Teknologi Smartphone Android dan Aplikasinya sebagai Pengendali Pintu Air Daerah Aliran Sungai (DAS)

Pengoperasian pintu air pada aliran sungai saat ini masih menggunakan sistem manual dengan menggunakan campur tangan tenaga manusia untuk pengendali buka tutupnya. Hal ini mendorong peneliti untuk melakukan penelitian dengan sistem kendali berbasis smartphone berbasis android. Dalam penelitian ini penulis menggunakan smartphone android sebagai sarana untuk kendali pintu air. Smartphone dipilih oleh penulis karena saat ini menjadi alat komunikasi sehari-hari yang mobile di semua kalangan masyarakat sedangkan andriod merupakan sistem operasi yang sebagian besar dipakai pada smartphone tersebut. Smartphone berbasis android akan secara langsung mengendalikan buka tutup pintu Daerah Aliran Sungai (DAS) dengan menggunakan program aplikasi. Masukan dari aplikasi akan memberikan informasi perintah yang diberikan, selanjutnya akan diterima oleh sistem kendali yang terhubung pada mekanisme gerakan mekanik pintu air sungai. Peralatan kendali menggunakan perangkat Arduino Uno yang mampu mengubah signal digital menjadi gerakan mekanik dalam mengoperasikan pintu DAS. Hasil penelitian yang diperoleh, penggunaan perangkat kendali Arduino Uno tidak menyediakan ruang dalam pengelolaan database secara online, maka dibutuhkan software pendukung lainnya untuk mengatasi hal tersebut. Sebagai pengendali dan sistem android merupakan media penghubung informasi saling terkait merupakan sumber informasi yang terbuka

APLIKASI MODEL PEMBELAJARAN OME-AKE DALAM PENINGKATAN KEAKTIFAN BELAJAR PESERTA DIDIK DI MTS. AL-ARIEF JATE GILI GENTING SUMENEP

This study began with the OME AKE learning model applied at MTs Al-Arief Jati Gili Genting Sumenep Madura, students were active in learning, even academic and non-academic achievements of students were very good. The study of this research is the application of the OME AKE learning model in MTs. Al-Arief Jate Gili Genteng Sumenep. This study uses a qualitative approach to the type of field research (field research). Steps The application of the OME AKE learning model in increasing the learning activeness of students at MTs Al-Arief Jate-Gili Genting-Sumenep runs according to the educational process standards. In learning, it refers to the syntax that is determined, with the first steps being learning orientation, modeling, topic exploration, analysis and problem solving, communicating the results and evaluation. The implementation of the OME AKE learning model in increasing student learning activeness is in children's learning being invited to do orientation or introduction to learning material, especially from the aspect of knowledge, after that children play a role according to their respective tasks, the children then analyze the material in detail, after the analysis is done then the results are conveyed to his friends in the form of presentations in groups and in class, the teacher then gives an evaluation of the process and results of the students. Students actively learn: such as paying attention (visual activities), listening, discussing, students 'readiness to ask questions, students' courage, listening and solving problems (mental activities). &nbsp

Fractal analysis of microCT images of the oviduct during the estrous cycle

It is well known that the oviduct plays a key role in several events deeply related with reproduction, such as sperm storage and capacitation, gametes interactions, fertilization and early embryo development, among others. To better understand some of the interactions and process occurring withing this organ, the study of its morphological modifications is of primordial importance. To that, we adopted a microtomografy (MicroTC) modelling system and the fractal analysis that allow to explore the 3D oviductal functional anatomy, by using eight swine oviducts at different stages of the estrous cycle. MicroCT datasets were acquired by using the high-resolution 3D-imaging system Skyscan 1172G (Bruker, Kontich – Belgium). CT images were analyzed using plugin on ImageJ software (NIH, Bethesda, MD), a box-counting method was applied to calculate the Fractal dimension of the oviduct. Focusing our attention on the utero-tubal junction (involved in sperm selection) and the isthmo-ampullar junction (the fertilization site). We found that by using PCA analysis it was possible to clearly differentiate the oviduct at different cycle stage on the basis of their values for: Db for grid, lacunarity for grid, R2 for Db, Media Db, lacunarity, σ for D for Db, Max for D, Min for D. Lacunarity, Media and Max for Db have a greater influence on the analysis. The results showed that 2 principal components were associated whit the morphological changes. This information, is obtained by a fast nondestructive method, and could be very useful because this innovative approach enables the achievement a 3D model and suggest that using fractal analysis techniques can aid to better understand the modifications of oviduct anatomy that depends on the neuroendocrine axis. This innovative approach could be a start point to design 3D cell culture systems, that could be applied in human and animal assisted reproductive techniques, improving the IVF outcomes

