2,823 research outputs found
The Slow X-Ray Expansion of the Northwestern Rim of the Supernova Remnant RX J0852.0-4622
The detection of radioactive decay line of 44Ti provides a unique evidence
that the gamma-ray source is a young (< 1,000 yr) supernova remnant because of
its short lifetime of about 90 yr. Only two Galactic remnants, Cassiopeia A and
RX J0852.0-4622, are hitherto reported to be the 44Ti line emitter, although
the detection from the latter has been debated. Here we report on an expansion
measurement of the northwestern rim of RX J0852.0-4622 obtained with X-ray
observations separated by 6.5 yr. The expansion rate is derived to be
0.023+/-0.006% that is about five times lower than those of young historical
remnants. Such a slow expansion suggests that RX J0852.0-4622 is not a young
remnant as has been expected. We estimate the age of 1,700-4,300 yr of this
remnant depending on its evolutionary stage. Assuming a high shock speed of
about 3000 km/sec, which is suggested by the detection of non-thermal X-ray
radiation, the distance of about 750 pc to this remnant is also derived.Comment: 12 pages, 3 figures, Accepted for publication in the Astrophysical
Journal Letter
TARGET: A Digitizing And Trigger ASIC For The Cherenkov Telescope Array
The future ground-based gamma-ray observatory Cherenkov Telescope Array (CTA)
will feature multiple types of imaging atmospheric Cherenkov telescopes, each
with thousands of pixels. To be affordable, camera concepts for these
telescopes have to feature low cost per channel and at the same time meet the
requirements for CTA in order to achieve the desired scientific goals. We
present the concept of the TeV Array Readout Electronics with GSa/s sampling
and Event Trigger (TARGET) Application Specific Circuit (ASIC), envisaged to be
used in the cameras of various CTA telescopes, e.g. the Gamma-ray Cherenkov
Telescope (GCT), a proposed 2-Mirror Small-Sized Telescope, and the
Schwarzschild-Couder Telescope (SCT), a proposed Medium-Sized Telescope. In the
latest version of this readout concept the sampling and trigger parts are split
into dedicated ASICs, TARGET C and T5TEA, both providing 16 parallel input
channels. TARGET C features a tunable sampling rate (usually 1 GSa/s), a 16k
sample deep buffer for each channel and on-demand digitization and transmission
of waveforms with typical spans of ~100 ns. The trigger ASIC, T5TEA, provides 4
low voltage differential signal (LVDS) trigger outputs and can generate a
pedestal voltage independently for each channel. Trigger signals are generated
by T5TEA based on the analog sum of the input in four independent groups of
four adjacent channels and compared to a threshold set by the user. Thus, T5TEA
generates four LVDS trigger outputs, as well as 16 pedestal voltages fed to
TARGET C independently for each channel. We show preliminary results of the
characterization and testing of TARGET C and T5TEA.Comment: 6 pages, 8 figures, Proceedings of the 6th International Symposium on
High-Energy Gamma-Ray Astronomy (Gamma2016
Suppression of geometrical barrier in crystals by Josephson vortex stacks
Differential magneto-optics are used to study the effect of dc in-plane
magnetic field on hysteretic behavior due to geometrical barriers in
crystals. In absence of in-plane field a vortex
dome is visualized in the sample center surrounded by barrier-dominated
flux-free regions. With in-plane field, stacks of Josephson vortices form
vortex chains which are surprisingly found to protrude out of the dome into the
vortex-free regions. The chains are imaged to extend up to the sample edges,
thus providing easy channels for vortex entry and for drain of the dome through
geometrical barrier, suppressing the magnetic hysteresis. Reduction of the
vortex energy due to crossing with Josephson vortices is evaluated to be about
two orders of magnitude too small to account for the formation of the
protruding chains. We present a model and numerical calculations that
qualitatively describe the observed phenomena by taking into account the
demagnetization effects in which flux expulsion from the pristine regions
results in vortex focusing and in the chain protrusion. Comparative
measurements on a sample with narrow etched grooves provide further support to
the proposed model.Comment: 12 figures (low res.) Higher resolution figures are available at the
Phys Rev B version. Typos correcte
Infrared/optical - X-ray simultaneous observations of X-ray flares in GRB 071112C and GRB 080506
We investigate the origin of short X-ray flares which are occasionally
observed in early stages of afterglows of gamma-ray bursts (GRBs). We observed
