STEP-NC-compliant implementation to support mixed-control technologies applied to stone-processing machines based on industrial automation standards

STEP-NC (Standard for the Exchange of Product Model Data–Numerical Control) for metal milling and turning is not implemented by industrial computer numerical controllers. Solutions reported are prototypes based on post-processing in G-code. Moreover, minority machining processes, such as stone cutting, have not yet been contemplated in the STEP-NC standard. This article takes that sector as a use case. An extended STEP-NC model for circular saw stone-cutting operations is proposed, and a prototype automation implementation is developed to work with this extended model. This article shows how modern technological resources for coordinated axes control provided by many industrial controllers for the automation of general-purpose machines can speed up the processes of implementing STEP-NC numerical controllers. This article proposes a mixed and flexible approach for STEP-NC-based machine automation, where different strategies can coexist when it comes to executing STEP-NC machining files, so controllers do not need to implement the standard in an exhaustive way for all the possible features, but only at selected ones when convenient. This is demonstrated in a prototype implementation which is able to process STEP-NC product files with mixed-feature types: standard milling and non-standard sawblade features for stone processing

Automatic generation of digital twin industrial system from a high level specification

A framework for the generation of industrial digital twins is presented in the paper. The framework supports industry automated systems preliminary design development, but also supports the following detailed designs implementation and final systems exploitation phases. The main problem is that requirements for first development phases are much more generic than those required for the later phases. The framework faces this problem by avoiding too detailed specifications for the digital twin generated software, but, at the same time, it takes advantage of the specific applications developed for each industrial implementation where that specificities are taken into account: the final control application and the management application. By properly linking both: the more generic digital twin and specific software applications specifically generated for the industry system, the framework may be ready to be used soon at the early development stages, but also may be used for detailed analyses at late booting and maintenance industry system phases. The system has been specialized in industrial transportation and warehouse systems. The paper presents an example of application for this kind of system

Information model to support PLCOpen Motion Control programming from Mechanical Design

The design of automated industrial machinery involves different areas of engineering, each of which employs its own and different information representation systems and software tools. The lack of a common information model to collect and organize the essential common data of each technology, prevents collaborative multidisciplinary engineering work, which complicates the use of a mechatronic approach. This article proposes the structure of an information model that allows to include geometric, kinematic and logical information related to the tools and objects that the machine manipulates, organized hierarchically according to the mechanical structure of the machine. This model complements an earlier development by the authors by calling MMCS “Mechanical and Motion Control Schematics”, which focuses on graphical representation. By combining them, the dynamic behavior can be visualized together

Cellular and Molecular Mechanisms of Methotrexate Resistance in Melanoma

Endocrinolog

3D printing as an enabling technology to implement maritime plastic Circular Economy

CircularSeas European Project, as part of the European Union Circular Economy [1], aims at promoting the Green Economy by encouraging the development of green products, parts and components by Maritime Industries. The strategy is a combination of Circular Economy principles, with the use of ocean plastic waste for developing new greener materials, and the uptake of advanced manufacturing technology, 3D printing, flexible enough to adapt to the manufacturing conditions for new eco-innovative small and medium parts and components. The paper presents the ongoing research in the project about strategies to introduce Circular Economy in the maritime sector from plastic wastes. This first prospective phase is focused on a series of interviews with each node stakeholders. The paper presents the survey results, together with the challenges to be faced for the implementation of Circular Economy in that specific scenario, despite the -apriori- short term low-profit disadvantages

Visual processing speed in hemianopia patients secondary to acquired brain injury: a new assessment methodology

Producción CientíficaBackground: There is a clinical need to identify diagnostic parameters that objectively quantify and monitor the effective visual ability of patients with homonymous visual field defects (HVFDs). Visual processing speed (VPS) is an objective measure of visual ability. It is the reaction time (RT) needed to correctly search and/or reach for a visual stimulus. VPS depends on six main brain processing systems: auditory-cognitive, attentional, working memory, visuocognitive, visuomotor, and executive. We designed a new assessment methodology capable of activating these six systems and measuring RTs to determine the VPS of patients with HVFDs. Methods: New software was designed for assessing subject visual stimulus search and reach times (S-RT and R-RT respectively), measured in seconds. Thirty-two different everyday visual stimuli were divided in four complexity groups that were presented along 8 radial visual field positions at three different eccentricities (10o, 20o, and 30o). Thus, for each HVFD and control subject, 96 S- and R-RT measures related to VPS were registered. Three additional variables were measured to gather objective data on the validity of the test: eye-hand coordination mistakes (ehcM), eye-hand coordination accuracy (ehcA), and degrees of head movement (dHM, measured by a head-tracker system). HVFD patients and healthy controls (30 each) matched by age and gender were included. Each subject was assessed in a single visit. VPS measurements for HFVD patients and control subjects were compared for the complete test, for each stimulus complexity group, and for each eccentricity. Results: VPS was significantly slower (p < 0.0001) in the HVFD group for the complete test, each stimulus complexity group, and each eccentricity. For the complete test, the VPS of the HVFD patients was 73.0% slower than controls. They also had 335.6% more ehcMs, 41.3% worse ehcA, and 189.0% more dHMs than the controls. Conclusions: Measurement of VPS by this new assessment methodology could be an effective tool for objectively quantifying the visual ability of HVFD patients. Future research should evaluate the effectiveness of this novel method for measuring the impact that any specific neurovisual rehabilitation program has for these patients

