Linear independence of Gamma values in positive characteristic

We investigate the arithmetic nature of special values of Thakur's function field Gamma function at rational points. Our main result is that all linear independence relations over the field of algebraic functions are consequences of the known relations of Anderson and Thakur arising from the functional equations of the Gamma function.Comment: 51 page

The Randomized Shortened Dental Arch Study: Tooth Loss

The evidence concerning the management of shortened dental arch (SDA) cases is sparse. This multi-center study was aimed at generating data on outcomes and survival rates for two common treatments, removable dental prostheses (RDP) for molar replacement or no replacement (SDA). The hypothesis was that the treatments lead to different incidences of tooth loss. We included 215 patients with complete molar loss in one jaw. Molars were either replaced by RDP or not replaced, according to the SDA concept. First tooth loss after treatment was the primary outcome measure. This event occurred in 13 patients in the RDP group and nine patients in the SDA group. The respective Kaplan-Meier survival rates at 38 months were 0.83 (95% CI: 0.74-0.91) in the RDP group and 0.86 (95% CI: 0.78-0.95) in the SDA group, the difference being non-significant

RELAÇÃO INTERPESSOAL EM AMBIENTE HOSPITALAR

Introduçao: A formação no Curso de Enfermagem,  considerando as Diretrizes Curriculares Nacionais (DCNs), é pautada no processo de aprender a ser, aprender a fazer, aprender a conviver e aprender a conhecer, com vistas à formação generalista, humanista, crítica, reflexiva, política e ético-legal (MINISTÉRIO DA SAÚDE, 2018). Dessa forma, falar sobre relacionamento interpessoal na área da saúde é de grande relevância, pois estimula o senso de responsabilidade social além de contribuir para a melhoria dos serviços prestados. Nesse sentido, o enfermeiro é o profissional que permanece mais tempo ao lado do paciente, logo, é o mais indicado para desenvolver e sugerir ações educativas, melhorando por consequência a satisfação no atendimento e relacionamento entre equipe (OLIVEIRA; TURRUNI; POVEDA, 2016). Objetivo: demonstrar e sensibilizar os profissionais de enfermagem durante o estágio curricular obrigatório do curso de Enfermagem da UNOESC/SMO, a importância de um bom relacionamento interpessoal entre profissionais da equipe e entre profissionais e pacientes. Metodologia: Para elaboração da ideia de intervenção, utilizou-se a metodologia problematizadora para avaliação da realidade e identificação de uma questão problema que poderia ser melhorada, pesquisa teórica para elaboração das hipóteses de solução, aplicação no campo de estágio e avaliação dos resultados. A intervenção foi realizada por meio de duas dinâmicas entre equipe de enfermagem em que foram entregues frases aleatórias no início do plantão com comandos que deveriam ser feitos até às 23 horas, para todos os colaboradores da equipe, para depois socializar sobre sua experiência ao realizar os comandos. Quando chegou o horário combinado, reuniu-se toda a equipe de enfermagem para a segunda dinâmica, “a dinâmica da bala”, a qual todos receberam uma bala que deveriam abrir sem utilizar as próprias mãos, para observarmos a capacidade de colaboração entre equipe. Enquanto abriam as balas, explanou-se em poucos minutos o objetivo das dinâmicas e a importância de uma boa relação interpessoal. Por fim agradeceu-se a todos ela colaboração e expôs-se frases, conceitos e breve história da relação interpessoal e dicas motivacionais para o profissional ler e praticar quando não estiver sentindo-se bem e dez dicas valiosas para conquistar-se um bom relacionamento interpessoal. Resultados e discussoes: Relacionamento interpessoal refere-se à interação e vínculo estabelecido entre pessoas, grupos e times, seja ele