Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochondrial homeostasis and hair cell function

The synthetic glucocorticoid dexamethasone is commonly used to treat inner ear disorders. Previous work in larval zebrafish has shown that dexamethasone treatment enhances hair cell regeneration, yet dexamethasone has also been shown to inhibit regeneration of peripheral nerves after lesion. We therefore used the zebrafish model to determine the impact of dexamethasone treatment on lateral-line hair cells and primary afferents. To explore dexamethasone in the context of regeneration, we used copper sulfate (CuS

Lateral line ablation by ototoxic compounds results in distinct rheotaxis profiles in larval zebrafish

The zebrafish lateral line is an established model for hair cell organ damage, yet few studies link mechanistic disruptions to changes in biologically relevant behavior. We used larval zebrafish to determine how damage via ototoxic compounds impact rheotaxis. Larvae were treated with CuS

2017 update of the WSES guidelines for emergency repair of complicated abdominal wall hernias

Emergency repair of complicated abdominal wall hernias may be associated with worsen outcome and a significant rate of postoperative complications. There is no consensus on management of complicated abdominal hernias. The main matter of debate is about the use of mesh in case of intestinal resection and the type of mesh to be used. Wound infection is the most common complication encountered and represents an immense burden especially in the presence of a mesh. The recurrence rate is an important topic that influences the final outcome. A World Society of Emergency Surgery (WSES) Consensus Conference was held in Bergamo in July 2013 with the aim to define recommendations for emergency repair of abdominal wall hernias in adults. This document represents the executive summary of the consensus conference approved by a WSES expert panel. In 2016, the guidelines have been revised and updated according to the most recent available literature.Peer reviewe

WSES guidelines for emergency repair of complicated abdominal wall hernias

Peer reviewe

Come Play With Me: A 0-3 Play Curriculum for Low-Income Families

Research indicates play is the developmentally appropriate way for young children to learn. Research also shows that socioeconomic status impacts child development, parental awareness of developmental milestones, and parent-child interaction. Published materials about play are often designed for middle class and wealthy families and are inappropriate or inaccessible for low-income families. In order to effectively work with low-income families, early intervention providers must understand the impact of socioeconomic status. Come PLAY With Me is designed to educate early intervention providers about working with low-income families and to educate low-income families about the importance of play in children\u27s lives. This information will enable service providers to provide appropriate education to low-income families and enable families to encourage their child\u27s play and learning

Los dilemas del sexo: (A-) Sexuación, (In-) Diferencia, (Des-) Igualdad

El artículo se propone explorar el campo de la diferencia sexual a través de\ua0la propuesta psicoanalítica. La reflexión parte del proceso de sexuación\ua0como inacabado y, por ello, permanentemente sometido a los avatares de la\ua0relación entre el saber y el sexo. De esta manera, la dimensión corporal\ua0deberá ser entendida no como producción “encarnada ” de significaciones,\ua0sino como punto de quiebre del discurso. Esta reflexión arroja tres dilemas\ua0sobre los cuáles el sujeto sexuado y la cultura se posicionan constantemente:\ua0a) Somos sexuados, pero nunca completamente, sobre todo por la inevitable\ua0sujeción al objeto causa de deseo, de ello resulta una (a)sexuación\ua0originaria; b) La diferencia sexual entre lo masculino y lo femenino no\ua0encuentra su rasgo diferenciador originario, pues de éste nada puede saberse;\ua0y c) De lo anterior se deduce que, al nivel de lo social, dicha indeterminación\ua0de la diferencia sexual y su sometimiento al objeto causa de deseo,\ua0trae como consecuencia un malestar con la igualdad