Нейроэндокринная опухоль тонкой кишки и карциноидный синдром: трудности диагностики (клиническое наблюдение)

Background. Neuroendocrine tumors (NETs) of the small bowel are rare and slow-growing tumors arising from intraepithelial endocrine cells that synthesize serotonin. Diagnosis of these tumors poses a signifcant challenge because they are often not diagnosed until an advanced stage, since the tumor may be asymptomatic or accompanied by non-specifc gastrointestinal complaints. Approximately 40 % of patients develop carcinoid syndrome due to hormonal activity of NETs. Surgery is the mainstay treatment of locoregional small bowel NETs. The fve-year survival rate of patients is about 85 %, with a median rate of 9.3 years.Case description. The female patient complained of facial redness and, to a lesser extent, redness of the skin of the trunk, accompanied by a feeling of heat, severe headache, lacrimation, and general feeling of weakness. The patient unsuccessfully received symptomatic treatment prescribed by various specialists (gynecologist, therapist, psychiatrist, endocrinologist, etc.) for 14 years. Based on the comprehensive examination, NET of the small bowel was diagnosed. The patient underwent radical surgery (pT2N1M0, stage IIIB, G2), but taking into account the unfavorable prognostic factors (metastases in the mesenteric lymph node, presence of carcinoid syndrome, elevated biochemical markers, Ki67 level = 6 %, presence of somatostatin receptors of 2 and 5 types in 60 % of tumor cells), the patient was further treated with somatostatin analogues.Conclusion. When small bowel NETs are suspected, especially with the evidence of carcinoid syndrome, every effort should be made to confrm the diagnosis using a combination of anatomical and functional tumor imaging with biochemical markers.Актуальность. Нейроэндокринные опухоли (НЭО) тонкой кишки являются редкими и медленно растущими опухолями, которые возникают из нейроэндокринных клеток желудочно-кишечного тракта, синтезирующих серотонин и другие вазоактивные молекулы. Диагностика является сложной задачей, и зачастую диагноз устанавливается на поздней стадии заболевания, поскольку опухоль длительное время может быть бессимптомной или сопровождаться неспецифическими жалобами со стороны желудочно-кишечного тракта. Примерно у 40 % пациентов в результате гормональной активности нейроэндокринных опухолей тонкой кишки развивается карциноидный синдром. Хирургическое лечение является единственным методом лечения локализованных НЭО тонкой кишки. Пятилетняя выживаемость пациентов составляет около 85 %, с медианой 9,3 года.Описание клинического случая. Больную длительное время беспокоили жалобы на сухие «приливы», представляющие собой выраженное покраснение кожи лица и в меньшей степени кожи туловища, сопровождающиеся чувством жара, выраженной головой болью и слезотечением, общей слабостью, ощущением истощения. Пациентка на протяжении 14 лет безуспешно проходила симптоматическое лечение у разных специалистов (гинеколога, терапевта, психиатра, эндокринолога и др.). В результате длительного и комплексного обследования был установлен диагноз нейроэндокринной опухоли подвздошной кишки. Пациентка была радикально прооперирована (pT2N1M0. Ст. IIIB, G2), но с учетом факторов неблагоприятного прогноза (метастаз в лимфатический узел брыжейки, наличие карциноидного синдрома, повышенные биохимические маркеры, уровень Ki67 6 %, наличие рецепторов соматостатина 2-го и 5-го типа в 60 % опухолевых клеток) в дальнейшем пациентке показано лечение аналогами соматостатина.Заключение. При подозрении на НЭО тонкой кишки, особенно при наличии карциноидного синдрома, следует приложить все усилия для подтверждения диагноза с помощью комбинации анатомической и функциональной визуализации опухоли с биохимическими маркерами. Правильная трактовка клинической картины позволила бы направить пациентку на такие исследования, как соматостатин-рецепторная сцинтиграфия и/или 68Ga-ПЭТ/КТ с исследованием биохимических маркеров в крови и моче и, соответственно, диагностировать НЭО тонкой кишки в более ранние сроки и на ранней стадии