no meio profissional, pessoal ou familiar que compartilham metas e objetivos comuns. Um termo usado pela sociologia e psicologia para definir qualquer tipo de relação entre duas ou mais pessoas. Eles variam em diferentes níveis de intimidade e compartilhamento, implicando a descoberta ou estabelecimento de um terreno comum (BERTONE, 2007). Relacionamento interpessoal vai muito além de uma simples relação entre colegas de trabalho ou entre prestadores de serviço e clientes. Quando se fala de relacionamento interpessoal se tange a seres emocionais e instáveis, que passam por transformações a todo tempo e isso requer habilidades para lidar com estas emoções. O conceito de relacionamentos interpessoais em um meio corporativo está associado à conduta do profissional diante de crises, conflitos, superação de obstáculos e a forma com que ele lida com diferentes perfis (OLIVEIRA, 2017). Quando as relações interpessoais enfraquecem em ambiente de trabalho, o clima organizacional torna-se negativo e desgastante, o profissional perde o foco e a produtividade, começam a surgir os desentendimentos, disputas internas e consequentemente perca do aproventamento profissional (FICHER, 2008). O cuidado centrado na pessoa exige que o enfermeiro crie um ambiente facilitador, sendo empático, congruente e aceitando o outro tal qual esse se apresenta, transformando qualquer interação ou relação interpessoal em um encontro com qualidade (VIVELA, 2012). Considerando que um bom relacionamento interpessoal é a base para a prestação de serviços de qualidade, uma intervenção que vise estimular a interação positiva entre colegas de profissão e atribuir/agregar conhecimento à equipe, torna-se indispensável, uma vez que contribui com a melhora na qualidade das ações de saúde voltadas aos pacientes (PONTES, 2008). A comunicação é um processo que pode ser utilizado como instrumento de ajuda terapêutica, em que o enfermeiro deve ter conhecimentos fundamentais sobre as bases teóricas da comunicação e adquirir habilidades de relacionamento interpessoal para agir positivamente na assistência ao paciente. Para que esta possa fluir bem, o profissional enfermeiro deve saber escutar, falar quando necessário, dar abertura para realização de perguntas, ser honesto, mostrar respeito, dispensar tempo suficiente para a conversa e mostrar interesse, entre outras habilidades (PONTES, 2008). Considerando que um bom relacionamento interpessoal é a base para a prestação de serviços de qualidade, uma intervenção que vise estimular a interação positiva entre colegas de profissão e atribuir/agregar conhecimento à equipe, torna-se indispensável, uma vez que contribui com a melhora na qualidade de das ações de saúde voltadas aos pacientes. Consideraçoes finais: A intervenção superou os resultados esperados, todos os profissionais da equipe de enfermagem participam, sensibilizaram-se, o que gerou uma conversa entre equipe e propostas para melhoria de comunicação e relacionamento entre equipe, o que nem sempre é possível, visto a demanda de serviços. Para acadêmicos é importante realizar esse modelo de trabalho e estudo, pois possibilita a percepção de uma unidade de trabalho como ela realmente é, com dias mais corridos e outros nem tanto, com conflitos entre equipe, que precisam ser manejados de forma resiliente, pois trata-se de seres humanos, não máquinas que podem ser meramente concertadas. A divulgação deste estuda torna-se relevante por servir como exemplo de intervenção para melhorar o relacionamento interpessoal entre seres humanos envolvidos em um ambiente de trabalho, estimulando por consequência, a busca por conhecimentos. Palavras chave: Cuidados de enfermagem. Relacionamento Interpessoal. Promoção da Saúde. &nbsp

A Small Conductance Calcium-Activated K⁺ Channel in C. elegans, KCNL-2, Plays a Role in the Regulation of the Rate of Egg-Laying

