THE RELATIONSHIP BETWEEN COMPLIANCE FUNCTION AND LEGAL DEPARTMENT OF THE INSURANCE COMPANY IN THE LIGHT OF THE SOLVENCY II DIRECTIVE

Funkcija praćenja usklađenosti poslovanja, u skladu sa odredbama Direktive Solventnost II, predstavlja jednu od ključnih funkcija u društvu. Međutim, budući da je reč o relativno novoj funkciji, organizovanje ove funkcije kao posebne organizacione jedinice može biti izazovno za pojedina osiguravajuća društva. Imajući to u vidu, javlja se dilema da li se ova funkcija može organizovati u okviru iste organizacione jedinice sa pravnim odeljenjem osiguravajućeg društva. Za razliku od funkcije praćenja usklađenosti, Direktiva ne pominje pravno odeljenje ni u jednom članu. Svakako da bi najadekvatnije rešenje bilo da funkcija praćenja usklađenosti poslovanja bude organizovana kao nezavisna i samostalna organizaciona jedinicu, ali kako se ne bi previše opteretila mala i srednja društva, Direktiva uvodi načelo proporcionalnosti. Primenjujući ovo načelo društvu se daje mogućnost da, između ostalog, organizovanje ključnih funkcija prilagodi prirodi, obimu i složenosti rizika koji u društvu postoje. Autor u radu analizira odnos funkcije praćenja usklađenosti poslovanja i pravnog odeljenja osiguravajućeg društva, najpre iz ugla njihovih nadležnosti, a zatim i iz ugla njihovih karakteristika. Cilj je da utvrdi da li postoje prepreke za organizovanje ovih dveju funkcija u okviru iste organizacione jedinice.The compliance function, in accordance with the provisions of the Solvency II Directive, is one of the key functions in the insurance company. Bearing in mind that compliance function is relatively young function in these companies, organizing this function as a separate organizational unit can be challenging. For these reasons, it is important to determine whether this function can be organized as a part of the legal department of the insurance company. However, unlike the compliance function, the Directive does not mention the legal department of insurance undertaking. Certainly, the most adequate is to organize compliance function as an independent organizational unit. On the other hand, in order not to overburden small and medium-sized companies, the Directive introduces the principle of proportionality. By introducing this principle Directive gives the opportunity to companies to adjust the organization of key functions to the nature, scale and complexity of the risks that exist in the insurance undertaking. In the paper, the author analyzes the relationship between the compliance function and the legal department, first by analyzing their competences, and then their characteristics. The goal is to determine whether there are obstacles to organizing these two functions within the same organizational unit

Crystal growth of K2TiGe3O9 in the glass

The kinetics and mechanism of isothermal crystal growth of K2TiGe3O9 from a glass of the same stoichiometric composition were studied. The crystal growth rate U = 1 x 10-11-1.27 x 10-10 m s-1 was experimentally determined in the temperature interval of t = 540-600°C. In the range of high undercooling, Δt=435-375°C, spherical crystals growing at (374 ± 19) kJ mol-1 was observed

Multielement determination using inductively coupled plasma optical emission spectrometry for metal characterization of water from artesian wells in Semberija region: Multivariate analysis of data

The concentrations of fifteen metals (Mg, Na, Ca, K, Se, Zn, Mn, Fe, Pb, Cr, Cu, Cd, Sb, Ni, Co) were determined in water from ten artesian wells (AW) in Semberija to obtain a general metal profile of water in this region. Principal components analysis (PCA) was used in this classification. Using principal component analysis two factors controlling the metal variability were obtained, which accounted for nearly 71.5% of the total variance. Natural (lithogenic) factor is represented by PC1, while anthropogenic factor is represented by PC2. PC1 with high contribution of Mn, Mg, Na, K, Ca, Zn and Se accounting for 41.84% of the total variance, while PC2 exhibits high loading for Cd, Ni, Sb, Cr and Pb (29.66%). Three general areas (clusters) with different metal characteristics were detected. Water from artesian wells in first cluster (AW1, AW2, AW3, AW4, AW5 and AW6) had much higher metal concentration compared with those in the second (AW7, AW8 and AW9) and third cluster (AW10). That is as a result of anthropogenic inputs. Also, the analysis of water demonstrated slightly elevated values for Mn (concentrations up to 0.176 mg/L), while concentrations of the other investigated elements are below the values recommended by the World Health Organization (WHO) and the United States Environmental Protection Agency (US EPA). [Projekat Ministarstva nauke Republike Srbije, br. 172047

SATURN D6.5 - Final Report

The objective of the SATURN (Strategic Allocation of Traffic Using Redistribution in the Network) project is to make novel and credible use of market-based demand-management mechanisms to redistribute air traffic in the European airspace. This reduces congestion and saves the airspace users operational costs. The project is motivated by frequent demand and capacity imbalances in the European airspace network, which are forecast to continue in the near future. The present and foreseen ways of dealing with such imbalances mainly concern strategic and tactical capacity-side interventions, such as resectorisation and opening of more sectors to deal with excess demand. These are followed by tactical demand management measures, if needed. As a result, not only do substantial costs arise, but airspace users are also typically left with no choice but to comply with imposed air traffic flow management measures. The project shows how economic signals could be given to airspace users and air navigation service providers (ANSPs) to improve capacity-demand balancing, airspace design and usage, and what the benefits would be of a centralised planner compared with those of decentralised maximisation of self interests (by the ANSPs and/or airspace users)

