Potential model calculations and predictions for heavy quarkonium

We investigate the spectroscopy and decays of the charmonium and upsilon systems in a potential model consisting of a relativistic kinetic energy term, a linear confining term including its scalar and vector relativistic corrections and the complete perturbative one-loop quantum chromodynamic short distance potential. The masses and wave functions of the various states are obtained using a variational technique, which allows us to compare the results for both perturbative and nonperturbative treatments of the potential. As well as comparing the mass spectra, radiative widths and leptonic widths with the available data, we include a discussion of the errors on the parameters contained in the potential, the effect of mixing on the leptonic widths, the Lorentz nature of the confining potential and the possible $c\bar{c}$ interpretation of recently discovered charmonium-like states.Comment: Physical Review published versio

Small animal disease surveillance: respiratory disease 2017

This report focuses on surveillance for respiratory disease in companion animals. It begins with an analysis of data from 392 veterinary practices contributing to the Small Animal Veterinary Surveillance Network (SAVSNET) between January and December 2017. The following section describes canine respiratory coronavirus infections in dogs, presenting results from laboratory-confirmed cases across the country between January 2010 and December 2017. This is followed by an update on the temporal trends of three important syndromes in companion animals, namely gastroenteritis, pruritus and respiratory disease, from 2014 to 2017. A fourth section presents a brief update on Streptococcus equi subspecies zooepidemicus in companion animals. The final section summarises some recent developments pertinent to companion animal health, namely eyeworm (Thelazzia callipaeda) infestations in dogs imported to the UK and canine influenza virus in the USA and Canada

Magnetic Monopoles, Electric Neutrality and the Static Maxwell-Dirac Equations

We study the full Maxwell-Dirac equations: Dirac field with minimally coupled electromagnetic field and Maxwell field with Dirac current as source. Our particular interest is the static case in which the Dirac current is purely time-like -- the "electron" is at rest in some Lorentz frame. In this case we prove two theorems under rather general assumptions. Firstly, that if the system is also stationary (time independent in some gauge) then the system as a whole must have vanishing total charge, i.e. it must be electrically neutral. In fact, the theorem only requires that the system be {\em asymptotically} stationary and static. Secondly, we show, in the axially symmetric case, that if there are external Coulomb fields then these must necessarily be magnetically charged -- all Coulomb external sources are electrically charged magnetic monopoles

Flat Low-Loss Silicon Gradient Index Lens for Millimeter and Submillimeter Wavelengths

We present the design, simulation, and planned fabrication process of a flat high resistivity silicon gradient index (GRIN) lens for millimeter and submillimeter wavelengths with very low absorption losses. The gradient index is created by sub wavelength holes whose size increases with the radius of the lens. The effective refractive index created by the subwavelength holes is constant over a very wide bandwidth, allowing the fabrication of achromatic lenses up to submillimeter wavelengths. The designed GRIN lens was successfully simulated and shows an expected efficiency better than that of a classic silicon plano-concave spherical lens with approximately the same thickness and focal length. Deep reactive ion etching (DRIE) and wafer-bonding of several patterned wafers will be used to realize our first GRIN lens prototype

Use of vaccines and factors associated with their uptake variability in dogs, cats and rabbits attending a large sentinel network of veterinary practices across Great Britain

Vaccination remains a mainstay of companion animal population health. However, how vaccine use at a population level complies with existing guidelines is unknown. Here we use electronic health records to describe vaccination in dogs, cats and rabbits attending a large sentinel network of UK veterinary practices. In total, 77.9% (95% CI: 77.6-78.1) of animals had recorded vaccinations. The percentage of animals with recorded vaccinations was higher in dogs, neutered animals, in insured dogs and cats and in purebred dogs. Vaccination rates varied in different regions of Great Britain in all species. Dogs and cats belonging to owners living in less deprived areas of England and Scotland were more likely to be recorded as vaccinated. In the vaccinated population, cats received more core vaccines per year of life (0.86) than dogs (0.75), with feline leukaemia vaccines almost as frequent as core vaccines. In dogs, leptospira vaccines were more frequent than core vaccines. This descriptive study suggests a substantial proportion of animals are not benefiting from vaccine protection. For the first time, we identify potential factors associated with variations in recorded vaccination frequency, providing a critical baseline against which to monitor future changes in companion animal vaccination and evidence to inform future targeted health interventions

Rates of lobar atrophy in asymptomatic MAPT mutation carriers.

IntroductionThe aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutation carriers.MethodsMAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from asymptomatic to symptomatic) and noncarriers (n = 13) underwent structural magnetic resonance imaging and were followed annually with a median of 9.2 years. Longitudinal changes in lobar atrophy were analyzed using the tensor-based morphometry with symmetric normalization algorithm.ResultsThe rate of temporal lobe atrophy in asymptomatic MAPT mutation carriers was faster than that in noncarriers. Although the greatest rate of atrophy was observed in the temporal lobe in converters, they also had increased atrophy rates in the frontal and parietal lobes compared to noncarriers.DiscussionAccelerated decline in temporal lobe volume occurs in asymptomatic MAPT mutation carriers followed by the frontal and parietal lobe in those who have become symptomatic. The findings have implications for monitoring the progression of neurodegeneration during clinical trials in asymptomatic MAPT mutation carriers

A one-dimensional lattice model for a quantum mechanical free particle

Two types of particles, A and B with their corresponding antiparticles, are defined in a one dimensional cyclic lattice with an odd number of sites. In each step of time evolution, each particle acts as a source for the polarization field of the other type of particle with nonlocal action but with an effect decreasing with the distance: A -->...\bar{B} B \bar{B} B \bar{B} ... ; B --> A \bar{A} A \bar{A} A ... . It is shown that the combined distribution of these particles obeys the time evolution of a free particle as given by quantum mechanics.Comment: 8 pages. Revte

Amyloid fibril length distribution quantified by atomic force microscopy single-particle image analysis

Amyloid fibrils are proteinaceous nano-scale linear aggregates. They are of key interest not only because of their association with numerous disorders, such as type II diabetes mellitus, Alzheimer's and Parkinson's diseases, but also because of their potential to become engineered high-performance nano-materials. Methods to characterise the length distribution of nano-scale linear aggregates such as amyloid fibrils are of paramount importance both in understanding the biological impact of these aggregates and in controlling their mechanical properties as potential nano-materials. Here, we present a new quantitative approach to the determination of the length distribution of amyloid fibrils using tapping-mode atomic force microscopy. The method described employs single-particle image analysis corrected for the length-dependent bias that is a common problem associated with surface-based imaging techniques. Applying this method, we provide a detailed characterisation of the length distribution of samples containing long-straight fibrils formed in vitro from β2-microglobulin. The results suggest that the Weibull distribution is a suitable model in describing fibril length distributions, and reveal that fibril fragmentation is an important process even under unagitated conditions. These results demonstrate the significance of quantitative length distribution measurements in providing important new information regarding amyloid assembly