Raspberry PI Based Artificial Vision Assisting System for Blind Persons

The main aim of this paper is to implement a system that will help blind person. This system is used by a RASPBERRY PI circuit to provide for the identification of the objects, the first level localization. It also incorporates additional components to provide more refined location and orientation information. The input process is to capture every object around 10m and it is convert into the output processing in voice command which is adopted in Bluetooth headset which is used by blind people using RASPBERRY PI component

研究課題

An Excel file containing information on lncRNAs probed for FM bias. The first sheet contains a README file with details on the contents of the other two sheets. The second sheet contains the list of all lncRNAs probed, a summary of their biological function, and the original source from which we extracted them. The third sheet contains the FM bias p value computed for each significantly FM biased lncRNA in each cohort. (ODS 13 kb

AN INVESTIGATION ON FRESH AND HARDENED PROPERTIES OF M30 CONCRETE WITH PLASTIC FIBRES AND M – SAND

The Construction industry has got several emoluments in terms of materials used as raw materials. All the materials that used as an alternative should be such that it should not affect of alter the properties of concrete such as workability, strength, durability etc., and also to contribute to the economy of the project. The usage of plastics has been increased to a greater extent in all fields, which leads to the generation of large quantum of plastic wastes. These non-degradable wastes can be recycled and reused in the field of civil engineering. Also in recent past, m-sand is popularly used in several projects as an alternative for river sand which reduces the cost and also helps in achieving uniform grain size. This article focuses on the use of plastic fibres and m-sand as replacement materials in concrete. In this work, an attempt has been made to replace the coarse aggregate with plastic fibres and m-sand with river sand to study the behavioral changes in concrete with varying proportions. The fresh properties of concrete are studied to ensure that the workability of concrete is not affected or reduced. Specimens such as cubes, cylinders and prisms has been casted and tested at the age of 28 days to study the strength of concrete with and without replacement materials. The study has been extended to analyze the structural behavior of concrete beams with optimum mix proportion

Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood. In this study, we determined the potential linkage of severe PE to the most central complement gene, C3. Three cohorts of Finnish patients and controls were recruited for a genetic case-control study. Participants were genotyped using Sequenom genotyping and Sanger sequencing. Initially, we studied 259 Finnish patients with severe PE and 426 controls from the Southern Finland PE and the Finnish population-based PE cohorts. We used a custom-made single nucleotide polymorphism (SNP) genotyping assay consisting of 98 SNPs in 18 genes that encode components of the complement system. Following the primary screening, C3 was selected as the candidate gene and consequently Sanger sequenced. Fourteen SNPs from C3 were also genotyped by a Sequenom panel in 960 patients with severe PE and 705 controls, including already sequenced individuals. Three of the 43 SNPs observed within C3 were associated with severe PE: rs2287845 (p = 0.038, OR = 1.158), rs366510 (p = 0.039, OR = 1.158), and rs2287848 (p = 0.041, OR = 1.155). We also discovered 16 SNP haplotypes with extreme linkage disequilibrium in the middle of the gene with a protective (p = 0.044, OR = 0.628) or a predisposing (p = 0.011, OR = 2.110) effect to severe PE depending on the allele combination. Genetic variants associated with PE are located in key domains of C3 and could thereby influence the function of C3. This is, as far as we are aware, the first candidate gene in the complement system with an association to a clinically relevant PE subphenotype, severe PE. The result highlights a potential role for the complement system in the pathogenesis of PE and may help in defining prognostic and therapeutic subgroups of preeclamptic women.Peer reviewe

Moisture-Driven Degradation Mechanisms in the Viscoelastic Properties of TPU-Based Syntactic Foams

Syntactic foams have found widespread usage in various applications including, marine, aerospace, automotive, pipe insulation, electrical cable sheathing, and shoe insoles. However, syntactic foams are often exposed to moisture when used in these applications that potentially alter their viscoelastic properties, which influences their long-term durability. Despite their significance, previous research has mainly focused on experimental studies concerning mechanical property changes resulting from filler loading and different matrix materials, overlooking the fundamental mechanisms resulting from moisture exposure. The current paper aims to bridge this gap in knowledge by elucidating the impact of long-term moisture exposure on TPU and TPU-based syntactic foam through multi-scale materials characterization approaches. Here, we choose a flexible syntactic foam manufactured using thermoplastic polyurethane elastomer (TPU) reinforced with glass microballoons (GMB) through selective laser sintering. Specifically, the research investigates the influence of moisture exposure time and the volume fraction of GMB on chemical and microphase morphological changes, along with their associated mechanisms. The study further examines how these microphase morphological changes manifest in viscoelastic properties

The role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: A proteomic study

BACKGROUND: The molecular basis of the increased susceptibility of steatotic livers to warm ischemia/reperfusion (I/R) injury during transplantation remains undefined. Animal model for warm I/R injury was induced in obese Zucker rats. Lean Zucker rats provided controls. Two dimensional differential gel electrophoresis was performed with liver protein extracts. Protein features with significant abundance ratios (p < 0.01) between the two cohorts were selected and analyzed with HPLC/MS. Proteins were identified by Uniprot database. Interactive protein networks were generated using Ingenuity Pathway Analysis and GRANITE software. RESULTS: The relative abundance of 105 proteins was observed in warm I/R injury. Functional grouping revealed four categories of importance: molecular chaperones/endoplasmic reticulum (ER) stress, oxidative stress, metabolism, and cell structure. Hypoxia up-regulated 1, calcium binding protein 1, calreticulin, heat shock protein (HSP) 60, HSP-90, and protein disulfide isomerase 3 were chaperonins significantly (p < 0.01) down-regulated and only one chaperonin, HSP-1was significantly upregulated in steatotic liver following I/R. CONCLUSION: Down-regulation of the chaperones identified in this analysis may contribute to the increased ER stress and, consequently, apoptosis and necrosis. This study provides an initial platform for future investigation of the role of chaperones and therapeutic targets for increasing the viability of steatotic liver allografts

