Total arthroplasty in cases of posttraumatic protrusion hip arthritis

A retrospective analysis THA results in patients with acetabular bottom protrusion was carried out. Clinical examination, anthropometric analisys and calculation results on a Harris scale were used. The 87 patients with acetabular protrusion hip arthritis were examined, including 56 (64%) women and 31 (36%) men. The number of patients with posttraumatic protrusion hip arthritis was 13 (15%): 9 women and 4 men. A mild degree of protrusion according to Soleo-Garza and Charnley classification was diagnosed in 6 (46.2%) patients, moderate degree - in 3 (23%) and severe degree - in 4 (44.4%) patients. In cases of mild protrusion average time between the trauma and operation was 5 years, in the moderate degree - 7 years and in the severe degree - 13 years. THA for different degrees of protrusion needs for special surgical technics. The need for plastic, as well as the size of the grafts, was determined during THA. In the group of patients with mild and moderate degrees of acetabular protrusion before the THA the average scores on the Harris scale were 35 and 27 points, respectively. After the operation, the indices doubled. One year after the operation, the average points on the Harris scale were 90 and 92. So the patients reached an excellent result. In the group of patients with severe grade before the THA the average score on the Harris scale was 20 points. After the operation, the average score on the Harris scale increased to 48, and one year later was 87 points, which corresponds to a good result. An unilateral protrusion of the acetabulum is a sign of posttraumatic protrusion hip arthritis. Between the beginning of the disease and the THA a period of 5 to 20 years passes. During this time the patient can forget about the fact of injury. Therefore, unilateral protrusion hip arthritis requires a precise analysis of the anamnesis. The screwed cup of the implant makes possible to perform a full grafting of the protrusion acetabular defect. The type of bone frafting of the protrusion defects do not have a significant effect on the restoration of hip joint function in the postoperative period. So obtaining results of THA in cases of posttraumatic protrusion hip arthritis are comparable with the results of routine THA

Over-expression of β-catenin is associated with high grade of prostatic cancer in Libyan patients

Objectives: At present, sufficient prognostic markers for prostate cancer (PCa) progression are still lacking, in spite of thorough investigation. The aim of this study was to evaluate abnormalities of β-catenin protein expression, subcellular localization and determine its relation to different clinicopathological features anddisease free survival in prostate cancer patients.Patients and methods: Forty prostate cancer specimens, obtained from patients with different stages of prostate cancer (83% stage IV) who underwent a radical prostatectomy or TURP flanked by 2006 and 2011, β-catenin was determined by immuno-histochemistry (IHC). The membranous expression was semi- quantitatively evaluated in four scores (0, 1+, 2+, 3+). Clinical records of these patients were studied for follow up data.Results: β-Catenin immune staining results show over-expression of β-catenin in PCa Libyan patients. There was no statistically significant difference in β-catenin immune expression as regards histopathological type, perineural invasion, tumor stage, biological recurrence. However, β-catenin over-expression showed significant correlation with old age (p < 0.014).Conclusions: We concluded that changes in expression and cell distribution of β-catenin correlated with the progression degree of prostate adenocarcinoma, signifying a role of this molecule as a marker of progression and prognosis. Further investigations, on a larger and more heterogeneous population, should be carried out to validate and extend our results.Keywords: Prostate cancer; β-Catenin expression; Immuno-histochemistry; Gleason score; Prognosi

Analysis of Blood Cultures in Major Burns in Tertiary Care Burn Unit in Oman

Objectives: In this study we review blood stream infections of major burns in a tertiary care burn unit to determine the most prevalent organisms in order to have a better empirical therapy protocol. Methods: This is a retrospective study where blood stream infection of major burns (>20% Total Body Surface Area) were analysed. Results:155 patients fulfilled the criteria. Median age was 33 years.  Median TBSA was 38%. 57.42% were males and 42.58% were females. Mortality was 25.16%. 50.9% of patients had positive blood culture. Expired patients had higher TBSA, Abbreviated Burns Severity Index score and earlier first positive blood culture. The most prevalent organisms grown from all blood cultures were Acinetobacter, staphylococci, Klebsiella, Enterococcus and pseudomonas. Candida is also commonly grown in blood cultures. All Acinetobacter species are always multidrug resistant. 8 of 14 patients had multidrug resistant Klebsiella.  There were only 4 patients who had Methicilin resistant Staphylococcus Aureus (MRSA) grown. The number of blood cultures samples taken ranged from 1 to 28 (median 6). First positive blood culture showed that Staphylococcus epidermidis   and Acinetobacter are the most common organisms. Conclusion: In conclusion multidrug resistant Acinetobcater has become the most predominant microorganism grown in blood cultures of major burns in our unit. Empirical therapy should include antibiotics that are effective against it to reduce the mortality. Keywords: Infection; Blood; Burn; Resistance; Antibiotics; Culture

