119 research outputs found
Criterios de Aplicación de las Medidas Sustitutivas a la Pena de Prisión Acorde al Cumplimiento de los Fines de la Pena.
Los Fines de la Pena y Principios Aplicables en la Legislación Salvadoreña – Medida sustitutiva a la Pena de Prisión – Criterios utilizados para aplicar el reemplazo o la suspensión de la pena – Atribuciones de las Instituciones encargadas de la Ejecución de las Medidas Sustitutivas de la Pena de Prisión
A new measurement of the neutron detection efficiency for the NaI Crystal Ball detector
We report on a measurement of the neutron detection efficiency in NaI
crystals in the Crystal Ball detector obtained from a study of single p0
photoproduction on deuterium using the tagged photon beam at the Mainz
Microtron. The results were obtained up to a neutron energy of 400 MeV. They
are compared to previous measurements made more than 15 years ago at the pion
beam at the BNL AGS
Determination of the scalar polarizabilities of the proton using beam asymmetry in Compton scattering
The scalar dipole polarizabilities, and , are
fundamental properties related to the internal dynamics of the nucleon. The
currently accepted values of the proton polarizabilities were determined by
fitting to unpolarized proton Compton scattering cross section data. The
measurement of the beam asymmetry in a certain kinematical range
provides an alternative approach to the extraction of the scalar
polarizabilities. At the Mainz Microtron (MAMI) the beam asymmetry was measured
for Compton scattering below pion photoproduction threshold for the first time.
The results are compared with model calculations and the influence of the
experimental data on the extraction of the scalar polarizabilities is
determined.Comment: 6 pages, 5 figure
Measurement of pi^0 photoproduction on the proton at MAMI C
Differential cross sections for the gamma p -> pi^0 p reaction have been
measured with the A2 tagged-photon facilities at the Mainz Microtron, MAMI C,
up to the center-of-mass energy W=1.9 GeV. The new results, obtained with a
fine energy and angular binning, increase the existing quantity of pi^0
photoproduction data by ~47%. Owing to the unprecedented statistical accuracy
and the full angular coverage, the results are sensitive to high partial-wave
amplitudes. This is demonstrated by the decomposition of the differential cross
sections in terms of Legendre polynomials and by further comparison to model
predictions. A new solution of the SAID partial-wave analysis obtained after
adding the new data into the fit is presented.Comment: 13 pages, 12 figures, 1 tabl
Helicity-dependent cross sections and double-polarization observable E in η photoproduction from quasifree protons and neutrons
Precise helicity-dependent cross sections and the double-polarization observable E were measured for η
photoproduction from quasifree protons and neutrons bound in the deuteron. The η → 2γ and η → 3π0 → 6γ
decay modes were used to optimize the statistical quality of the data and to estimate systematic uncertainties. The
measurement used the A2 detector setup at the tagged photon beam of the electron accelerator MAMI in Mainz.
A longitudinally polarized deuterated butanol target was used in combination with a circularly polarized photon
beam from bremsstrahlung of a longitudinally polarized electron beam. The reaction products were detected with
the electromagnetic calorimeters Crystal Ball and TAPS, which covered 98% of the full solid angle. The results
show that the narrow structure observed earlier in the unpolarized excitation function of η photoproduction off
the neutron appears only in reactions with antiparallel photon and nucleon spin (σ1/2). It is absent for reactions
with parallel spin orientation (σ3/2) and thus very probably related to partial waves with total spin 1/2. The
behavior of the angular distributions of the helicity-dependent cross sections was analyzed by fitting them with Legendre polynomials. The results are in good agreement with a model from the Bonn-Gatchina group, which
uses an interference of P11 and S11 partial waves to explain the narrow structure
Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking. Here, we first discuss the generality of stress-induced reinstatement to different drugs of abuse, different stressors, and different behavioral procedures. We also discuss neuropharmacological mechanisms, and brain areas and circuits controlling stress-induced reinstatement of drug seeking. We conclude by discussing results from translational human laboratory studies and clinical trials that were inspired by results from rat studies on stress-induced reinstatement. Our main conclusions are (1) The phenomenon of stress-induced reinstatement, first shown with an intermittent footshock stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicotine, and alcohol, and is also observed in the conditioned place preference model in rats and mice. This phenomenon, however, is stressor specific and not all stressors induce reinstatement of drug seeking. (2) Neuropharmacological studies indicate the involvement of corticotropin-releasing factor (CRF), noradrenaline, dopamine, glutamate, kappa/dynorphin, and several other peptide and neurotransmitter systems in stress-induced reinstatement. Neuropharmacology and circuitry studies indicate the involvement of CRF and noradrenaline transmission in bed nucleus of stria terminalis and central amygdala, and dopamine, CRF, kappa/dynorphin, and glutamate transmission in other components of the mesocorticolimbic dopamine system (ventral tegmental area, medial prefrontal cortex, orbitofrontal cortex, and nucleus accumbens). (3) Translational human laboratory studies and a recent clinical trial study show the efficacy of alpha-2 adrenoceptor agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse
VIP Enhances Phagocytosis of Fibrillar Beta-Amyloid by Microglia and Attenuates Amyloid Deposition in the Brain of APP/PS1 Mice
Vasoactive intestinal peptide (VIP) is a multifunctional neuropeptide with demonstrated immunosuppressive and neuroprotective activities. It has been shown to inhibit Amyloid beta (Aβ)-induced neurodegeneration by indirectly suppressing the production and release of a variety of inflammatory and neurotoxic factors by activated microglia. We demonstrated that VIP markedly increased microglial phagocytosis of fibrillar Aβ42 and that this enhanced phagocytotic activity depended on activation of the Protein kinase C (PKC) signaling pathway. In addition, VIP suppressed the release of tumor necrosis factor alpha (TNF-α) and nitric oxide(NO) from microglia activated by combined treatment with fibrillar Aβ42 and low dose interferon-γ (IFN-γ). We utilized an adenovirus-mediated gene delivery method to overexpress VIP constitutively in the hippocampus of APPswPS1 transgenic mice. The Aβ load was significantly reduced in the hippocampus of this animal model of Alzheimer's disease, possibly due to the accumulation and activation of cd11b-immunoactive microglial cells. The modulation of microglial activation, phagocytosis, and secretion by VIP is a promising therapeutic option for the treatment of Alzheimer's disease(AD)
Spin polarizabilities of the proton by measurement of Compton double-polarization observables
The Compton double-polarization observable has been measured
for the first time in the resonance region using a circularly
polarized photon beam incident on a longitudinally polarized target at the
Mainz Microtron. This paper reports these results, together with the
model-dependent extraction of four proton spin polarizabilities from fits to
additional asymmetry data using dispersion relation and chiral perturbation
theory calculations, with the former resulting in: , , and
, in units of .Comment: 7 pages, 5 figures, 2 tables, accepted for publication in PR
Measurement of the decay η′ →π0π0η at MAMI
An experimental study of the η′→π0π0η→6γ decay has been conducted with the best up-to-date statistical accuracy, by measuring η′ mesons produced in the γp→η′p reaction with the A2 tagged-photon facility at the Mainz Microtron, MAMI. The results obtained for the standard parametrization of the η′→π0π0η matrix element are consistent with the most recent results for η′→ππη decays, but have smaller uncertainties. The available statistics and experimental resolution allowed, for the first time, an observation of a structure below the π+π- mass threshold, the magnitude and sign of which, checked within the framework of the nonrelativistic effective-field theory, demonstrated good agreement with the cusp that was predicted based on the ππ scattering length combination, a0-a2, extracted from K→3π decays
Experimental study of the γp→π0ηp reaction with the A2 setup at the Mainz Microtron
The data available from the A2 Collaboration at MAMI were analyzed to select the γp→π0ηp reaction on an event-by-event basis, which allows for partial-wave analyses of three-body final states to obtain more reliable results, compared to fits to measured distributions. These data provide the world's best statistical accuracy in the energy range from threshold to Eγ=1.45 GeV, allowing a finer energy binning in the measurement of all observables needed for understanding the reaction dynamics. The results obtained for the measured observables are compared to existing models, and the impact from the new data is checked by the fit with the revised Mainz model
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