97 research outputs found
Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4â6Â weeks, followed by ivermectin (IVM) after 6Â months. After 6â27Â months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxycycline resulted in endobacteria depletion and female worm sterilization. The 6-week treatment was macrofilaricidal, with >60% of the female worms found dead, despite the presence of new, Wolbachia-containing worms acquired after the administration of doxycycline. Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections
Agronomic performance, seed quality and nitrogen uptake of Descurainia sophia in response to different nitrogen rates and water regimes
Effect of herbicides and doses on shortâ and longâterm control of Eleusine tristachya
Gastrointestinal Morphology and Motility in American Kestrels Receiving High or Low Fat Diets
Effect of Dietary Lipase Enzyme on Gut Morphology, Gastric Motility, and Long-Term Performance of Broiler Chicks
Research Note: Feeding Various Levels of Ground Sesbania macrocarpa Muhl. Seed to Bobwhite Quail
Production of napiergrass as a forage and bioenergy feedstock with swineâlagoon effluent
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