Configuration-specific attentional modulation of flanker target lateral interactions

Elements of a contour are often easier to detect when they possess collinearity, with their local orientations matching the global orientation of the contour. We recently reported attentional modulation of such lateral interactions between a central near-threshold target Gabor patch and flanking high-contrast patches (Freeman et al, 2001 Nature Neuroscience 4 1032-1036). Here, we examined whether such attentional effects reflect specific modulation of mechanisms sensitive to collinear configurations, or instead more general modulation of sensitivity to either the global or local orientation-components of the stimulus. Thresholds for detecting a central Gabor target were measured, while observers also judged the Vernier alignment between one pair of flankers and ignored a second flanker pair (when present). Target contrast-thresholds were facilitated only when attending collinear flankers. There was no facilitation when attending flankers that shared only local orientation with the target, or flankers that fell on a global axis aligned with target orientation but having orthogonal local orientation. Ignored collinear flankers had no effect on target thresholds. These results demonstrate strong and specific attentional modulation of contour-integration mechanisms in early vision sensitive to collinear configurations

Kalsifikasi Skeleton Aksial Pada Regenerat Ekor Kadal {Mabouya multifasciata Kuhl)

Kadal {Mabouya multifasciata Kuhl) merupakan salah satu anggota Lacertilia yang terdapat di Indonesia yang dapat mengalami regenerasi setelah hewan tersebut mengalami autotomi ekor. Penelitian ini bertujuan untuk mengetahui kalsifikasi yang terjadi pada skeleton aksial regenerat ekor kadal. Empat puluhdelapan ekor kadal jantan dewasa berekor asli diautotomi ekornya, dipelihara, dan dibagi menjadi 4 kelompok yang terdiri dari 12 individu ( kelompok I, kelompok II, kelompok III, kelompok IV), masing-masing kelompck berturut-turut mempunyai umur regenerat 4,5,6, dan 12 minggu. Setelah itu dibuat preparat utuh regenerat ekor dengan pewamaan Alizarin RedS-Alcian Blue dan preparat irisan melintang regenerat ekor dengan pewamaan perak nitrat von Kossa. Hasil penelitian menunjukkan bahwa penulangan secara endokondralis diawali dengan kalsifikasi pada scbagian sisi dalam dan sebagian sisi luar tabung tulang rawan regenerat ekor umur 5 minggu. Pada regenerat ekor berumur 6 dan 12 minggu kalsifikasi sudah meluas ke_seluruh sisi dalam dan sisi luar tabung tulang rawan. Kata kunci: kalsifikasi, skeleton aksial, regenerat ekor, kada

Molt-inhibiting hormone stimulates vitellogenesis at advanced ovarian developmental stages in the female blue crab, Callinectes sapidus 2: novel specific binding sites in hepatopancreas and cAMP as a second messenger

The finding that molt-inhibiting hormone (MIH) regulates vitellogenesis in the hepatopancreas of mature Callinectes sapidus females, raised the need for the characterization of its mode of action. Using classical radioligand binding assays, we located specific, saturable, and non-cooperative binding sites for MIH in the Y-organs of juveniles (J-YO) and in the hepatopancreas of vitellogenic adult females. MIH binding to the hepatopancreas membranes had an affinity 77 times lower than that of juvenile YO membranes (KD values: 3.22 × 10-8 and 4.19 × 10-10 M/mg protein, respectively). The number of maximum binding sites (BMAX) was approximately two times higher in the hepatopancreas than in the YO (BMAX values: 9.24 × 10-9 and 4.8 × 10-9 M/mg protein, respectively). Furthermore, MIH binding site number in the hepatopancreas was dependent on ovarian stage and was twice as high at stage 3 than at stages 2 and 1. SDS-PAGE separation of [125I] MIH or [125I] crustacean hyperglycemic hormone (CHH) crosslinked to the specific binding sites in the membranes of the J-YO and hepatopancreas suggests a molecular weight of ~51 kDa for a MIH receptor in both tissues and a molecular weight of ~61 kDa for a CHH receptor in the hepatopancreas. The use of an in vitro incubation of hepatopancreas fragments suggests that MIH probably utilizes cAMP as a second messenger in this tissue, as cAMP levels increased in response to MIH. Additionally, 8-Bromo-cAMP mimicked the effects of MIH on vitellogenin (VtG) mRNA and heterogeneous nuclear (hn) VtG RNA levels. The results imply that the functions of MIH in the regulation of molt and vitellogenesis are mediated through tissue specific receptors with different kinetics and signal transduction. MIH ability to regulate vitellogenesis is associated with the appearance of MIH specific membrane binding sites in the hepatopancreas upon pubertal/final molt

HESS Opinions "Should we apply bias correction to global and regional climate model data?"

