Flight Planning Tool an Aid for Efficient Flight Evaluation

Airborne surveillance systems have multiple sensors and communication links on board a suitable platform. They work in a cohesive manner to provide effective surveillance over the region of interest. The performance proving of such a system is challenging and requires flight trails extending over years. The test results often have to be interpreted using statistical analysis of the flight test data. An efficient way is to carefully design the flight test profiles such that enough samples can be collected during the test and multiple requirements can be tested in a single sortie. Such meticulous test strategies where both own ship platform and test targets are moving with high dynamics call for software based tool for planning of test sorties and the test points. Flight Planning Tool (FPT) plays an important role in pre-flight stage during developmental trials for analysis of the MOEs and MOPs of overall system and of various on-board sensors of an airborne multi-sensor system. The FPT provides statistical & graphical analysis for sensor behaviour for various scenarios (flight trials) before actual flight test is conducted. It provides prior information on number of valid samples for sensor testing during flight trials. In addition, the tool aids in assessing number of profiles to be flown for proving each MOE. The profiles can also be optimised such that valid samples are collected for evaluation

MYCbase: a database of functional sites and biochemical properties of Myc in both normal and cancer cells

Abstract Background Myc is an essential gene having multiple functions such as in cell growth, differentiation, apoptosis, genomic stability, angiogenesis, and disease biology. A large number of researchers dedicated to Myc biology are generating a substantial amount of data in normal and cancer cells/tissues including Burkitt’s lymphoma and ovarian cancer. Results MYCbase ( http://bicresources.jcbose.ac.in/ssaha4/mycbase ) is a collection of experimentally supported functional sites in Myc that can influence the biological cellular processes. The functional sites were compiled according to their role which includes mutation, methylation pattern, post-translational modifications, protein-protein interactions (PPIs), and DNA interactions. In addition, biochemical properties of Myc are also compiled, which includes metabolism/pathway, protein abundance, and modulators of protein-protein interactions. The OMICS data related to Myc- like gene expression, proteomics expression using mass-spectrometry and miRNAs targeting Myc were also compiled in MYCbase. The mutation and pathway data from the MYCbase were analyzed to look at the patterns and distributions across different diseases. There were few proteins/genes found common in Myc-protein interactions and Myc-DNA binding, and these can play a significant role in transcriptional feedback loops. Conclusion In this report, we present a comprehensive integration of relevant information regarding Myc in the form of MYCbase. The data compiled in MYCbase provides a reliable data resource for functional sites at the residue level and biochemical properties of Myc in various cancers

Labor analgesia in parturients of fetal growth restriction having raised umbilical Doppler vascular indices

Background and Aims: Fetuses with abnormal umbilical blood flow are at a higher risk of adverse perinatal outcome than those with normal flow. Epidural analgesia (EA) has shown to decrease villous vascular resistance in preeclamptic women during labor. The present study evaluates the effects of epidural ropivacaine and intramuscular (IM) tramadol on Doppler blood flow in parturients with fetal growth restriction and raised umbilical artery (UmA) blood flow. Material and Methods: In this prospective nonrandomized comparative study, 36 term parturients with sonographic evidence of UmA systolic-diastolic (S-D) ratio ≥3 were enrolled. Parturients received either continuous epidural ropivacaine 0.2% or 1 mg/kg IM tramadol 4–6 hourly. Doppler flow parameters of UmA and bilateral uterine arteries (UtAs) were measured at 0, 1, and 6 h of labor analgesia. Doppler indices change with time during labor analgesia was assessed as the primary outcome. Change of Doppler indices of UtAs, Apgar score, and cord blood gases was considered as secondary measures. Results: Data from thirty laboring women who completed the study were analyzed. The pulsatility index, resistance index, and S-D ratio in UmA and right UtA reduced significantly with continuous epidural infusion during first 6 h of labor. However, these values increased or unchanged with tramadol administration. Better neonatal pH and base deficit (P = 0.039) were observed with EA. Conclusions: Continuous epidural ropivacaine causes improved fetoplacental circulation in parturients with growth-restricted fetuses having raised Doppler indices during labor analgesia. We also found better neonatal outcome with continuous infusion of epidural ropivacaine as compared to IM tramadol

Supplementary tables and figures for PPIMpred: A web server for high throughput screening of small molecules targeting Protein- Protein Interaction_ESM from PPIMpred: a web server for high-throughput screening of small molecules targeting protein–protein interaction

Supplementary 30 tables and 29 figure