The Inhalation Characteristics of Patients When They Use Different Dry Powder Inhalers

Background: The characteristics of each inhalation maneuver when patients use dry powder inhalers (DPIs) are important, because they control the quality of the emitted dose. Methods: We have measured the inhalation profiles of asthmatic children [CHILD; n=16, mean forced expiratory volume in 1 sec (FEV1) 79% predicted], asthmatic adults (ADULT; n=53, mean predicted FEV1 72%), and chronic obstructive pulmonary disease (COPD; n=29, mean predicted FEV1 42%) patients when they inhaled through an Aerolizer, Diskus, Turbuhaler, and Easyhaler using their “real-life” DPI inhalation technique. These are low-, medium-, medium/high-, and high-resistance DPIs, respectively. The inhalation flow against time was recorded to provide the peak inhalation flow (PIF; in L/min), the maximum pressure change (ΔP; in kPa), acceleration rates (ACCEL; in kPa/sec), time to maximum inhalation, the length of each inhalation (in sec), and the inhalation volume (IV; in liters) of each inhalation maneuver. Results: PIF, ΔP, and ACCEL values were consistent with the order of the inhaler's resistance. For each device, the inhalation characteristics were in the order ADULT>COPD>CHILD for PIF, ΔP, and ACCEL (p4 L and ΔP >4 kPa. Conclusion: The large variability of these inhalation characteristics and their range highlights that if inhalation profiles were used with compendial in vitro dose emission measurements, then the results would provide useful information about the dose patients inhale during routine use. The inhalation characteristics highlight that adults with asthma have greater inspiratory capacity than patients with COPD, whereas children with asthma have the lowest. The significance of the inhaled volume to empty doses from each device requires investigation

Methodology for environmental assessment of agri-environment schemes: the Agri Environmental Footprint Index

End of project reportAgri-environment schemes pay farmers for the provision of environmental services. Such schemes tend to have multiple measures that deliver multiple environmental objectives, and there is a lack of consistent methodology with which to measure the environmental benefits of such schemes. Funded by EU FP6, the Agri-Environment Footprint project (www.footprint.rdg.ac.uk) aimed to address this challenge, and this report provides results from selected components of the project.European Unio

Stepped vitrification technique for human ovarian tissue cryopreservation

The advantage of stepped vitrification (SV) is avoiding ice crystal nucleation, while decreasing the toxic effects of high cryoprotectant concentrations. We aimed to test this method for human ovarian tissue cryopreservation. Ovarian cortex was taken from 7 fertile adult women. Samples were subjected to an SV protocol performed in an automatic freezer, which allowed sample transfer to ever higher concentrations of dimethyl sulfoxide (DMSO) as the temperature was reduced. Histological evaluation of the vitrified-warmed tissue showed large numbers of degenerated follicles after 24 hours of in vitro culture. We therefore evaluated DMSO perfusion rates by X-ray computed tomography, ice crystal formation by freeze-substitution, and cell toxicity by transmission electron microscopy, seeking possible reasons why follicles degenerated. Although cryoprotectant perfusion was considered normal and no ice crystals were formed in the tissue, ultrastructural analysis detected typical signs of DMSO toxicity, such as mitochondria degeneration, alterations in chromatin condensation, cell vacuolization and extracellular matrix swelling in both stromal and follicular cells. The findings indicated that the method failed to preserve follicles due to the high concentrations of DMSO used. However, adaptations can be made to avoid toxicity to follicles caused by elevated levels of cryoprotectants.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2016/22947-

Effect of oxygen pressure on the structural and optical properties of BaSnO3 films prepared by pulsed laser deposition method.

BaSnO3 thin films were deposited on quartz substrate by pulsed laser deposition technique under different background oxygen pressures and the effects of oxygen pressure on the structural, morphological and optical properties of BaSnO3 thin films are systematically investigated using different characterization techniques. The BaSnO3 films deposited without and with oxygen pressures are polycrystalline in nature with cubic crystalline phase. Moderate oxygen ambience favors enhanced crystallinity of the BaSnO3 films and 0.02 mbar is found to be optimum oxygen pressure for highest crystallinity. The surface morphology of the deposited films was strongly affected by the oxygen pressure in the deposition chamber. A systematic increase of film thickness and decrease of RMS surface roughness is observed with increase in oxygen pressure. XPS analysis reveals that barium is in the + 2 oxidation state and Sn is in the + 4 oxidation state in the film deposited at optimum oxygen pressure of 0.02 mbar. The deposited BaSnO3 films have photoluminescence emissions in the visible region and have high transmittance in the visible and infrared regions. The BaSnO3 films deposited at oxygen ambience shows a blue shift in the optical band gap. The optimized film shows high crystallinity, high value of transmittance and wide band gap energy which indicates its suitability for optoelectronic devices

Mask-less lithography for fabrication of optical waveguides

A flexible method for fabricating shallow optical waveguides by using femtosecond laser writing of patterns on a metal coated glass substrate followed by ion-exchange is described. This overcomes the drawbacks of low index contrast and high induced stress in waveguides directly written using low-repetition rate ultrafast laser systems. When compared to conventional lithography, the technique is simpler and has advantages in terms of flexibility in the types of structures which can be fabricated