Validation and uncertainty estimation of an analytical method for the determination of phenolic compounds in concrete

Organic contaminants from building materials negatively affect the health of people. This study presents an analytical method for the simultaneous identification and quantification of 9 phenolic compounds, i.e., phenol, 2-chloro-phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, 2,6-dichlorophenol, 4-chloro-3-methylphenol, 2,4,6-trichlorophenol, 2,3,4,6-tetrahlorophenol and pentachlorophenol, in concrete by a gas chromatographic method with mass spectrometric detection (GC–MS). By comparing the MS spectra of the test compounds with MS spectra of analytical standards, reliable identification was achieved. The method could be applied in a given range (from 0.01 to 7.5 mg kg -1 ) with appropriate parameters of precision, accuracy, repeatability and linearity. The developed method could be used for quality control testing of phenols in concrete during the construction of new buildings, old residences and construction waste. The measurement uncertainty of the phenolic compounds in concrete was evaluated using two approaches, i.e., GUM recommendations and a Monte Carlo method. Disagreement of those methods was observed. The Monte Carlo method could be used in the evaluation of combined measurement uncertainty for the determination of phenolic compounds in concrete. © 2019 Serbian Chemical Society. All rights reserved

A guided tour of asynchronous cellular automata

Research on asynchronous cellular automata has received a great amount of attention these last years and has turned to a thriving field. We survey the recent research that has been carried out on this topic and present a wide state of the art where computing and modelling issues are both represented.Comment: To appear in the Journal of Cellular Automat

EFFECT OF STORAGE TEMPERATURE AND THERMAL PROCESSING ON CATECHINS, PROCYANIDINS AND TOTAL FLAVONOIDS STABILITY IN COMMERCIALLY AVAILABLE COCOA POWDERS

Storage stability of catechin, epicatechin, procyanidins B1-B4 and total flavonoids in cocoa powder samples was studied over the temperature range 4-35 ºC. Thermal stability of total flavonoids was studied over the temperature range 95-125 ºC. Total flavonoids concentration decreased as a function of time and the degradation was accelerated at higher temperatures: a half-life (t1/2) of total flavonoids was much shorter at room temperature than during cold storage. A first-order kinetic model fitted well to all the data. Temperature dependence of the degradation rate constants, described by the Arrhenius equation, was more pronounced during heating than during storage. In the temperature interval from 4 ºC to 35 ºC, the calculated activation energies (Ea) for catechin, epicatechin and procyanidins B1-B4 were 20.4 kJ/mol, 12.5 kJ/mol, 9.4 kJ/mol, 21.6 kJ/mol, 19.4 kJ/mol, 23.7 kJ/mol, respectively. UTICAJ TEMPERTURE ČUVANJA I ZAGREVANJA NA SADRŽAJ KATEHINA; PROCIJANIDINA I UKUPNIH FENOLA KOMERCIJALNIM UZORCIMA KAKAOA U PRAHUUticaj temperature čuvanja na stabilnost katehina, epikatehina, procijanidina B1-B4 i ukupnih flavonoida u uzorcima kakaoa u prahu praćen je u temperaturnom opsegu od 4 ºC do 35 ºC. Uticaj zagrevanja na sadržaj ukupnih flavonoida je praćen u temperaturnom opsegu od 95 ºC do 125 ºC. U toku skladištenja uzoraka je došlo do smanjenja u sadržaju ukupnih flavonoida. Pomenuta promena je bila izraženija na višim temperaturama: vreme polu-života (t1/2) ukupnih flavonoida u ispitivanom uzorku kakaoa u prahu bilo je kraće kada je on čuvan na sobnoj temperaturi nego kada je čuvan u frižideru. Promene u sadržaju flavonoida u ispitivanim uzorcima prate kinetiku prvog reda. Konstante brzine degradacije, izračunate pomoću Arenijusove jednačine, veće su tokom zagrevanja nego tokom čuvanja ispitivanih uzoraka na nižim temperaturama. Izračunate energije aktivacije (Ea) za katehin, epikatehin i procijanidine B1, B2, B3 i B4 u temperaturnom intevalu od 4 ºC do 35 ºC  bile su: 20,4 kJ/mol, 12,5 kJ/mol, 9,4 kJ/mol, 21,6 kJ/mol, 19,4 kJ/mol i 23,7 kJ/mol. HIGHLIGHTS Storage stability of (epi)catechin, procyanidins B1-B4 and total flavonoids in cocoa powder samples was studied(temperature range 4-35 °C)The stability of the total flavonoids was studied over the temperature range 95-125 °CThe degradation of the total flavonoids was significantly accelerated at higher temperaturesTemperature dependence of the degradation rate constants was more pronounced during heating than during storag

