An Analysis Of Apology Expressions Found In Twilight Movie Series

This study aims at classifying apology strategies used by the characters in Twilight movie series as well as classifying factors that influence how the characters apologize. This study analyzed all utterances consisting of apology expressions uttered by the characters. The technique of collecting data was document analysis.The data were analyzed by using apology strategies theory by Ishihara & Cohen (2010) and apology factors theory by Holmes (1989). The findings showed that from the 73 data discovered, the researcher only found less than ten apology strategies and less than twelve apology factors. Apology strategies used by the characters were expression of an apology, explanation or account, promise of nonrecurrence, accepting the blame, expressing self-deficiency, and offer of repair.Factors that influence how the characters apologize were intimates, very close friends, friends, distant acquaintances, strangers, light, medium, heavy, upwards, equal, and downwards. Interestingly, the researcher does not only find single apology strategy, the researcher also finds combination of two apology strategies.The researcher finds that all of the apology factors are in combination forms

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.

Inhibitors against the p110δ isoform of phosphoinositide-3-OH kinase (PI(3)K) have shown remarkable therapeutic efficacy in some human leukaemias. As p110δ is primarily expressed in leukocytes, drugs against p110δ have not been considered for the treatment of solid tumours. Here we report that p110δ inactivation in mice protects against a broad range of cancers, including non-haematological solid tumours. We demonstrate that p110δ inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression. Thus, p110δ inhibitors can break tumour-induced immune tolerance and should be considered for wider use in oncology

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

HUBUNGAN PENGETAHUAN ORANG TUA TERHADAP KETERAMPILAN MENGGOSOK GIGI ANAK USIA TK DAN SD DI INDONESIA (STUDI LITERATUR)

INTISARIHanani Safina F., 2020. Hubungan Pengetahuan Orangtua Terhadap Keterampilan Anak Kelas 1 di SD Negeri Srondol Wetan 04 (Studi Literatur), Karya Tulis Ilmiah, Jurusan keperawatan Gigi Politeknik Kesehatan Kemenkes Semarang, Pembimbing : (1) Dr. Bedjo Santoso, S,SiT,M.Kes, (II) Prasko,S,SiT,M.H. Berdasarkan Riset Kesehatan Dasar (Riskesdas) tahun 2018 menyebutkan prevalensi nasional perilaku menyikat gigi setiap hari pada penduduk umur ? 3 tahun dijumpai sebesar 94,7%. Namun pada perilaku menggosok gigi dengan benar pada penduduk umur ? 3 tahun hanya sebesar 2,8%. Kesehatan gigi dan mulut merupakan hal penting dan harus dijaga kebersihannya, termasuk menggosok gigi. Agar terbentuknya kebiasaan menggosok gigi diperlukannya peran serta orangtua di rumah. Begitu pula dengan keterampilan anak menggosok gigi. Tentunya dengan peran orang tua akan berpengaruh pada keterampilan anak menggosok gigi. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan orang tua tentang menggosok gigi terhadap keterampilan menggosok gigi anak. Jenis penelitian ini merupakan studi kepustakaan, dengan sumber literatur maupun jurnal. Variabel pengaruh penelitian ini adalah pengetahuan orang tua tentang menggosok gigi dan variabel terpengaruhnya adalah keterampilan menggosok gigi anak.Hasil studi literartur menujukan pengetahuan orang tua tentang menggosok gigi berpengaruh terhadap keterampilan menggosok gigi anak. Hal ini tetap dikatakan adanya hubungan walaupun orang tua yang memiliki pengetahuan cukup baik belum tentu anak terampil dalam menggosok gigi yang baik dan benar dan hanya saja anak yang belum begitu memperhatikan pentingnya menggosok gigi dengan benar. Oleh karena itu diharapkan peran besar orang tua yang dalam mendampingi anak menggosok gigi.Kata kunci: Menggosok Gigi, Keterampilan Anak, Pengetahuan Orang Tu

Pengembangan Pelabuhan Penyeberangan Desa Bajoe Sebagai Penunjang Wisata Pulau Bokori, Sulawesi Tenggara

Pelabuhan merupakan infrastuktur transportasi air untuk menunjang pergerakan manusia dan barang dalam lintas pulau dengan menempuh jalur laut maupun sungai. Pelabuhan Penyeberangan Desa Bajoe sebagai pelabuhan yang khusus melayani pergerakan wisatawan Pulau Bokori yang telah beroperasi selama delapan tahun. Jumlah wisatawan yang menggunakan jasa pelabuhan ini mencapai 40.194 penumpang pada tahun 2019 akan tetapi pelayanan pada pelabuhan masih memiliki kekurangan. Tujuan penelitian ini untuk melakukan evaluasi terhadap fasilitas pelayanan pelabuhan berdasarkan presepsi penumpang agar kinerja pelayanan Pelabuhan Penyeberangan Desa Bajoe tetap maksimal dalam melayani wisatawan dan memberikan arahan pengembangan untuk Pelabuhan Desa Bajoe. Teknik analisis yang digunakan untuk meninjau kondisi internal dan eksternal Pelabuhan yang terdiri dari analsisi deskriptif 5 aspek (Spasial, social, ekonomi, infarstruktur dan lingkungan), analisis oseanografi analisis konten, analisis jaringan jalan, analisis linkage system, analisis potensi dan masalah, analisis SWOT, Analisis IPA dan QFD. Hasil analisis menunjukan jalan akses ke Pelabuhan memiliki lebar yang belum memenuhi standar dan arus lalu lintas stabil serta sudah terintegrasi dengan objek wisata, pusat kuliner dan oleh-oleh serta sarana akomodasi akan tetapi lebar jalan tidak sesusai standar serta lampu penerangan jalan tidak tersedia. Kondisi surut dermaga mencapai 1,8 meter. Kemudian, berdasarkan presepsi penumpang fasilitas yang perlu ditingkatkan adalah toilet, aksesbilitas, lampu penerangan, dan fasilitas pelayanan informasi. Sehingga, arahan pengembangan Pelabuhan Penyebrangan Desa Bajoe yang terdiri dari pengembangan eksternak (luar Pelabuhan) yaitu peningkatan lebar jalan, pengerukan lahan dan penyediaan lampu penerangan jalan. Kemudian, strategi internal Pelabuhan meliputi penyediaan dermaga apung, dan peyediaan fasilitas pada pelabuhan berupa toilet, kesehatan, keamanan, fasilitas difabel, informasi pelayanan dan lain sebagainya

BDNF-TrkB axis regulates migration of the lateral line primordium and modulates the maintenance of mechanoreceptor progenitors.

BDNF and its specialized receptor TrkB are expressed in the developing lateral line system of zebrafish, but their role in this organ is unknown. To tackle this problem in vivo, we used transgenic animals expressing fluorescent markers in different cell types of the lateral line and combined a BDNF gain-of-function approach by BDNF mRNA overexpression and by soaking embryos in a solution of BDNF, with a loss-of-function approach by injecting the antisence ntrk2b-morpholino and treating embryos with the specific Trk inhibitor K252a. Subsequent analysis demonstrated that the BDNF-TrkB axis regulates migration of the lateral line primordium. In particular, BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a