Despite considerable progress in recent years, output of both global and regional circulation models is still afflicted with biases to a degree that precludes its direct use, especially in climate change impact studies. This is well known, and to overcome this problem, bias correction (BC; i.e. the correction of model output towards observations in a post-processing step) has now become a standard procedure in climate change impact studies. In this paper we argue that BC is currently often used in an invalid way: it is added to the GCM/RCM model chain without sufficient proof that the consistency of the latter (i.e. the agreement between model dynamics/model output and our judgement) as well as the generality of its applicability increases. BC methods often impair the advantages of circulation models by altering spatiotemporal field consistency, relations among variables and by violating conservation principles. Currently used BC methods largely neglect feedback mechanisms, and it is unclear whether they are time-invariant under climate change conditions. Applying BC increases agreement of climate model output with observations in hindcasts and hence narrows the uncertainty range of simulations and predictions without, however, providing a satisfactory physical justification. This is in most cases not transparent to the end user.We argue that this hides rather than reduces uncertainty, which may lead to avoidable forejudging of end users and decision makers. We present here a brief overview of state-of-the-art bias correction methods, discuss the related assumptions and implications, draw conclusions on the validity of bias correction and propose ways to cope with biased output of circulation models in the short term and how to reduce the bias in the long term. The most promising strategy for improved future global and regional circulation model simulations is the increase in model resolution to the convection-permitting scale in combination with ensemble predictions based on sophisticated approaches for ensemble perturbation. With this article, we advocate communicating the entire uncertainty range associated with climate change predictions openly and hope to stimulate a lively discussion on bias correction among the atmospheric and hydrological community and end users of climate change impact studies

NMR characterization of spin-1/2 alternating antiferromagnetic chains in the high-pressure phase of (VO)2P2O7

Local-susceptibility measurements via the NMR shifts of $^{31}$P and $^{51}$V nuclei in the high-pressure phase of (VO)$_{2}$P$_{2}$O$_{7}$ confirmed the existence of a unique alternating antiferromagnetic chain with a zero-field spin gap of 34 K. The $^{31}$P nuclear spin-lattice relaxation rate scales with the uniform spin susceptibility below about 15 K which shows that the temperature dependence of both the static and dynamical spin susceptibilities becomes identical at temperatures not far below the spin-gap energy.Comment: 6 pages, 5 figures; To be published in J. Phys. Condens. Matte

Bannayan Ruvalcaba Riley Syndrome

A 63-year-old male with history of prostate cancer treated with radiation presented for a colonoscopy for small volume hematochezia. The colonoscopy revealed numerous polyps, which were found to be ganglioneuromas on histological examination. He was referred to medical genetics with suspicion for hamartomatous polyposis syndrome and was found to have a mutation in the PTEN gene. Based on this and suggestive clinical findings, he was diagnosed with Bannayan Ruvalcaba Riley syndrome

Interactions of Generated Weather Raster and Soil Profiles in Simulating Adaptive Crop Management and Consequent Yields for Five Major Crops throughout a Region in Southern Germany

Klimaanpassung und MitigationThe ability of bioeconomic simulation modelling to realistically predict agricultural adaptation is limited by the degree of detail in crucial model components. Model robustness must be tested before localized calibrations can be applied to regions of heterogenous environmental conditions. The agent-based model FARMACTOR was used to simulate the timing of field management actions (planting, harvest etc.) in response to environmental conditions, and consequent yields of winter wheat, barley and rapeseed, spring barley and silage maize as the predominant crops in a distinct region of Germany, by linking weather data and the crop growth simulation model EXPERT-N. The integrated models were calibrated to observed experimental data and official phenological observations and then run from 1990 to 2009, forced with climate data from ERA-interim Reanalyses data which was downscaled with the Weather and Research Forecast (WRF) model to a 12 X 12 km² grid. Variability in regional soils was replicated with 10 different soil profiles mapped at 1/25,000 scale. The nature of the forcing climate data dictates temporal aggregation for analysis, so that validity is examined by comparing mean simulated planting and harvest dates and yields to official records in the area. The mean predicted planting dates are very close to observations over the period, within a few days of observations, but show less variance. Harvest dates are accurately predicted as well, within one to two weeks, and the variances are closer to observations. Predicted winter wheat yields are well simulated in comparison to observed data, but maize yields are underestimated, while winter and spring barley and winter rapeseed yields are greater than observed district ("Landkreis") yields. The degree of variance in simulated yields is acceptable in wheat, winter barley and maize, but excessive in spring barley and winter rapeseed. Cross-sectional examination of yields shows that the different soil profiles are responsible for more yield variance than simulated weather cells in all crops. While the coupled models appear accurate in predicting crop management dates and physiological development, the inaccuracy in yields in all crops except winter wheat calls into question the reliability of the integrated models when applied, as is, outside of calibration conditions. That soil parameterization is responsible for more variance than generated weather is helpful in seeking to improve performance and encouraging in terms of the method of weather generation. Reliable extension of the coupled models to include all soils in an area together with artificial spatial climatic variability may require regionalized calibration to increase crop model stability

Staggered-spin contribution to nuclear spin-lattice relaxation in two-leg antiferromagnetic spin-1/2 ladders

We study the nuclear spin-lattice relaxation rate $1/T_1$ in the two-leg antiferromagnetic spin-1/2 Heisenberg ladder. More specifically, we consider the contribution to $1/T_1$ from the processes with momentum transfer $(\pi,\pi)$. In the limit of weak coupling between the two chains, this contribution is of activation type with gap $2\Delta$ at low temperatures ($\Delta$ is the spin gap), but crosses over to a slowly-decaying temperature dependence at the crossover temperature $T\approx\Delta$. This crossover possibly explains the recent high-temperature NMR results on ladder-containing cuprates by T. Imai et al.Comment: 6 pages, 2 figures, REVTeX, uses eps