Application of the transferrin receptor-mediated drug delivery systems in the treatment of acute cerebral infarction

2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

DESIGNING OPTIMAL FUZZY CONTROLLER FOR MRD-BASED TRAIN-CAR SUSPENSION SYSTEMS

Random time-varying chassis mass, which consists of passenger and cargo mass as well as the normalized wind force, causes reducing the effectiveness of smart vehicle suspensions. In order to deal with this, we develop a novel fuzzy-based dynamic inversion controller (FDIC) for the control of a train-car suspension system using a magneto-rheological damper (MRD) or MRDs. The FDIC is constituted of three main parts: i) an inverse MRD model (ANFIS-I-MRD) via a measured data set and an adaptive neuro-fuzzy inference system (ANFIS), ii) a fuzzy-based sliding mode controller (FSMC) and iii) a disturbance and uncertainty observer (DUO). The FSMC is designed via the two following steps. The first one is to establish and optimize parameters of a sliding mode controller (SMC). The next is to design a fuzzy logic system to expand the ability of the SMC to face with the larger ranges of the load variation. The DUO is used to compensate for disturbance and uncertainty. By using the ANFIS-I-MRD and the control force estimated by the FDIC, current for the MRD at each time for stamping out chassis vibration is specified. The stability of the FDIC is analyzed via Lyapunov stability theory. Surveys shown that the FDIC could provide the improved control competence to reduce unwanted vibrations in an enlarged range of the varying chassis load

Carbon nanotube four-terminal devices for pressure sensing applications

Carbon nanotubes (CNTs) are of high interest for sensing applications,owing to their superior mechanical strength, high Young’s modulus and low density. In this work, we report on a facile approach for the fabrication of carbon nanotube devices using a four terminal configuration. Oriented carbon nanotube films were pulled out from a CNT forest wafer and then twisted into a yarn. Both the CNT film and yarn were arranged on elastomer membranes/diaphragms which were arranged on a laser cut acrylic frame to form pressure sensors. The sensors were calibrated using a precisely controlled pressure system, showing a large change of the output voltage of approximately 50 mV at a constant supply current of 100 μA and under a low applied pressure of 15 mbar. The results indicate the high potential of using CNT films and yarns for pressure sensing applications

SỬ DỤNG AXIT OXALIC LÀM CHẤT CHUẨN ĐỂ XÁC ĐỊNH NHU CẦU OXI HÓA HỌC BẰNG PHƯƠNG PHÁP ĐUN HỒI LƯU KÍN – TRẮC QUANG

Potassium hydrogen phthalate (KHP) is used as a standard to determine the chemical oxygen demand (COD) with the closed reflux-colourimetric method (colourimetric method). Besides KHP, it is possible to utilize oxalic acid for this purpose. After boiling at 150 °C for more than 30 minutes in H2SO4 containing Ag2SO4, K2Cr2O7 reacts completely with H2C2O4 at a molar ratio of 1:3. The experimentally determined chemical oxygen demand of H2C2O4 coincides with its theoretical value at 16.0 mg O2/mole H2C2O4. The average COD values of two river water samples, determined with the colourimetric method by using KHP standard and oxalic acid, are not statistically different. Oxalic acid can be used as a standard to determine COD with the colourimetric method.Kali hydro phthalate (KHP) được dùng làm chất chuẩn để xác định nhu cầu oxi hóa học (COD) bằng phương pháp đun hồi lưu kín – trắc quang (phương pháp trắc quang). Ngoài KHP, có thể sử dụng axit oxalic cho mục đích này. Sau khi đun hơn 30 phút ở 150 °C trong môi trường H2SO4 chứa Ag2SO4, K2Cr2O7 sẽ phản ứng hoàn toàn với H2C2O4 theo tỷ lệ mol 1:3. Nhu cầu oxi hóa học của H2C2O4 đã xác định bằng thực nghiệm hoàn toàn trùng khớp với giá trị nhu cầu oxi lý thuyết của hợp chất này là 16,0 mg O2/mol H2C2O4. Nhu cầu oxi hóa học trung bình của hai mẫu nước sông xác định bằng phương pháp trắc quang với hai đường chuẩn dùng KHP và axit oxalic không khác nhau về mặt thống kê. Như vậy, có thể sử dụng axit oxalic làm chất chuẩn để xác định COD bằng phương pháp đã nêu

The expression of hephaestine during focal cerebral ischemia in rats

2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Impacts of Economic Development on the Awareness of Cultural Preservation of Ethnic Minority People in the Border Region of Northern Vietnam