Physics-Constrained Neural Network for the Analysis and Feature-Based Optimization of Woven Composites

Woven composites are produced by interlacing warp and weft fibers in a pattern or weave style. By changing the pattern or material, the mechanical properties of woven composites can be significantly changed; however, the role of woven composite architecture (pattern, material) on the mechanical properties is not well understood. In this paper, we explore the relationship between woven composite architectures (weave pattern, weave material sequence) and the corresponding modulus through our proposed Physics-Constrained Neural Network (PCNN). Furthermore, we apply statistical learning methods to optimize the woven composite architecture to improve mechanical responses. Our results show that PCNN can effectively predict woven architecture for the desired modulus with much higher accuracy than several baseline models. PCNN can be further combined with feature-based optimization to determine the optimal woven composite architecture at the initial design stage. In addition to relating woven composite architecture to its mechanical responses, our research also provides an in-depth understanding of how architectural features govern mechanical responses. We anticipate our proposed frameworks will primarily facilitate the woven composite analysis and optimization process and be a starting point to introduce Physics knowledge-guided Neural Networks into the complex structural analysis

Formulation and Evaluation of Sustained Release Microspheres of Venlafaxine Hydrochloride.

The goal of a sustained release dosage form is to maintain therapeutic blood or tissue levels of the drug for an extended and specified period of time. This is generally accomplished by attempting to obtain "zero-order" release from the dosage form. Zero-order release constitutes drug release from the dosage form which is independent of the amount of drug in the delivery system (i.e. a constant release rate). Sustained-release systems generally do not attain this type of release and usually try to mimic zero-order release by providing drug in a slow first-order fashion (i.e., concentration release dependent). Systems that are designated as prolonged release can also be considered as attempts at achieving sustained-release delivery. Based on the in vitro drug released characteristics, entrapment efficiency and t25, t50 and t90 values, the formulation F3 was found to be best formulation. By increasing the concentration of polymer, decreased the rate of drug released. According to stability study it was found that there was no variation in Percentage yield, Entrapment efficiency, and in vitro drug released profile of selected formulation F3 at specified period. The formulation F3 was concluded best formulation among the formulations were prepared

Awareness Level of Geographical Indication (GI) on Madurai Malli

The study aims to assess the awareness level of Geographical indication on Madurai Malli in Madurai district. It was found that Majority of the respondents were having low level of awareness on GI Madurai malli. It was inferred from farmers in the study area doesn’t know the real benefits of GI and its importance in the socio-economic development of the community. In the domestic market the farmers really find any changes in the price hike due to GI tag might be the reason for low level of awareness on Geographical indication on Madurai Malli among the beneficiary respondents

The microaerophilic microbiota of de-novo paediatric inflammatory bowel disease: the BISCUIT study

&lt;p&gt;Introduction: Children presenting for the first time with inflammatory bowel disease (IBD) offer a unique opportunity to study aetiological agents before the confounders of treatment. Microaerophilic bacteria can exploit the ecological niche of the intestinal epithelium; Helicobacter and Campylobacter are previously implicated in IBD pathogenesis. We set out to study these and other microaerophilic bacteria in de-novo paediatric IBD.&lt;/p&gt; &lt;p&gt;Patients and Methods: 100 children undergoing colonoscopy were recruited including 44 treatment naïve de-novo IBD patients and 42 with normal colons. Colonic biopsies were subjected to microaerophilic culture with Gram-negative isolates then identified by sequencing. Biopsies were also PCR screened for the specific microaerophilic bacterial groups: Helicobacteraceae, Campylobacteraceae and Sutterella wadsworthensis.&lt;/p&gt; &lt;p&gt;Results: 129 Gram-negative microaerophilic bacterial isolates were identified from 10 genera. The most frequently cultured was S. wadsworthensis (32 distinct isolates). Unusual Campylobacter were isolated from 8 subjects (including 3 C. concisus, 1 C. curvus, 1 C. lari, 1 C. rectus, 3 C. showae). No Helicobacter were cultured. When comparing IBD vs. normal colon control by PCR the prevalence figures were not significantly different (Helicobacter 11% vs. 12%, p = 1.00; Campylobacter 75% vs. 76%, p = 1.00; S. wadsworthensis 82% vs. 71%, p = 0.312).&lt;/p&gt; &lt;p&gt;Conclusions: This study offers a comprehensive overview of the microaerophilic microbiota of the paediatric colon including at IBD onset. Campylobacter appear to be surprisingly common, are not more strongly associated with IBD and can be isolated from around 8% of paediatric colonic biopsies. S. wadsworthensis appears to be a common commensal. Helicobacter species are relatively rare in the paediatric colon.&lt;/p&gt