23 research outputs found
Teknologi Smartphone Android dan Aplikasinya sebagai Pengendali Pintu Air Daerah Aliran Sungai (DAS)
Pengoperasian pintu air pada aliran sungai saat ini masih menggunakan sistem manual dengan menggunakan campur tangan tenaga manusia untuk pengendali buka tutupnya. Hal ini mendorong peneliti untuk melakukan penelitian dengan sistem kendali berbasis smartphone berbasis android. Dalam penelitian ini penulis menggunakan smartphone android sebagai sarana untuk kendali pintu air. Smartphone dipilih oleh penulis karena saat ini menjadi alat komunikasi sehari-hari yang mobile di semua kalangan masyarakat sedangkan andriod merupakan sistem operasi yang sebagian besar dipakai pada smartphone tersebut. Smartphone berbasis android akan secara langsung mengendalikan buka tutup pintu Daerah Aliran Sungai (DAS) dengan menggunakan program aplikasi. Masukan dari aplikasi akan memberikan informasi perintah yang diberikan, selanjutnya akan diterima oleh sistem kendali yang terhubung pada mekanisme gerakan mekanik pintu air sungai. Peralatan kendali menggunakan perangkat Arduino Uno yang mampu mengubah signal digital menjadi gerakan mekanik dalam mengoperasikan pintu DAS. Hasil penelitian yang diperoleh, penggunaan perangkat kendali Arduino Uno tidak menyediakan ruang dalam pengelolaan database secara online, maka dibutuhkan software pendukung lainnya untuk mengatasi hal tersebut. Sebagai pengendali dan sistem android merupakan media penghubung informasi saling terkait merupakan sumber informasi yang terbuka
APLIKASI MODEL PEMBELAJARAN OME-AKE DALAM PENINGKATAN KEAKTIFAN BELAJAR PESERTA DIDIK DI MTS. AL-ARIEF JATE GILI GENTING SUMENEP
This study began with the OME AKE learning model applied at MTs Al-Arief Jati Gili Genting Sumenep Madura, students were active in learning, even academic and non-academic achievements of students were very good. The study of this research is the application of the OME AKE learning model in MTs. Al-Arief Jate Gili Genteng Sumenep. This study uses a qualitative approach to the type of field research (field research). Steps The application of the OME AKE learning model in increasing the learning activeness of students at MTs Al-Arief Jate-Gili Genting-Sumenep runs according to the educational process standards. In learning, it refers to the syntax that is determined, with the first steps being learning orientation, modeling, topic exploration, analysis and problem solving, communicating the results and evaluation. The implementation of the OME AKE learning model in increasing student learning activeness is in children's learning being invited to do orientation or introduction to learning material, especially from the aspect of knowledge, after that children play a role according to their respective tasks, the children then analyze the material in detail, after the analysis is done then the results are conveyed to his friends in the form of presentations in groups and in class, the teacher then gives an evaluation of the process and results of the students. Students actively learn: such as paying attention (visual activities), listening, discussing, students 'readiness to ask questions, students' courage, listening and solving problems (mental activities).
 
Fractal analysis of microCT images of the oviduct during the estrous cycle
It is well known that the oviduct plays a key role in several events deeply related with reproduction, such as sperm storage and capacitation, gametes interactions, fertilization and early embryo development, among others. To better understand some of the interactions and process occurring withing this organ, the study of its morphological modifications is of primordial importance. To that, we adopted a microtomografy (MicroTC) modelling system and the fractal analysis that allow to explore the 3D oviductal functional anatomy, by using eight swine oviducts at different stages of the estrous cycle.
MicroCT datasets were acquired by using the high-resolution 3D-imaging system Skyscan 1172G (Bruker, Kontich β Belgium). CT images were analyzed using plugin on ImageJ software (NIH, Bethesda, MD), a box-counting method was applied to calculate the Fractal dimension of the oviduct. Focusing our attention on the utero-tubal junction (involved in sperm selection) and the isthmo-ampullar junction (the fertilization site).
We found that by using PCA analysis it was possible to clearly differentiate the oviduct at different cycle stage on the basis of their values for: Db for grid, lacunarity for grid, R2 for Db, Media Db, lacunarity, Ο for D for Db, Max for D, Min for D. Lacunarity, Media and Max for Db have a greater influence on the analysis. The results showed that 2 principal components were associated whit the morphological changes.
