1,175 research outputs found
Chaotic Interaction of Langmuir Solitons and Long Wavelength Radiation
In this work we analyze the interaction of isolated solitary structures and
ion-acoustic radiation. If the radiation amplitude is small solitary structures
persists, but when the amplitude grows energy transfer towards small spatial
scales occurs. We show that transfer is particularly fast when a fixed point of
a low dimensional model is destroyed.Comment: LaTex + 4 eps file
Rethinking professional practice: the logic of competition and the crisis of identity in housing practice
The relationship between professionalism, education and housing practice has become increasingly strained following the introduction of austerity measures and welfare reforms across a range of countries. Focusing on the development of UK housing practice, this article considers how notions of professionalism are being reshaped within the context of welfare retrenchment and how emerging tensions have both affected the identity of housing professionals and impacted on the delivery of training and education programmes. The article analyses the changing knowledge and skills valued in contemporary housing practice and considers how the sector has responded to the challenges of austerity. The central argument is that a dominant logic of competition has culminated in a crisis of identity for the sector. Although the focus of the article is on UK housing practice, the processes identified have a wider relevance for the analysis of housing and welfare delivery in developed economies
Audit of head injury management in Accident and Emergency at two hospitals: implications for NICE CT guidelines
BACKGROUND:
The National Institute for Clinical Excellence (NICE) has produced guidelines on the early management of head injury. This study audits the process of the management of patients with head injury presenting at Accident and Emergency (A&E) departments and examines the impact upon resources of introducing NICE guidelines for eligibility of a CT scan.
METHODS:
A retrospective audit of consecutive patients of any age, presenting at A&E with a complaint of head injury during one month in two northern District General Hospitals forming part of a single NHS Trust.
RESULTS:
419 patients presented with a median age of 15.5 years, and 61% were male. 58% had a Glasgow Coma Score (GCS) recorded and 33 (8%) were admitted. Only four of the ten indicators for a CT scan were routinely assessed, but data were complete for only one (age), and largely absent for another (vomiting). Using just three (incomplete) indicators showed a likely 4 fold increase in the need for a CT scan.
CONCLUSIONS:
The majority of patients who present with a head injury to Accident and Emergency departments are discharged home. Current assessment processes and associated data collection routines do not provide the information necessary to implement NICE guidelines for CT brain scans. The development of such clinical audit systems in a busy A&E department is likely to require considerable investment in technology and/or staff. The resource implications for radiology are likely to be substantial
Enhanced normalisation of CD4/CD8 ratio with earlier antiretroviral therapy at Primary HIV Infection.
BACKGROUND: Total CD4 T-cell counts predict HIV disease progression, but do not necessarily reflect normalization of immune function. CD4/CD8 ratio is a marker of immune dysfunction, a prognostic indicator for non-AIDS mortality, and reflects viral reservoir size. Despite ART, recovery of CD4/CD8 ratio in chronic HIV infection is incomplete; we hypothesize enhanced CD4/CD8 ratio recovery with earlier treatment initiation in recently infected individuals. METHODS: CD4 count and CD4/CD8 ratio were analyzed using data from two cohorts: SPARTAC trial, and the UK HIV Seroconverters Cohort where Primary HIV infection (PHI) was defined as within 6 months from estimated date of infection. Using time-to-event methods and Cox proportional hazard models we examined the effect of CD4/CD8 ratio at seroconversion on disease progression (CD41.0). FINDINGS: Of 573 seroconverters, 482 (84%) had abnormal CD4/CD8 ratios at HIV seroconversion. Individuals with higher CD4/CD8 ratio at seroconversion were significantly less likely to reach the disease progression end point (aHR [95% CI] = 0.52 [0.32, 0.82], p=0.005). The longer the interval between seroconversion and ART initiation (HR [95% CI] =0.98 per month increase [0.97, 0.99], p<0.001) the less likely CD4/CD8 ratio normalization. ART initiation within 6 months from seroconversion was significantly more likely to normalize (HR [95% CI] =2.47 [1.67, 3.67], p<0.001) than those initiating later. INTERPRETATION: The majority of individuals presenting in PHI have abnormal CD4/CD8 ratios. The sooner ART is initiated in PHI the greater the probability of achieving normal CD4/CD8 ratio
Brown carbon aerosol in the North American continental troposphere: sources, abundance, and radiative forcing
Chemical components of organic aerosol (OA) selectively absorb light at short wavelengths. In this study, the prevalence, sources, and optical importance of this so called brown carbon (BrC) aerosol component are investigated throughout the North American continental tropospheric column during a summer of extensive biomass burning. Spectrophotometric absorption measurements on extracts of bulk aerosol samples collected from an aircraft over the central USA were analyzed to directly quantify BrC abundance. BrC was found to be prevalent throughout the 1 to 12 km altitude measurement range, with dramatic enhancements in biomass-burning plumes. BrC to black carbon (BC) ratios, under background tropospheric conditions, increased with altitude, consistent with a corresponding increase in the absorption Ă
