Local law-of-the-wall in complex topography: a confirmation from wind tunnel experiments

It is well known that in a neutrally-stratified turbulent flow in a deep constant-stress layer above a flat surface, the variation of the mean velocity with respect to the distance from the surface obeys the logarithmic law (the so-called ``law-of-the-wall''). More recently, the same logarithmic law has been found also in the presence of non flat surfaces. It governs the dynamics of the mean velocity (i.e. all the smaller scales are averaged out) and involves renormalized effective parameters. Recent numerical simulations analyzed by the authors of the present Letter show that a more intrinsic logarithmic shape actually takes place also at smaller scales. Such a generalized law-of-the-wall involves effective parameters smoothly depending on the position along the underlying topography. Here, we present wind tunnel experimental evidence confirming and corroborating this new-found property. New results and their physical interpretation are also presented and discussed.Comment: 9 pages, (Latex), 4 figure

Situação atual e perspectivas do OGMS no Brasil.

Avaliando o panorama, percebe-se com clareza a ampliação de áreas de uso de OGM no país. Eles saem do escopo exclusivo da agropecuária e se expandem para os mais diversos setores industriais e de produtos disponibilizados à sociedade. O que antes estava exclusivamente nas prateleiras de comida dos supermercados, passa a estar nos setores de limpeza, higiene pessoal, nos postos de saúde, em lojas de roupa e especializadas em cosméticos, farmácias e até em postos de combustíveis. Ao contrário dos preconceitos e comportamentos anticientíficos em relação às plantas GM ? que estão mais amenos, mas não desapareceram ? o debate sobre a nova leva de produtos desenvolvidos usando OGMs ou derivados é mais sereno na maioria do tempo. Hoje, pode-se afirmar que nenhum brasileiro passa um dia sequer sem usar algum tipo de produto que contenha componentes avaliados pela CTNBio/MCTI. Essa ampliação de escopo de produtos e uso torna necessário um contínuo aprimoramento das Resoluções Normativas, o que a CTNBio/MCTI vem fazendo periodicamente. Considerando que não houve qualquer relato de problemas no escopo das avaliações da CTNBio/MCTI ? segurança ambiental e à saúde humana e animal ? pode-se ter como certo que as avaliações foram corretas. A aprovação da CTNBio/MCTI para a liberação comercial torna-se, cada vez mais, quase um selo de qualidade no que diz respeito à segurança do OGM ou de seus derivados. As pessoas podem não querer consumir produtos contendo OGM, mas certamente a opção não terá relação com sua segurança. Os OGMs aprovados pela CTNBio/MCTI são seguros

RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis

BACKGROUND: Alterations of synaptic transmission induced by inflammatory activity have been linked to the pathogenic mechanisms of multiple sclerosis (MS). Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a pro-inflammatory chemokine involved in MS pathophysiology, potentially able to regulate glutamate release and plasticity in MS brains, with relevant consequences on the clinical manifestations of the disease. OBJECTIVE: To assess the role of RANTES in the regulation of cortical excitability. METHODS: We explored the association of RANTES levels in the cerebrospinal fluid (CSF) of newly diagnosed MS patients with magnetic resonance imaging (MRI) and laboratory measures of inflammatory activity, as well its role in the control of cortical excitability and plasticity explored by means of transcranial magnetic stimulation (TMS), and in hippocampal mouse slices in vitro. RESULTS: CSF levels of RANTES were remarkably high only in active MS patients and were correlated with the concentrations of interleukin-1β. RANTES levels were associated with TMS measures of cortical synaptic excitability, but not with long-term potentiation (LTP)-like plasticity. Similar findings were obtained in mouse hippocampal slices in vitro, where we observed that RANTES enhanced basal excitatory synaptic transmission with no effect on LTP. CONCLUSION: RANTES correlates with inflammation and synaptic excitability in MS brains

Molecular and structural characterization of a trypsin highly expressed in larval stage of Zabrotes subfasciatus.

Made available in DSpace on 2018-06-07T00:58:44Z (GMT). No. of bitstreams: 1 ID290151.pdf: 538429 bytes, checksum: 619093268774950941b2bc88664c1c44 (MD5) Previous issue date: 2008-02-0

MEGAPOLI: concept of multi-scale modelling of megacity impact on air quality and climate

The EU FP7 Project MEGAPOLI: "Megacities: Emissions, urban, regional and Global Atmospheric POLlution and climate effects, and Integrated tools for assessment and mitigation" (http://megapoli.info) brings together leading European research groups, state-of-the-art scientific tools and key players from non-European countries to investigate the interactions among megacities, air quality and climate. MEGAPOLI bridges the spatial and temporal scales that connect local emissions, air quality and weather with global atmospheric chemistry and climate. The suggested concept of multi-scale integrated modelling of megacity impact on air quality and climate and vice versa is discussed in the paper. It requires considering different spatial and temporal dimensions: time scales from seconds and hours (to understand the interaction mechanisms) up to years and decades (to consider the climate effects); spatial resolutions: with model down- and up-scaling from street- to global-scale; and two-way interactions between meteorological and chemical processes