This information, is obtained by a fast nondestructive method, and could be very useful because this innovative approach enables the achievement a 3D model and suggest that using fractal analysis techniques can aid to better understand the modifications of oviduct anatomy that depends on the neuroendocrine axis.
This innovative approach could be a start point to design 3D cell culture systems, that could be applied in human and animal assisted reproductive techniques, improving the IVF outcomes
ΠΠ΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½Π°Ρ ΠΎΠΏΡΡ ΠΎΠ»Ρ ΡΠΎΠ½ΠΊΠΎΠΉ ΠΊΠΈΡΠΊΠΈ ΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΈΠ΄Π½ΡΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌ: ΡΡΡΠ΄Π½ΠΎΡΡΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ (ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅)
Background. Neuroendocrine tumors (NETs) of the small bowel are rare and slow-growing tumors arising from intraepithelial endocrine cells that synthesize serotonin. Diagnosis of these tumors poses a signifcant challenge because they are often not diagnosed until an advanced stage, since the tumor may be asymptomatic or accompanied by non-specifc gastrointestinal complaints. Approximately 40 % of patients develop carcinoid syndrome due to hormonal activity of NETs. Surgery is the mainstay treatment of locoregional small bowel NETs. The fve-year survival rate of patients is about 85 %, with a median rate of 9.3 years.Case description. The female patient complained of facial redness and, to a lesser extent, redness of the skin of the trunk, accompanied by a feeling of heat, severe headache, lacrimation, and general feeling of weakness. The patient unsuccessfully received symptomatic treatment prescribed by various specialists (gynecologist, therapist, psychiatrist, endocrinologist, etc.) for 14 years. Based on the comprehensive examination, NET of the small bowel was diagnosed. The patient underwent radical surgery (pT2N1M0, stage IIIB, G2), but taking into account the unfavorable prognostic factors (metastases in the mesenteric lymph node, presence of carcinoid syndrome, elevated biochemical markers, Ki67 level = 6 %, presence of somatostatin receptors of 2 and 5 types in 60 % of tumor cells), the patient was further treated with somatostatin analogues.Conclusion. When small bowel NETs are suspected, especially with the evidence of carcinoid syndrome, every effort should be made to confrm the diagnosis using a combination of anatomical and functional tumor imaging with biochemical markers.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΠ΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ (ΠΠΠ) ΡΠΎΠ½ΠΊΠΎΠΉ ΠΊΠΈΡΠΊΠΈ ΡΠ²Π»ΡΡΡΡΡ ΡΠ΅Π΄ΠΊΠΈΠΌΠΈ ΠΈ ΠΌΠ΅Π΄Π»Π΅Π½Π½ΠΎ ΡΠ°ΡΡΡΡΠΈΠΌΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΡΠΌΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡ ΠΈΠ· Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ-ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ°, ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΡΡΡΠΈΡ
ΡΠ΅ΡΠΎΡΠΎΠ½ΠΈΠ½ ΠΈ Π΄ΡΡΠ³ΠΈΠ΅ Π²Π°Π·ΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ. ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ»ΠΎΠΆΠ½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ, ΠΈ Π·Π°ΡΠ°ΡΡΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ· ΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π΅ΡΡΡ Π½Π° ΠΏΠΎΠ·Π΄Π½Π΅ΠΉ ΡΡΠ°Π΄ΠΈΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΠΎΠΏΡΡ
ΠΎΠ»Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ Π±Π΅ΡΡΠΈΠΌΠΏΡΠΎΠΌΠ½ΠΎΠΉ ΠΈΠ»ΠΈ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΡΡ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΆΠ°Π»ΠΎΠ±Π°ΠΌΠΈ ΡΠΎ ΡΡΠΎΡΠΎΠ½Ρ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ-ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ°. ΠΡΠΈΠΌΠ΅ΡΠ½ΠΎ Ρ 40 % ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΡΠΎΠ½ΠΊΠΎΠΉ ΠΊΠΈΡΠΊΠΈ ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΈΠ΄Π½ΡΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌ. Π₯ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ Π΅Π΄ΠΈΠ½ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π»Π΅ΡΠ΅Π½ΠΈΡ Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΡ
ΠΠΠ ΡΠΎΠ½ΠΊΠΎΠΉ ΠΊΠΈΡΠΊΠΈ. ΠΡΡΠΈΠ»Π΅ΡΠ½ΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ ΠΎΠΊΠΎΠ»ΠΎ 85 %, Ρ ΠΌΠ΅Π΄ΠΈΠ°Π½ΠΎΠΉ 9,3 Π³ΠΎΠ΄Π°.ΠΠΏΠΈΡΠ°Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ»ΡΡΠ°Ρ. ΠΠΎΠ»ΡΠ½ΡΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²ΡΠ΅ΠΌΡ Π±Π΅ΡΠΏΠΎΠΊΠΎΠΈΠ»ΠΈ ΠΆΠ°Π»ΠΎΠ±Ρ Π½Π° ΡΡΡ
ΠΈΠ΅ Β«ΠΏΡΠΈΠ»ΠΈΠ²ΡΒ», ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅ ΡΠΎΠ±ΠΎΠΉ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ΅ ΠΏΠΎΠΊΡΠ°ΡΠ½Π΅Π½ΠΈΠ΅ ΠΊΠΎΠΆΠΈ Π»ΠΈΡΠ° ΠΈ Π² ΠΌΠ΅Π½ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΊΠΎΠΆΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡΠ°, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠΈΠ΅ΡΡ ΡΡΠ²ΡΡΠ²ΠΎΠΌ ΠΆΠ°ΡΠ°, Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ Π³ΠΎΠ»ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΡΡ ΠΈ ΡΠ»Π΅Π·ΠΎΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ, ΠΎΠ±ΡΠ΅ΠΉ ΡΠ»Π°Π±ΠΎΡΡΡΡ, ΠΎΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΡΡΠΎΡΠ΅Π½ΠΈΡ. ΠΠ°ΡΠΈΠ΅Π½ΡΠΊΠ° Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ 14 Π»Π΅Ρ Π±Π΅Π·ΡΡΠΏΠ΅ΡΠ½ΠΎ ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΠ»Π° ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Ρ ΡΠ°Π·Π½ΡΡ
ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠΎΠ² (Π³ΠΈΠ½Π΅ΠΊΠΎΠ»ΠΎΠ³Π°, ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠ°, ΠΏΡΠΈΡ
ΠΈΠ°ΡΡΠ°, ΡΠ½Π΄ΠΎΠΊΡΠΈΠ½ΠΎΠ»ΠΎΠ³Π° ΠΈ Π΄Ρ.). Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ» ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ Π΄ΠΈΠ°Π³Π½ΠΎΠ· Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΏΠΎΠ΄Π²Π·Π΄ΠΎΡΠ½ΠΎΠΉ ΠΊΠΈΡΠΊΠΈ. ΠΠ°ΡΠΈΠ΅Π½ΡΠΊΠ° Π±ΡΠ»Π° ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎ ΠΏΡΠΎΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π° (pT2N1M0. Π‘Ρ. IIIB, G2), Π½ΠΎ Ρ ΡΡΠ΅ΡΠΎΠΌ ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π° (ΠΌΠ΅ΡΠ°ΡΡΠ°Π· Π² Π»ΠΈΠΌΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ·Π΅Π» Π±ΡΡΠΆΠ΅ΠΉΠΊΠΈ, Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°, ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠ΅ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ°ΡΠΊΠ΅ΡΡ, ΡΡΠΎΠ²Π΅Π½Ρ Ki67 6 %, Π½Π°Π»ΠΈΡΠΈΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² ΡΠΎΠΌΠ°ΡΠΎΡΡΠ°ΡΠΈΠ½Π° 2-Π³ΠΎ ΠΈ 5-Π³ΠΎ ΡΠΈΠΏΠ° Π² 60 % ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ) Π² Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π°Π½Π°Π»ΠΎΠ³Π°ΠΌΠΈ ΡΠΎΠΌΠ°ΡΠΎΡΡΠ°ΡΠΈΠ½Π°.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠΈ ΠΏΠΎΠ΄ΠΎΠ·ΡΠ΅Π½ΠΈΠΈ Π½Π° ΠΠΠ ΡΠΎΠ½ΠΊΠΎΠΉ ΠΊΠΈΡΠΊΠΈ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°, ΡΠ»Π΅Π΄ΡΠ΅Ρ ΠΏΡΠΈΠ»ΠΎΠΆΠΈΡΡ Π²ΡΠ΅ ΡΡΠΈΠ»ΠΈΡ Π΄Π»Ρ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Π°Π½Π°ΡΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Ρ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠ°ΠΌΠΈ. ΠΡΠ°Π²ΠΈΠ»ΡΠ½Π°Ρ ΡΡΠ°ΠΊΡΠΎΠ²ΠΊΠ° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Ρ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»Π° Π±Ρ Π½Π°ΠΏΡΠ°Π²ΠΈΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΡ Π½Π° ΡΠ°ΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΊΠ°ΠΊ ΡΠΎΠΌΠ°ΡΠΎΡΡΠ°ΡΠΈΠ½-ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½Π°Ρ ΡΡΠΈΠ½ΡΠΈΠ³ΡΠ°ΡΠΈΡ ΠΈ/ΠΈΠ»ΠΈ 68Ga-ΠΠΠ’/ΠΠ’ Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π² ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΌΠΎΡΠ΅ ΠΈ, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°ΡΡ ΠΠΠ ΡΠΎΠ½ΠΊΠΎΠΉ ΠΊΠΈΡΠΊΠΈ Π² Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π½Π½ΠΈΠ΅ ΡΡΠΎΠΊΠΈ ΠΈ Π½Π° ΡΠ°Π½Π½Π΅ΠΉ ΡΡΠ°Π΄ΠΈΠΈ
ΠΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½Π°Ρ Π°Π΄ΡΡΠ²Π°Π½ΡΠ½Π°Ρ Ρ ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ IIβIII ΡΡΠ°Π΄ΠΈΠΉ
