Origin and thermal evolution of Mars

The thermal evolution of Mars is governed by subsolidus mantle convection beneath a thick lithosphere. Models of the interior evolution are developed by parameterizing mantle convective heat transport in terms of mantle viscosity, the superadiabatic temperature rise across the mantle, and mantle heat production. Geological, geophysical, and geochemical observations of the compositon and structure of the interior and of the timing of major events in Martian evolution are used to constrain the model computations. Such evolutionary events include global differentiation, atmospheric outgassing, and the formation of the hemispherical dichotomy and Tharsis. Numerical calculations of fully three-dimensional, spherical convection in a shell the size of the Martian mantle are performed to explore plausible patterns of Martian mantel convection and to relate convective features, such as plumes, to surface features, such as Tharsis. The results from the model calculations are presented

A Clinical study on Role of Collagen Dressings in Diabetic Ulcer Management

INTRODUCTION: Diabetic foot ulcer is the commonest cause of lower-extremity amputation, major source of morbidity, limb loss and mortality. Collagen components such as fibroblast and keratinocytes are fundamental to the process of wound healing. Dressings that contain collagen products act as scaffold that supports the regulation of extracellular components and promotes wound healing. AIM OF THE STUDY: 1. To estimate the efficacy of Collagen dressing in patients with diabetic foot ulcer. 2. To estimate the rate of healing of the diabetic ulcer after collagen dressings and to finally assess whether SSG was required or not. STUDY DESIGN: This is a cross sectional study. The study was carried out at Tirunelveli Medical College Hospital from Sep 2017 to Aug 2019. Sample size: 80 patients with diabetic foot ulcer. TECHNIQUE: The study was conducted on total eighty patients with diabetic foot ulcer, patients who reported at Tirunelveli Medical College Hospital. All diabetic foot ulcer patients, with ulcer size less than 150 sqcm attending the Surgery Department were invited to participate in the study and written informed consent was taken. All patients underwent a standard clinical and laboratory evaluation. Briefly, information about age, known DM duration, smoking habits, arterial blood pressure, and anthropometric measurements were collected. Critically ill patients and patients with underlying bone osteomyelitis or malignancy were excluded. In all patients, wound size was measured before treatment initiation. A collagen dressing was applied to wound, and all patients were followed as per standard post-application treatment protocol. Patients underwent dressing changes every 3 to 4 days until wound healing or for maximum period of 12 weeks. Changes in wound size was recorded when the dressing was removed; and at 4 and 12 weeks. Healing time, follow up period was noted. All patients were followed up for adverse events. All the data was captured in the pre-printed pro-forma. RESULTS: Study shows that there is significant reduction in ulcer size after collagen treatment (p value < 0.0001). In our study 80% of the patients required SSG after collagen dressing. There is no significant difference in healing in both the gender (p value 0.326). Ulcer healing is decreased by the presence of infection (p value <0.0001), in smokers (p value 0.009), and in patients with hypertension (p value < 0.0001). Patients who are having adequate glycemic control had better reduction in ulcer size (p value 0.001). CONCLUSION: There is no evidence to support that collagen products should replace the gold standard of diabetic wound management, which includes etiology identification, infection management, securement of an adequate vascular supply, regular debridement of nonviable tissue, and offloading. However, despite the limited studies, and the need for improved study designs and increased number of randomized controlled trials, wound dressings containing collagen do appear to have some benefit in the treatment of diabetic foot ulcers and should be carefully considered by clinicians that manage wounds

An event study to provide validation of TING and CMIT geomagnetic middle-latitude electron densities at the F2 peak

[1] The coupled thermosphere-ionosphere magnetosphere (CMIT) model and the Thermosphere Ionosphere Nested Grid (TING) model have been run to simulate the 15 May 1997 interplanetary coronal mass ejection\u27s (ICME) effects on the Earth\u27s ionosphere and thermosphere. Comparisons were made between these model runs, the IRI-2007 model, and geomagnetic middle-latitude ionosonde data (NmF2) from the World Data Center to determine how well the models simulated the event and to understand the causes of model-data disagreement. The following conclusions were drawn from this study: (1) skill scores were more often negative than positive on average; (2) the best and the worst skill scores occurred on the recovery day; (3) the line plots comparing models to data look better than the skill scores might suggest; (4) skill scores are significantly affected by timing issues and large, short-duration variability; (5) skill scores give an indication of the relative ability of one model relative to another, rather than an absolute statement of model accuracy; (6) the models capture negative storm effects better than they capture positive storm effects; (7) the TING model captured many short duration features seen in the data at high middle latitude stations that result from changes in the size of the auroral oval; (8) CMIT overestimates the energy driving changes in NmF2, whereas TING provides approximately the correct energy input as a result of the saturation effects on potential that are included in TING; and (9) both TING and CMIT electron densities decreased too rapidly after sunset

