531 research outputs found
Artificial Rheotaxis
Motility is a basic feature of living microorganisms, and how it works is
often determined by environmental cues. Recent efforts have focused on develop-
ing artificial systems that can mimic microorganisms, and in particular their
self-propulsion. Here, we report on the design and characterization of syn-
thetic self-propelled particles that migrate upstream, known as positive rheo-
taxis. This phenomenon results from a purely physical mechanism involving the
interplay between the polarity of the particles and their alignment by a
viscous torque. We show quantitative agreement between experimental data and a
simple model of an overdamped Brownian pendulum. The model no- tably predicts
the existence of a stagnation point in a diverging flow. We take advantage of
this property to demonstrate that our active particles can sense and
predictably organize in an imposed flow. Our colloidal system represents an
important step towards the realization of biomimetic micro-systems withthe
ability to sense and respond to environmental changesComment: Published in Science Advances [Open access journal of Science
Magazine
Self Assembled Particles
A self-assembling structure using non-equilibrium driving forces leading to 'living crystals' and other maniputable particles with a complex dynamics. The dynamic self-assembly assembly results from a competition between self-propulsion of particles and an attractive interaction between the particles. As a result of non-equilibrium driving forces, the crystals form, grow, collide, anneal, repair themselves and spontaneously self-destruct, thereby enabling reconfiguration and assembly to achieve a desired property
Modulation of Immune Responses by Particle Size and Shape
The immune system has to cope with a wide range of irregularly shaped pathogens that can actively move (e.g., by flagella) and also dynamically remodel their shape (e.g., transition from yeast-shaped to hyphal fungi). The goal of this review is to draw general conclusions of how the size and geometry of a pathogen affect its uptake and processing by phagocytes of the immune system. We compared both theoretical and experimental studies with different cells, model particles, and pathogenic microbes (particularly fungi) showing that particle size, shape, rigidity, and surface roughness are important parameters for cellular uptake and subsequent immune responses, particularly inflammasome activation and T cell activation. Understanding how the physical properties of particles affect immune responses can aid the design of better vaccines
Interstitial Fractionalization and Spherical Crystallography
Finding the ground states of identical particles packed on spheres has
relevance for stabilizing emulsions and a venerable history in the literature
of theoretical physics and mathematics. Theory and experiment have confirmed
that defects such as disclinations and dislocations are an intrinsic part of
the ground state. Here we discuss the remarkable behavior of vacancies and
interstitials in spherical crystals. The strain fields of isolated
disclinations forced in by the spherical topology literally rip interstitials
and vacancies apart, typically into dislocation fragments that combine with the
disclinations to create small grain boundary scars. The fractionation is often
into three charge-neutral dislocations, although dislocation pairs can be
created as well. We use a powerful, freely available computer program to
explore interstitial fractionalization in some detail, for a variety of power
law pair potentials. We investigate the dependence on initial conditions and
the final state energies, and compare the position dependence of interstitial
energies with the predictions of continuum elastic theory on the sphere. The
theory predicts that, before fragmentation, interstitials are repelled from
5-fold disclinations and vacancies are attracted. We also use vacancies and
interstitials to study low energy states in the vicinity of "magic numbers"
that accommodate regular icosadeltahedral tessellations.Comment: 21 pages, 9 figure
Characterization of anisotropic nano-particles by using depolarized dynamic light scattering in the near field
Light scattering techniques are widely used in many fields of condensed and
sof t matter physics. Usually these methods are based on the study of the
scattered light in the far field. Recently, a new family of near field
detection schemes has been developed, mainly for the study of small angle light
scattering. These techniques are based on the detection of the light intensity
near to the sample, where light scattered at different directions overlaps but
can be distinguished by Fourier transform analysis. Here we report for the
first time data obtained with a dynamic near field scattering instrument,
measuring both polarized and depolarized scattered light. Advantages of this
procedure over the traditional far field detection include the immunity to
stray light problems and the possibility to obtain a large number of
statistical samples for many different wave vectors in a single instantaneous
measurement. By using the proposed technique we have measured the translational
and rotational diffusion coefficients of rod-like colloidal particles. The
obtained data are in very good agreement with the data acquired with a
traditional light scattering apparatus.Comment: Published in Optics Express. This version has changes in bibliograph
Fabrication of polyhedral particles from spherical colloids and their self-assembly into rotator phases
Particle shape is a critical parameter that plays an important role in
self-assembly, for example, in designing targeted complex structures with
desired properties. In the last decades an unprecedented range of monodisperse
nanoparticle systems with control over the shape of the particles have become
available. In contrast, the choice of micron-sized colloidal building blocks of
particles with flat facets, i.e., particles with polygonal shapes, is
significantly more limited. This can be attributed to the fact that, contrary
to nanoparticles, the larger colloids are significantly harder to synthesize as
single crystals. Herein, we demonstrate that the simplest building block, such
as the micron-sized polymeric spherical colloidal particle, is already enough
to fabricate particles with regularly placed flat facets, including completely
polygonal shapes with sharp edges. As an illustration that the yields are high
enough for further self-assembly studies we demonstrate the formation of 3D
rotator phases of fluorescently labelled, micron-sized and charged rhombic
dodecahedron particles. Our method for fabricating polyhedral particles opens a
new avenue for designing new materials.Comment: 5 pages, published in Angewandte Chemie International Editio
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