Photodermatosis and Photo protection in Metropolitan Traffic Police in Kathmandu city

Background: Police officer serves a vital role in maintaining safety and serve are role model for discipline throughout the world, they are non–intentional type sun exposure(NISE).The objective of our present study was to evaluate photo protector practice, knowledge in response to  Ultra violet Radiation ,Sunscreens and  sun related photodermatosis. Methodology: A cross sectional study was conducted in traffic police officer at different locations at Kathmandu. Data was collected by using self-administered questionnaires and interviewed by Dermatologist to establish their knowledge and behaviour and practice in relation to ultra violet radiation and photo-protection. Result: Out of 265 participants, mean age was 27.1 years. Respondent with graduation and master degrees had knowledge and practice toward UVR, follow by higher secondary education. Regarding the practice for photo protection only 59.6% had knowledge about sunscreen, 39.6% knowledge about Ultraviolet Radiation and 24.9% had knowledge about Ultra Violet Index .Skin problem like melasma, premature wrinkles, and hardening of skin, polymorphic light eruption, burning foot syndrome, dermatophytes, and varicose vein. Conclusion: Traffic police officers showed good practices in term of wearing hat, clothes that cover most of the body parts but poor practice over sunscreen, UVR, UVI. Lectures & seminar regarding the awareness and photo protection practice should be recommended. With lack of awareness among police officers and providing sunscreen for free should be considered by Police authorities. Similarly lectures & seminar on sun protection should be provided in regularly

Occupational Hand Eczema among Cement users in Nepal

Background: Occupational dermatitis among cement workers is a major occupational health concern and skin contact with cement has been associated with contact dermatitis, which ranges from cement burns to cumulative irritant contact dermatitis. Objective: The objective of this study was to investigate the prevalence and severity of occupational cement contact dermatitis amongst cement workers in Nepal which is the first of its kind. Methods: A cross sectional descriptive study amongst patients in construction site and hardware shops within the Kathmandu valley were selected. A structured questionnaire was used to evaluate the demographic data and work-related activities of these cement workers. A complete skin examination was conducted and skin manifestations were assessed by a dermatologist. The data collected was compiled and appropriate statistical tools was used to find out the significance of variables. Result: Out of the total number of workers screened 164/377 (43.50%) had hand contact dermatitis. There were males 148(90.2%) and females16 (9.8%) and the age ranged from 15-51 years ( mean 27.41± 7.68 years).The duration of the disease ranged from 1-360 months (median 36months (IQR=60).The most common site of lesion was palms (62.8%) followed by tip of the fingers in 39.0% patients and the most common morphology of the lesion was erythema seen in 59.1% followed by scaling seen in 51.8 % patients. Conclusion: The issue of contact and irritant hand eczema amongst cement workers in Nepal has had a considerable morbidity. Identification of these patients with adequate treatment, test of the suspected allergens and counseling could further help the patients involved

Bimatoprost versus clobetasol propionate in scalp alopecia areata: A prospective non-randomized open-label clinical trial