two events, GRB 071112C and GRB 080506, before the start of X-ray flares in the
optical and near-infrared (NIR) bands with the 1.5-m Kanata telescope. In
conjunction with published X-ray and optical data, we analyzed densely sampled
light curves of the early afterglows and spectral energy distributions (SEDs)
in the NIR-X-ray ranges. We found that the SEDs had a break between the optical
and X-ray bands in the normal decay phases of both GRBs regardless of the model
for the correction of the interstellar extinction in host galaxies of GRBs. In
the X-ray flares, X-ray flux increased by 3 and 15 times in the case of GRB
071112C and 080506, respectively, and the X-ray spectra became harder than
those in the normal decay phases. No significant variation in the optical-NIR
range was detected together with the X-ray flares. These results suggest that
the X-ray flares were associated with either late internal shocks or external
shocks from two-component jets.Comment: 10 pages, 5 figures, accepted to Astronomy and Astrophysic
Measuring the Broad-band X-Ray Spectrum from 400 eV to 40 keV in the Southwest Part of the Supernova Remnant RX J1713.7-3946
We report on results from Suzaku broadband X-ray observations of the
southwest part of the Galactic supernova remnant (SNR) RX J1713.7-3946 with an
energy coverage of 0.4-40 keV. The X-ray spectrum, presumably of synchrotron
origin, is known to be completely lineless, making this SNR ideally suited for
a detailed study of the X-ray spectral shape formed through efficient particle
acceleration at high speed shocks. With a sensitive hard X-ray measurement from
the HXD PIN on board Suzaku, we determine the hard X-ray spectrum in the 12--40
keV range to be described by a power law with photon index Gamma = 3.2+/- 0.2,
significantly steeper than the soft X-ray index of Gamma = 2.4+/- 0.05 measured
previously with ASCA and other missions. We find that a simple power law fails
to describe the full spectral range of 0.4-40 keV and instead a power-law with
an exponential cutoff with hard index Gamma = 1.50+/- 0.09 and high-energy
cutoff epsilon_c = 1.2+/- 0.3 keV formally provides an excellent fit over the
full bandpass. If we use the so-called SRCUT model, as an alternative model, it
gives the best-fit rolloff energy of epsilon_{roll} = 0.95+/- 0.04 keV.
Together with the TeV gamma-ray spectrum ranging from 0.3 to 100 TeV obtained
recently by HESS observations, our Suzaku observations of RX J1713.7-3946
provide stringent constraints on the highest energy particles accelerated in a
supernova shock.Comment: 11 pages, 11 figures, accepted for publication in Publications of the
Astronomical Society of Japan (PASJ
Spatio-temporal expression patterns of Arabidopsis thaliana and Medicago truncatula defensin-like genes
Plant genomes contain several hundred defensin-like (DEFL) genes that encode short cysteine-rich proteins resembling defensins, which are well known antimicrobial polypeptides. Little is known about the expression patterns or functions of many DEFLs because most were discovered recently and hence are not well represented on standard microarrays. We designed a custom Affymetrix chip consisting of probe sets for 317 and 684 DEFLs from Arabidopsis thaliana and Medicago truncatula, respectively for cataloging DEFL expression in a variety of plant organs at different developmental stages and during symbiotic and pathogenic associations. The microarray analysis provided evidence for the transcription of 71% and 90% of the DEFLs identified in Arabidopsis and Medicago, respectively, including many of the recently annotated DEFL genes that previously lacked expression information. Both model plants contain a subset of DEFLs specifically expressed in seeds or fruits. A few DEFLs, including some plant defensins, were significantly up-regulated in Arabidopsis leaves inoculated with Alternaria brassicicola or Pseudomonas syringae pathogens. Among these, some were dependent on jasmonic acid signaling or were associated with specific types of immune responses. There were notable differences in DEFL gene expression patterns between Arabidopsis and Medicago, as the majority of Arabidopsis DEFLs were expressed in inflorescences, while only a few exhibited root-enhanced expression. By contrast, Medicago DEFLs were most prominently expressed in nitrogen-fixing root nodules. Thus, our data document salient differences in DEFL temporal and spatial expression between Arabidopsis and Medicago, suggesting distinct signaling routes and distinct roles for these proteins in the two plant species
Sudomotor and cardiovascular dysfunction in patients with early untreated Parkinson's disease.