Персонализированная адъювантная химиотерапия немелкоклеточного рака легкого II–III стадий

Surgery is the standard of care for non-small cell lung cancer (NSCLC). The overall survival rates especially in patients with locally advanced lung cancer are low. The resistance of cancer cells to chemotherapeutic drugs reduces the efficacy of treatment. Special attention is paid to the feasibility of assessing the tumor sensitivity to certain chemotherapy drugs. Currently, the most studied predictors are monoresistance and multidrug resistance genes, such as ABCC5, RRM1, ERCC1, BRCA1, TOP1, TOP2a, TUBB3 and TYMS.The aim of the study was to analyze the outcomes of combined modality treatment using radical surgery and personalized adjuvant chemotherapy for stage II–III NSCLC.Material and Methods. The study included 120 patients with stage II–III NSCLC, who underwent radical lung resection with mediastinal ipsilateral lymph node dissection. The patients were then divided into two groups. The main group consisted of 60 patients who received personalized platinum-based adjuvant chemotherapy based on the expression levels of the genes, such as ABCC5, RRM1, ERCC1, BRCA1, TOP1, TOP2a, TUBB3 and TYMS. The control group consisted of 60 patients who received postoperative chemotherapy empirically.Results. In the main group, disease progression occurred in 14 out of 60 patients, three-year disease-free survival (DFS) was 76.7 % (the median was not reached). In the control group, DFS was 53.3 % (28 out of 60 patients), the median was 31.0 (4–36 months); the differences were statistically significant: Logrank test χ2 =4.382 p=0.036. The overall three–year survival rate was 90.0 % in the main group (6/60 patients died) and 61.7 % in the control group (23/60 patients died), the differences were statistically signifcant: Logrank test χ2 =6.915, p=0.009.Conclusion. The personalized adjuvant chemotherapy resulted in the improved three-year relapse-free and overall survival rates in NSCLC patients.Основным методом лечения немелкоклеточного рака легкого (НМРЛ) является хирургический, при этом показатели общей выживаемости, особенно при местнораспространенном процессе, низкие. Химиорезистентность опухоли определяет низкую эффективность проводимого адъювантного лекарственного лечения. Особое внимание исследователей привлекает возможность оценки чувствительности опухоли к определенным химиопрепаратам. Наиболее изученными предикторами в настоящее время являются такие гены монорезистентности и множественной лекарственной устойчивости, как АВСС5, RRM1, ERCC1, BRCA1, TOP1, TOP2α, TUBB3 и TYMS. Цель исследования – изучить результаты комбинированного лечения немелкоклеточного рака легкого II–III стадии с использованием радикального хирургического вмешательства и персонализированной адъювантной химиотерапии.Материал и методы. В исследование включены 120 больных с немелкоклеточным раком легкого II–III стадии, которым на первом этапе комбинированного лечения проводилось хирургическое лечение, включающее радикальную резекцию легкого в объеме лоб-, билоб- или пульмонэктомии с медиастинальной ипсилатеральной лимфодиссекцией. Далее больные были распределены на две группы. Основную группу составили 60 пациентов, которым после операции проведены курсы персонализированной адъювантной химиотерапии, назначенной на основании уровней экспрессии генов АВСС5, RRM1, ERCC1, BRCA1, TOP1, TOP2α, TUBB3 и TYMS в виде платиносодержащих дублетов. Контрольную группу составили 60 пациентов, которым послеоперационная химиотерапия назначалась эмпирически.Результаты. В основной группе прогрессирование заболевания зафиксировано у 14 из 60 пациентов, трехлетняя безрецидивная выживаемость (БРВ) – 76,7 % (медиана не достигнута). В группе контроля БРВ составила 53,3 % (28 из 60 пациентов), медиана составила 31,0 мес (от 4 до 36 мес); различия статистически значимы: Logrank test χ2 =4,382 р=0,036. Общая 3-летняя выживаемость в основной группе составила 90,0 % (умерло 6/60 пациентов), в группе контроля – 61,7 % (умерло 23/60 пациентов), различия статистически значимы: Logrank test χ2 =6,915, р=0,009.Заключение. Разработанная программа комбинированного лечения НМРЛ с персонализированным назначением послеоперационной химиотерапии позволяет добиться улучшения показателей 3-летней безрецидивной и общей выживаемости

