15,599 research outputs found
Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia
High frequencies of blasts in primary acute lymphoblastic leukaemia (ALL) samples have the potential to induce leukaemia and to engraft mice. However, it is unclear how individual ALL cells each contribute to drive leukaemic development in a bulk transplant and the extent to which these blasts vary functionally. We used cellular barcoding as a fate mapping tool to track primograft ALL blasts in vivo. Our results show that high numbers of ALL founder cells contribute at similar frequencies to leukaemic propagation over serial transplants, without any clear evidence of clonal succession. These founder cells also exhibit equal capacity to home and engraft to different organs, although stochastic processes may alter the composition in restrictive niches. Our findings enhance the stochastic stem cell model of ALL by demonstrating equal functional abilities of singular ALL blasts and show that successful treatment strategies must eradicate the entire leukaemic cell population
Determinants of physical activity promotion by smoking cessation advisors as an aid for quitting: Support for the Transtheoretical Model
Objectives: Physical activity (PA) can reduce cigarette cravings and aid quitting but little is known about its promotion by smoking cessation advisors. This study aimed to: (1) determine the extent to which smoking cessation advisors promote PA; and (2) examine the relationship between PA promotion as a cessation aid and advisor characteristics and cognitions, within the Transtheoretical
Model (TM) framework.
Methods: Self-report surveys assessing PA promotion, TM variables, advisorsâ own PA levels and demographics were completed by 170 advisors in England and Scotland.
Results: Advisors reported spending 29 minutes promoting PA over a 6/7-week clinic. Those in later stages of readiness for promoting PA as a cessation aid and those spending more time promoting PA held more positive beliefs regarding pros and cons, self-efficacy, outcome efficacy and importance
of PA within smoking cessation. Time spent promoting PA and stage of readiness were strongly associated. There was a trend for the more physically active advisors to promote PA more often.
Conclusions: About half the advisors promoted PA and TM variables predicted this variability.
Practice Implications: PA promotion among smoking cessation advisors may be facilitated by enhancing self-efficacy, outcome efficacy and pro and con-beliefs related to PA promotion
Multiple scattering of matter waves: an analytic model of the refractive index for atomic and molecular gases
We present an analytic model of the refractive index for matter waves
propagating through atomic or molecular gases. The model, which combines a WKB
treatment of the long range attraction with the Fraunhofer model treatment of
the short range repulsion, furnishes a refractive index in compelling agreement
with recent experiments of Jacquey et al. [Phys. Rev. Lett. 98, 240405 (2007)]
on Li atom matter waves passing through dilute noble gases. We show that the
diffractive contribution, which arises from scattering by a two dimensional
"hard core" of the potential, is essential for obtaining a correct imaginary
part of the refractive index.Comment: 5 pages, 1 figure, 2 table
Reconstruction of Fundamental SUSY Parameters
We summarize methods and expected accuracies in determining the basic
low-energy SUSY parameters from experiments at future ee linear
colliders in the TeV energy range, combined with results from LHC. In a second
step we demonstrate how, based on this set of parameters, the fundamental
supersymmetric theory can be reconstructed at high scales near the grand
unification or Planck scale. These analyses have been carried out for minimal
supergravity [confronted with GMSB for comparison], and for a string effective
theory.Comment: 8 pages, latex, 7 figures, expanded version of contributions to the
proceedings of ICHEP.2002 (Amstersdam) and LCWS.2002 (Jeju Island
The Slow X-Ray Expansion of the Northwestern Rim of the Supernova Remnant RX J0852.0-4622
The detection of radioactive decay line of 44Ti provides a unique evidence
that the gamma-ray source is a young (< 1,000 yr) supernova remnant because of
its short lifetime of about 90 yr. Only two Galactic remnants, Cassiopeia A and
RX J0852.0-4622, are hitherto reported to be the 44Ti line emitter, although
the detection from the latter has been debated. Here we report on an expansion
measurement of the northwestern rim of RX J0852.0-4622 obtained with X-ray
observations separated by 6.5 yr. The expansion rate is derived to be
0.023+/-0.006% that is about five times lower than those of young historical
remnants. Such a slow expansion suggests that RX J0852.0-4622 is not a young
remnant as has been expected. We estimate the age of 1,700-4,300 yr of this
remnant depending on its evolutionary stage. Assuming a high shock speed of
about 3000 km/sec, which is suggested by the detection of non-thermal X-ray
radiation, the distance of about 750 pc to this remnant is also derived.Comment: 12 pages, 3 figures, Accepted for publication in the Astrophysical
Journal Letter
Readiness to use physical activity as a smoking cessation aid: a multiple behaviour change application of the Transtheoretical Model among quitters attending Stop Smoking Clinics
Objective: Physical activity (PA) reduces cigarette cravings during smoking abstinence. However, little is known about quittersâ use of PA. This study aimed to: (1) determine the extent of quittersâ past and current use of PA as a cessation aid, while attempting to quit; (2) examine the relationship between use of PA and quitter characteristics and cognitions, within the Transtheoretical Model framework.
Methods: Self-report surveys were completed by 181 smokers attending Stop Smoking Services in England and Scotland.
Results: Twenty-two percent of quitters reported currently using PA to control their smoking, and 35% had used it during a previous quit attempt. Those in a more advanced stage of readiness for using PA as a cessation aid, held more positive beliefs regarding self-efficacy and outcome efficacy.
Conclusion: Quitters were more likely to use PA to help them quit when they had greater belief in their own ability to use PA and in the efficacy of PA to help them to quit, and were also meeting weekly PA targets for health.
Practice implications: Strategies by stop smoking advisors that aim to enhance client self-efficacy and outcome efficacy beliefs regarding PA as a cessation aid may help to increase the use of this behavioural strategy, since it seems that most quitters do not use PA
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