The Many Ways of Justice

Much of my background lies in social ministry, but after ordination the provincial decreed that I was to work in philosophy also. It seemed an odd mix at the time: philosophers tend to be squeamish about the rough-and-tumble of social action, while some social activists give the impression that garlic should be worn to ward off the anemia-inducing influence of philosophers. The combination has given a certain Janus-like quality to my life; but it has worked, and I have felt no need to look back. Justice is the theme of my essay. Many of those in ministries such as education argue, rightly, that we need a wider notion of justice. People in social ministry worry about the notion of justice being made so wide that it means little more than doing good, and about the poor being taken to mean anyone in need; they too are right. A more careful analysis of the claim that justice promotion is integral to faith-service is the key to resolving the problem

On Setting Near-term Climate Policy while the Dust Begins to Settle: The Legacy of the Stern Review

We review the explosion of commentary that has followed the release of the Stern Review: The Economics of Climate Change, and agree with most of what has been written. The Review is right when it argues on economic grounds for immediate intervention to reduce emissions of greenhouse gases, but we feel that it is right for the wrong reasons. A persuasive case can be made that climate risks are real and increasingly threatening. If follows that some sort of policy will be required, and the least cost approach necessarily involves starting now. Since policy implemented in 2007 will not “solve” the climate problem, near term interventions can be designed to begin the process by working to avoid locking in high carbon investments and providing adequate incentives for carbon sequestration. We argue that both objectives can be achieved without undue economic harm in the near term by pricing carbon at something on the order of $15 per ton as long as it is understood that the price will increase persistently and predictably at something like the rate of interest; and we express support for a tax alternative to the usual cap-and-trade approach.Stern Review, climate change, climate policy, social discount rate; risk and equity aversion

Estimating Historical Landfill Quantities to Predict Methane Emissions. ESRI WP333, December 2009

We estimate Irish historical landfill quantities from 1960 -2008 and Irish methane emissions from 1968-2006. A model is constructed in which waste generation is a function of income, price of waste disposal and, household economies of scale. A transformation ratio of waste to methane is also included in the methane emissions model. Our results contrast significantly with the Irish Environmental Protection Agency’s (EPA) figures due to the differences in the underlying assumptions. The EPA’s waste generation and methane emission figures are larger than our estimates from the early 1990s onwards. Projections of the distance to target show that the EPA overestimates the required policy effort

ADAM9 Is Present At Endothelial Cell - Cell Junctions And Regulates Monocyte – Endothelial Transmigration

We have found that A Disintegrin And Metalloproteinase-9 (ADAM9) localises to cell-cell junctions with VE-Cadherin in confluent endothelial monolayers. Co-cultures of cells separately transfected with ADAM9-EGFP or ADAM9-HA showed expression is required in two adjacent cells for localisation to cell-cell junctions suggesting the ADAM9 ectodomain may self-associate. A direct interaction between ADAM9 ectodomains was confirmed using recombinant proteins and an ELISA based method. As the ADAM9 ectodomain can also exist as a soluble form physiologically, we examined if this could inhibit endothelial functions dependent on cell-cell junctions. The soluble ADAM9 ectodomain could not increase endothelial monolayer permeability or inhibit monocyte-endothelial adhesion, but could inhibit monocyte-endothelial transmigration. These novel findings point to ADAM9 playing an important role in endothelial cell biology that is distinct from the other ADAMs

Closure to “Time Development of Scour around a Cylinder in Simulated Tidal Currents”

A Discussion Closure to “Time Development of Scour around a Cylinder in Simulated Tidal Currents

White matter development in infants at risk for schizophrenia

Background: Schizophrenia is considered a neurodevelopmental disorder with a pathophysiology that likely begins long before the onset of clinical symptoms. White matter abnormalities have been observed in schizophrenia and we hypothesized that the first 2 years of life is a period in which white matter abnormalities associated with schizophrenia risk may emerge. Methods: 38 infants at high risk for schizophrenia and 202 healthy controls underwent diffusion tensor MRIs after birth and at 1 and 2 years of age. Quantitative tractography was used to determine diffusion properties (fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD)) of 18 white matter tracts and a general linear model was used to analyze group differences at each age. Results: Adjusting gestational age at birth, postnatal age at MRI, gender, MRI scanner type, and maternal education, neonates at high risk had significantly lower FA (p = 0.02) and AD (p = 0.03) in the superior segment of the left cingulate, and higher RD in the hippocampal segment of the left cingulate (p = 0.04). High risk one year olds had significantly lower FA (p < 0.01) and AD (p = 0.02) in the hippocampal segment of the left cingulate. High risk two year olds had significantly lower FA in the left prefrontal cortico-thalamic tract (p = 0.04) and higher RD in the right uncinate fasciculus (p = 0.04). None of the tract differences remained significant after correction for multiple comparisons. Conclusions: There is evidence of abnormal white matter development in young children at risk for schizophrenia, especially in the hippocampal segment of left cingulum. These results support the neurodevelopmental theory of schizophrenia and indicate that impaired white matter may be present in early childhood