The Influence of Organizational Culture, Motivation and Work Discipline on Employee Performance at the department of Food Security and Fisheries of Malaka District, Indonesia

This study aims to analyze the influence of organizational culture, motivation and work discipline, employee performance at the Department of Food Security and Fisheries of Malaka District.  The secondary objective is to study the dominant influence among organizational culture, motivation and work discipline, employee performance at the Department of Food Security and Fisheries of Malaka District. The population in the study was 53 employees, so all members of the population became the object of research. The analysis technique uses multiple regression analysis. The results of the analysis show that organizational culture, motivation, and work discipline affect the performance of the employees of the Food and Fisheries Security Service of Malaka Regency, which means that the better the organizational culture, supported by employees who have high motivation in completing work, and employees who have a high level of discipline can improve employee performance. Work discipline has a dominant effect on the performance of the employees of the Department of Food Security and Fisheries of Malaka Regency. This shows that the main thing that is considered to improve employee performance is work discipline which is reflected in employees doing tasks according to their responsibilities

Supplay Eksitasi Output Generator 300 Mw Menggunakan Metode Pola Titik Daya Reaktif

Excitation system is a system that conducts electric current in the same direction as a generator in a power plant, so that it produces electricity and a large voltage on the increase in the excitation current. In modern regulatory systems, excitation plays an important role in controlling the stability of a development because it involves load fluctuations, so excitation as a controller will require control of the generator output such as voltage, current and power factors in a necessary manner. If the excitation current rises, the reactive power supplied by the system generator will increase otherwise if the reactive power supplied will decrease. If the given excitation current is too small, the reactive power flow will move from the system to the generator so that the generator absorbs the reactive power from the system. This situation is very dangerous because it will cause excessive savings on the stator

Strategi Pemasaran Jasa Pendidikan Islam Transformatif Di MTs Diponegoro Plandaan Jombang

This research aims to identify and analyze the transformative Islamic educational services marketing strategy applied in Diponegoro Plandaan Jombang MTs. Transformative Islamic education is an educational approach that focuses on the development of the character, morals, and spirituality of students in order to promote positive transformation in themselves. MTs Diponegoro Plandaan Jombang, as an Islamic educational institution, has adopted this approach and strives to attract the interest of prospective students as well as retain existing students. The research uses qualitative methods with data collection techniques such as interviews, observations, and document analysis. The results of the research show that MTs Diponegoro Plandaan Jombang have implemented various effective marketing strategies, such as building a positive image of the institution, improving the quality of education, promoting through social media, and engaging with the local community. In the context of transformative Islamic education, marketing focuses not only on the number of students enrolled but also on the positive changes that students can make in terms of character and spirituality. Therefore, these marketing strategies must be linked to real efforts to produce better students in moral and spiritual aspects. This research provides valuable insights for other Islamic educational institutions that want to adopt a transformative approach to their education. By understanding and implementing appropriate marketing strategies, these kinds of institutions can be more effective in attracting students and achieving their transformative Islamic education goals

LC-MS/MS method for the determination of hormones: Validation, application and health risk assessment in various bovine matrices

A new method, using liquid chromatography coupled to mass spectrometry (LC-MS/MS) for the detection of fourteen natural and synthetic hormones in muscles, was validated in other bovine matrices (liver, kidney, bile and hair) according to the Decision Commission 2002/657/EC. As result, this method demonstrates good linearity (R2 > 0.99) as well as accuracy with coefficients of variation for repeatability and reproducibility lower than 23%. Moreover, the values of decision limit (CCα) and detection capability (CCβ) were determined indicating values ranging from 0.13 to 0.86 μg/kg and 0.25–1.72 μg/k for the majority of analytes. Recovery rate in the different matrices varied from 51.5 to 107%. Indeed, this method has been successfully applied to detect anabolic hormones in eighty-eight samples (muscle, liver, kidney, and bile) collected from different local slaughterhouses. Results showed that progesterone was found in 30 samples at concentrations ranging from 0.11 to 11.7 μg/kg, while testosterone was detected in 34 samples at concentrations ranging from 0.5 to 9.52 μg/kg. All bile samples contain epi-testosterone at concentration ranging from 0.89 to 280 μg/kg. These obtained data were used to calculate the estimated daily intake, hazard quotient and hazard index as exposure assessment