60 research outputs found
Statistical properties of substorm auroral onset beads/rays
Auroral substorms are often associated with optical ray or bead structures during initial brightening (substorm auroral onset waves). Occurrence probabilities and properties of substorm onset waves have been characterized using 112 substorm events identified in Time History of Events and Macroscale Interactions during Substorms (THEMIS) all-sky imager data and compared to Rice Convection Model–Equilibrium (RCM-E) and kinetic instability properties. All substorm onsets were found to be associated with optical waves, and thus, optical waves are a common feature of substorm onset. Eastward propagating wave events are more frequent than westward propagating wave events and tend to occur during lower-latitude substorms (stronger solar wind driving). The wave propagation directions are organized by orientation of initial brightening arcs. We also identified notable differences in wave propagation speed, wavelength (wave number), period, and duration between westward and eastward propagating waves. In contrast, the wave growth rate does not depend on the propagation direction or substorm strength but is inversely proportional to the wave duration. This suggests that the waves evolve to poleward expansion at a certain intensity threshold and that the wave properties do not directly relate to substorm strengths. However, waves are still important for mediating the transition between the substorm growth phase and poleward expansion. The relation to arc orientation can be explained by magnetotail structures in the RCM-E, indicating that substorm onset location relative to the pressure peak determines the wave propagation direction. The measured wave properties agree well with kinetic ballooning interchange instability, while cross-field current instability and electromagnetic ion cyclotron instability give much larger propagation speed and smaller wave period
Alternative Signature of TeV Strings
In string theory, it is well known that any hard scattering amplitude
inevitably suffers exponential suppression. We demonstrate that, if the string
scale is M_s < 2TeV, this intrinsically stringy behavior leads to a dramatic
reduction in the QCD jet production rate with very high transverse momenta p_T
> 2TeV at LHC. This suppression is sufficient to be observed in the first year
of low-luminosity running. Our prediction is based on the universal behavior of
string theory, and therefore is qualitatively model-independent. This signature
is alternative and complementary to conventional ones such as Regge resonance
(or string ball/black hole) production.Comment: a note added; version to appear in Phys. Rev. D; 11 pages, 1 eps
figure, LaTeX2e; BibTeX with utphys style use
Effective Functional Form of Regge Trajectories
We present theoretical arguments and strong phenomenological evidence that
hadronic Regge trajectories are essentially nonlinear and can be well
approximated, for phenomenological purposes, by a specific square-root form.Comment: 29 pages, LaTeX. Published versio
Anthropogenic Space Weather
Anthropogenic effects on the space environment started in the late 19th
century and reached their peak in the 1960s when high-altitude nuclear
explosions were carried out by the USA and the Soviet Union. These explosions
created artificial radiation belts near Earth that resulted in major damages to
several satellites. Another, unexpected impact of the high-altitude nuclear
tests was the electromagnetic pulse (EMP) that can have devastating effects
over a large geographic area (as large as the continental United States). Other
anthropogenic impacts on the space environment include chemical release ex-
periments, high-frequency wave heating of the ionosphere and the interaction of
VLF waves with the radiation belts. This paper reviews the fundamental physical
process behind these phenomena and discusses the observations of their impacts.Comment: 71 pages, 35 figure
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
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Energetic particle influence on the Earth's atmosphere
This manuscript gives an up-to-date and comprehensive overview of the effects of energetic particle precipitation (EPP) onto the whole atmosphere, from the lower thermosphere/mesosphere through the stratosphere and troposphere, to the surface. The paper summarizes the different sources and energies of particles, principally
galactic cosmic rays (GCRs), solar energetic particles (SEPs) and energetic electron precipitation (EEP). All the proposed mechanisms by which EPP can affect the atmosphere
are discussed, including chemical changes in the upper atmosphere and lower thermosphere, chemistry-dynamics feedbacks, the global electric circuit and cloud formation. The role of energetic particles in Earth’s atmosphere is a multi-disciplinary problem that requires expertise from a range of scientific backgrounds. To assist with this synergy, summary tables are provided, which are intended to evaluate the level of current knowledge of the effects of energetic particles on processes in the entire atmosphere
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
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