Constraints on w0w_0 and waw_a of Dark Energy from High Redshift Gamma Ray Bursts

We extend the Hubble diagram up to $z = 5.6$ using 63 gamma-ray bursts (GRBs) via peak energy-peak luminosity relation (so called Yonetoku relation), and obtain constraints on cosmological parameters including dynamical dark energy parametrized by $P/\rho\equiv w(z) = w_0 + w_a \cdot z/(1+z)$. It is found that the current GRB data are consistent with the concordance model, ($\Omega_m = 0.28, \Omega_{\Lambda} = 0.72, w_0 = -1, w_a = 0$), within two sigma level. Although constraints from GRBs themselves are not so strong, they can improve the conventional constraints from SNeIa because GRBs have much higher redshifts. Further we estimate the constraints on the dark-energy parameters expected by future observations with GLAST (Gamma-ray Large Area Space Telescope) and \swift by Monte-Carlo simulation. Constraints would improve substantially with another 150 GRBs.Comment: 5 pages, 6 figures. Submitted tu MNRA

Clinical evaluation was examined between mixed type barium sulfate suspensions "BarytgenHD" and "Barytgen"

混合粒子型硫酸バリウムバリトゲンHD200w/v%懸濁液について,バリトゲン160w/v%懸濁液と比較検討を行った｡懸濁液安定性は両者共良かった｡臨床評価においては,付着性,胃小区描出能は同程度であり,辺縁の描出能は良かったが凝集･ムラ付き,気泡は多くみられ懸濁液濃度について検討を加える必要があると考える｡飲み易さは,バリトゲンHD200w/v%懸濁液のほうが濃度が高いのにもかかわらず飲み易く好評であった｡Both barium sulfate suspensions, Barytgen HD and Barytgen, had good stability. Although significant difference was not abserved in coating and visualization of gastric area, BarytgenHD showed better marginal visualization of gastric margin. Further study is needed to improve the visualization of sticky coating of gastric mucosa and many bubbles. BarytgenHD was easily to drink instead of high density barium sulfate suspensions

Basic properies of beam flatness analyzer (THEBES 7000)

癌の有力な治療法の1つである放射線治療はシステム全体の許容誤差が±5％と、正確な治療が要求されている。正確な線量を正確な場所に照射されなければならない。そのためには日頃から照射装置のQuality Control が重要である。Beam平坦度の測定はその中でも、重要な項目で1／6月の測定頻度が勧告されている。今回、市販のBeam Flatness Analyzer (7000型 THEBES) を使用する機会を得たので、その基礎的性能であるChamber 相互の感度のちがい、測定値の再現性、識別可能な最小線量について実験を行った。各項目とも誤差が非常に少なく、日常の使用に際してそのデータは十分信頼できるものであることがわかった。Lrradiation, which is one of the effective therapies to Cancer, is required to be accurate within ±5% of the tolerable error of the total system. An accurate dose has to be irradiated accurately at a target volume. For that Quality Control of the irradiation equipment is cotinually important. As the measurement of Beam Flatness is an important item, it is obligated to be measured once a week. In this paper as we have an opportunity to use a Beam Flatness Analyzer sold on a corporation of medical instrument, we experiment about the difference of sensitivity of mutual Chamber which is its basic property, the reproducibility of the measured score, and the minimum value of measuralbe dose. We find that the difference in every item is so small that its data is very reliable in a daily use

A case of hyperprogressive disease following atezolizumab therapy for pulmonary pleomorphic carcinoma with epidermal growth factor receptor mutation

A 66-year old man with non-smoking history was diagnosed with pulmonary pleomorphic carcinoma of the right lower lobe. The carcinoma metastasized to the brain, lungs, pleura, and mediastinal lymph nodes. It was positive for epidermal growth factor receptor (EGFR) L858R mutation, and tumor cells highly expressed programmed death-ligand 1(PD-L1). Atezolizumab was initiated as the fourth treatment. After three days, he developed cardiac tamponade and immediately underwent pericardial drainage. Computed tomography showed bilateral ground-glass opacity (GGO), significant worsening of multiple lung metastases, and increased size of metastatic lesions. Newly developed metastasis was noted in the lung, and the patient's respiratory condition rapidly deteriorated. He died of respiratory failure on day 13 after atezolizumab administration. The autopsy showed widespread metastasis in all lobes of the bilateral lungs, cardiac tamponade due to carcinomatous pericarditis, carcinomatous lymphangiopathy, and multiple lung metastases, which were thought to be comprehensively the cause of death. These symptoms suggested hyperprogressive disease (HPD). Hence, we report the first case of HPD following atezolizumab therapy for pulmonary pleomorphic carcinoma with EGFR mutation

The Selaginella Genome Identifies Genetic Changes Associated with the Evolution of Vascular Plants

International audienceVascular plants appeared ~410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes

The compact Selaginella genome identifies changes in gene content associated with the evolution of vascular plants

We report the genome sequence of the nonseed vascular plant, Selaginella moellendorffii, and by comparative genomics identify genes that likely played important roles in the early evolution of vascular plants and their subsequent evolutio