Drinking water requirements for lactating dairy cows

A study to determine the amount and location of water consumption in dairy freestall barns located in northeastern Kansas was conducted during the summer of 2000. Three farms, two Holstein farms with either 2-row or 4-row freestall barns and one Jersey farm with 4-row freestall buildings, were used. Summer water usage averaged 30 to 40 gallons per Holstein cow/day and 20 to 40 gallons/cow/day for Jersey cows depending on age and stage of lactation. The farms with Holstein cows had a water usage ratio of 4 to 4.5 lb of water per lb of milk produced and Jersey cows required 3.1 lb of water per lb of milk production. However, at the Holstein dairies, only about 85% of this water was consumed and the other 15% was utilized to refill the tanks after tipping twice daily to clean cross-overs and water troughs. In addition, 35 to 45% of the water consumed is from a water station in the center crossover of each pen. Cattle also drank the least amount of water from the trough located in the crossover furthest from the pen entrance. When given access to a water trough on the milking parlor exit, cattle consumed 10% (3.5 gallons/cow/day) of the daily water intake at this location. Water usage for drinking increased as milk production increased. Adequate water system capacity and water rights are needed to make allowances for future increases in milk production. Water consumption was greater at the center alleys. Therefore, engineers should consider additional space and/or water troughs at these watering stations.; Dairy Day, 2001, Kansas State University, Manhattan, KS, 2001

Would Functional Agricultural Foods Improve Human Health?

Concern over diet-health relationships has moved to the forefront of public health concerns in the UK and much of the developed world. It has been estimated, for example, that obesity costs the UK National Health Service up to £6b per year (Rayner and Scarborough, 2005), but if all consumers were to follow recommended healthy eating guidelines there would be major implications for food consumption, land use and international trade (Srinivasan et al, 2006). This is unlikely to happen, at least in the short term, but it is realistic to anticipate some dietary adjustment toward the recommendations, resulting in an improvement in diet quality (Mazzocchi et al, 2007). Although consumers are reluctant to make major changes to their diets, they may be prepared to substitute existing foods for healthier alternatives. Three of the most prominent nutritional recommendations are to consume more fruit and vegetables, which contain phytochemicals beneficial to health, reduce consumption of saturated fatty acids (SFA) and increase intake of long-chain n-3 fatty acids (FA). In the first case, consumption of fruit and vegetables has been stable at around three 80 g portions per person per day according to the Health Survey for England. It is estimated that 42,200 deaths per year could be avoided in England and 411,000 Quality Adjusted Life Years (QALYs) could be saved if fruit and vegetable consumption were increased to the recommended 5 portions per day (Ofcom 2006). As well as continuing to encourage people to eat more, it could be desirable to ‘intensify’ the beneficial phytochemical content of existing fruit and vegetables.Agribusiness, Agricultural and Food Policy, Farm Management, Food Consumption/Nutrition/Food Safety, Industrial Organization,

Properties of the conditionally filtered equations: Conservation, normal modes, and variational formulation

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.Conditionally filtered equations have recently been proposed as a basis for modelling the atmospheric boundary layer and convection. Conditional filtering decomposes the fluid into a number of categories or components, such as convective updrafts and the background environment, and derives governing equations for the dynamics of each component. Because of the novelty and unfamiliarity of these equations, it is important to establish some of their physical and mathematical properties, and to examine whether their solutions might behave in counter-intuitive or even unphysical ways. It is also important to understand the properties of the equations in order to develop suitable numerical solution methods. The conditionally filtered equations are shown to have conservation laws for mass, entropy, momentum or axial angular momentum, energy, and potential vorticity. The normal modes of the conditionally filtered equations include the usual acoustic, inertio-gravity, and Rossby modes of the standard compressible Euler equations. In addition, they posses modes with different perturbations in the different fluid components that resemble gravity modes and inertial modes but with zero pressure perturbation. These modes make no contribution to the total filter-scale fluid motion, and their amplitude diminishes as the filter scale diminishes. Finally, it is shown that the conditionally filtered equations have a natural variational formulation, which can be used as a basis for systematically deriving consistent approximations.We are grateful to two anonymous reviewers for their constructive comments on an earlier version of this paper. This work was funded by the Natural Environment Research Council under grant NE/N013123/1 as part of the ParaCon programme

Brane/Flux Annihilation and the String Dual of a Non-Supersymmetric Field Theory

We consider the dynamics of p anti-D3 branes inside the Klebanov-Strassler geometry, the deformed conifold with M units of RR 3-form flux around the S^3. We find that for p<<M the system relaxes to a nonsupersymmetric NS 5-brane ``giant graviton'' configuration, which is classically stable, but quantum mechanically can tunnel to a nearby supersymmetric vacuum with M-p D3 branes. This decay mode is exponentially suppressed and proceeds via the nucleation of an NS 5-brane bubble wall. We propose a dual field theory interpretation of the decay as the transition between a nonsupersymmetric ``baryonic'' branch and a supersymmetric ``mesonic'' branch of the corresponding SU(2M-p)x SU(M-p) low energy gauge theory. The NS 5-brane tunneling process also provides a simple explanation of the geometric transition by which D3-branes can dissolve into 3-form flux.Comment: 27 pages, 4 figures, typo correcte