Half-sandwich ruthenium(II)-arene complexes: synthesis, spectroscopic studies, biological properties, and molecular modeling

In search for antitumor metal-based drugs that would mitigate the severe side-effects of cisplatin, Ru(II) complexes are gaining increasing recent interest. In this work, we report on the synthesis, characterization (1H- and 13C-NMR, FT-IR), and cytotoxicity studies of two new half-sandwich organometallic Ru(II) complexes of the general formula [Ru(η6-arene)(XY)Cl](PF6) where arene = benzene or toluene and XY = bidentates: dipyrido[3,2-a:2′,3′-c]phenazine (dppz) or 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip), which are bound to Ru(II) via two phenanthroline-N atoms in a characteristic “piano-stool” configuration of Ru(II)-arene complexes—as confirmed by vibrational and NMR spectra. In addition, cytotoxic studies were performed for similar half-sandwich organometallic [Ru(η6-p-cymene)(Me2dppz)Cl]PF6 complex (Me2dppz = 11,12-dimethyl-dipyrido[3,2-a:2′,3′-c]phenazine). This study is complemented with elaborate modeling with density functional theory (DFT) calculations, which provided insight into reactive sites of Ru(II) structures, further detailed by molecular docking on the B-DNA dodecamer, which identified binding sites and affinities: most pronounced for the [Ru(η6-benzene)(aip)Cl](PF6) in both A-T and G-C regions of the DNA minor groove. Cytotoxic activity was probed versus tumor cell lines B16, C6, and U251 (B16 mouse melanoma, C6 rat glioma, U251 human glioblastoma) and non-tumor cell line HACAT (HACAT normal human keratinocytes).This is the peer-reviewed version of the following article:Nikolić, S.; Grgurić-Šipka, S.; Djordjević, I. S.; Dahmani, R.; Dekanski, D.; Vidičević, S.; Tošić, J.; Mitić, D.; Grubišić, S. Half-Sandwich Ruthenium(II)-Arene Complexes: Synthesis, Spectroscopic Studies, Biological Properties, and Molecular Modeling. Journal of Coordination Chemistry 2019, 72 (1), 148–163. [https://doi.org/10.1080/00958972.2018.1553298].Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3753

Electronic structure of silver-bismuth iodide rudorffite nanomaterials studied by synchrotron radiation soft X-ray photoemission spectroscopy

Silver-bismuth iodide (Ag-Bi-I) rudorffites are chemically stable and non-toxic materials that can act as a possible replacement for methylammonium lead halide perovskites in optoelectronic devices. In this report we will present innovative routes for fabrication of AgBi-I nanomaterials, as well as the results of the investigation of the electronic structure of isolated Ag-Bi-I nanoparticles by soft X-ray aerosol photoemission spectroscopy [1, 2]. Aerosol photoemission spectroscopy allows studies of the electronic structure of submicrometer particles that are free from the influence of a substrate or solvent [1-5]. In this approach the aerosol particles can be produced directly from a solution or a colloidal dispersion, which opens a possibility for investigation of a variety of nanosystems that can be produced by wet chemistry methods. This technique relies on the interaction of focused beam of isolated particles with ionizing radiation under high vacuum conditions. In addition, by using tunable synchrotron radiation as an excitation source it is possible to obtain highresolution photoelectron spectra in the investigated photoelectron energy range.X Serbian Ceramic Society Conference - Advanced Ceramics and Application : new frontiers in multifunctional material science and processing : program and the book of abstracts; September 26-27, 2022; Belgrad

Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies

Chronic myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) have an inherent tendency to progress to acute myeloid leukemia (AML). Using high-resolution SNP microarrays, we studied a total of 517 MPN and MDS patients in different disease stages, including 77 AML cases with previous history of MPN (N = 46) or MDS (N = 31). Frequent chromosomal deletions of variable sizes were detected, allowing the mapping of putative tumor suppressor genes involved in the leukemic transformation process. We detected frequent deletions on the short arm of chromosome 6 (del6p). The common deleted region on 6p mapped to a 1.1-Mb region and contained only the JARID2 genemember of the polycomb repressive complex 2 (PRC2). When we compared the frequency of del6p between chronic and leukemic phase, we observed a strong association of del6p with leukemic transformation (P = 0.0033). Subsequently, analysis of deletion profiles of other PRC2 members revealed frequent losses of genes such as EZH2, AEBP2, and SUZ12; however, the deletions targeting these genes were large. We also identified two patients with homozygous losses of JARID2 and AEBP2. We observed frequent codeletion of AEBP2 and ETV6, and similarly, SUZ12 and NF1. Using next generation exome sequencing of 40 patients, we identified only one somatic mutation in the PRC2 complex member SUZ12. As the frequency of point mutations in PRC2 members was found to be low, deletions were the main type of lesions targeting PRC2 complex members. Our study suggests an essential role of the PRC2 complex in the leukemic transformation of chronic myeloid disorders. Am. J. Hematol. 2012