BACKGROUND: According to Braak staging of Parkinson's disease (PD), detection of autonomic dysfunction would help with early diagnosis of PD. OBJECTIVE: To determine whether the autonomic nervous system is involved in the early stage of PD, we evaluated cardiovascular and sudomotor function in early untreated PD patients. METHODS: Orthostatic blood pressure regulation, heart rate variability, skin vasomotor function, and palmar sympathetic sweat responses were examined in 50 early untreated PD patients and 20 healthy control subjects. RESULTS: The mean decrease in systolic blood pressure during head-up tilt in PD patients was mildly but significantly larger than in controls (p = 0.0001). There were no differences between the 2 groups in heart rate variability, with analysis of low frequency (LF; mediated by baroreflex feedback), and high frequency (HF; mainly reflecting parasympathetic vagal) modulation. However, LF/HF, an index of sympatho-parasympathetic balance, was lower in the PD group than in controls (p = 0.02). Amplitudes of palmar sweat responses to deep inspiration (p = 0.004), mental arithmetic (p = 0.01), and exercise (p = 0.01) in PD patients were lower than in controls, with negative correlations with motor severity. Amplitudes of palmar skin vasomotor reflexes in PD patients did not differ from controls. CONCLUSIONS: Our study indicates impairment of sympathetic cardiovascular and sudomotor function with orthostatic dysregulation of blood pressure control, reduced LF/HF and reduction in palm sweat responses even in early untreated PD patients
KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer
This study examined the status of KRAS and BRAF mutations, in relation to extracellular signal-regulated protein kinase (ERK) activation in 58 ovarian carcinomas to clarify the clinicopathological and prognostic significance of KRAS/BRAF mutations. Somatic mutations of either KRAS or BRAF were identified in 12 (20.6%) out of 58 ovarian carcinomas. The frequency of KRAS/BRAF mutations in conventional serous high-grade carcinomas (4.0%β:β1/25) was significantly lower than that in the other histological type (32.3%β:β10/31). Phosphorylated ERK1/2 (p-ERK1/2) expression was identified in 18 (38.2%) out of 45 ovarian carcinomas. KRAS/BRAF mutation was significantly correlated with International Federation of Gynecology and Obstetrics (FIGO) stage I, II (P<0.001), and p-ERK1/2 (P<0.001). No significant correlations between KRAS/BRAF mutations or p-ERK1/2 expression and overall survival were found in patients with ovarian carcinoma treated with platinum and taxane chemotherapy (P=0.2460, P=0.9339, respectively). Next, to clarify the roles of ERK1/2 activation in ovarian cancers harbouring KRAS or BRAF mutations, we inactivated ERK1/2 in ovarian cancer cells using CI-1040. Cl-1040 is a compound that selectively inhibits MAP kinase kinase (MEK), an upstream regulator of ERK1/2, and thus prevents ERK1/2 activation. Profound growth inhibition and apoptosis were observed in CI-1040-treated cancer cells with mutations in either KRAS or BRAF in comparison with the ovarian cancer cells containing wild-type sequences. This was evident in both in vitro and in vivo studies. The findings in this study indicate that an activated ERK1/2 pathway is critical to tumour growth and survival of ovarian cancers with KRAS or BRAF mutations. Furthermore, they suggest that the CI-1040-induced phenotypes depend on the mutational status of KRAS and BRAF in ovarian cancers. Therefore, ovarian cancer patients with KRAS or BRAF mutations may benefit from CI-1040 treatment
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