Surgery is the standard of care for non-small cell lung cancer (NSCLC). The overall survival rates especially in patients with locally advanced lung cancer are low. The resistance of cancer cells to chemotherapeutic drugs reduces the efficacy of treatment. Special attention is paid to the feasibility of assessing the tumor sensitivity to certain chemotherapy drugs. Currently, the most studied predictors are monoresistance and multidrug resistance genes, such as ABCC5, RRM1, ERCC1, BRCA1, TOP1, TOP2a, TUBB3 and TYMS.The aim of the study was to analyze the outcomes of combined modality treatment using radical surgery and personalized adjuvant chemotherapy for stage IIβIII NSCLC.Material and Methods. The study included 120 patients with stage IIβIII NSCLC, who underwent radical lung resection with mediastinal ipsilateral lymph node dissection. The patients were then divided into two groups. The main group consisted of 60 patients who received personalized platinum-based adjuvant chemotherapy based on the expression levels of the genes, such as ABCC5, RRM1, ERCC1, BRCA1, TOP1, TOP2a, TUBB3 and TYMS. The control group consisted of 60 patients who received postoperative chemotherapy empirically.Results. In the main group, disease progression occurred in 14 out of 60 patients, three-year disease-free survival (DFS) was 76.7 % (the median was not reached). In the control group, DFS was 53.3 % (28 out of 60 patients), the median was 31.0 (4β36 months); the differences were statistically significant: Logrank test Ο2 =4.382 p=0.036. The overall threeβyear survival rate was 90.0 % in the main group (6/60 patients died) and 61.7 % in the control group (23/60 patients died), the differences were statistically signifcant: Logrank test Ο2 =6.915, p=0.009.Conclusion. The personalized adjuvant chemotherapy resulted in the improved three-year relapse-free and overall survival rates in NSCLC patients.ΠΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π»Π΅ΡΠ΅Π½ΠΈΡ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (ΠΠΠ Π) ΡΠ²Π»ΡΠ΅ΡΡΡ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΎΠ±ΡΠ΅ΠΉ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΠΏΡΠΈ ΠΌΠ΅ΡΡΠ½ΠΎΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅, Π½ΠΈΠ·ΠΊΠΈΠ΅. Π₯ΠΈΠΌΠΈΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ Π½ΠΈΠ·ΠΊΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠΌΠΎΠ³ΠΎ Π°Π΄ΡΡΠ²Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΡΠΎΠ±ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ ΠΏΡΠΈΠ²Π»Π΅ΠΊΠ°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΊ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠΌ Ρ
ΠΈΠΌΠΈΠΎΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΠΌΠΈ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠ°ΠΌΠΈ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΠ²Π»ΡΡΡΡΡ ΡΠ°ΠΊΠΈΠ΅ Π³Π΅Π½Ρ ΠΌΠΎΠ½ΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ ΠΈ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ, ΠΊΠ°ΠΊ ΠΠΠ‘Π‘5, RRM1, ERCC1, BRCA1, TOP1, TOP2Ξ±, TUBB3 ΠΈ TYMS. Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠΈΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ IIβIII ΡΡΠ°Π΄ΠΈΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° ΠΈ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π°Π΄ΡΡΠ²Π°Π½ΡΠ½ΠΎΠΉ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 120 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ IIβIII ΡΡΠ°Π΄ΠΈΠΈ, ΠΊΠΎΡΠΎΡΡΠΌ Π½Π° ΠΏΠ΅ΡΠ²ΠΎΠΌ ΡΡΠ°ΠΏΠ΅ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅Π΅ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ ΡΠ΅Π·Π΅ΠΊΡΠΈΡ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π² ΠΎΠ±ΡΠ΅ΠΌΠ΅ Π»ΠΎΠ±-, Π±ΠΈΠ»ΠΎΠ±- ΠΈΠ»ΠΈ ΠΏΡΠ»ΡΠΌΠΎΠ½ΡΠΊΡΠΎΠΌΠΈΠΈ Ρ ΠΌΠ΅Π΄ΠΈΠ°ΡΡΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΈΠΏΡΠΈΠ»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ Π»ΠΈΠΌΡΠΎΠ΄ΠΈΡΡΠ΅ΠΊΡΠΈΠ΅ΠΉ. ΠΠ°Π»Π΅Π΅ Π±ΠΎΠ»ΡΠ½ΡΠ΅ Π±ΡΠ»ΠΈ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π½Π° Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ. ΠΡΠ½ΠΎΠ²Π½ΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 60 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΌ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΠΊΡΡΡΡ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π°Π΄ΡΡΠ²Π°Π½ΡΠ½ΠΎΠΉ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ, Π½Π°Π·Π½Π°ΡΠ΅Π½Π½ΠΎΠΉ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² ΠΠΠ‘Π‘5, RRM1, ERCC1, BRCA1, TOP1, TOP2Ξ±, TUBB3 ΠΈ TYMS Π² Π²ΠΈΠ΄Π΅ ΠΏΠ»Π°ΡΠΈΠ½ΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