Purpose: The aim of this study is to examine how the Vietnamese government's economic development strategies affect ethnic minority people's knowledge of cultural preservation in the border area of Northern Vietnam.   Theoretical framework: The study focuses on three main driven factors of the awareness of cultural preservation that are economic changes, societal changes, and environmental changes from three economic fields: agriculture, industry, and trade and services.   Design/methodology/approach: The research sample was taken from ethnic minorities in Northern Vietnam's border area. For questionnaire administration, interviewees are selected at random from the population. Face-to-face, drop-off, and phone-calling approaches were used to disseminate the questionnaire. We received 544 completed returns out of 725 surveys sent out. The data was then cleaned and analyzed with SPSS 20 software using Partial Least Squares Structural Equation Modelling (PLS-SEM).   Findings: The results of a study of ethnic minority communities in seven provinces in Northern Vietnam's border region show that the development of agriculture, industry, trade and service significantly impacts ethnic minority people's awareness of cultural preservation issues due to environmental changes. In contrast, economic and sociological developments appear to have little influence on ethnic minority people's attention to cultural preservation. This phenomenon may be due to the long-term effects of economic and sociological changes, which mostly affect intangible cultural heritages. In contrast, environmental impats are felt swiftly and primarily on physical cultural heritages that can be seen.   Research, Practical & Social implications: The findings of the research provide policymakers with valuable insights on the effects of economic development on cultural preservation. The study's recommendations can inform policies that promote sustainable economic development while preserving the cultural heritage of ethnic minority communities.   Originality/value: The research focuses on the border region of Northern Vietnam, which is an area of strategic importance for economic development and cultural preservation. The study's unique focus on this region provides insights into the cultural and economic dynamics of a specific area that has not been extensively studied

Mangrove Mapping and Above-Ground Biomass Change Detection using Satellite Images in Coastal Areas of Thai Binh Province, Vietnam

Mangroves are recognized as a highly valuable resource due to their provision of multiple ecosystem services. Therefore, mangrove ecosystems mapping and monitoring is a crucial objective, especially for tropical regions. Thai Binh province is one of the most important mangrove ecosystems in Vietnam. The mangrove ecosystem in this province has faced threats of deforestation from urban development, land reclamation, tourism activities, and natural disasters. Recently, to maintain the fundamental functions of the ecosystems, a large mangrove area was planted in Thai Binh. The aim of this research is to detect the change in the mangrove areas and to create an aboveground biomass map for mangrove forests in Thai Binh province. Landsat and Sentinel-2 satellite images from 1998 to 2018 were analysed using the supervised classification method to detect mangrove area change. Mangrove Above-ground Biomass (AGB) was estimated using linear regression between vegetation indices and field AGB survey. The accuracy assessment for the classified images of 1998, 2003 and 2007, 2013 and 2018 are 93%, 86%, 96%, 94% and 91% respectively with kappa of 0.8881, 0.7953, 0.9357, 0.9114 and 0.8761. The mangrove cover in the study area was estimated at 5874.93 ha in 1998. This figure decreased significantly to 4433.85 ha in 2007, before recovery began to take place in the study area, which was estimated at 6587.88 ha in 2018. In 1998, the average AGB in this study area was 22.57 ton/ha, and in 2018 it was 37.74 ton/ha with a standard error of 12.41 ton/ha and the root mean square error (RMSE) was ±12.08 ton/ha

Radial Growth of Qilian Juniper on the Northeast Tibetan Plateau and Potential Climate Associations

There is controversy regarding the limiting climatic factor for tree radial growth at the alpine treeline on the northeastern Tibetan Plateau. In this study, we collected 594 increment cores from 331 trees, grouped within four altitude belts spanning the range 3550 to 4020 m.a.s.l. on a single hillside. We have developed four equivalent ring-width chronologies and shown that there are no significant differences in their growth-climate responses during 1956 to 2011 or in their longer-term growth patterns during the period AD 1110–2011. The main climate influence on radial growth is shown to be precipitation variability. Missing ring analysis shows that tree radial growth at the uppermost treeline location is more sensitive to climate variation than that at other elevations, and poor tree radial growth is particularly linked to the occurrence of serious drought events. Hence water limitation, rather than temperature stress, plays the pivotal role in controlling the radial growth of Sabina przewalskii Kom. at the treeline in this region. This finding contradicts any generalisation that tree-ring chronologies from high-elevation treeline environments are mostly indicators of temperature changes

Lack of correlation of stem cell markers in breast cancer stem cells

BACKGROUND: Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic response is controversial. METHODS: We investigated the expression of multiple cancer stem cell markers in human breast cancer samples and cell lines in vitro and in vivo, comparing across and within samples and relating expression with growth and therapeutic response to doxorubicin, docetaxol and radiotherapy. RESULTS: CD24, CD44, ALDH and SOX2 expression, the ability to form mammospheres and side-population cells are variably present in human cancers and cell lines. Each marker identifies a unique rather than common population of cancer cells. In vivo, cells expressing these markers are not specifically localized to the presumptive stem cell niche at the tumour/stroma interface. Repeated therapy does not consistently enrich cells expressing these markers, although ER-negative cells accumulate. CONCLUSIONS: Commonly employed methods identify different cancer cell sub-populations with no consistent therapeutic implications, rather than a single population of cells. The relationships of breast cancer stem cells to clinical parameters will require identification of specific markers or panels for the individual cancer

Study, Design and Construction of an Early Warning Environmental Radiation Monitoring Station

We report on the design and construction of an Early Warning Environmental Radiation Monitoring Station (EWERMS), used ONLINE in the environmental radiation monitoring and early warning network. It has a  high sensitivity and can send a prompt alarm signal via Internet to the emergency management office. It includes four gamma probes: one NaI(Tl) and three Geiger Mueller (GM) detectors. The NaI(TL) detector is used to monitor spectrum environmental radiation and measure the isotopic composition, the GM detectors are used to detect and measure high gamma ray rates. The instrument has been designed to be used outdoor and tolerate large and rapid temperature variations. The photomultiplier tubes (PMT), amplifiers and Analog To Digital (ADC) gains are stabilized using pulsed LEDs as precision reference light sources