30 research outputs found
A comparison of soil moisture relations between standing and clearfelled plots with burnt and unburnt harvest residue treatments of a clonal eucalypt plantation on the Zululand Coastal Plain, South Africa
The effects of clearfelling and subsequent residue retention or burning on water and nutrient balances needs to be understood and quantified on forest sites that are sensitive to loss, so that the long-term sustainable productivity of such sites can be maintained and promoted. An experimental site was established in a clonal eucalypt compartment on the Zululand Coastal Plain, to compare changes in water fluxes through the mature undisturbed eucalypt stand with those after felling and re-planting, under 2 conditions: burning, and retention of the harvesting residues. The study was located in an area of high rainfall and high stand productivity, with sandy soils and low soil carbon and nutrient status; chosen so that the effects of intensive demands on water and nutrient fluxes on a potentially sensitive site could be investigated. This paper presents only the hydrological component of the study. Data collection included weekly determination of rainfall, throughfall, stemflow and soil moisture fluxes from the surface to a depth of 1 m. Drainage rates through the profile were established using time domain reflectometry probes while water drainage volumes were assessed using shallow plate lysimeters. Despite slow growth in the unfelled crop during the monitoring period (attributed to a pest infestation), soil moisture depletion remained rapid and drainage below 1 m remained low. Soil moisture was recharged within a few months after clearfelling, but became rapidly depleted as the canopy of new crop developed and approached canopy closure. A decreased wetting-front velocity and a marginally higher field capacity were proposed as evidence of pore clogging that appeared to occur during the inter-rotation period. The soil profile under the unburnt residue maintained a marginally higher soil moisture status and lower drainage than the soil profile under the burnt residue. Although soil moisture and drainage in the burnt and unburnt residue treatments became similar to the unfelled crop from canopy closure onwards, rainfall additions to soil moisture were depleted faster under the new crop during the first few months after canopy closure. Small differences in soil moisture status between the burnt and unburnt residue treatments presented here may not be sufficient to influence residue management decisions. The length of the inter-rotation period and practice of residue burning may, however, need consideration where soil carbon and nutrient loss or displacement may negatively affect the sustainability of the site.Keywords: Soil moisture drainage, residue burning, post felling, inter-rotatio
Home: The place the older adult can not imagine living without
<p>Abstract</p> <p>Background</p> <p>Rapidly aging populations with an increased desire to remain at home and changes in health policy that promote the transfer of health care from formal places, as hospitals and institutions, to the more informal setting of one's home support the need for further research that is designed specifically to understand the experience of home among older adults. Yet, little is known among health care providers about the older adult's experience of home. The aim of this study was to understand the experience of home as experienced by older adults living in a rural community in Sweden.</p> <p>Methods</p> <p>Hermeneutical interpretation, as developed by von Post and Eriksson and based on Gadamer's philosophical hermeneutics, was used to interpret interviews with six older adults. The interpretation included a self examination of the researcher's experiences and prejudices and proceeded through several readings which integrated the text with the reader, allowed new questions to emerge, fused the horizons, summarized main and sub-themes and allowed a new understanding to emerge.</p> <p>Results</p> <p>Two main and six sub-themes emerged. Home was experienced as the place the older adult could not imagine living without but also as the place one might be forced to leave. The older adult's thoughts vacillated between the well known present and all its comforts and the unknown future with all its questions and fears, including the underlying threat of loosing one's home.</p> <p>Conclusions</p> <p>Home has become so integral to life itself and such an intimate part of the older adult's being that when older adults lose their home, they also loose the place closest to their heart, the place where they are at home and can maintain their identity, integrity and way of living. Additional effort needs to be made to understand the older adult's experience of home within home health care in order to minimize intrusion and maximize care. There is a need to more fully explore the older adult's experience with health care providers in the home and its impact on the older adult's sense of "being at home" and their health and overall well-being.</p
Histone Deacetylase Inhibition Enhances Self Renewal and Cardioprotection by Human Cord Blood-Derived CD34+ Cells
Abstract
BACKGROUND:
Use of peripheral blood- or bone marrow-derived progenitors for ischemic heart repair is a feasible option to induce neo-vascularization in ischemic tissues. These cells, named Endothelial Progenitors Cells (EPCs), have been extensively characterized phenotypically and functionally. The clinical efficacy of cardiac repair by EPCs cells remains, however, limited, due to cell autonomous defects as a consequence of risk factors. The devise of "enhancement" strategies has been therefore sought to improve repair ability of these cells and increase the clinical benefit.
