Formulation and evaluation of Theophylline controlled release matrix tablets using Guar gum.

Theophylline controlled release matrix tablets were prepared with guar gum in two ratios and with three different hardness of 5, 6 and 7kg/cm2. Theophylline controlled release granules were prepared and evaluated for the angle of repose, bulk density, tapped density, compressibility index and hausners ratio. All the formulation showed good flow properties. The compressed tablets were evaluated for the hardness, uniformity of weight, friability, drug content and invitro dissolution studies. All the formulations showed compliance with pharmacopial standards. There was no interaction between drug, polymer and other excipients. It was confirmed by FTIR studies. Among all the formulations F6 (i.e. polymer ratio1:2 and hardness 7kg/cm2) showed prolong release when compare to other formulations. The drug release kinetics showed zero order. The optimum formulation (F6) was stable when it was stored at 40 + 20 C, 280 + 20 C and at 450 + 20 C for 6 months

Spawning concentrations of the sardine, Sardinella gibbosa (Bleeker), off the north Andhra Coast in March - April 1969

Adult Sardinella gibbosa in pre-spawning and spawning stages were observed in March 1969 in Waltair - Kakinada region from catches made 15-20 km from shore. Plankton collections made during this period off Kakinada contained eggs which have been assigned to S. gibbosa based on circumstantial evidence and resemblances. Most of the stomachs of 5. ^/'66oM examined during the period were either empty or contained very little food. These indicate that there was extensive spawning of the species off the North Andhra coast in March-April 1969

Exploratory trawling on the continental shelf along the north-western part of the Bay of Bengal

The results of exploratory trawl'ng undertaken from 1961 to 1965 on the continental shelf along the north-western part of the Bay of Bengal, between latitudes 16''40'N and 2rOO'N are presented. The composition of the catch, the distribution of the various categories of fishes and their relative abundance in space and time are indicated. It is estimated that in commercial fishing, with Visakhapatnam as the base, a 25 m side-trawler with 15 m trawl should be able to land 250-390 metric tons of fishes, a 14 m stern-trawler with 14m trawl, 67-174 metric tons, and a 13-7 m stern-trawler with 12 m trawl, 56-94 metric tons per year from the area

Transverse-spin dependence of the p-p total cross section ΔσT from 0.8 to 2.5 GeV/c

The difference ΔσT=σ(↓↑)-σ(↑↑) between the proton-proton total cross sections for protons in pure transverse-spin states, was measured at incident momenta 0.8 to 2.5 GeV/c in experiments performed at the Los Alamos Clinton P. Anderson Meson Physics Facility and the Argonne Zero Gradient Synchrotron. In agreement with other data, peaks were observed at center-of-mass energies of 2.14 and 2.43 GeV/c2, where 1D2 and 1G4 dibaryon resonances have been proposed

Quasiparticle Line Shape of Sr2RuO4 and its Relation to Anisotropic Transport

The bulk-representative low-energy spectrum of Sr2RuO4 can be directly measured by angle-resolved photoemission. We find that the quasiparticle spectral line shape of Sr2RuO4 is sensitive to both temperature and momentum. Along the (0, 0)-(π, 0) direction, both gamma and ß bands develop a sharp quasiparticle peak near kF at low temperatures, but as the temperature increases the spectra quickly lose coherent weight and become broad backgrounds above ~130 K, which is the metal-nonmetal crossover temperature, TM, in the c-axis resistivity. However, spectra along the (0, 0)-(π, π) direction evolve smoothly across TM. A simple transport model can describe both in-plane and c-axis resistivity in terms of the quasiparticle line shape. Comparisons are also made to the cuprates, with implications for two dimensionality, magnetic fluctuations, and superconductivit

Correlates of caregiving burden in schizophrenia:A cross-sectional, comparative analysis from India

Schizophrenia is a global mental health issue that has serious implications not only for the person with the diagnosis, but for caregivers as well. In Asian societies, the family tends to be the “natural” caregiver in such situations and the caregiving function is usually shouldered by parents or the spouse. Asian communities tend to be more closely knit, and it would be expected that more social support would be available to those facing distressing circumstances such as managing the demands of a person with mental illness. This study seeks to explore the perceived burden in family caregivers of persons diagnosed with schizophrenia, the coping strategies that come into play, as well as the extent of social support available to them. Standardized instruments were administered to collect data at a teaching cum treatment facility in south India. A quantitative methodology was used to analyze cross-sectional data from 75 primary caregivers of people with a diagnosis of schizophrenia and a reference group of caregivers of patients with general medical ailments. Results indicate high levels of burden, low social support, and poor coping in the caregivers of people with schizophrenia than the reference group. Implications for intervention with caregivers are also discussed in this article

Primordial Nucleosynthesis for the New Cosmology: Determining Uncertainties and Examining Concordance

Big bang nucleosynthesis (BBN) and the cosmic microwave background (CMB) have a long history together in the standard cosmology. The general concordance between the predicted and observed light element abundances provides a direct probe of the universal baryon density. Recent CMB anisotropy measurements, particularly the observations performed by the WMAP satellite, examine this concordance by independently measuring the cosmic baryon density. Key to this test of concordance is a quantitative understanding of the uncertainties in the BBN light element abundance predictions. These uncertainties are dominated by systematic errors in nuclear cross sections. We critically analyze the cross section data, producing representations that describe this data and its uncertainties, taking into account the correlations among data, and explicitly treating the systematic errors between data sets. Using these updated nuclear inputs, we compute the new BBN abundance predictions, and quantitatively examine their concordance with observations. Depending on what deuterium observations are adopted, one gets the following constraints on the baryon density: OmegaBh^2=0.0229\pm0.0013 or OmegaBh^2 = 0.0216^{+0.0020}_{-0.0021} at 68% confidence, fixing N_{\nu,eff}=3.0. Concerns over systematics in helium and lithium observations limit the confidence constraints based on this data provide. With new nuclear cross section data, light element abundance observations and the ever increasing resolution of the CMB anisotropy, tighter constraints can be placed on nuclear and particle astrophysics. ABRIDGEDComment: 54 pages, 20 figures, 5 tables v2: reflects PRD version minor changes to text and reference