Advances in air quality research – current and emerging challenges

This review provides a community\u27s perspective on air quality research focusing mainly on developments over the past decade. The article provides perspectives on current and future challenges as well as research needs for selected key topics. While this paper is not an exhaustive review of all research areas in the field of air quality, we have selected key topics that we feel are important from air quality research and policy perspectives. After providing a short historical overview, this review focuses on improvements in characterizing sources and emissions of air pollution, new air quality observations and instrumentation, advances in air quality prediction and forecasting, understanding interactions of air quality with meteorology and climate, exposure and health assessment, and air quality management and policy. In conducting the review, specific objectives were (i) to address current developments that push the boundaries of air quality research forward, (ii) to highlight the emerging prominent gaps of knowledge in air quality research, and (iii) to make recommendations to guide the direction for future research within the wider community. This review also identifies areas of particular importance for air quality policy. The original concept of this review was borne at the International Conference on Air Quality 2020 (held online due to the COVID 19 restrictions during 18–26 May 2020), but the article incorporates a wider landscape of research literature within the field of air quality science. On air pollution emissions the review highlights, in particular, the need to reduce uncertainties in emissions from diffuse sources, particulate matter chemical components, shipping emissions, and the importance of considering both indoor and outdoor sources. There is a growing need to have integrated air pollution and related observations from both ground-based and remote sensing instruments, including in particular those on satellites. The research should also capitalize on the growing area of low-cost sensors, while ensuring a quality of the measurements which are regulated by guidelines. Connecting various physical scales in air quality modelling is still a continual issue, with cities being affected by air pollution gradients at local scales and by long-range transport. At the same time, one should allow for the impacts from climate change on a longer timescale. Earth system modelling offers considerable potential by providing a consistent framework for treating scales and processes, especially where there are significant feedbacks, such as those related to aerosols, chemistry, and meteorology. Assessment of exposure to air pollution should consider the impacts of both indoor and outdoor emissions, as well as application of more sophisticated, dynamic modelling approaches to predict concentrations of air pollutants in both environments. With particulate matter being one of the most important pollutants for health, research is indicating the urgent need to understand, in particular, the role of particle number and chemical components in terms of health impact, which in turn requires improved emission inventories and models for predicting high-resolution distributions of these metrics over cities. The review also examines how air pollution management needs to adapt to the above-mentioned new challenges and briefly considers the implications from the COVID-19 pandemic for air quality. Finally, we provide recommendations for air quality research and support for policy

What About my Privacy, Habibi? Understanding Privacy Concerns and Perceptions of Users From Different Socioeconomic Groups in the Arab World

This paper contributes an in-depth understanding of privacy concerns and perceptions of Arab users. We report on the first comparison of privacy perceptions among (1) users from high socioeconomic groups in Arab countries (HSA), (2) users from medium to low socioeconomic groups in Arab countries (LSA), and (3) as a baseline, users from high socioeconomic groups in Germany (HSG). Our work is motivated by the fact that most research in privacy focused on Western, Educated, Industrialized, Rich, and Democratic (WEIRD) societies. This excludes a segment of the population whose cultural norms and socioeconomic status influence privacy perception and needs. We report on multiple novel findings and unexpected similarities and differences across the user groups. For example, shoulder surfing is more common across LSA and HSG, and defamation is a major threat in LSA. We discuss the implications of our findings on the design of privacy protection measures for investigated groups

Policy masquerading as science: an examination of non-state actor involvement in European risk assessment policy for genetically modified animals

In 2013, at the request of the European Commission, the European Food Safety Authority (EFSA) announced a new risk assessment policy: Guidance on the environmental risks of genetically modified (GM) animals (‘Guidance’). This policy specifies the issues to be addressed in future risk assessments for GM animals. EFSA is the European Commission's scientific arm, responsible for food-related risk assessment. EFSA relies heavily on independent experts and consults non-state actors. Employing expert interviews and documentary analysis, the article explores non-state actor involvement in a traditionally expert domain through a case study. Analysis of EFSA's consultation demonstrates the inability of non-state actors to influence policy. The article argues that despite international legal obligations to develop risk assessment policy, the European Commission failed to recognize the Guidance as policy. When policy masquerades as science, unjustified restrictions are placed on non-state actor involvement and value judgements are cloaked from public scrutiny