ngström exponent (AAE) determined from a three-wavelength particle soot absorption photometer (PSAP). The sum of inferred BC absorption and measured BrC absorption at 365 nm was within 3 % of the measured PSAP absorption for background conditions and 22 % for biomass burning. A radiative transfer model showed that BrC absorption reduced top-of atmosphere (TOA) aerosol forcing by ⌠20 % in the background troposphere. Extensive radiative model simulations applying this study background tropospheric conditions provided a look-up chart for determining radiative forcing efficiencies of BrC as a function of a surface-measured BrC : BC ratio and single scattering albedo (SSA). The chart is a first attempt to provide a tool for better assessment of brown carbonâs forcing effect when one is limited to only surface data. These results indicate that BrC is an important contributor to direct aerosol radiative forcing
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Mortality Risk Assessment of Total Knee Arthroplasty and Related Surgery After Percutaneous Coronary Intervention
Background: The optimal antiplatelet therapy (APT) treatment strategy after Coronary Artery Stenting (CAS) in non-cardiac surgery, such as total knee arthroplasty (TKA) or urgent TKA-related surgery remains unknown. Methods: We built a decision tree model to examine the mortality outcomes of two alternative strategies for APT after CAS use in the perioperative period namely, continuous use and discontinuation. Results: If surgery was performed in the first month after CAS placement, discontinuing APT led to an estimated 30-day post TKA mortality of 10.5%, compared to 1.0% in a strategy with continuous APT use. Mortality with both strategies decreased with longer intervals. Conclusion: Our model demonstrated that APT discontinuation in patients undergoing TKA or urgent TKA related surgery after CAS placement might lead to greater 30-day mortality up to one year
The first GCT camera for the Cherenkov Telescope Array
The Gamma Cherenkov Telescope (GCT) is proposed to be part of the Small Size
Telescope (SST) array of the Cherenkov Telescope Array (CTA). The GCT
dual-mirror optical design allows the use of a compact camera of diameter
roughly 0.4 m. The curved focal plane is equipped with 2048 pixels of
~0.2{\deg} angular size, resulting in a field of view of ~9{\deg}. The GCT
camera is designed to record the flashes of Cherenkov light from
electromagnetic cascades, which last only a few tens of nanoseconds. Modules
based on custom ASICs provide the required fast electronics, facilitating
sampling and digitisation as well as first level of triggering. The first GCT
camera prototype is currently being commissioned in the UK. On-telescope tests
are planned later this year. Here we give a detailed description of the camera
prototype and present recent progress with testing and commissioning.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
A major electronics upgrade for the H.E.S.S. Cherenkov telescopes 1-4
The High Energy Stereoscopic System (H.E.S.S.) is an array of imaging
atmospheric Cherenkov telescopes (IACTs) located in the Khomas Highland in
Namibia. It consists of four 12-m telescopes (CT1-4), which started operations
in 2003, and a 28-m diameter one (CT5), which was brought online in 2012. It is
the only IACT system featuring telescopes of different sizes, which provides
sensitivity for gamma rays across a very wide energy range, from ~30 GeV up to
~100 TeV. Since the camera electronics of CT1-4 are much older than the one of
CT5, an upgrade is being carried out; first deployment was in 2015, full
operation is planned for 2016. The goals of this upgrade are threefold:
reducing the dead time of the cameras, improving the overall performance of the
array and reducing the system failure rate related to aging. Upon completion,
the upgrade will assure the continuous operation of H.E.S.S. at its full
sensitivity until and possibly beyond the advent of CTA. In the design of the
new components, several CTA concepts and technologies were used and are thus
being evaluated in the field: The upgraded read-out electronics is based on the
NECTAR readout chips; the new camera front- and back-end control subsystems are
based on an FPGA and an embedded ARM computer; the communication between
subsystems is based on standard Ethernet technologies. These hardware solutions
offer good performance, robustness and flexibility. The design of the new
cameras is reported here.Comment: Proceedings of the 34th International Cosmic Ray Conference, 30 July-
6 August, 2015, The Hague, The Netherland
How is female mate choice affected by male competition?
Author Posting. © Cambridge Philosophical Society, 2005. This article is posted here by permission of Cambridge Philosophical Society for personal use, not for redistribution. The definitive version was published in Biological Reviews 80: (2005) 559-571, doi:10.1017/S1464793105006809.The plethora of studies devoted to the topics of male competition and female mate choice belie the fact that their interaction remains poorly understood. Indeed, on the question of whether competition should help or hinder the choice process, opinions scattered throughout the sexual selection literature seem unnecessarily polarised. We argue, in the light of recent theoretical and empirical advances, that the effect of competition on mate choice depends on whether it results in the choosy sex attaining high breeding value for total fitness, considering both direct and indirect fitness benefits. Specifically, trade-offs may occur between different fitness benefits if some are correlated with male competitive ability whilst others are not. Moreover, the costs and benefits of mating with competitive males may vary in time and/or space. These considerations highlight the importance of injecting a life-history perspective into sexual selection studies. Within this context, we turn to the sexual selection literature to try to offer insights into the circumstances when competition might be expected to have positive or negative implications for pre-copulatory female choice. In this regard, we elaborate on three stages where competition might impact upon the choice process: (i) during mate detection, (ii) mate evaluation, and (iii) in dictating actual mating outcomes. We conclude by offering researchers several potentially rewarding avenues for future research.This study was supported by an Australian Postgraduate Award, a
Sir Keith Murdoch Fellowship, and a Centre for International
Mobility Fellowship (to B.B.M.W) and the Academy of Finland
(to U.C.)
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