1,484 research outputs found

    Update on the Challenge Program "Unlocking Genetic Diversity in Crops for the Resource-Poor

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    This report is an update on the CGIAR challenge program "Unlocking Genetic Diversity in Crops for Resource-Poor". It was presented by Robert Ziegler during the Stakeholder Meeting at AGM 2003

    Synthesis of calculational methods for the design and analysis of radiation shields for nuclear rocket systems. Volume 2 - Analysis of radiation measurements in a nuclear rocket propellant tank mockup using simulated liquid hydrogen

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    Calculational methods for nuclear rocket radiation shield design - analysis of radiation measurements in nuclear rocket propellant tank mockup using simulated liquid hydroge

    Nuclear rocket shielding methods, modification, updating, and input data preparation. Volume 5 - Two-dimensional, discrete ordinates transport technique Final progress report

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    Two dimensional, discrete ordinates transport technique for use with nuclear rocket shielding methods, modification, updating, and data input preparation - Vol.

    Nuclear rocket shielding methods, modification, updating, and input data preparation. Volume 1 - Synopsis of methods and results of analysis Final progress report

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    Analysis of data systems and computer programs for nuclear rocket shielding methods, modification, updating, and data input preparation - Vol.

    Application of remote sensing to study nearshore circulation

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    The research to use remote sensing techniques for studying the continental shelf is reported. The studies reported include: (1) nearshore circulation in the vincinity of a natural tidal inlet; (2) identification of indicators of biological activity; (3) remote navigation system for tracking free drifting buoys; (4) experimental design of an estuaring tidal circulation; and (5) Skylab support work

    Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response.

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    BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue. We used microarray analysis to determine which genes, pathways and networks were significantly altered using a rat model of TBI. Adult rats received a unilateral controlled cortical impact (CCI) and were sacrificed 24 h post-injury. The ipsilateral hemi-brain tissue at the site of the injury, the corresponding contralateral hemi-brain tissue, and naïve (control) brain tissue were used for microarray analysis. Ingenuity Pathway Analysis (IPA) software was used to identify molecular pathways and networks that were associated with the altered gene expression in brain tissues following TBI.ResultsInspection of the top fifteen biological functions in IPA associated with TBI in the ipsilateral tissues revealed that all had an inflammatory component. IPA analysis also indicated that inflammatory genes were altered on the contralateral side, but many of the genes were inversely expressed compared to the ipsilateral side. The contralateral gene expression pattern suggests a remote anti-inflammatory molecular response. We created a network of the inversely expressed common (i.e., same gene changed on both sides of the brain) inflammatory response (IR) genes and those IR genes included in pathways and networks identified by IPA that changed on only one side. We ranked the genes by the number of direct connections each had in the network, creating a gene interaction hierarchy (GIH). Two well characterized signaling pathways, toll-like receptor/NF-kappaB signaling and JAK/STAT signaling, were prominent in our GIH.ConclusionsBioinformatic analysis of microarray data following TBI identified key molecular pathways and networks associated with neural injury following TBI. The GIH created here provides a starting point for investigating therapeutic targets in a ranked order that is somewhat different than what has been presented previously. In addition to being a vehicle for identifying potential targets for post-TBI therapeutic strategies, our findings can also provide a context for evaluating the potential of therapeutic agents currently in development

    Set and Drift

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    Erosion of the cliffs of Outer Cape Cod : tables and graphs

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    Originally issued as Reference No. 64-21, series later renamed WHOI-.The following tables and graphs place in convenient storage the results of several years of careful surveying and at the same time provide rudimentary interpretation of resuIts by comparing erosion rates. The reader will find listed in the bibliography pertinent published papers which analyze these coastal erosion data in great detail.This work has been supported by the Geography Branch of the Office of Naval Research, Contract Number Nonr 1254 (00), (NR-388-018), and by Nonr 2196 (00)
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