Sinusoidal Excitations in Two Component Bose-Einstein Condensates

The non-linear coupled Gross-Pitaevskii equation governing the dynamics of the two component Bose-Einstein condensate (TBEC) is shown to admit pure sinusoidal, propagating wave solutions in quasi one dimensional geometry. These solutions, which exist for a wide parameter range, are then investigated in the presence of a harmonic oscillator trap with time dependent scattering length. This illustrates the procedure for coherent control of these modes through temporal modulation of the parameters, like scattering length and oscillator frequency. We subsequently analyzed this system in an optical lattice, where the occurrence of an irreversible phase transition from superfluid to insulator phase is seen.Comment: 6 pages, 1 figur

Dimensions of biodiversity in Chesapeake Bay demersal fishes: patterns and drivers through space and time

Biodiversity has typically been described in terms of species richness and composition, but theory and growing empirical evidence indicate that the diversity of functional traits, the breadth of evolutionary relationships, and the equitability with which individuals or biomass are distributed among species better characterize patterns and processes within ecosystems. Yet, the advantages of including such data come at the expense of measuring traits, sequencing genes, and counting or weighing individuals, and it remains unclear whether this greater resolution yields substantial benefits in describing diversity. We summarized a decade of high-resolution trawl data from a bimonthly trawl survey to investigate spatial and seasonal patterns of demersal fish diversity in the Chesapeake Bay, USA, with the goal of identifying areas and times of mismatch between different dimensions of diversity, and their response to environmental forcing. We found moderate to strong positive relationships among all metrics of diversity, and that functional and phylogenetic differences were well-reflected in an index derived from taxonomic (Linnaean) hierarchy. Compared with species richness and species diversity, functional, phylogenetic, and taxonomic indices peaked later in the year, which was a consequence of the distribution of biomass among functionally and evolutionarily divergent species. Generalized additive models revealed that spatial, temporal, and environmental variables explained roughly similar proportions of deviance across all aspects of diversity, suggesting that these three factors do not differentially affect the functional and phylogenetic aspects of community structure. We conclude that an index of diversity derived from taxonomic hierarchy served well as a practical surrogate for functional and phylogenetic diversity of the demersal fish community in this system. We also emphasize the importance of evenness in understanding diversity patterns, especially since most ecological communities in nature are dominated by one or few species

Patient-reported outcomes of pain and physical functioning in neurofibromatosis clinical trials.

ObjectiveTumors and other disease complications of neurofibromatosis (NF) can cause pain and negatively affect physical functioning. To document the clinical benefit of treatment in NF trials targeting these manifestations, patient-reported outcomes (PROs) assessing pain and physical functioning should be included as study endpoints. Currently, there is no consensus on the selection and use of such measures in the NF population. This article presents the recommendations of the PRO group of the Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration for assessing the domains of pain and physical functioning for NF clinical trials.MethodsThe REiNS PRO group reviewed and rated existing PRO measures assessing pain intensity, pain interference, and physical functioning using their systematic method. Final recommendations are based primarily on 4 main criteria: patient characteristics, item content, psychometric properties, and feasibility for clinical trials.ResultsThe REiNS PRO group chose the Numeric Rating Scale-11 (≥8 years) to assess pain intensity, the Pain Interference Index (6-24 years) and the Patient-Reported Outcome Measurement Information System (PROMIS) Pain Interference Scale (≥18 years) to evaluate pain interference, and the PROMIS Physical Functioning Scale to measure upper extremity function and mobility (≥5 years) for NF clinical trials.ConclusionsThe REiNS Collaboration currently recommends these PRO measures to assess the domains of pain and physical functioning for NF clinical trials; however, further research is needed to evaluate their use in individuals with NF. A final consensus recommendation for the pain interference measure will be disseminated in a future publication based on findings from additional published research

Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk–outcome pairs, and new data on risk exposure levels and risk–outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk–outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017. Findings In 2017, 34·1 million (95% uncertainty interval [UI] 33·3–35·0) deaths and 1·21 billion (1·14–1·28) DALYs were attributable to GBD risk factors. Globally, 61·0% (59·6–62·4) of deaths and 48·3% (46·3–50·2) of DALYs were attributed to the GBD 2017 risk factors. When ranked by risk-attributable DALYs, high systolic blood pressure (SBP) was the leading risk factor, accounting for 10·4 million (9·39–11·5) deaths and 218 million (198–237) DALYs, followed by smoking (7·10 million [6·83–7·37] deaths and 182 million [173–193] DALYs), high fasting plasma glucose (6·53 million [5·23–8·23] deaths and 171 million [144–201] DALYs), high body-mass index (BMI; 4·72 million [2·99–6·70] deaths and 148 million [98·6–202] DALYs), and short gestation for birthweight (1·43 million [1·36–1·51] deaths and 139 million [131–147] DALYs). In total, risk-attributable DALYs declined by 4·9% (3·3–6·5) between 2007 and 2017. In the absence of demographic changes (ie, population growth and ageing), changes in risk exposure and risk-deleted DALYs would have led to a 23·5% decline in DALYs during that period. Conversely, in the absence of changes in risk exposure and risk-deleted DALYs, demographic changes would have led to an 18·6% increase in DALYs during that period. The ratios of observed risk exposure levels to exposure levels expected based on SDI (O/E ratios) increased globally for unsafe drinking water and household air pollution between 1990 and 2017. This result suggests that development is occurring more rapidly than are changes in the underlying risk structure in a population. Conversely, nearly universal declines in O/E ratios for smoking and alcohol use indicate that, for a given SDI, exposure to these risks is declining. In 2017, the leading Level 4 risk factor for age-standardised DALY rates was high SBP in four super-regions: central Europe, eastern Europe, and central Asia; north Africa and Middle East; south Asia; and southeast Asia, east Asia, and Oceania. The leading risk factor in the high-income super-region was smoking, in Latin America and Caribbean was high BMI, and in sub-Saharan Africa was unsafe sex. O/E ratios for unsafe sex in sub-Saharan Africa were notably high, and those for alcohol use in north Africa and the Middle East were notably low. Interpretation By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health plannin

Computational Analysis of Pulsed Radiofrequency Ablation in Treating Chronic Pain

In this paper, a parametric study has been conducted to evaluate the effects of frequency and duration of the short burst pulses during pulsed radiofrequency ablation (RFA) in treating chronic pain. Affecting the brain and nervous system, this disease remains one of the major challenges in neuroscience and clinical practice. A two-dimensional axisymmetric RFA model has been developed in which a single needle radiofrequency electrode has been inserted. A finite-element-based coupled thermo-electric analysis has been carried out utilizing the simplified Maxwell’s equations and the Pennes bioheat transfer equation to compute the electric field and temperature distributions within the computational domain. Comparative studies have been carried out between the continuous and pulsed RFA to highlight the significance of pulsed RFA in chronic pain treatment. The frequencies and durations of short burst RF pulses have been varied from 1 Hz to 10 Hz and from 10 ms to 50 ms, respectively. Such values are most commonly applied in clinical practices for mitigation of chronic pain. By reporting such critical input characteristics as temperature distributions for different frequencies and durations of the RF pulses, this computational study aims at providing the first-hand accurate quantitative information to the clinicians on possible consequences in those cases where these characteristics are varied during the pulsed RFA procedure. The results demonstrate that the efficacy of pulsed RFA is significantly dependent on the duration and frequency of the RF pulses

Using Site Visits to Strengthen Collaboration

The SUMMIT-P project is a multi-institutional endeavor to leverage interdisciplinary collaboration in order to improve the teaching of undergraduate mathematics courses in the first two years of college. One goal of this work is to establish collaborative communities among the institutions involved. As part of the project, institutions visit one another on site visits that are structured according to a common protocol. The site visits have been valuable to the project. Participating institutions report the exchange of actionable ideas and feedback; members of the grant leadership team have used the site visits to direct the overall project, and evaluators have refined questions and identified trends that will help their assessment of the project. At a deeper level, the site visits have created a strong sense of community among those involved in every aspect of the SUMMIT-P project