Observation of a new charged charmoniumlike state in B -> J/psi K pi decays

We present the results of an amplitude analysis of anti-B0 -> J/psi K- pi+ decays. A new charged charmoniumlike state Zc(4200)+ decaying to J/psi pi+ is observed with a significance of 6.2 sigma. The mass and width of the Zc(4200)+ are 4196 +31-29 +17-13 MeV/c^2 and 370 +70-70 +70-132 MeV, respectively; the preferred assignment of the quantum numbers is J^P = 1^+. In addition, we find evidence for Zc(4430)+ -> J/psi pi+. The analysis is based on a 711 fb^-1 data sample collected by the Belle detector at the asymmetric-energy e+ e- collider KEKB.Comment: 14 pages, 13 figure

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

Drugs targeting atrial-specific ion channels, K(v)1.5 or K(ir)3.1/3.4, are being developed as new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried out in non-cardiac cell lines or animal models may not accurately represent the physiology of a human cardiomyocyte (CM). In the current study, we tested whether human embryonic stem cell (hESC)-derived atrial CMs could predict atrial selectivity of pharmacological compounds. By modulating retinoic acid signaling during hESC differentiation, we generated atrial-like (hESC-atrial) and ventricular-like (hESC-ventricular) CMs. We found the expression of atrial-specific ion channel genes, KCNA5 (encoding Kv1.5) and KCNJ3 (encoding K-ir 3.1), in hESC-atrial CMs and further demonstrated that these ion channel genes are regulated by COUP-TF transcription factors. Moreover, in response to multiple ion channel blocker, vernakalant, and K(v)1.5 blocker, XEN-D0101, hESC-atrial but not hESC-ventricular CMs showed action potential (AP) prolongation due to a reduction in early repolarization. In hESC-atrial CMs, XEN-R0703, a novel K(ir)3.1/3.4 blocker restored the AP shortening caused by CCh. Neither CCh nor XEN-R0703 had an effect on hESC-ventricular CMs. In summary, we demonstrate that hESC-atrial CMs are a robust model for pre-clinical testing to assess atrial selectivity of novel antiarrhythmic drugs

Semi-inclusive studies of semileptonic BsB_s decays at Belle

We present an analysis of the semi-inclusive decays $B_s \to D_s^- X \ell^+ \nu$ and $B_s \to D_s^{*-} X \ell^+ \nu$, where $X$ denotes a final state that may consist of additional hadrons or photons and $\ell$ is an electron or muon. The studied $B_s$ decays are contained in the $121.4~{\rm fb}^{-1}$ $\Upsilon(5S)$ data sample collected by the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. The branching fractions of the decays are measured to be $\mathcal{B}(B_s \to D_s^- X \ell^+ \nu) = [8.2 \pm 0.2 (\text{stat}) \pm 0.6 (\text{syst}) \pm 1.4 (\text{ext})]\%$ and $\mathcal{B}(B_s \to D_s^{*-} X \ell^+ \nu) = [5.4 \pm 0.4 (\text{stat}) \pm 0.4 (\text{syst}) \pm 0.9 (\text{ext})]\%$, where the first two uncertainties are statistical and systematic and the last is due to external parameters. The measurement also provides an estimate of the $B_s^{(*)}\bar{B}_s^{(*)}$ production cross-section, $\sigma(e^+e^- \to B_s^{(*)}\bar{B}_s^{(*)}) = (53.8 \pm 1.4 (\text{stat}) \pm 4.0 (\text{syst}) \pm 3.4 (\text{ext}))\,{\rm pb}$, at the center-of-mass energy $\sqrt{s} = 10.86\,{\rm GeV}$.Comment: 13 pages, 2 figures, submitted to Phys. Rev.

Allergic Rhinitis and its Associated Co-Morbidities at Bugando Medical Centre in Northwestern Tanzania; A Prospective Review of 190 Cases.

