The Magnon Spectrum in the Domain Ferromagnetic State of Antisite Disordered Double Perovskites

In their ideal structure, double perovskites like Sr_2FeMoO_6 have alternating Fe and Mo along each cubic axes, and a homogeneous ferromagnetic metallic ground state. Imperfect annealing leads to the formation of structural domains. The moments on mislocated Fe atoms that adjoin each other across the domain boundary have an antiferromagnetic coupling between them. This leads to a peculiar magnetic state, with ferromagnetic domains coupled antiferromagnetically. At short distance the system exhibits ferromagnetic correlation while at large lengthscales the net moment is strongly suppressed due to inter-domain cancellation. We provide a detailed description of the spin wave excitations of this complex magnetic state, obtained within a 1/S expansion, for progressively higher degree of mislocation, i.e., antisite disorder. At a given wavevector the magnons propagate at multiple energies, related, crudely, to `domain confined' modes with which they have large overlap. We provide a qualitative understanding of the trend observed with growing antisite disorder, and contrast these results to the much broader spectrum that one obtains for uncorrelated antisites

Production of cellulase by Clostridium papyrosolvens CFR-703

Clostridium papyrosolvens producing filter paperase, carboxymethyl cellulase and cellobiase under anaerobic cultivation conditions at 35°C is described. Higher activities of filter paperase and carboxymethylcellulases wereassayed in 48 h culture filtrate, while maximum cellobiase accumulated in the culture broth at 72 h. Filter paperase,carboxymethylcellulase and cellobiase activities were optimum at 35 °C and pH values of 7.0, 6.5 and 7.5 respectively. Cultivation of the strain in 1000 ml Hungate bottles with 1% cellulose at pH 6.5 and 35°C produced carboxymethyl cellulase, filter paperase and cellobiase activities of 45, 35 and 20 IU/ml respectively

Performance Comparison of Automated Warehouses Using Simulation

The purpose of this study is to compare the performance of two types of warehouses, both of which use autonomous vehicles (AVs). One warehouse uses movable racks (MR) for storing mini-loads, whereas the other uses fixed racks (FR). In general, warehouse automation not only increases the speed of the fulfillment process but also makes the picking process more accurate. We simulate three scenarios for the MR and FR systems using Simio. Four performance measures are considered for the comparison – the average order processing time (WR), the average utilization of AVs (U), the average order processing queue length (Nq) and the average distance travelled by AVs (d). We also estimate the capital costs of both systems and use it to compare the two systems. On the basis of our assumptions and simulation results, we find that the FR system not only requires an average 56 % less capital investment than the MR system, but it also provides a more efficient warehousing automation option with relatively lower utilization of AVs, lower order processing time and lower average number of orders waiting to be processed

Moth Search Optimization for Optimal DERs Integration in Conjunction to OLTC Tap Operations in Distribution Systems

In this paper, a newly developed moth search optimization (MSO) technique is introduced to solve the complex distributed energy resources (DER) integration problems of distribution systems. In order to overcome some of the limitations observed in the standard variant of MSO, minor corrections are also suggested. On the other hand, a new optimization problem is formulated for optimal deployment of dispatchable distributed generations and shunt capacitors while simultaneously optimizing the tap positions of on-load tap-changing transformers, already deployed in grid substations. The objective of this work is to minimize the cost of annual energy loss and node voltage deviations over multiple load levels. The proposed model is implemented and solved for two benchmark test distribution networks of 33 and 118 buses. The suggested corrections are also validated by comparing the performance of the proposed approach with standard MSO and other available optimization methods. The simulation results show that the developed model optimally utilizes the existing distribution system resources and generates higher deployment benefits at lesser DER penetration as compared to the planning model which ignores these resources

Characteristic study, its identification and self-tuned approach to control hydro-power plants

The water time constant and mechanical time constant greatly influences the power and speed oscillations of hydro-turbine-generator unit. This paper discusses the turbine power transients in response to different nature and changes in the gate position. The work presented here analyses the characteristics of hydraulic system with an emphasis on changes in the above time constants. The simulation study is based on mathematical first-, second-, third- and fourth-order transfer function models. The study is further extended to identify discrete time-domain models and their characteristic representation without noise and with noise content of 10 & 20 dB signal-to-noise ratio (SNR). The use of self-tuned control approach in minimising the speed deviation under plant parameter changes and disturbances is also discussed

Molecular Cloning and Expression of Bacterial Mercuric Reductase Gene

In order to characterize the bacterial mercuric reductase (merA) gene, mercury resistant (Hgr) Escherichia coli strains have been isolated from various mercury contaminated sites of India. Their minimum inhibitory concentration (MIC) for Hg and zone of inhibition for different antibiotics were measured, and finally mer operon was localized by transforming isolated E. coli plasmid into mercury sensitive (Hgs) host E. coli DH5a cells. Oligonucleotide primers were designed by comparing the knownreported sequences of merA from Gram-negative bacterium (E. coli plasmid R100) and 1695 bp full length merA gene was amplified by PCR. A 1.695-kb DNA fragment of merA was inserted into isopropyl- -D-thiogalactopyranoside (IPTG) inducible bacterial expression vector pQE-30U/A. E. coli DH5 strains harboring the merA constructs showed higher mercury reductase enzyme (MerA) activity and expressed significantly more MerA than the control strains under aerobic conditions. The purified merA gene over expressed in the specific host E. coli BL21(DE3)Plys cells. Finally, expressed MerA protein was purifiedby Immobilized Metal-chelate Affinity Chromatography (IMAC) by using Ni- NTA column; and ~66.2 kDa bacterial MerA protein was detected after resolving on 10% sodium dodecyl sulphate poly acrylamide gel electrophoresis (SDS PAGE)

A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity

Treatment response to clopidogrel is associated with CYP2C19 activity through the formation of the active H4 metabolite. The aims of this study were to develop a physiologically based pharmacokinetic (PBPK) model of clopidogrel and its metabolites for populations of European ancestry, to predict the pharmacokinetics in the Japanese population by CYP2C19 phenotype, and to investigate the effect of clinical and demographic factors. A PBPK model was developed and verified to describe the two metabolic pathways of clopidogrel (H4 metabolite, acyl glucuronide metabolite) for a population of European ancestry using plasma data from published studies. Subsequently, model predictions in the Japanese population were evaluated. The effects of CYP2C19 activity, fluvoxamine coadministration (CYP2C19 inhibitor), and population-specific factors (age, sex, BMI, body weight, cancer, hepatic, and renal dysfunction) on the pharmacokinetics of clopidogrel and its metabolites were then characterized. The predicted/observed ratios for clopidogrel and metabolite exposure parameters were acceptable (twofold acceptance criteria). For all CYP2C19 phenotypes, steady-state AUC0-τ of the H4 metabolite was lower for the Japanese (e.g., EM, 7.69 [6.26–9.45] ng·h/ml; geometric mean [95% CI]) than European (EM, 24.8 [20.4–30.1] ng·h/ml, p <.001) population. In addition to CYP2C19-poor metabolizer phenotype, fluvoxamine coadministration, hepatic, and renal dysfunction were found to reduce H4 metabolite but not acyl glucuronide metabolite concentrations. This is the first PBPK model describing the two major metabolic pathways of clopidogrel, which can be applied to populations of European and Japanese ancestry by CYP2C19 phenotype. The differences between the two populations appear to be determined primarily by the effect of varying CYP2C19 liver activity