In the nervous system of mice, small conductance calcium-activated potassium (SK) channels function to regulate neuronal excitability through the generation of a component of the medium afterhyperpolarization that follows action potentials. In humans, irregular action potential firing frequency underlies diseases such as ataxia, epilepsy, schizophrenia and Parkinson's disease. Due to the complexity of studying protein function in the mammalian nervous system, we sought to characterize an SK channel homologue, KCNL-2, in C. elegans, a genetically tractable system in which the lineage of individual neurons was mapped from their early developmental stages. Sequence analysis of the KCNL-2 protein reveals that the six transmembrane domains, the potassium-selective pore and the calmodulin binding domain are highly conserved with the mammalian homologues. We used widefield and confocal fluorescent imaging to show that a fusion construct of KCNL-2 with GFP in transgenic lines is expressed in the nervous system of C. elegans. We also show that a KCNL-2 null strain, kcnl-2(tm1885), demonstrates a mild egg-laying defective phenotype, a phenotype that is rescued in a KCNL-2-dependent manner. Conversely, we show that transgenic lines that overexpress KCNL-2 demonstrate a hyperactive egg-laying phenotype. In this study, we show that the vulva of transgenic hermaphrodites is highly innervated by neuronal processes and by the VC4 and VC5 neurons that express GFP-tagged KCNL-2. We propose that KCNL-2 functions in the nervous system of C. elegans to regulate the rate of egg-laying. © 2013 Chotoo et al

Group 2 ITI Consensus Report: Technological developments in implant prosthetics

Objectives Group‐2 reviewed the scientific evidence in the field of «Technology». Focused research questions were: (1) additive versus subtractive manufacturing of implant restorations; (2) survival, complications, and esthetics comparing prefabricated versus customized abutments; and (3) survival of posterior implant‐supported multi‐unit fixed dental prostheses.Materials and MethodsLiterature was systematically screened, and 67 publications could be critically reviewed following PRISMA guidelines, resulting in three systematic reviews. Consensus statements were presented to the plenary where after modification, those were accepted.ResultsAdditively fabricated implant restorations of zirconia and polymers were investigated for marginal/internal adaptation and mechanical properties without clear results in favor of one technology or material. Titanium base abutments for screw‐retained implant single crowns compared to customized abutments did not show significant differences concerning 1‐year survival. PFM, veneered and monolithic zirconia implant‐supported multi‐unit posterior fixed dental prostheses demonstrated similar high 3‐year survival rates, whereas veneered restorations exhibited the highest annual ceramic fracture and chipping rates.ConclusionsFor interim tooth‐colored implant single crowns both additive and subtractive manufacturing are viable techniques. The clinical performance of additively produced restorations remains to be investigated. Implant single crowns on titanium base abutments show similar clinical performance compared to other type of abutments; however, long‐term clinical data from RCTs are needed. The abutment selection should be considered already during the planning phase. Digital planning facilitates 3D visualization of the prosthetic design including abutment selection. In the posterior area, monolithic zirconia is recommended as the material of choice for multi‐unit implant restorations to reduce technical complications

A pp-adic Approach to the Weil Representation of Discriminant Forms Arising from Even Lattices

Suppose that $M$ is an even lattice with dual $M^{*}$ and level $N$. Then the group $Mp_{2}(\mathbb{Z})$, which is the unique non-trivial double cover of $SL_{2}(\mathbb{Z})$, admits a representation $\rho_{M}$, called the Weil representation, on the space $\mathbb{C}[M^{*}/M]$. The main aim of this paper is to show how the formulae for the $\rho_{M}$-action of a general element of $Mp_{2}(\mathbb{Z})$ can be obtained by a direct evaluation which does not depend on ``external objects'' such as theta functions. We decompose the Weil representation $\rho_{M}$ into $p$-parts, in which each $p$-part can be seen as subspace of the Schwartz functions on the $p$-adic vector space $M_{\mathbb{Q}_{p}}$. Then we consider the Weil representation of $Mp_{2}(\mathbb{Q}_{p})$ on the space of Schwartz functions on $M_{\mathbb{Q}_{p}}$, and see that restricting to $Mp_{2}(\mathbb{Z})$ just gives the $p$-part of $\rho_{M}$ again. The operators attained by the Weil representation are not always those appearing in the formulae from 1964, but are rather their multiples by certain roots of unity. For this, one has to find which pair of elements, lying over a matrix in $SL_{2}(\mathbb{Q}_{p})$, belong to the metaplectic double cover. Some other properties are also investigated.Comment: 29 pages, shortened a lo

