Performance of a tandem-rotor/tandem-stator conical-flow compressor designed for a pressure ratio of 3

A conical-flow compressor stage with a large radius change through the rotor was tested at three values of rotor tip clearance. The stage had a tandem rotor and a tandem stator. Peak efficiency at design speed was 0.774 at a pressure ratio of 2.613. The rotor was tested without the stator, and detailed survey data were obtained for each rotor blade row. Overall peak rotor efficiency was 0.871 at a pressure ratio of 2.952

Shuttle landing facility cloud cover study: Climatological analysis and two tenths cloud cover rule evaluation

The two-tenths cloud cover rule in effect for all End Of Mission (EOM) STS landings at the Kennedy Space Center (KSC) states: 'for scattered cloud layers below 10,000 feet, cloud cover must be observed to be less than or equal to 0.2 at the de-orbit burn go/no-go decision time (approximately 90 minutes before landing time)'. This rule was designed to protect against a ceiling (below 10,000 feet) developing unexpectedly within the next 90 minutes (i.e., after the de-orbit burn decision and before landing). The Applied Meteorological Unit (AMU) developed and analyzed a database of cloud cover amounts and weather conditions at the Shuttle Landing Facility for a five-year (1986-1990) period. The data indicate the best time to land the shuttle at KSC is during the summer while the worst time is during the winter. The analysis also shows the highest frequency of landing opportunities occurs for the 0100-0600 UTC and 1300-1600 UTC time periods. The worst time of the day to land a shuttle is near sunrise and during the afternoon. An evaluation of the two-tenths cloud cover rule for most data categorizations has shown that there is a significant difference in the proportions of weather violations one and two hours subsequent to initial conditions of 0.2 and 0.3 cloud cover. However, for May, Oct., 700 mb northerly wind category, 1500 UTC category, and 1600 UTC category there is some evidence that the 0.2 cloud cover rule may be overly conservative. This possibility requires further investigation. As a result of these analyses, the AMU developed nomograms to help the Spaceflight Meteorological Group (SMG) and the Cape Canaveral Forecast Facility (CCFF) forecast cloud cover for EOM and Return to Launch Site (RTLS) at KSC. Future work will include updating the two tenths database, further analysis of the data for several categorizations, and developing a proof of concept artificial neural network to provide forecast guidance of weather constraint violations for shuttle landings

The symbolosphere, conceptualization, language, and neo-dualism

It is shown that Schumann’s (2003) notion of the Symbolosphere, the non-physical world of symbolic relationships and Logan’s (2000a) Extended Mind model in which the mind is defined as the brain plus language entail a form of dualism. A distinction is made between the symbolosphere, which includes the human mind and all its thoughts and communication processes such as language and the physiosphere which is simply the physical world and includes the human brain. No distinction is made between substance and property dualism, hence the use of the term neo-dualism. The neo-dualistic approach is justified on the basis that at our current understanding of neuroscience is unable to connect the functions of the mind with the actions of the brain and hence it makes sense from a practical point of view to distinguish between these two levels of phenomena. The neo-dualism formulated here is also used to critique strong AI and deconstructionism

Emergence of noise-induced barren plateaus in arbitrary layered noise models

In variational quantum algorithms the parameters of a parameterized quantum circuit are optimized in order to minimize a cost function that encodes the solution of the problem. The barren plateau phenomenon manifests as an exponentially vanishing dependence of the cost function with respect to the variational parameters, and thus hampers the optimization process. We discuss how, and in which sense, the phenomenon of noise-induced barren plateaus emerges in parameterized quantum circuits with a layered noise model. Previous results have shown the existence of noise-induced barren plateaus in the presence of local Pauli noise [arXiv:2007.14384]. We extend these results analytically to arbitrary completely-positive trace preserving maps in two cases: 1) when a parameter-shift rule holds, 2) when the parameterized quantum circuit at each layer forms a unitary $2$-design. The second example shows how highly expressive unitaries give rise not only to standard barren plateaus [arXiv:1803.11173], but also to noise-induced ones. In the second part of the paper, we study numerically the emergence of noise-induced barren plateaus in QAOA circuits focusing on the case of MaxCut problems on $d$-regular graphs and amplitude damping noise.Comment: 34 pages, 9 Figures, added Refs. [31,32] and fixed typo in Eq (B.30

Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome.

BackgroundWilliams syndrome (WS) and autism spectrum disorder (ASD) are neurodevelopmental disorders that demonstrate overlapping genetic associations, dichotomous sociobehavioral phenotypes, and dichotomous pathological differences in neuronal distribution in key social brain areas, including the prefrontal cortex and the amygdala. The serotonergic system is critical to many processes underlying neurodevelopment and is additionally an important neuromodulator associated with behavioral variation. The amygdala is heavily innervated by serotonergic projections, suggesting that the serotonergic system is a significant mediator of neuronal activity. Disruptions to the serotonergic system, and atypical structure and function of the amygdala, are implicated in both WS and ASD.MethodsWe quantified the serotonergic axon density in the four major subdivisions of the amygdala in the postmortem brains of individuals diagnosed with ASD and WS and neurotypical (NT) brains.ResultsWe found opposing directions of change in serotonergic innervation in the two disorders, with ASD displaying an increase in serotonergic axons compared to NT and WS displaying a decrease. Significant differences (p < 0.05) were observed between WS and ASD data sets across multiple amygdala nuclei.LimitationsThis study is limited by the availability of human postmortem tissue. Small sample size is an unavoidable limitation of most postmortem human brain research and particularly postmortem research in rare disorders.ConclusionsDifferential alterations to serotonergic innervation of the amygdala may contribute to differences in sociobehavioral phenotype in WS and ASD. These findings will inform future work identifying targets for future therapeutics in these and other disorders characterized by atypical social behavior

Beyond Patient Reported Pain: Perfusion Magnetic Resonance Imaging Demonstrates Reproducible Cerebral Representation of Ongoing Post-Surgical Pain

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Depressive rumination and heart rate variability: A pilot study on the effect of biofeedback on rumination and its physiological concomitants

ObjectiveRecent studies suggest that lower resting heart rate variability (HRV) is associated with elevated vulnerability to depressive rumination. In this study, we tested whether increases in HRV after HRV-biofeedback training are accompanied by reductions in rumination levels. Materials and methodsSixteen patients suffering from depression completed a 6-week HRV-biofeedback training and fourteen patients completed a control condition in which there was no intervention (waitlist). The training included five sessions per week at home using a smartphone application and an ECG belt. Depressive symptoms and autonomic function at rest and during induced rumination were assessed before and after each of the two conditions. We used a well-established rumination induction task to provoke a state of pervasive rumination while recording various physiological signals simultaneously. Changes in HRV, respiration rate, skin conductance, and pupil diameter were compared between conditions and time points. ResultsA significant correlation was found between resting HRV and rumination levels, both assessed at the first laboratory session (r = -0.43, p < 0.05). Induction of rumination led to an acceleration of heart rate and skin conductance increases. After biofeedback training, resting vagal HRV was increased (p < 0.01) and self-ratings of state anxiety (p < 0.05), rumination (p < 0.05), perceived stress (p < 0.05), and depressive symptoms (QIDS, BDI; both p < 0.05) were decreased. In the control condition, there were no changes in autonomic indices or depressive symptomatology. A significant interaction effect group x time on HRV was observed. ConclusionOur results indicate that a smartphone-based HRV-biofeedback intervention can be applied to improve cardiovagal function and to reduce depressive symptoms including self-rated rumination tendencies