11,526 research outputs found
Electroweak radiative corrections to deep-inelastic neutrino scattering - implications for NuTeV ?
We calculate the O(alpha) electroweak corrections to charged- and
neutral-current deep-inelastic neutrino scattering off an isoscalar target. The
full one-loop-corrected cross sections, including hard photonic corrections,
are evaluated and compared to an earlier result which was used in the NuTeV
analysis. In particular, we compare results that differ in input-parameter
scheme, treatment of real photon radiation and factorization scheme. The
associated shifts in the theoretical prediction for the ratio of neutral- and
charged-current cross sections can be larger than the experimental accuracy of
the NuTeV result.Comment: 19 pages late
Ornamental plants, 1988: a summary of research
Follow-up evaluation of Cyanazine, Terbacil and Metolachlor slow-release herbicide tablets on woody landscape crops / E. M. Smith and S. A. Treaster -- Tolerance of daylily and peony to Surflan, Devrinol and Treflan / E. M. Smith and S. A. Treaster -- Growth response of euonymus, juniper and azalea treated with differing rates of Osmocote 18-6-12 / E. M. Smith and S. A. Treaster -- Evaluation of Ronstar wettable powder on woody landscape crops / E. M. Smith and S. A. Treaster -- An evaluation of Ronstar plus Diflufenican on container-grown landscape crops / E. M. Smith and S. A. Treaster -- Prodiamine evaluation in container-grown landscape / E. M. Smith and S. A. Treaster -- Evaluation of flowering crabapple susceptibility to apple scab in Ohio-1987 / E. M. Smith and S. A. Treaster -- Field study of root zone heating systems in greenhouses / M. F. Brugger and R. H. Zondag -- Costs of producing field rapid-growing evergreens (]uniperus) in Ohio / R. D. Taylor, H. H. Kneen, E. M. Smith, D. E. Hahn and S. Uchida -- Costs of producing field ornamental trees (Malus) in Ohio / R. D. Taylor, H. H. Kneen, E. M. Smith, D. E. Hahn and S. Uchid
Phonon and plasmon excitation in inelastic electron tunneling spectroscopy of graphite
The inelastic electron tunneling spectrum (IETS)of highly oriented pyrolitic
graphite (HOPG) has been measured with scanning tunneling spectroscopy (STS) at
6K. The observed spectral features are in very good agreement with the
vibrational density of states (vDOS) of graphite calculated from first
principles. We discuss the enhancement of certain phonon modes by
phonon-assisted tunneling in STS based on the restrictions imposed by the
electronic structure of graphite. We also demonstrate for the first time the
local excitation of surface-plasmons in IETS which are detected at an energy of
40 meV.Comment: PRB rapid communication, submitte
Ornamental plants, 1987: a summary of research
Wound healing in street trees / James M. Martin and T. Davis Sydnor -- Evaluation of flowering crabapple susceptibility to apple scab in Ohio—1986 / Elton M. Smith and Sharon A. Treaster -- Fertilizing trees in the landscape: a 15 year evaluation / Elton M. Smith and Sharon A. Treaster -- Juniper injury from Poast / Elton M. Smith and Sharon A. Treaster -- Pre-emergence herbicides for Canna / Elton M. Smith and Sharon A. Treaster -- An evaluation of Cyanazine and Terbacil and metolachlor slow-release herbicide tablets on woody landscape crops / Elton M. Smith and Sharon A. Treaster -- Tolerance of landscape vines to selected pre-emergence herbicides / Elton M. Smith and Sharon A. Treaster -- Influences of supplementary high intensity discharge lighting upon the growth of 'Ringo' geranium and 'Scarletta' begonia plug propagated plants / John C. Peterson and Richard P. Vetanovetz -- Fixed costs of operating field nurseries in Ohio by size of firm and species of plant / Reed D. Taylor, Harold H. Kneen, Elton M. Smith, David E. Hahn and Stanley Uchida -- Costs of producing slow-growing evergreens (Taxus) in the field by size of firm in Ohio / Harold H. Kneen, Reed D. Taylor, Elton M. Smith, David E. Hahn and Stanley Uchida -- Costs of producing deciduous shrubs (Viburnum) in the field by size of firm in Ohio / Reed D. Taylor, Harold H. Kneen, Elton M. Smith, David E. Hahn and Stanley Uchida -- Costs of producing shade trees (Acer rubrum) in the field by size of firm in Ohio / Reed D. Taylor, Harold H. Kneen, Elton M. Smith, David E. Hahn and Stanley Uchid
Reactions of a Be-10 beam on proton and deuteron targets
The extraction of detailed nuclear structure information from transfer
reactions requires reliable, well-normalized data as well as optical potentials
and a theoretical framework demonstrated to work well in the relevant mass and
beam energy ranges. It is rare that the theoretical ingredients can be tested
well for exotic nuclei owing to the paucity of data. The halo nucleus Be-11 has
been examined through the 10Be(d,p) reaction in inverse kinematics at
equivalent deuteron energies of 12,15,18, and 21.4 MeV. Elastic scattering of
Be-10 on protons was used to select optical potentials for the analysis of the
transfer data. Additionally, data from the elastic and inelastic scattering of
Be-10 on deuterons was used to fit optical potentials at the four measured
energies. Transfers to the two bound states and the first resonance in Be-11
were analyzed using the Finite Range ADiabatic Wave Approximation (FR-ADWA).
