Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Application of elasto-magnetic based stress sensors for measurements of cable tension force in cable-stayed bridge

Recently, a novel stress sensor, which utilizes the elasto-magnetic (EM) effect of ferromagnetic materials, has been developed to measure stress in steel cables and wires. In this study, the effectiveness of this EM based stress sensors for monitoring of the cable tension force of a real scale cable-stayed bridge is investigated. The reference forces were used to calibrate and validate cable tension force measurements from the EM sensors. Tension force variations of two test cables during the second tensioning work on Hwa- Myung Bridge were monitored using the EM sensors

Allantoin accumulation through overexpression of ureide permease1 improves rice growth under limited nitrogen conditions

10.1111/pbi.13054Plant Biotechnology Journal1771289-130

System identification of a cable-stayed bridge using vibration responses measured by a wireless sensor network

In this paper, system identification of a cable-stayed bridge in Korea, the Hwamyung Bridge, is performed using vibration responses measured by a wireless sensor system. First, an acceleration based-wireless sensor system is employed for the structural health monitoring of the bridge, and wireless sensor nodes are deployed on a deck, a pylon and several selected cables. Second, modal parameters of the bridge are obtained both from measured vibration responses and finite element (FE) analysis. Frequency domain decomposition and stochastic subspace identification methods are used to obtain the modal parameters from the measured vibration responses. The FE model of the bridge is established using commercial FE software package. Third, structural properties of the bridge are updated using a modal sensitivity-based method. The updating work improves the accuracy of the FE model so that structural behaviors of the bridge can be represented better using the updated FE model. Finally, cable forces of the selected cables are also identified and compared with both design and lift-off test values.open

Efficiency of recombinant CRISPR/rCas9-mediated miRNA gene editing in rice

10.3390/ijms21249606International Journal of Molecular Sciences21241-1

Overexpression of OsTF1L, a rice HD-Zip transcription factor, promotes lignin biosynthesis and stomatal closure that improves drought tolerance

10.1111/pbi.12951Plant Biotechnology Journal171118-13