Controlled Release of Drugs FromHydrogel Based Matrices Systems: Experiments and Modeling

Hydrogels are materials largely used in the formulation of pharmaceuticals since, in principle, they could produce a release system of zero-order kinetics, which is of great therapeutic interest. In this paper, a model was proposed for the description of the main transport phenomena involved in the drug release process from hydrogel matrices (water diffusion, polymer swelling, drug diffusion and polymer dissolution); the model predictions are successfully compared with a large set of experimental data, obtained working with matrices systems based on HPMC (Hydroxy Propyl Methyl Cellulose). The proposed model was found able to reproduce main features of the observed phenomena, it can thus be adopted for prediction of the performances of drug release systems from hydrogel matrices

Seismic Analysis of Traditional Stone Rural Buildings: Case study of a one-storey building

Specific features of traditional rural buildings can influence the assessment of their seismic behaviour. When a change in intended use of traditional rural buildings is necessary, restoration work must comply with specific seismic norms and should preserve their original features. In this paper, a model for the seismic safety verification of masonry walls for inplane actions was applied to investigate the structural behaviour of one-storey stone-masonry traditional rural buildings, in relation to standards application and possible retrofitting interventions. The results showed that pier-panel collapse mechanisms and the simulation method of masonry spandrel behaviour are of importance and affect the need to provide for strengthening interventions

Controlled Release of Drugs FromHydrogel Based Matrices Systems: Experiments and Modeling

Hydrogels are materials largely used in the formulation of pharmaceuticals since, in principle, they could produce a release system of zero-order kinetics, which is of great therapeutic interest. In this paper, a model was proposed for the description of the main transport phenomena involved in the drug release process from hydrogel matrices (water diffusion, polymer swelling, drug diffusion and polymer dissolution); the model predictions are successfully compared with a large set of experimental data, obtained working with matrices systems based on HPMC (Hydroxy Propyl Methyl Cellulose). The proposed model was found able to reproduce main features of the observed phenomena, it can thus be adopted for prediction of the performances of drug release systems from hydrogel matrices

ACLAS – a method to define geologically significant lineaments from potential fields data

Geological features, such as faults, dikes and contacts appear as lineaments in gravity and magnetic data. The Automated Coherent Lineament Analysis and Selection (ACLAS) method is a new approach to automatically compare and combine sets of lineaments or edges derived from two or more existing enhancement techniques applied to the same gravity or magnetic data set. ACLAS can be applied to the results of any edge detection algorithms and overcomes discrepancies between techniques to generate a coherent set of detected lineaments, which can be more reliably incorporated into geological interpretation. We demonstrate that the method increases spatial accuracy, removes artefacts not related to real edges, increases stability and that it is fast to implement and execute. The direction of lower density or susceptibility can also be automatically determined representing, for example, the downthrown side of a fault. Here, ACLAS is demonstrated on magnetic anomalies calculated from a simple slab model and from a synthetic continental margin model with noise added to the result. The approach helps to identify and discount artefacts of the different techniques, although the success of the combination is limited by the appropriateness of the individual techniques and their inherent assumptions. ACLAS has been applied separately to gravity and magnetic data from the NW Australia shelf displaying results from the two data sets together helps the appreciation of similarities and differences between gravity and magnetic results and indicates the application of the new approach to large scale structural mapping. Future developments could include refinement of depth estimates for ACLAS lineaments

Integrins: A flexible platform for endothelial vascular tyrosine kinase receptors.

Compared to lower metazoans, vertebrates built up an exclusively new set of adhesion-related genes involved in the tissue development and in their functions. They include a large variety of extracellular matrix proteins and their heterodimeric integrin adhesive receptors. Integrins control the adhesive state of the cell through complex molecular mechanisms. Outside-in signalling informs the cell about the extracellular matrix environment, while Inside-out signalling results in changes in integrin functional activity. In the last 10 years it has well established a reciprocal integration of signals originating from integrins and receptors for soluble growth factors. This review summarizes the current understanding of this connection in vascular endothelial cells and highlights how integrins regulate a genetic program triggered by angiogenic inducers during embryo development and in adult life

Potential biogas production from agricultural by-products in Sicily. A case study of citrus pulp and olive pomace

Renewable energy sources represent a suitable alternative to conventional fossil fuels, due to the possible advantages in terms of environmental impact reduction. Anaerobic digestion of biomasses could be considered an environmental friendly way to treat and revalorise large amounts of by-products from farming industries because it ensures both pollution control and energy recovery. Therefore, the objective of this study was to define a methodology for evaluating the potential biogas production available from citrus pulp and olive pomace, which are suitable agricultural by-products for biogas production. In the first phase of the study, the spatial distribution of both olive and citrus-producing areas was analysed in Sicily, a geographical area of the Mediterranean basin highly representative of these types of cultivation. Then, a GIS-based model, which had been previously defined and utilised to evaluate the amount of citrus pulp and olive pomace production, was applied to this case study. Based on the results obtained for the different provinces of Sicily, the province of Catania was chosen as the study area of this work since it showed the highest production of both citrus pulp and olive pomace. Therefore, a further analysis regarded the quantification of olive pomace and citrus pulp at municipal level. The results of this analysis showed that the total amount of available citrus pulp and olive pomace corresponded theoretically to about 11,102,469 Nm3/year biogas. Finally, the methodology adopted in this study made it possible to identify suitable areas for the development of new biogas plants by considering both the spatial distribution of the olive and citrus growing areas and the locations of the existing processing industries

Improving natural ventilation in renovated free-stall barns for dairy cows: Optimized building solutions by using a validated computational fluid dynamics model

Natural ventilation is the most used system to create suitable conditions, removing gases, introducing oxygen in livestock buildings. Its efficiency depends on several factors and above all on the number, the dimensions and the position of wall openings and internal layout of livestock buildings. The aim of this research was to develop optimized layout solutions for improving natural ventilation effectiveness in free-stall barns for dairy cows by using a CFD approach. A validated computational fluid dynamics (CFD) model was applied in a case study which is highly representative of building interventions for renovating the layout of free-stall barns for dairy cows located in an area of the Mediterranean basin. Firstly, dairy cow behaviour was analysed by visual examination of time-lapse video-recordings. Then, simulations were carried out by using the validated CFD model and changing the position of internal and external building elements (i.e., internal office and external buildings for milking) in order to find the best condition for the thermal comfort of the animals. The results showed that the best conditions were recorded for a new configuration of the building in terms of air velocity distribution within the resting area, the service alley and the feeding alley for dairy cows, and in the pens for calves. In this new layout, the office areas and the north-west wall openings were located by mirroring them along the transversal axis of the barn. Therefore, the CFD approach proposed in this study could be used during the design phase, as a decision support system aimed at improving the natural ventilation within the barn

Development of a CFD model to simulate natural ventilation in a semi-open free-stall barn for dairy cows

Natural ventilation is the most common passive cooling system in livestock buildings. The aim of this research is to assess airflow distribution inside a free-stall barn for dairy cows by computational fluid dynamics (CFD) modelling and simulation. The model is validated by using the average values of experimental data acquired in a free-stall barn, which is considered relevant because it is located in a region characterised by hot climate conditions during the summer that could induce animal heat stress. Simulations are carried out in steady-state conditions, and simulated data are validated by the average values of air velocity measurements. Since the modelled air velocity distribution in the barn fits the real one well, the CFD model is considered reliable to simulate other conditions. The application of the proposed CFD model in the simulation of specific building design alternatives could be aimed at studying the related airflow distribution in order to find the best configuration