Consistent values of the spectroscopic factor of both the ground and first
excited states were extracted from the four measurements, with average values
of 0.71(5) and 0.62(4) respectively. The calculations for transfer to the first
resonance were found to be sensitive to the size of the energy bin used and
therefore could not be used to extract a spectroscopic factor.Comment: 16 Pages, 10 figure
In their own words: qualitative study of high-utilising primary care patients with medically unexplained symptoms
Study of galaxies in the Lynx-Cancer void. -- III. New extreme LSB dwarf galaxies
(Abridged) We present the results of the complex study of the low surface
brightness dwarf (LSBD) gas-rich galaxies J0723+3621, J0737+4724 and
J0852+1350, which reside in the nearby Lynx-Cancer void. Their ratios
M(HI)/L_B, according to HI data obtained with the NRT, are respectively ~3.9,
~2, ~2.6. For the two latter galaxies, we derived oxygen abundance
corresponding to the value of 12+log(O/H) <~7.3, using spectra from the Russian
6m telescope and from the SDSS database. We found two additional blue LSB
dwarfs, J0723+3622 and J0852+1351, which appear to be physical companions of
J0723+3621 and J0852+1350 situated at the projected distances of ~12--13 kpc.
The companion relative velocities, derived from the BTA spectra, are dV = +89
km/s and +30 km/s respectively. The geometry and the relative orientation of
orbits and spins in these pairs indicate, respectively, prograde and polar
encounters for J0723+3621 and J0852+1350. The NRT HI profiles of J0723+3621 and
J0723+3622 indicate a sizable gas flow in this system. The SDSS u,g,r,i images
of the five dwarfs are used to derive the photometric parameters and the
exponential or Sersic disc model fits. For three of them, the (u-g),(g-r),(r-i)
colours of the outer parts, being compared with the PEGASE evolutionary tracks,
evidence for the dominance of the old stellar populations with ages of T
~(8-10)+-3 Gyr. For J0723+3622 and J0737+4724, the outer region colours appear
rather blue, implying the ages of the oldest visible stars of T <~1-3 Gyr. The
new LSB galaxies complement the list of the known most metal-poor and
`unevolved' dwarfs in this void, including DDO 68, SDSS J0926+3343 and others.
This unique concentration of 'unevolved' dwarf galaxies in a small cell of the
nearby Universe implies a physical relationship between the slow galaxy
evolution and the void-type global environment.Comment: 16 pages, 5 tables, 9 figures. MNRAS, in pres
Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research
Epigenetics is the study of all mechanisms that regulate gene transcription and genome stability that are maintained throughout the cell division, but do not include the DNA sequence itself. The best-studied epigenetic mechanism to date is DNA methylation, where methyl groups are added to the cytosine base within cytosine–guanine dinucleotides (CpG sites). CpGs are frequently clustered in high density (CpG islands (CGIs)) at the promoter of over half of all genes. Current knowledge of transcriptional regulation by DNA methylation centres on its role at the promoter where unmethylated CGIs are present at most actively transcribed genes, whereas hypermethylation of the promoter results in gene repression. Over the last 5 years, research has gradually incorporated a broader understanding that methylation patterns across the gene (so-called intragenic or gene body methylation) may have a role in transcriptional regulation and efficiency. Numerous genome-wide DNA methylation profiling studies now support this notion, although whether DNA methylation patterns are a cause or consequence of other regulatory mechanisms is not yet clear. This review will examine the evidence for the function of intragenic methylation in gene transcription, and discuss the significance of this in carcinogenesis and for the future use of therapies targeted against DNA methylation
Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia
Approximately 20% of patients with acute myeloid leukaemia (AML) have a mutation in FMS-like-tyrosine-kinase-3 (FLT3). FLT3 is a trans-membrane receptor with a tyrosine kinase domain which, when activated, initiates a cascade of phosphorylated proteins including the SRC family of kinases. Recently our group and others have shown that pharmacologic inhibition and genetic knockdown of Bruton's tyrosine kinase (BTK) blocks AML blast proliferation, leukaemic cell adhesion to bone marrow stromal cells as well as migration of AML blasts. The anti-proliferative effects of BTK inhibition in human AML are mediated via inhibition of downstream NF-ÎşB pro-survival signalling however the upstream drivers of BTK activation in human AML have yet to be fully characterised. Here we place the FLT3-ITD upstream of BTK in AML and show that the BTK inhibitor ibrutinib inhibits the survival and proliferation of FLT3-ITD primary AML blasts and AML cell lines. Furthermore ibrutinib inhibits the activation of downstream kinases including MAPK, AKT and STAT5. In addition we show that BTK RNAi inhibits proliferation of FLT3-ITD AML cells. Finally we report that ibrutinib reverses the cyto-protective role of BMSC on FLT3-ITD AML survival. These results argue for the evaluation of ibrutinib in patients with FLT3-ITD mutated AML
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