PirB regulates a structural substrate for cortical plasticity

Experience-driven circuit changes underlie learning and memory. Monocular deprivation (MD) engages synaptic mechanisms of ocular dominance (OD) plasticity and generates robust increases in dendritic spine density on L5 pyramidal neurons. Here we show that the paired immunoglobulin-like receptor B (PirB) negatively regulates spine density, as well as the threshold for adult OD plasticity. In PirB(-/-) mice, spine density and stability are significantly greater than WT, associated with higher-frequency miniature synaptic currents, larger long-term potentiation, and deficient long-term depression. Although MD generates the expected increase in spine density in WT, in PirB(-/-) this increase is occluded. In adult PirB(-/-), OD plasticity is larger and more rapid than in WT, consistent with the maintenance of elevated spine density. Thus, PirB normally regulates spine and excitatory synapse density and consequently the threshold for new learning throughout life

Effect of temporary cements on the shear bond strength of luting cements

OBJECTIVE: The purpose of this study was to evaluate, by shear bond strength (SBS) testing, the influence of different types of temporary cements on the final cementation using conventional and self-etching resin-based luting cements. Material and Methods: Forty human teeth divided in two halves were assigned to 8 groups (n=10): I and V (no temporary cementation); II and VI: Ca(OH)2-based cement; III and VII: zinc oxide (ZO)-based cement; IV and VIII: ZO-eugenol (ZOE)-based cement. Final cementation was done with RelyX ARC cement (groups I to IV) and RelyX Unicem cement (groups V to VIII). Data were analyzed statistically by ANOVA and Tukey's test at 5% significance level. RESULTS: Means were (MPa): I - 3.80 (&plusmn;1.481); II - 5.24 (&plusmn;2.297); III - 6.98 (&plusmn;1.885); IV - 6.54 (&plusmn;1.459); V - 5.22 (&plusmn;2.465); VI - 4.48 (&plusmn;1.705); VII - 6.29 (&plusmn;2.280); VIII - 2.47 (&plusmn;2.076). Comparison of the groups that had the same temporary cementation (Groups II and VI; III and VII; IV and VIII) showed statistically significant difference (p<0.001) only between Groups IV and VIII, in which ZOE-based cements were used. The use of either Ca(OH)2-based (Groups II and VI) or ZO-based (Groups III and VII) cements showed no statistically significant difference (p>0.05) for the different luting cements (RelyX TM ARC and RelyX TM Unicem). The groups that had no temporary cementation (Groups I and V) did not differ significantly from each other either (p>0.05). CONCLUSION: When temporary cementation was done with ZO- or ZOE-based cements and final cementation was done with RelyX ARC, there was an increase in the SBS compared to the control. In the groups cemented with RelyX Unicem, however, the use of a ZOE-based temporary cement affected negatively the SBS of the luting agent used for final cementation

An SK3 Channel/nWASP/Abi-1 Complex Is Involved in Early Neurogenesis

BACKGROUND: The stabilization or regulated reorganization of the actin cytoskeleton is essential for cellular structure and function. Recently, we could show that the activation of the SK3-channel that represents the predominant SK-channel in neural stem cells, leads to a rapid local outgrowth of long filopodial processes. This observation indicates that the rearrangement of the actin based cytoskeleton via membrane bound SK3-channels might selectively be controlled in defined micro compartments of the cell. PRINCIPAL FINDINGS: We found two important proteins for cytoskeletal rearrangement, the Abelson interacting protein 1, Abi-1 and the neural Wiskott Aldrich Syndrome Protein, nWASP, to be in complex with SK3- channels in neural stem cells (NSCs). Moreover, this interaction is also found in spines and postsynaptic compartments of developing primary hippocampal neurons and regulates neurite outgrowth during early phases of differentiation. Overexpression of the proteins or pharmacological activation of SK3 channels induces obvious structural changes in NSCs and hippocampal neurons. In both neuronal cell systems SK3 channels and nWASP act synergistic by strongly inducing filopodial outgrowth while Abi-1 behaves antagonistic to its interaction partners. CONCLUSIONS: Our results give good evidence for a functional interplay of a trimeric complex that transforms incoming signals via SK3-channel activation into the local rearrangement of the cytoskeleton in early steps of neuronal differentiation involving nWASP and Abi-1 actin binding proteins