Sensory ecologies, plant-persons, and multinatural landscapes in Amazonia

Seeking to generate a deeper methodological and theoretical dialogue between botanical science and anthropology, this paper summarizes interdisciplinary approaches to human–plant interactions we have described as “sensory ecology” and “phytoethnography”, applying these concepts to vital questions about human–plant relations in Amazonia. Building on this work, we broaden the scope of our investigations by considering their relevance to the field of historical ecology. In particular, we discuss Eduardo Viveiros de Castro’s concept of “multinaturalism” and explore how it can be applied to understanding management and domestication of forest landscapes in Amazonia by Indigenous Peoples

Sensory Ecology, Bioeconomy, and the Age of COVID: A Parallax View of Indigenous and Scientific Knowledge

Drawing on original ethnobotanical and anthropological research among Indigenous peoples across the Amazon, we examine synergies and dissonances between Indigenous and Western scientific knowledge about the environment, resource use, and sustainability. By focusing on the sensory dimension of Indigenous engagements with the environment—an approach we have described as “sensory ecology” and explored through the method of “phytoethnography”—we promote a symmetrical dialogue between Indigenous and scientific understandings around such phenomena as animal–plant mutualisms, phytochemical toxicity, sustainable forest management in “multinatural” landscapes, and the emergence of new diseases like the novel coronavirus SARS‐CoV‐2 (COVID‐19). Drawing examples from our own and other published works, we explore the possibilities and limitations of a “parallax view” attempting to hold Indigenous and scientific knowledge in focus simultaneously. As the concept of “bioeconomy” emerges as a key alternative for sustainable development of the Amazon, we encourage a critical and urgent engagement between dominant Western conceptions and Indigenous Amazonian knowledge, practices, and cultural values. Cognitive science, which has long contributed to studies of Indigenous categorization and conceptualization of the natural world, continues to play an important role in building bridges of mutual communication and respect between Indigenous and scientific approaches to sustainability and biodiversity conservation

Políticas públicas e indígenas en aislamiento en Perú y Brasil

This article comparatively reviews the role of public policies in the situation of indigenous peoples in isolation in two countries, Brazil and Peru. It presents the great paradigms that have dominated national policies on indigenous peoples in the Amazon, assimilation (or integration) and autonomy, analyzing how they have affected the situation of peoples in isolation in the past and how they do it today. As a case study, we developed that of the Mashco Piro indigenous people of the Alto Madre de Dios River (Madre de Dios, Peru), which highlights the complexity of the application of policies on the ground, in a context of growing threats to the Amazon territories. Finally, we explore the problematic relationships between policies related to indigenous peoples in isolation and those related to the economy and the use of the territory, which are closely linked in the Amazon region.El presente artículo revisa comparativamente el papel de las políticas públicas en la situación de los pueblos indígenas en aislamiento en dos países, Brasil y Perú. Presenta los grandes paradigmas que han dominado las políticas nacionales sobre los pueblos indígenas en la Amazonia, la asimilación (o integración) y la autonomía, analizando cómo han afectado la situación de los pueblos en aislamiento en el pasado y cómo lo hacen hoy en día. Como estudio de caso, desarrollamos el de los indígenas mashco piro del río Alto Madre de Dios (Madre de Dios, Perú), que pone de relieve la complejidad de la aplicación de las políticas en el terreno, en un contexto de crecientes amenazas para los territorios amazónicos. Finalmente, exploramos las problemáticas relaciones entre las políticas relativas a los indígenas en aislamiento con aquellas relacionadas a la economía y el uso del territorio, las cuales se encuentran estrechamente ligadas en la región amazónica

Políticas públicas e indígenas en aislamiento en Perú y Brasil: Entre la asimilación y la autonomía

El presente artículo revisa comparativamente el papel de las políticas públicas en la situación de los pueblos indígenas en aislamiento en dos países, Brasil y Perú. Presenta los grandes paradigmas que han dominado las políticas nacionales sobre los pueblos indígenas en la Amazonia, la asimilación (o integración) y la autonomía, analizando cómo han afectado la situación de los pueblos en aislamiento en el pasado y cómo lo hacen hoy en día. Como estudio de caso, desarrollamos el de los indígenas mashco piro del río Alto Madre de Dios (Madre de Dios, Perú), que pone de relieve la complejidad de la aplicación de las políticas en el terreno, en un contexto de crecientes amenazas para los territorios amazónicos. Finalmente, exploramos las problemáticas relaciones entre las políticas relativas a los indígenas en aislamiento con aquellas relacionadas a la economía y el uso del territorio, las cuales se encuentran estrechamente ligadas en la región amazónica. </p

Senses of Self, Society, and Cosmos

The pervasiveness of ayahuasca use in lowland South America, alongside its rising global diaspora spurred by ayahuasca tour-ism, religious movements, and the psychedelic renaissance, makes Gearin and Calavia Sáez’s critical scholarship particularly welcome. The authors’ comparative attention to visualise and individualism across“glocal” contexts of ayahuasca practices, namely, neoshamanic uses in Australia and indigenous practices in Amazonia, is compelling. They invite us to focus on diverging notions of property and personhood to understand ayahuasca visualism as an expression of divergent cultural viewpoints. I concur with their proposal that ayahuasca visions are sites of equivocation whose interpretations are rendered meaningful by particular socialities. They view the Australian neoshamanic individual as a product of the philosophical Enlightenmentwho becomes the center of the ayahuasca experience, interpretation, and outcome, while for“Amazonians,” the centrality of the individual is a product of animistic and perspectival ontologies and is therefore by default fractal and more broadly connected to larger social worlds

Global importance of Indigenous Peoples, their lands, and knowledge systems for saving the world’s primates from extinction

Primates, represented by 521 species, are distributed across 91 countries primarily in the Neotropic, Afrotropic, and Indo-Malayan realms. Primates inhabit a wide range of habitats and play critical roles in sustaining healthy ecosystems that benefit human and nonhuman communities. Approximately 68% of primate species are threatened with extinction because of global pressures to convert their habitats for agricultural production and the extraction of natural resources. Here, we review the scientific literature and conduct a spatial analysis to assess the significance of Indigenous Peoples’ lands in safeguarding primate biodiversity. We found that Indigenous Peoples’ lands account for 30% of the primate range, and 71% of primate species inhabit these lands. As their range on these lands increases, primate species are less likely to be classified as threatened or have declining populations. Safeguarding Indigenous Peoples’ lands, languages, and cultures represents our greatest chance to prevent the extinction of the world’s primates.info:eu-repo/semantics/publishedVersio

Global importance of Indigenous Peoples, their lands, and knowledge systems for saving the world's primates from extinction

Publisher Copyright: Copyright © 2022 The Authors, some rights reserved.Primates, represented by 521 species, are distributed across 91 countries primarily in the Neotropic, Afrotropic, and Indo-Malayan realms. Primates inhabit a wide range of habitats and play critical roles in sustaining healthy ecosystems that benefit human and nonhuman communities. Approximately 68% of primate species are threatened with extinction because of global pressures to convert their habitats for agricultural production and the extraction of natural resources. Here, we review the scientific literature and conduct a spatial analysis to assess the significance of Indigenous Peoples' lands in safeguarding primate biodiversity. We found that Indigenous Peoples' lands account for 30% of the primate range, and 71% of primate species inhabit these lands. As their range on these lands increases, primate species are less likely to be classified as threatened or have declining populations. Safeguarding Indigenous Peoples' lands, languages, and cultures represents our greatest chance to prevent the extinction of the world's primates.Peer reviewe

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival