CLEAR: Covariant LEAst-square Re-fitting with applications to image restoration

In this paper, we propose a new framework to remove parts of the systematic errors affecting popular restoration algorithms, with a special focus for image processing tasks. Generalizing ideas that emerged for $\ell_1$ regularization, we develop an approach re-fitting the results of standard methods towards the input data. Total variation regularizations and non-local means are special cases of interest. We identify important covariant information that should be preserved by the re-fitting method, and emphasize the importance of preserving the Jacobian (w.r.t. the observed signal) of the original estimator. Then, we provide an approach that has a "twicing" flavor and allows re-fitting the restored signal by adding back a local affine transformation of the residual term. We illustrate the benefits of our method on numerical simulations for image restoration tasks

Does diet mediate associations of volume and bouts of sedentary time with cardiometabolic health indicators in adolescents?

Objective: Examine the mediating role of diet in the relationship between volume and duration of sedentary time with cardiometabolic health in adolescents. Methods: Adolescents (12-19 years) participating in the 2003/04 and 2005/06 U.S. National Health and Nutrition Examination Survey (NHANES) were examined. Cardiometabolic health indicators were body mass index z-scores (zBMI) (n 5 1,797) and metabolic syndrome (MetS) (n 5 812). An ActiGraph hip-worn accelerometer was used to derive total sedentary time and usual sedentary bout duration. Dietary intake was assessed using two 24-hour dietary recalls. Mediation analyses were conducted to examine five dietary mediators [total energy intake, discretionary foods, sugar-sweetened beverages (SSB), fruits and vegetables, and dietary quality] of the relationship between total sedentary time and usual sedentary bout duration with zBMI and MetS. Results: Total sedentary time was inversely associated with zBMI (b 5 21.33; 95% CI 22.53 to 20.13) but attenuated after adjusting for moderate-to-vigorous physical activity. No significant associations were observed between usual sedentary bout duration with zBMI or either sedentary measure with MetS. None of the five dietary variables mediated any of the relationships examined. Conclusions: Further studies are needed to explore associations of specific time periods (e.g., after school) and bout durations with both cardiometabolic health indicators and dietary behaviors

Diamonds are Forever

We defend the thesis that every necessarily true proposition is always true. Since not every proposition that is always true is necessarily true, our thesis is at odds with theories of modality and time, such as those of Kit Fine and David Kaplan, which posit a fundamental symmetry between modal and tense operators. According to such theories, just as it is a contingent matter what is true at a given time, it is likewise a temporary matter what is true at a given possible world; so a proposition that is now true at all worlds, and thus necessarily true, may yet at some past or future time be false in the actual world, and thus not always true. We reconstruct and criticize several lines of argument in favor of this picture, and then argue against the picture on the grounds that it is inconsistent with certain sorts of contingency in the structure of time

Interdisciplinary (retail) research: The business of geography and the geography of business

NoAt the 2005 British Academy of Management conference several well-known economic geographers, including Neil Wrigley, Gordon Clark, and Susan Christopherson, called for management researchers to engage with economic geographers on interrelated geographical and managerial issues in the study of (retail) firms. In this commentary we reflect upon the present geography -management interface.We begin by considering the term `interdisciplinary research' and its relationship to any management - geography interface. This is followed by a context-specific discussion of international retailing and the role of research on the retail transnational corporation (TNC) in developing an interdisciplinary agenda. This commentary represents an initial more business and management focused response to the call from geography academics for more/better interdisciplinary research at the geography - management interface

Slow flows of an relativistic perfect fluid in a static gravitational field

Relativistic hydrodynamics of an isentropic fluid in a gravitational field is considered as the particular example from the family of Lagrangian hydrodynamic-type systems which possess an infinite set of integrals of motion due to the symmetry of Lagrangian with respect to relabeling of fluid particle labels. Flows with fixed topology of the vorticity are investigated in quasi-static regime, when deviations of the space-time metric and the density of fluid from the corresponding equilibrium configuration are negligibly small. On the base of the variational principle for frozen-in vortex lines dynamics, the equation of motion for a thin relativistic vortex filament is derived in the local induction approximation.Comment: 4 pages, revtex, no figur

ANALISIS FAKTOR – FAKTOR YANG MEMPENGARUHI PRESTASI AKADEMIK MAHASISWA JURUSAN MATEMATIKA FMIPA UNPATTI DENGAN MENGGUNAKAN REGRESI LOGISTIK BINER

Perguruan tinggi sejauh ini telah berkembang mengikuti tuntutan global dalam mempersiapkan mahasiswa menjadi insan yang siap bersaing dalam segala hal. Untuk mendapatkan hasil lulusan yang berdaya saing, perguruan tinggi juga memiliki tolak ukur kesuksesan studi. Perguruan tinggi sejauh ini telah berkembang mengikuti tuntutan global dalam mempersiapkan mahasiswa menjadi insan yang siap bersaing dalam segala hal. Untuk mendapatkan hasil lulusan yang berdaya saing, perguruan tinggi juga memiliki tolak ukur kesuksesan studi. Bagi mahasiswanya, yakni nilai akademik yang biasa dikenal dengan Indeks Prestasi Komulatif (IPK). IPK dapat dikategorikan menjadi dua yaitu IPK baik dan kurang. Regresi Logistik adalah regresi yang digunakan atau diterapkan pada saat variabel respon bersifat kualitatif. Model regresi logistik yang variabel responnya memiliki dua kategori disebut regresi logistik biner. Tujuan dari penelitian ini yaitu untuk mengetahui faktor-faktor yang mempengaruhi prestasi akademik mahasiswa Jurusan Matematika FMIPA UNPATTI dengan menggunakan Regresi Logistik Biner. Hasil penelitian menunjukan bahwa faktor yang signifikan mempengaruhi prestasi akademik mahasiswa Jurusan Matematika FMIPA UNPATTI dengan menggunakan Regresi Logistik Biner adalah lama belajar ( ). Besarnya ketepatan pengklasifikasian prestasi akademik mahasiswa Jurusan Matematika FMIPA UNPATTI untuk kategori baik dan kurang adalah 80% &nbsp

HUBUNGAN ANTARA PENGETAHUAN DAN SIKAP DENGAN PERILAKU HIDUP BERSIH DAN SEHAT (PHBS)TATANAN RUMAH TANGGA DI KELURAHAN KIMA ATAS KOTA MANADO

Kegiatan Perilaku hidup bersih dan sehat inii tatanan rumah tangga dapat berpengaruh pada derajat kesehatan keluarga itu sendiri. Pengembangdesa dankeurahan dapat memberdayakan keluarga-keluarga agar mampu melaksanakan kegiatan PHBS. Tndkanhdiup Bersih dan Sehat merupakan tindakan dalam mewujudkan kesehatan masyarakat dalam hal ini yaitu sekumpulan perilaku yang dapat di praktikkan dalam menjadikan seseorang, keluarga, atau masyarakat bisa berperan aktif dn mampu membantudirinya sendiridalam bidanykesehitan. Penelitian ini jugadilakukanumtuk mengetahui hubunganpengetahuan dan sikap dengan Perilaku Hidup Bersih dan Sehat (PHBS) rumahangga di Kelurahan Kima Atas Kota Manado. Metodde penliitian adallah survei nalitik dengan desaign penelitan yaitu cross sectional (potong lintang). Penelitian ini dilakukan pada bulan Mei-Oktober 2019 di Kelurahan KimaAtas KataManado. Populasi dalam penelitian ini adalah seluruh rumah tangga yang berada di Kelurahan Kima Atas Kota Manado yang berjumlah 319 rumah tangga. Sampel dalam penelitian ini berjumlah 77sanpel. Teknik pengambilan sampel yaitupurposiivesampling. Analisis data yang diipergunakan adalah analisis univariatbivariat. Hasil penelitian yang didapatkan yaitu pengetahuan responden baik 45,5% dan pengetahuan responden kurang baik 54,5%, sikap responden baik 40,3% dan sikap responden kurang baik 59,7%. Kesimpulan yang diadapatkann penelitian ini adalah bahwa terdapat hubungan antarapenetghuan dan sikap dengan PHBS tatananrumah tanga. Kata Kunci : Pengetahuan, Sikap, Perilaku Hidup Bersih dan Sehat ABSTRACTClean and healthy behavior in the household setting can affect the health status of the family itself. Rural and urban village development can empower families to be able to practice . Clern and HoalthyBenavior is an action in realizing public health in this case, namely a set of behaviors that can be practiced in making a person, family, or community cm play dan active role and be able to help then selves in the heahsector. This resech wasconucted to dertrmine the relationp of ledge an attitudes with theClea and helt Behaviof the household order in the KimAtas Village, Manado City. The research method is an analytical survey with a research design that is cross sectional. This research was conducted in May-Oktober 2019 in the Kima Atas Village, Manado City. The popution inthis study were all houesholdsin the Kima Atas Kelurahan of the City of Manado, amountinto 319 households. The sample in this study amounted to 77 samples. The sampling technique is purposive sampling. Analysis of the data used is univariate and bivariate analysis. The results of this research are 45.5% of respondents 'good knowledge and 54.5% of respondents' poor knowledge, 40.3% of respondents 'good attitude and 59.7% of respondents' poor attitude. The conclusion or thisstudy showe that there is a relationsh betweeknowledge and attitude with PHBS household order. Keywords: Knowledge, Attitude, Clean and Healthy Behavio