Π΄ΡΠ±Π»Π΅ΡΠΎΠ². ΠΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 60 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΡ Π½Π°Π·Π½Π°ΡΠ°Π»Π°ΡΡ ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π·Π°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΎ Ρ 14 ΠΈΠ· 60 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΡΠ΅Ρ
Π»Π΅ΡΠ½ΡΡ Π±Π΅Π·ΡΠ΅ΡΠΈΠ΄ΠΈΠ²Π½Π°Ρ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ (ΠΠ Π) β 76,7 % (ΠΌΠ΅Π΄ΠΈΠ°Π½Π° Π½Π΅ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡΠ°). Π Π³ΡΡΠΏΠΏΠ΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΠΠ Π ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 53,3 % (28 ΠΈΠ· 60 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²), ΠΌΠ΅Π΄ΠΈΠ°Π½Π° ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 31,0 ΠΌΠ΅Ρ (ΠΎΡ 4 Π΄ΠΎ 36 ΠΌΠ΅Ρ); ΡΠ°Π·Π»ΠΈΡΠΈΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡ: Logrank test Ο2 =4,382 Ρ=0,036. ΠΠ±ΡΠ°Ρ 3-Π»Π΅ΡΠ½ΡΡ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 90,0 % (ΡΠΌΠ΅ΡΠ»ΠΎ 6/60 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²), Π² Π³ΡΡΠΏΠΏΠ΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ β 61,7 % (ΡΠΌΠ΅ΡΠ»ΠΎ 23/60 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ²), ΡΠ°Π·Π»ΠΈΡΠΈΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡ: Logrank test Ο2 =6,915, Ρ=0,009.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½Π°Ρ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ° ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΠΠ Π Ρ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΄ΠΎΠ±ΠΈΡΡΡΡ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ 3-Π»Π΅ΡΠ½Π΅ΠΉ Π±Π΅Π·ΡΠ΅ΡΠΈΠ΄ΠΈΠ²Π½ΠΎΠΉ ΠΈ ΠΎΠ±ΡΠ΅ΠΉ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ
The Influence of Organizational Culture, Motivation and Work Discipline on Employee Performance at the department of Food Security and Fisheries of Malaka District, Indonesia
This study aims to analyze the influence of organizational culture, motivation and work discipline, employee performance at the Department of Food Security and Fisheries of Malaka District. The secondary objective is to study the dominant influence among organizational culture, motivation and work discipline, employee performance at the Department of Food Security and Fisheries of Malaka District. The population in the study was 53 employees, so all members of the population became the object of research. The analysis technique uses multiple regression analysis. The results of the analysis show that organizational culture, motivation, and work discipline affect the performance of the employees of the Food and Fisheries Security Service of Malaka Regency, which means that the better the organizational culture, supported by employees who have high motivation in completing work, and employees who have a high level of discipline can improve employee performance. Work discipline has a dominant effect on the performance of the employees of the Department of Food Security and Fisheries of Malaka Regency. This shows that the main thing that is considered to improve employee performance is work discipline which is reflected in employees doing tasks according to their responsibilities
Supplay Eksitasi Output Generator 300 Mw Menggunakan Metode Pola Titik Daya Reaktif