Background: Alopecia areata (AA) is one of the most common forms of alopecia presenting to the dermatology out patient department (OPD) worldwide as well as in Nepal. It is mostly diagnosed clinically. Treatment depends on the extent, location, and severity of the condition. Various treatment options available are topical, intralesional, and oral medications. Bimatoprost is a relatively newer treatment modality in AA. Aim and Objective: To compare the efficacy and safety of topical bimatoprost 0.01% solution versus clobetasol propionate 0.05% cream in scalp AA. Materials and Methods: A total of 50 patients attending the dermatology OPD of a tertiary hospital between March 2018 and February 2019 were included in this prospective non-randomized open-label clinical trial. Patients were divided into two groups i.e., Group A- topical bimatoprost solution 0.01% and Group B- topical clobetasol propionate cream 0.05%, and followed up at weeks 4, 8, and 12. The improvement was analyzed subjectively by hair regrowth and objectively by Severity of Alopecia Tool (SALT) score. Side effects, nature of terminal hair and onset of initial response were also recorded. Results: Out of 50 patients, 27 were males and 23 were females with a mean age of 28.5 ± 9.34 years and mean duration of disease of 18.67 ± 46.1 weeks. Hair regrowth rate and reduction in SALT score from baseline were seen more in clobetasol group compared to bimatoprost (p = 0.282 and P = 0.246, respectively). Side effects were seen more in the clobetasol group compared to bimatoprost group (p = 0.002). Onset of cosmetically acceptable hair regrowth was seen earlier in the bimatoprost group (p = 0.017) and also the nature of regrown hairs was more pigmented in bimatoprost group (p = 0.024). Conclusions: There is no significant difference in hair regrowth between clobetasol and bimatoprost in the treatment of AA on scalp at the end of 12 weeks, although bimatoprost has an advantage of lesser side effects, more rapid response and growth of more pigmented hairs

Role of Receptors in Relation to Plaques and Tangles in Alzheimer’s Disease Pathology

Despite the identification of Aβ plaques and NFTs as biomarkers for Alzheimer’s disease (AD) pathology, therapeutic interventions remain elusive, with neither an absolute prophylactic nor a curative medication available to impede the progression of AD presently available. Current approaches focus on symptomatic treatments to maintain AD patients’ mental stability and behavioral symptoms by decreasing neuronal degeneration; however, the complexity of AD pathology requires a wide range of therapeutic approaches for both preventive and curative treatments. In this regard, this review summarizes the role of receptors as a potential target for treating AD and focuses on the path of major receptors which are responsible for AD progression. This review gives an overall idea centering on major receptors, their agonist and antagonist and future prospects of viral mimicry in AD pathology. This article aims to provide researchers and developers a comprehensive idea about the different receptors involved in AD pathogenesis that may lead to finding a new therapeutic strategy to treat AD

Acceptability and feasibility of using vaginal menstrual cups among schoolgirls in rural Nepal: a qualitative pilot study

Introduction Menstrual hygiene management can be challenging in low-income settings and among school-aged girls due to traditional beliefs, lack of knowledge and information on best hygienic practices, and limited access to appropriate and affordable menstrual hygiene products. An alternative method for menstrual hygiene management, instead of sanitary pads or tampons, is the vaginal menstrual cup. As evidence on the use of menstrual cups is relatively limited, this study aimed to explore the acceptability and feasibility of using vaginal menstrual cups among school-aged girls in Thokarpa, Sindupalchowk, Nepal. Methods This is an exploratory study based on four focus group discussions with a purposive sample of 28 schoolgirls between 13 and 19 years of age who were provided with vaginal menstrual cups in Thokarpa, Sindupalchowk, Nepal. The data were collected between February and March 2019, i.e. approximately three months after the distribution of the menstrual cup. Participants were included in the study if they had started their menstruation and never given birth. Conventional content analysis was applied. Results Most participants perceived the menstrual cup positively. Not missing a single class in school due to problems related to menstrual hygiene management was described as a major benefit. The participants found using the menstrual cup easy and convenient, and described economic and environmental advantages of using it. Cleaning the menstrual cup did not cause any problems, according to the participants. Discomforts mentioned by the participants were: pain when inserting the menstrual cup, feeling the menstrual cup sticking out of the vagina, feeling a constant urge to urinate and leakage. Concerns were related to the size, shape and texture of the menstrual cup, and that it may "get stuck" in the vagina, while relatives were said to be concerned about the use of the menstrual cup leading to reduced fertility or losing virginity. Conclusion The use of vaginal menstrual cups for menstrual hygiene management among schoolgirls in Thokarpa, Sindupalchowk, Nepal, appears feasible and acceptable, as it involves practical, economic and environmental advantages. However, the scale-up of menstrual cups will require resolving described concerns and discomforts and fostering peer and family support