36 research outputs found

    The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

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    Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy

    Rapid Advances in Immunotherapy to Treat Cancer

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    Isolamento e seleção de fungos causadores da podridão-branca da madeira em florestas de Eucalyptus spp. com potencial de degradação de cepas e raízes Isolation and screening of wood white rot fungi from Eucalyptus spp. forests with potential for use in degradation of stumps and roots

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    Este trabalho objetivou isolar fungos causadores da podridão-branca da madeira, a partir de basidiocarpos e de fragmentos de madeira de eucalipto coletados em várias regiões do país, bem como testar seu potencial de degradação de cepas e raízes mortas em plantios comerciais de eucalipto, após o corte raso. Para o isolamento dos fungos foi desenvolvido um meio de cultura de serragem de eucalipto-ágar. Dentre 292 isolados obtidos e submetidos ao teste de Bavendamm, 144 foram classificados como causadores de podridão-branca, capazes de produzir fenoloxidases. Dentre as nove relações C/N testadas, observou-se uma tendência de ocorrer maior degradação de cavacos naquelas iguais a 60 : 1, 200 : 1 e 300 : 1. Utilizando a relação C/N igual a 60 : 1, realizaram-se dois experimentos para avaliar a degradação de cavacos de Eucalyptus saligna por isolados fúngicos de podridão-branca. No primeiro experimento, avaliado aos 90 dias de incubação, foram selecionados sete isolados, que causaram perda de peso em cavacos superior ou igual à causada por Trametes versicolor, usado para comparação. No segundo experimento foram testados 46 isolados fúngicos. Dentre os mais eficientes estavam os sete isolados selecionados no primeiro teste, além de outros quatro isolados. Baseado na análise de DNA, seis isolados foram identificados, sendo três pertencentes à espécie Pycnoporus sanguineus, um ao gênero Peniophora sp., um ao gênero Pestalotiopsis sp. e um ao gênero Ganoderma sp.<br>The aim of this work was to isolate native wood white-rot fungi from fungal fruit-bodies and eucalyptus wood fragments from different regions of Brazil and to test their potential for degrading dead stumps and roots in Eucalyptus plantings after harvest. Fungi isolates were obtained in a culture medium composed by Eucalyptus sawdust and agar. Among 292 isolates submitted to the Banvedamm test, 144 were classified as phenoloxidases producing isolates. Among nine C/N ratios tested, it was observed a tendency of occurring larger chip decay in the C/N ratios equal to 60 : 1, 200 : 1 and 300 : 1. Two decay assays were performed in wood chips of Eucalyptus saligna using the C/N ratio 60 : 1 in order to verify which isolates were able to cause larger reduction of dry matter. In the first assay, which was evaluated at 90 days of incubation, seven isolates that stood out in relation to Trametes versicolor were selected. The second assay evaluated the capacity of 46 isolates in promoting decay. The isolates selected in the first assay were among the 11 most efficient in the second assay. Based on DNA analysis, six isolates were identified as Pycnoporus sanguineus (3 isolates), Peniophora sp., Pestalotiopsis sp. e Ganoderma sp

    Measurement of proton electromagnetic form factors in the time-like region using initial state radiation at BESIII

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    The electromagnetic process is studied with the initial-state-radiation technique using 7.5 fb−1 of data collected by the BESIII experiment at seven energy points from 3.773 to 4.600 GeV. The Born cross section and the effective form factor of the proton are measured from the production threshold to 3.0 GeV/ using the invariant-mass spectrum. The ratio of electric and magnetic form factors of the proton is determined from the analysis of the proton-helicity angular distribution

    Observation of Resonance Structures in e+e- →π+π-ψ2 (3823) and Mass Measurement of ψ2 (3823)

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    © 2022 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3.Using a data sample corresponding to an integrated luminosity of 11.3 fb-1 collected at center-of-mass energies from 4.23 to 4.70 GeV with the BESIII detector, we measure the product of the e+e-→π+π-ψ2(3823) cross section and the branching fraction B[ψ2(3823)→γχc1]. For the first time, resonance structure is observed in the cross section line shape of e+e-→π+π-ψ2(3823) with significances exceeding 5σ. A fit to data with two coherent Breit-Wigner resonances modeling the s-dependent cross section yields M(R1)=4406.9±17.2±4.5 MeV/c2, Γ(R1)=128.1±37.2±2.3 MeV, and M(R2)=4647.9±8.6±0.8 MeV/c2, Γ(R2)=33.1±18.6±4.1 MeV. Though weakly disfavored by the data, a single resonance with M(R)=4417.5±26.2±3.5 MeV/c2, Γ(R)=245±48±13 MeV is also possible to interpret data. This observation deepens our understanding of the nature of the vector charmoniumlike states. The mass of the ψ2(3823) state is measured as (3823.12±0.43±0.13) MeV/c2, which is the most precise measurement to date

    Study of the processes χcJ → Ξ−Ξ¯+ and Ξ0Ξ¯0

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    Using 448.1 × 106 ψ(3686) decays collected with the BESIII detector at the BEPCII e+e− storage rings, the branching fractions and angular distributions of the decays χcJ → Ξ−Ξ¯¯¯¯+ and Ξ0Ξ¯¯¯¯0 (J = 0, 1, 2) are measured based on a partial-reconstruction technique. The decays χc1 → Ξ0Ξ¯¯¯¯0 and χc2 → Ξ0Ξ¯¯¯¯0 are observed for the first time with statistical significances of 7σ and 15σ, respectively. The results of this analysis are in good agreement with previous measurements and have significantly improved precision
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