Novel design for an all-sky low-energy gamma-ray observatory (ALLEGRO)

We present a novel concept for a MIDEX satellite mission that allows all sky coverage for gamma-ray bursts and hard x-ray transients. The multiscale alternating shadow collimator (MASC) alone allows for arc minute positioning of 1 second bursts 3 times weaker than the BATSE sensitivity. Our scientific objectives include the ability: (a) to detect and monitor thousands of gamma-ray bursts (GRBs) and hard x- ray sources with sensitivity 3-10 times better than BATSE; (b) to solve the gamma-ray burst mystery; (c) to use gamma- ray bursts as probes of cosmological star formation and to measure cosmological parameters; (d) to understand the physics of the high energy radiation from AGNs and BLAZARs; (e) to study the physics of matter in the extreme around black holes and neutron stars; (f) to determine the pulsar birth rate and physical characteristics. The mission concept, MASC concept, and simulations are presented

Cygnus X-3 with ISO: investigating the wind

We observed the energetic binary Cygnus X-3 in both quiescent and flaring states between 4 and 16 microns using the ISO satellite. We find that the quiescent source shows the thermal free-free spectrum typical of a hot, fast stellar wind, such as from a massive helium star. The quiescent mass-loss rate due to a spherically symmetric, non-accelerating wind is found to be in the range 0.4-2.9 x 10E-4 solar masses per year, consistent with other infrared and radio observations, but considerably larger than the 10E-5 solar masses per year deduced from both the orbital change and the X-ray column density. There is rapid, large amplitude flaring at 4.5 and 11.5 microns at the same time as enhanced radio and X-ray activity, with the infrared spectrum apparently becoming flatter in the flaring state. We believe non-thermal processes are operating, perhaps along with enhanced thermal emission.Comment: Accepted for publication in MNRAS, 11 pages, 6 figure

Initial Results from OSSE on the Compton Observatory

The Oriented Scintillation Spectrometer Experiment (OSSE) was launched on NASA\u27s Compton Observatory on 1991 April 5. OSSE uses large area scintillation detectors to undertake gamma-ray line and continuum observations in the 0.05 - 10 MeV energy range. During the first months of the mission, OSSE has obtained observations on a number of high priority sources including AGNs, SN1991T, the galactic center region, and several discrete galactic sources. The capabilities and performance of OSSE are discussed and initial results for several of the early observations are presented

SPI observations of the diffuse 60Fe emission in the Galaxy

Gamma-ray line emission from radioactive decay of 60Fe provides constraints on nucleosynthesis in massive stars and supernovae. The spectrometer SPI on board INTEGRAL has accumulated nearly three years of data on gamma-ray emission from the Galactic plane. We have analyzed these data with suitable instrumental-background models and sky distributions to produce high-resolution spectra of Galactic emission. We detect the gamma-ray lines from 60Fe decay at 1173 and 1333 keV, obtaining an improvement over our earlier measurement of both lines with now 4.9 sigma significance for the combination of the two lines. The average flux per line is (4.4 \pm 0.9) \times 10^{-5} ph cm^{-2} s^{-1} rad^{-1} for the inner Galaxy region. Deriving the Galactic 26Al gamma-ray line flux with using the same set of observations and analysis method, we determine the flux ratio of 60Fe/26Al gamma-rays as 0.148 \pm 0.06. The current theoretical predictions are still consistent with our result.Comment: 10 pages, 7 figures, 2 tables, A&A in pres

Money buys happiness when spending fits our personality

In contrast to decades of research reporting surprisingly weak relationships between consumption and happiness, recent findings suggest that money can indeed increase happiness if it is spent the “right way” (e.g., on experiences or on other people). Drawing on the concept of psychological fit, we extend this research by arguing that individual differences play a central role in determining the “right” type of spending to increase well-being. In a field study using more than 76,000 bank-transaction records, we found that individuals spend more on products that match their personality, and that people whose purchases better match their personality report higher levels of life satisfaction. This effect of psychological fit on happiness was stronger than the effect of individuals’ total income or the effect of their total spending. A follow-up study showed a causal effect: Personality-matched spending increased positive affect. In summary, when spending matches the buyer’s personality, it appears that money can indeed buy happiness

Frame Theory for Signal Processing in Psychoacoustics

This review chapter aims to strengthen the link between frame theory and signal processing tasks in psychoacoustics. On the one side, the basic concepts of frame theory are presented and some proofs are provided to explain those concepts in some detail. The goal is to reveal to hearing scientists how this mathematical theory could be relevant for their research. In particular, we focus on frame theory in a filter bank approach, which is probably the most relevant view-point for audio signal processing. On the other side, basic psychoacoustic concepts are presented to stimulate mathematicians to apply their knowledge in this field

Very Bright Green Fluorescent Proteins from the Pontellid Copepod Pontella mimocerami

Marguerite E. Hunt is with UT Austin; Michael P. Scherrer is with UT Austin; Frank D. Ferrari is with the National Museum of Natural History at the Smithsonian Institution; Mikhail V. Matz is with UT Austin.Background -- Fluorescent proteins (FP) homologous to the green fluorescent protein (GFP) from the jellyfish Aequorea victoria have revolutionized biomedical research due to their usefulness as genetically encoded fluorescent labels. Fluorescent proteins from copepods are particularly promising due to their high brightness and rapid fluorescence development. Results -- Here we report two novel FPs from Pontella mimocerami (Copepoda, Calanoida, Pontellidae), which were identified via fluorescence screening of a bacterial cDNA expression library prepared from the whole-body total RNA of the animal. The proteins are very similar in sequence and spectroscopic properties. They possess high molar extinction coefficients (79,000 M−1 cm−) and quantum yields (0.92), which make them more than two-fold brighter than the most common FP marker, EGFP. Both proteins form oligomers, which we were able to counteract to some extent by mutagenesis of the N-terminal region; however, this particular modification resulted in substantial drop in brightness. Conclusions -- The spectroscopic characteristics of the two P. mimocerami proteins place them among the brightest green FPs ever described. These proteins may therefore become valuable additions to the in vivo imaging toolkit.This work was supported by the Ocean Exploration program of the National Oceanic and Atmospheric Administration (“Operation Deep Scope 2007”), and the National Institutes of Health grant R01 GM078247 to M. V. M. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Biological Sciences, School o

The Src Homology and Collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development

ShcA (Src Homology and Collagen A) is an adaptor protein that binds to tyrosine kinase receptors. Its germ line deletion is embryonic lethal with abnormal cardiovascular system formation, and its role in cardiovascular development is unknown. To investigate its functional role in cardiovascular development in mice, ShcA was deleted in cardiomyocytes and vascular smooth muscle cells by crossing ShcA flox mice with SM22a-Cre transgenic mice. Conditional mutant mice developed signs of severe dilated cardiomyopathy, myocardial infarctions, and premature death. No evidence of a vascular contribution to the phenotype was observed. Histological analysis of the heart revealed aberrant sarcomeric Z-disk and M-band structures, and misalignments of T-tubules with Z-disks. We find that not only the ErbB3/Neuregulin signaling pathway but also the baroreceptor reflex response, which have been functionally associated, are altered in the mutant mice. We further demonstrate that ShcA interacts with Caveolin-1 and the costameric protein plasma membrane Ca2+/calmodulin-dependent ATPase (PMCA), and that its deletion leads to abnormal dystrophin signaling. Collectively, these results demonstrate that ShcA interacts with crucial proteins and pathways that link Z-disk and costamere