Efficacy of the Combination of Pinaverium Bromide 100mg Plus Simethicone 300mg in Abdominal Pain and Bloating in Irritable Bowel Syndrome: A Randomized, Placebo-controlled Trial

Goals: We aimed to evaluate the efficacy and safety of PB+S (pinaverium bromide 100 mg plus simethicone 300 mg) in patients with irritable bowel syndrome (IBS). Background: IBS is a multifactorial disorder; thus, combination therapy with different mechanisms of action is expected to be useful. PB+S has shown effectiveness in an open-label clinical study in IBS. However, there are no placebo-controlled trials. Materials and Methods: IBS-Rome III patients with abdominal pain/discomfort for at least 2 days within the week prior to baseline assessment were included in this 12-week, randomized, doubleblind, placebo-controlled study of PB+S versus placebo, bid. The primary endpoint was overall symptom improvement, evaluated weekly by the patient (Likert Scale). Secondary endpoints included the weekly improvement in the severity of abdominal pain and bloating assessed both by patients (10-cm Visual Analogue Scale) and investigators (Likert Scale); frequency of Bristol Scale stool types (consistency) evaluated by patients and the IBS Quality of Life scores. Results: A total of 285 patients (female: 83%; 36.5±8.9 y old) received at least 1 dose of PB+S (n=140) or placebo (n=145). No difference was observed in overall symptom improvement between the groups (P=0.13). However, PB+S was superior in abdominal pain (effect size: 31%, P=0.038) and bloating (33%, P=0.019). Patients with IBS-C and IBS-M showed the best improvement in the frequency of stool types with PB+S. No differences were observed in IBS Quality of Life scores and adverse events

Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice

The remodeling of the extracellular matrix is a central function in endochondral ossification and bone homeostasis. During secondary fracture healing, vascular invasion and bone growth requires the removal of the cartilage intermediate and the coordinate action of the collagenase matrix metalloproteinase (MMP)-13, produced by hypertrophic chondrocytes, and the gelatinase MMP-9, produced by cells of hematopoietic lineage. Interfering with these MMP activities results in impaired fracture healing characterized by cartilage accumulation and delayed vascularization. MMP-10, Stromelysin 2, a matrix metalloproteinase with high homology to MMP-3 (Stromelysin 1), presents a wide range of putative substrates identified in vitro, but its targets and functions in vivo and especially during fracture healing and bone homeostasis are not well defined. Here, we investigated the role of MMP-10 through bone regeneration in C57BL/6 mice. During secondary fracture healing, MMP-10 is expressed by hematopoietic cells and its maximum expression peak is associated with cartilage resorption at 14 days post fracture (dpf). In accordance with this expression pattern, when Mmp10 is globally silenced, we observed an impaired fracture-healing phenotype at 14 dpf, characterized by delayed cartilage resorption and TRAP-positive cell accumulation. This phenotype can be rescued by a non-competitive transplant of wild-type bone marrow, indicating that MMP-10 functions are required only in cells of hematopoietic linage. In addition, we found that this phenotype is a consequence of reduced gelatinase activity and the lack of proMMP-9 processing in macrophages. Our data provide evidence of the in vivo function of MMP-10 during endochondral ossification and defines the macrophages as the lead cell population in cartilage removal and vascular invasio

Improving girls’ perception of computer science as a viable career option through game playing and design: Lessons from a systematic literature review

The objective of exposing girls to Computer Science as a career option has led to research directed towards gaming activities for girls. These activities include both game play and game design. Research about gaming activities for increasing girls’ interest in computer science has gained much attention over the past few years and has resulted in a number of contributions. We follow up with an overview of the status of research through a Systematic Literature Review. We investigate the relation between the various game playing or designing activities and their impact on girls’ perception of Computer Science as a career choice. We further present the design consideration for the games and related activities to potentially improve the perception of girls towards a Computer Science career. The applied method is a Systematic Literature Review through which we investigate which contributions were made, which knowledge areas were most explored, and which research facets have been used. We identify 25 papers to distill a common understanding of the state-of-the-art. Specifically, we investigate the effects that the game play/design activities had on girls’ perception about Computer Science; and what are the key design factors to be kept in mind while designing a serious game to improve girls’ perception about Computer Science. The results of this systematic literature review show that game playing or designing could indeed improve how girls perceive having a career in CS. The key aspects that such activities require are personalizing, opportunity for collaboration and the presence of a female lead characterThis work has been done during the tenure of an ERCIM Alain Bensoussan fellowshi