Excitation system is a system that conducts electric current in the same direction as a generator in a power plant, so that it produces electricity and a large voltage on the increase in the excitation current. In modern regulatory systems, excitation plays an important role in controlling the stability of a development because it involves load fluctuations, so excitation as a controller will require control of the generator output such as voltage, current and power factors in a necessary manner. If the excitation current rises, the reactive power supplied by the system generator will increase otherwise if the reactive power supplied will decrease. If the given excitation current is too small, the reactive power flow will move from the system to the generator so that the generator absorbs the reactive power from the system. This situation is very dangerous because it will cause excessive savings on the stator
Strategi Pemasaran Jasa Pendidikan Islam Transformatif Di MTs Diponegoro Plandaan Jombang
This research aims to identify and analyze the transformative Islamic educational services marketing strategy applied in Diponegoro Plandaan Jombang MTs. Transformative Islamic education is an educational approach that focuses on the development of the character, morals, and spirituality of students in order to promote positive transformation in themselves. MTs Diponegoro Plandaan Jombang, as an Islamic educational institution, has adopted this approach and strives to attract the interest of prospective students as well as retain existing students. The research uses qualitative methods with data collection techniques such as interviews, observations, and document analysis. The results of the research show that MTs Diponegoro Plandaan Jombang have implemented various effective marketing strategies, such as building a positive image of the institution, improving the quality of education, promoting through social media, and engaging with the local community. In the context of transformative Islamic education, marketing focuses not only on the number of students enrolled but also on the positive changes that students can make in terms of character and spirituality. Therefore, these marketing strategies must be linked to real efforts to produce better students in moral and spiritual aspects. This research provides valuable insights for other Islamic educational institutions that want to adopt a transformative approach to their education. By understanding and implementing appropriate marketing strategies, these kinds of institutions can be more effective in attracting students and achieving their transformative Islamic education goals
LC-MS/MS method for the determination of hormones: Validation, application and health risk assessment in various bovine matrices
A new method, using liquid chromatography coupled to mass spectrometry (LC-MS/MS) for the detection of fourteen natural and synthetic hormones in muscles, was validated in other bovine matrices (liver, kidney, bile and hair) according to the Decision Commission 2002/657/EC. As result, this method demonstrates good linearity (R2 > 0.99) as well as accuracy with coefficients of variation for repeatability and reproducibility lower than 23%. Moreover, the values of decision limit (CCΞ±) and detection capability (CCΞ²) were determined indicating values ranging from 0.13 to 0.86 ΞΌg/kg and 0.25β1.72 ΞΌg/k for the majority of analytes. Recovery rate in the different matrices varied from 51.5 to 107%. Indeed, this method has been successfully applied to detect anabolic hormones in eighty-eight samples (muscle, liver, kidney, and bile) collected from different local slaughterhouses. Results showed that progesterone was found in 30 samples at concentrations ranging from 0.11 to 11.7 ΞΌg/kg, while testosterone was detected in 34 samples at concentrations ranging from 0.5 to 9.52 ΞΌg/kg. All bile samples contain epi-testosterone at concentration ranging from 0.89 to 280 ΞΌg/kg. These obtained data were used to calculate the estimated daily intake, hazard quotient and hazard index as exposure assessment