PRINCIPAL FINDINGS:
Pharmacologic inhibition of histone deacetylases (HDACs) is known to enhance hematopoietic stem cells engraftment by improvement of self renewal and inhibition of differentiation in the presence of mitogenic stimuli in vitro. In the present study cord blood-derived CD34(+) were pre-conditioned with the HDAC inhibitor Valproic Acid. This treatment affected stem cell growth and gene expression, and improved ischemic myocardium protection in an immunodeficient mouse model of myocardial infarction.
CONCLUSIONS:
Our results show that HDAC blockade leads to phenotype changes in CD34(+) cells with enhanced self renewal and cardioprotection
Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect
The histone deacetylase inhibitors (HDACi) have demonstrated anticancer efficacy across a range of malignancies, most impressively in the hematological cancers. It is uncertain whether this clinical efficacy is attributable predominantly to their ability to induce apoptosis and differentiation in the cancer cell, or to their ability to prime the cell to other pro-death stimuli such as those from the immune system. HDACi-induced apoptosis occurs through altered expression of genes encoding proteins in both intrinsic and extrinsic apoptotic pathways; through effects on the proteasome/aggresome systems; through the production of reactive oxygen species, possibly by directly inducing DNA damage; and through alterations in the tumor microenvironment. In addition HDACi increase the immunogenicity of tumor cells and modulate cytokine signaling and potentially T-cell polarization in ways that may contribute the anti-cancer effect in vivo. Here, we provide an overview of current thinking on the mechanisms of HDACi activity, with attention given to the hematological malignancies as well as scientific observations arising from the clinical trials. We also focus on the immune effects of these agents
Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study
Purpose Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes
Estimating biomass and macronutrient content of some commercially‚ important plantation species in South Africa
The removal of biomass, in any combination of stemwood, bark or branch harvesting, can cause a significant increase in nutrient loss from commercial timber plantations. Ensuring long-term site productivity of forest plantations is a key issue for forestry management. Managers need to secure a continued supply of tree biomass components, while understanding the impact of various harvesting operations on plantation nutrient reserves. It is imperative to quantify the biomass and nutrient stocks and their removal during silvicultural operations, such as harvesting, burning and various forms of site preparation. At present, there are no simple methods to estimate inherent site nutrient reserves, or nutrient gains through processes such as atmospheric deposition or rock weathering, or the quantities of nutrients lost through silvicultural operations (harvesting, burning and site preparation). The aim of this work was to construct simple multipliers that can be used in conjunction with plantation timber volumes to estimate stem, branch and bark biomass and nutrient contents. The multipliers were developed from data existing for Eucalyptus spp., Pinus patula and Acacia mearnsii stands throughout the summer rainfall region of South Africa and Swaziland. Due to limited data unique nutrient multipliers were not developed for each productivity range and the multipliers were assumed to be consistent across all productivity ranges. The ratios may underestimate on fertile sites where luxury consumption of nutrients may occur and not accurately predict where stand management practices have altered wood density, allometry or canopy architecture. Although genus and species impacted on the quantity of nutrients held in the plantation biomass, productivity and harvesting intensity were the biggest driver of nutrient removal. Although the multipliers developed here have value in creating a general estimate of nutrient content they are from a limited dataset and need to be expanded upon across species, site and age ranges before being able to precisely estimate nutrient contents. Although harvesting is a major component of nutrient export, natural additions and losses of nutrients, and site nutrient reserves need to be known in order to gain a complete understanding of the impact of nutrient loss on site nutrient reserves. Keywords: Acacia mearnsii, biomass, Eucalyptus, nutrient content, Pinus patula, sustainabilitySouthern Forests 2009, 71(3): 245–25
A review of nutrient fluxes across South African plantation forestry areas
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Effects of site management on nutrient accretion of a Eucalyptus grandis plantation in South Africa
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Effects of Slash and Site Management Treatments on Soil Properties, Nutrition and Growth of a Eucalyptus grandis Plantation in south Africa
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