250 research outputs found
Galvanic exchange as a novel method for carbon nitride supported coag catalyst synthesis for oxygen reduction and carbon dioxide conversion
A bimetallic alloy of CoAg nanoparticles (NPs) on a carbon nitride (CN) surface was synthesized using a galvanic exchange process for the oxygen reduction reaction (ORR) and carbon dioxide electrocatalytic conversion. The reduction potential of cobalt is ([Co2+(aq) + 2e? ? Co(s)], ?0.28 eV) is smaller than that of Ag ([Ag+(aq) + e? ? Ag(s)], 0.80 eV), which makes Co(0) to be easily replaceable by Ag+ ions. Initially, Co NPs (nanoparticles) were synthesized on a CN surface via adsorbing the Co2+ precursor on the surface of CN and subsequently reducing them with NaBH4 to obtain Co/CN NP. The Co NPs on the surface of CN were then subjected to galvanic exchange, where the sacrificial Co atoms were replaced by Ag atoms. As the process takes place on a solid surface, only the partial replacement of Co by Ag was possible generating CoAg/CN NPs. Synthesized CoAg/CN bimetallic alloy were characterized using different techniques such as powder x-ray diffraction (PXRD), x-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and electron diffraction spectroscopy (EDS) to confirm the product. Both the catalysts, Co/CN and CoAg/CN, were evaluated for oxygen reduction reaction in 1M KOH solution and carbon dioxide conversion in 0.5 M KHCO3. In the case of ORR, the CoAg/CN was found to be an efficient electrocatalyst with the onset potential of 0.93 V, which is comparable to commercially available Pt/C having Eonset at 0.91 V. In the electrocatalytic conversion of CO2, the CoAg/CN showed better performance than Co/CN. The cathodic current decreased dramatically below ?0.9V versus Ag/AgCl indicating the high conversion of CO2. - 2019 by the authors. Licensee MDPI, Basel, Switzerland.Acknowledgements: The authors would like to gratefully acknowledge financial support from Total Research & Technology Feluy (Grant Number: QUEX-CENG-TRT-17/18) in conducting this research. The statements made herein are solely the responsibility of the authors. The authors also wish to gratefully acknowledge the Gas Processing Centre (GPC) at Qatar University for carrying out XRD and XPS analysis, and the Central Laboratory Unit (CLU) at Qatar University for services related to electron microscopy.Scopu
β-thalassemia Intermedia In A Brazilian Patient With - 101 (c > T) And Codon 39 (c > T) Mutations
Context: We verified molecular alterations in a 72-year-old Brazilian male patient with a clinical course of homozygous β-thalassemia intermedia, who had undergone splenectomy and was surviving without regular blood transfusions. The blood cell count revealed microcytic and hypochromic anemia (hemoglobin = 6.5 g/dl, mean cell volume = 74 ft, mean cell hemoglobin = 24 pg) and hemoglobin electrophoresis showed fetal hemoglobin = 1.3%, hemoglobin A 2 = 6.78% and hemoglobin A = 79.4%. Objective: To identify mutations in a patient with the symptoms of β-thalassemia intermedia. Design: Molecular inquiry into the mutations possibly responsible for the clinical picture described. Setting: The structural molecular biology and genetic engineering center of the Universidade Estadual de Campinas, Campinas, Brazil. Procedures: DNA extraction was performed on the patient's blood samples. The polymerase chain reaction (PCR) was done using five specific primers that amplified exons and the promoter region of the β globin gene. The samples were sequenced and then analyzed via computer programs. Results: Two mutations that cause the disease were found: -101 (C > T) and codon 39 (C > T). Conclusions: This cases represents the first description of -101 (C > T) mutation in a Brazilian population and it is associated with a benign clinical course.12112830Baysal, E., Carver, M.F.H., The beta and delta-thalassemia repository (1995) Hemoglobin., 19 (3-4), pp. 213-236Zago, M.A., Costa, F., Bottura, C., Beta-thalassemia in Brazil (1981) Braz. J. Med. Biol. Res., 14 (6), pp. 383-388Ewing, B., Green, P., Base-calling of automated sequencer traces using Phred. II Error probabilities (1998) Genome Res., 8 (3), pp. 186-194Green, P., (2002), http://bozeman.genome.washington.edu/phrap.docs/phrap.html, The Phred/Phrap/Consed System Home Page. Phrap Assembler. Available at URL September 30Gordon, D., Abajian, C., Green, P., Consed: A graphical tool for sequence finishing (1998) Genome Res., 8 (3), pp. 195-20
Holographic dual of the Standard Model on the throat
We apply recent techniques to construct geometries, based on local Calabi-Yau
manifolds, leading to warped throats with 3-form fluxes in string theory, with
interesting structure at their bottom. We provide their holographic dual
description in terms of RG flows for gauge theories with almost conformal
duality cascades and infrared confinement. We describe a model of a throat with
D-branes at its bottom, realizing a 3-family Standard Model like chiral sector.
