Aqueous Humor Outflow Structure and Function Imaging At the Bench and Bedside: A Review.

Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire conventional aqueous humor outflow (AHO) pathway from the anterior chamber to the episcleral vein. AHO investigation can be divided into structural and functional assessments using different methods. The historical basis for studying the anterior segment of the eye and AHO in glaucoma is discussed. Structural studies of AHO are reviewed and include traditional pathological approaches to modern tools such as multi-model two-photon microscopy and optical coherence tomography. Functional assessment focuses on visualizing AHO itself through a variety of non-real-time and real-time techniques such as aqueous angiography. Implications of distal outflow resistance and segmental AHO are discussed with an emphasis on melding bench-side research to viable clinical applications. Through the development of an improved structure: function relationship for AHO in the anterior segment of the normal and diseased eye, a better understanding of the eye with improved therapeutics may be developed

Radio Astronomy

Contains a report on a research project.National Science Foundation (Grant G-13904)National Aeronautics and Space Administration (Contract Nasr-101)National Radio Astronomy Observator

Cryogenic MMIC low noise amplifiers

Monolithic (MMIC) and discrete transistor (MIC) low noise amplifiers are compared on the basis of performance, cost, and reliability. The need for cryogenic LNA’s for future large microwave arrays for radio astronomy is briefly discussed and data is presented on a prototype LNA for the 1 to 10 GHz range along with a very wideband LNA for the 1 to 60 GHz range. A table of MMIC LNA and mixer designs under development for the frequencies up to 210 GHz is reported and data on cryogenic amplifiers in the 85 to 115 GHz is reviewed. The current status of the topics of transconductance fluctuations and cryogenic noise modeling will be briefly summarized

Novel technique of phase velocity equalization for microstrip coupled-line phase shifters

By properly selecting the characteristic impedance and electrical length of the linking line between the coupled lines, phase velocity compensation for microstrip coupled-line phase shifters can be achieved. This technique does not introduce extra element or modification to the coupling in the main coupled lines. It is simple to implement and it has the potential to be used at mm-wave frequencies

Empirical load-line capacitance models for HEMT

Models for describing the gate-source and gate-drain capacitances' variation along a resistive load line have been proposed. They are charge conservative and consistent with the small-signal model at bias points along the load line. The extraction procedure for the models' parameters is fast and intuitive. The models can be implemented easily in most circuit simulator programs

Full W-band MMIC medium power amplifier

A full W-band, MMIC amplifier has been tested on-wafer. The chip delivers 25-43 mW with 6.2±1.2 dB associated large-signal gain across 75-110 GHz when input power is held constant at 8 mW. This is the widest bandwidth MMIC amplifier ever published that delivers at least 25 mW over the entire W-band

High-resolution wide-band Fast Fourier Transform spectrometers

We describe the performance of our latest generations of sensitive wide-band high-resolution digital Fast Fourier Transform Spectrometer (FFTS). Their design, optimized for a wide range of radio astronomical applications, is presented. Developed for operation with the GREAT far infrared heterodyne spectrometer on-board SOFIA, the eXtended bandwidth FFTS (XFFTS) offers a high instantaneous bandwidth of 2.5 GHz with 88.5 kHz spectral resolution and has been in routine operation during SOFIA's Basic Science since July 2011. We discuss the advanced field programmable gate array (FPGA) signal processing pipeline, with an optimized multi-tap polyphase filter bank algorithm that provides a nearly loss-less time-to-frequency data conversion with significantly reduced frequency scallop and fast sidelobe fall-off. Our digital spectrometers have been proven to be extremely reliable and robust, even under the harsh environmental conditions of an airborne observatory, with Allan-variance stability times of several 1000 seconds. An enhancement of the present 2.5 GHz XFFTS will duplicate the number of spectral channels (64k), offering spectroscopy with even better resolution during Cycle 1 observations.Comment: Accepted for publication in A&A (SOFIA/GREAT special issue

Circuit Theory

Contains reports on two research projects.Lincoln Laboratory, Purchase Order DDL-B222U.S. Air Force under Air Force Contract AF19(604)-520

Exploring the next generation Deep Space Network

As the current 70-meter antennas are quite old (28-35 years) it is necessary to consider replacing these antennas in the near term as well as providing a capability beyond 70-meters in the future. A study was conducted that investigated the remaining service life of the existing antennas and considered alternatives for eventual replacement of the 70 m-subnet capability. This paper examines several of the concepts considered and explores some of the options for the next generation Deep Space Network