generalized-gradient approximations kernels. A comparison between the TDEXX and the GW-approximation-Bethe-Salpeter-equation approach is also made.Comment: two column format 6 pages + 1 figure, to be publisehd in Physical Review

A large-solid-angle X-ray Raman scattering spectrometer at ID20 of the European Synchrotron Radiation Facility

An end-station for X-ray Raman scattering spectroscopy at beamline ID20 of the European Synchrotron Radiation Facility is described. This end-station is dedicated to the study of shallow core electronic excitations using non-resonant inelastic X-ray scattering. The spectrometer has 72 spherically bent analyzer crystals arranged in six modular groups of 12 analyzer crystals each for a combined maximum flexibility and large solid angle of detection. Each of the six analyzer modules houses one pixelated area detector allowing for X-ray Raman scattering based imaging and efficient separation of the desired signal from the sample and spurious scattering from the often used complicated sample environments. This new end-station provides an unprecedented instrument for X-ray Raman scattering, which is a spectroscopic tool of great interest for the study of low-energy X-ray absorption spectra in materials under insitu conditions, such as inoperando batteries and fuel cells, insitu catalytic reactions, and extreme pressure and temperature conditions.Peer reviewe