Allergic rhinitis is one of the commonest atopic diseases which contribute to significant morbidity world wide while its epidemiology in Tanzania remains sparse. There was paucity of information regarding allergic rhinitis in our setting; therefore it was important to conduct this study to describe our experience on allergic rhinitis, associated co-morbidities and treatment outcome in patients attending Bugando Medical Centre. This was descriptive cross-sectional study involving all patients with a clinical diagnosis of allergic rhinitis at Bugando Medical Centre over a three-month period between June 2011 and August 2011. Data was collected using a pre-tested coded questionnaire and analyzed using SPSS statistical computer software version 17.0. A total of 190 patients were studied giving the prevalence of allergic rhinitis 14.7%. The median age of the patients was 8.5 years. The male to female ratio was 1:1. Adenoid hypertrophy, tonsillitis, hypertrophy of inferior turbinate, nasal polyps, otitis media and sinusitis were the most common co-morbidities affecting 92.6% of cases and were the major reason for attending hospital services. Sleep disturbance was common in children with adenoids hypertrophy (χ2 = 28.691, P = 0.000). Allergic conjunctivitis was found in 51.9%. The most common identified triggers were dust, strong perfume odors and cold weather (P < 0.05). Strong perfume odors affect female than males (χ2 = 4.583, P = 0.032). In this study family history of allergic rhinitis was not a significant risk factor (P =0.423). The majority of patients (68.8%) were treated surgically for allergic rhinitis co morbidities. Post operative complication and mortality rates were 2.9% and 1.6% respectively. The overall median duration of hospital stay of in-patients was 3 days (2 - 28 days). Most patients (98.4%) had satisfactory results at discharge. The study shows that allergic rhinitis is common in our settings representing 14.7% of all otorhinolaryngology and commonly affecting children and adolescent. Sufferers seek medical services due to co-morbidities of which combination of surgical and medical treatment was needed. High index of suspicions in diagnosing allergic rhinitis and early treatment is recommended

Measurement of the Decays B→ηℓνℓ\boldsymbol{B\to\eta\ell\nu_\ell} and B→η′ℓνℓ\boldsymbol{B\to\eta^\prime\ell\nu_\ell} in Fully Reconstructed Events at Belle

We report branching fraction measurements of the decays $B^+\to\eta\ell^+\nu_\ell$ and $B^+\to\eta^\prime\ell^+\nu_\ell$ based on 711~fb$^{-1}$ of data collected near the $\Upsilon(4S)$ resonance with the Belle experiment at the KEKB asymmetric-energy $e^+e^-$ collider. This data sample contains 772 million $B\bar B$~events. One of the two $B$~mesons is fully reconstructed in a hadronic decay mode. Among the remaining ("signal-$B$") daughters, we search for the $\eta$~meson in two decay channels, $\eta\to\gamma\gamma$ and $\eta\to\pi^+\pi^-\pi^0$, and reconstruct the $\eta^{\prime}$~meson in $\eta^\prime\to\eta\pi^+\pi^-$ with subsequent decay of the $\eta$ into $\gamma\gamma$. Combining the two $\eta$ modes and using an extended maximum likelihood, the $B^+\to\eta\ell^+\nu_\ell$ branching fraction is measured to be $(4.2\pm 1.1 (\rm stat.)\pm 0.3 (\rm syst.))\times 10^{-5}$. For $B^+\to\eta^\prime\ell^+\nu_\ell$, we observe no significant signal and set an upper limit of $0.72\times 10^{-4}$ at 90\% confidence level.Comment: 8 pages, 4 figure

Search for a dark vector gauge boson decaying to π+π−\pi^+ \pi^- using η→π+π−γ\eta \rightarrow \pi^+\pi^- \gamma decays

We report a search for a dark vector gauge boson $U^\prime$ that couples to quarks in the decay chain $D^{*+} \to D^0 \pi^+, D^0 \to K^0_S \eta, \eta \to U^\prime \gamma$, $U^\prime \to \pi^+ \pi^-$. No signal is found and we set a mass-dependent limit on the baryonic fine structure constant of $10^{-3} - 10^{-2}$ in the $U^\prime$ mass range of 290 to 520 MeV/$c^2$. This analysis is based on a data sample of 976 fb$^{-1}$ collected by the Belle experiment at the KEKB asymmetric-energy $e^+e^-$ collider.Comment: 6 pages, 4 figure