Exploring young people's interpretations of female genital mutilation in the UK using a community-based participatory research approach

BACKGROUND: Female genital mutilation (FGM) is a deeply-rooted cultural practice mainly undertaken in Africa, the Middle East and Asian countries. Evidence to date suggests that although first-generation migrants to the West are abandoning FGM, the custom continues in some places, albeit in small numbers. This study examined how young people living in FGM affected communities in the United Kingdom (UK), interpreted and explained FGM. METHODS: A community-based participatory research (CBPR) approach was used to recruit and train nine young people aged 15-18 as co-researchers. These comprised eight females and one male from second-generation FGM affected communities, living in Bristol. The co-researchers then undertook focus groups and semi-structured interviews with twenty participants aged 13-15 living in Bristol, Cardiff and Milton Keynes. The qualitative data from the training workshops, interviews and focus groups were collected and analysed using thematic analysis. RESULTS: There were conflicting views among participants. Some perceived FGM as a historical tradition that was of very little, if any, relevance to them. In contrast, others perceived that the more archaic, cultural interpretation of FGM, more commonly shared by older generations, had been supplanted by a new form of FGM, which they believed to be a safe procedure, made so by the availability of highly-trained, qualified doctors and better equipment in the UK. Participants spoke of challenges encountered when attempting to raise the issue of FGM with parents. Nevertheless, they acknowledged that- being born and raised in the UK - enabled them to talk openly and to challenge others. CONCLUSION: Future strategies to address and prevent FGM in the UK will require a public health approach that is holistic, intersectional and empowering. Such measures should be relevant to young people born and raised in the UK who interpret FGM differently to previous first-generation migrant relatives and communities. Tackling FGM requires a shift away from a principal preoccupation with harm reduction and criminalisation towards collaboration and active dialogue with communities, in positive and productive ways that acknowledge and engage issues of identity, race, gender, and generation, enabling people affected by FGM to take control of their health and well-being

Pharmaceutical Inhibition of mTOR in the Common Marmoset: Effect of Rapamycin on Regulators of Proteostasis in a Non-Human Primate

Background: Inhibition of mechanistic target of rapamycin (mTOR) has emerged as a viable means to lengthen lifespan and healthspan in mice, although it is still unclear whether these benefits will extend to other mammalian species. We previously reported results from a pilot experiment wherein common marmosets (Callithrix jacchus) were treated orally with rapamycin to reduce mTOR signaling in vivo in line with previous reports in mice and humans. Further, long-term treatment did not significantly alter body weight, daily activity, blood lipid concentrations, or glucose metabolism in this cohort. Methods: In this study, we report on the molecular consequences of rapamycin treatment in marmosets on mechanisms that regulate protein homeostasis (proteostasis) in vivo. There is growing appreciation for the role of proteostasis in longevity and for the role that mTOR plays in regulating this process. Tissue samples of liver and skeletal muscle from marmosets in our pilot cohort were assessed for expression and activity of components of the ubiquitin-proteasome system, macroautophagy, and protein chaperones. Results: Rapamycin treatment was associated with increased expression of PSMB5, a core subunit of the 20S proteasome, but not PSMB8 which is involved in the formation of the immunoproteasome, in the skeletal muscle and liver. Surprisingly, proteasome activity measured in these tissues was not affected by rapamycin. Rapamycin treatment was associated with an increased expression of mitochondria-targeted protein chaperones in skeletal muscle, but not liver. Finally, autophagy was increased in skeletal muscle and adipose, but not liver, from rapamycin-treated marmosets. Conclusions: Overall, these data show tissue-specific upregulation of some, but not all, components of the proteostasis network in common marmosets treated with a pharmaceutical inhibitor of mTOR