We provide the explicit holographic dual gauge theory RG flow, and describe the
appearance of the SM degrees of freedom after confinement. As a second
application, we describe throats within throats, namely warped throats with
discontinuous warp factor in different regions of the radial coordinate, and
discuss possible model building applications.Comment: 46 pages, 21 figures, reference adde
Kinin b(1) receptor in adipocytes regulates glucose tolerance and predisposition to obesity
BACKGROUND: Kinins participate in the pathophysiology of obesity and type 2 diabetes by mechanisms which are not fully understood. Kinin B(1) receptor knockout mice (B(1) (-/-)) are leaner and exhibit improved insulin sensitivity. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that kinin B(1) receptors in adipocytes play a role in controlling whole body insulin action and glucose homeostasis. Adipocytes isolated from mouse white adipose tissue (WAT) constitutively express kinin B(1) receptors. In these cells, treatment with the B(1) receptor agonist des-Arg(9)-bradykinin improved insulin signaling, GLUT4 translocation, and glucose uptake. Adipocytes from B(1) (-/-) mice showed reduced GLUT4 expression and impaired glucose uptake at both basal and insulin-stimulated states. To investigate the consequences of these phenomena to whole body metabolism, we generated mice where the expression of the kinin B(1) receptor was limited to cells of the adipose tissue (aP2-B(1)/B(1) (-/-)). Similarly to B(1) (-/-) mice, aP2-B(1)/B(1) (-/-) mice were leaner than wild type controls. However, exclusive expression of the kinin B(1) receptor in adipose tissue completely rescued the improved systemic insulin sensitivity phenotype of B(1) (-/-) mice. Adipose tissue gene expression analysis also revealed that genes involved in insulin signaling were significantly affected by the presence of the kinin B(1) receptor in adipose tissue. In agreement, GLUT4 expression and glucose uptake were increased in fat tissue of aP2-B(1)/B(1) (-/-) when compared to B(1) (-/-) mice. When subjected to high fat diet, aP2-B(1)/B(1) (-/-) mice gained more weight than B(1) (-/-) littermates, becoming as obese as the wild types. CONCLUSIONS/SIGNIFICANCE: Thus, kinin B(1) receptor participates in the modulation of insulin action in adipocytes, contributing to systemic insulin sensitivity and predisposition to obesity
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Controlled mobility in stochastic and dynamic wireless networks
We consider the use of controlled mobility in wireless networks where messages arriving randomly in time and space are collected by mobile receivers (collectors). The collectors are responsible for receiving these messages via wireless transmission by dynamically adjusting their position in the network. Our goal is to utilize a combination of wireless transmission and controlled mobility to improve the throughput and delay performance in such networks. First, we consider a system with a single collector. We show that the necessary and sufficient stability condition for such a system is given by ρ<1 where ρ is the expected system load. We derive lower bounds for the expected message waiting time in the system and develop policies that are stable for all loads ρ<1 and have asymptotically optimal delay scaling. We show that the combination of mobility and wireless transmission results in a delay scaling of Θ([1 over 1−ρ]) with the system load ρ, in contrast to the Θ([1 over (1−ρ)[superscript 2]]) delay scaling in the corresponding system without wireless transmission, where the collector visits each message location. Next, we consider the system with multiple collectors. In the case where simultaneous transmissions to different collectors do not interfere with each other, we show that both the stability condition and the delay scaling extend from the single collector case. In the case where simultaneous transmissions to different collectors interfere with each other, we characterize the stability region of the system and show that a frame-based version of the well-known Max-Weight policy stabilizes the system asymptotically in the frame length.National Science Foundation (U.S.) (Grant CNS-0915988)United States. Army Research Office. Multidisciplinary University Research Initiative (Grant W911NF-08-1-0238
The ReLPM Exponential Integrator for FE Discretizations of Advection-Diffusion Equations
We implement an exponential integrator for large and sparse systems of ODEs, generated by FE (Finite Element) discretization with mass-lumping of advection-diffusion equations. The relevant exponential-like matrix function is approximated by polynomial interpolation, at a sequence of real Leja points related to the spectrum of the FE matrix (ReLPM, Real Leja Points Method). Application to 2D and 3D advection-dispersion models shows speed-ups of one order of magnitude with respect to a classical variable step-size Crank-Nicolson solver
Manejo hídrico em viveiro e uso de hidrogel na sobrevivência pós-plantio de Eucalyptus urograndis em dois solos diferentes
Corneal Biomechanics in Ectatic Diseases: Refractive Surgery Implications.
BACKGROUND: Ectasia development occurs due to a chronic corneal biomechanical decompensation or weakness, resulting in stromal thinning and corneal protrusion. This leads to corneal steepening, increase in astigmatism, and irregularity. In corneal refractive surgery, the detection of mild forms of ectasia pre-operatively is essential to avoid post-operative progressive ectasia, which also depends on the impact of the procedure on the cornea.
METHOD: The advent of 3D tomography is proven as a significant advancement to further characterize corneal shape beyond front surface topography, which is still relevant. While screening tests for ectasia had been limited to corneal shape (geometry) assessment, clinical biomechanical assessment has been possible since the introduction of the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Buffalo, USA) in 2005 and the Corvis ST (Oculus Optikgerate GmbH, Wetzlar, Germany) in 2010. Direct clinical biomechanical evaluation is recognized as paramount, especially in detection of mild ectatic cases and characterization of the susceptibility for ectasia progression for any cornea.
CONCLUSIONS: The purpose of this review is to describe the current state of clinical evaluation of corneal biomechanics, focusing on the most recent advances of commercially available instruments and also on future developments, such as Brillouin microscopy.(undefined)info:eu-repo/semantics/publishedVersio
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