Polymer Dissolution Model: An Energy Adaptation Of The Critical Ionization Theory

The current scale of features size in the microelectronics industry has reached the point where molecular level interactions affect process fidelity and produce excursions from the continuum world like line edge roughness (LER). Here we present a 3D molecular level model based on the adaptation of the critical ionization (CI) theory using a fundamental interaction energy approach. The model asserts that it is the favorable interaction between the ionized part of the polymer and the developer solution which renders the polymer soluble. Dynamic Monte Carlo methods were used in the current model to study the polymer dissolution phenomenon. The surface ionization was captured by employing an electric double layer at the interface, and polymer motion was simulated using the Metropolis algorithm. The approximated interaction parameters, for different species in the system, were obtained experimentally and used to calibrate the simulated dissolution rate response to polymer molecular weight and developer concentration. The predicted response is in good agreement with experimental dissolution rate data. The simulation results support the premise of the CI theory and provide an insight into the CI model from a new prospective. This model may provide a means to study the contribution of development to LER and other related defects based on molecular level interactions between distinct components in the polymer and the developer.Chemical Engineerin

Solar total irradiance in cycle 23

The apparently unusual behaviour of the TSI during the most recent minimum of solar activity has been interpreted as evidence against solar surface magnetism as the main driver of the secular change in the TSI. We test claims that the evolution of the solar surface magnetic field does not reproduce the observed TSI in cycle 23. We use sensitive, 60-minute averaged MDI magnetograms and quasi-simultaneous continuum images as an input to our SATIRE-S model and calculate the TSI variation over cycle 23, sampled roughly twice-monthly. The computed TSI is then compared to the PMOD composite of TSI measurements and to the data from two individual instruments, SORCE/TIM and UARS/ACRIM II, that monitored the TSI during the declining phase of cycle 23 and over the previous minimum in 1996, respectively. Excellent agreement is found between the trends shown by the model and almost all sets of measurements. The only exception is the early, i.e. 1996 to 1998, PMOD data. Whereas the agreement between the model and the PMOD composite over the period 1999-2009 is almost perfect, the modelled TSI shows a steeper increase between 1996 and 1999 than implied by the PMOD composite. On the other hand, the steeper trend in the model agrees remarkably well with the ACRIM II data. A closer look at the VIRGO data, that make the basis of the PMOD composite after 1996, reveals that only one of the two VIRGO instruments, the PMO6V, shows the shallower trend present in the composite, whereas the DIARAD measurements indicate a steeper trend. We conclude that (1) the sensitivity changes of the PMO6V radiometers within VIRGO during the first two years have very likely not been correctly evaluated, and that (2) the TSI variations over cycle 23 and the change in the TSI levels between the minima in 1996 and 2008 are consistent with the solar surface magnetism mechanism

Lower Extremity Strength and Mechanics During Jumping in Women With Patellofemoral Pain

Context: Lower extremity (LE) weakness might be associated with altered mechanics during weight bearing in subjects with patellofemoral pain syndrome (PFPS). Objective: To analyze LE strength, mechanics, and the association between these variables among women with and without PFPS during a simulated athletic task. Design: Case control. Setting: Motion-analysis laboratory. Subjects: 20 women with PFPS and 20 healthy women. Main Outcome Measures: Peak isometric lateral trunk-flexion, hipabduction, hip external-rotation, knee-flexion, and knee-extension strength, as well as hip- and knee-joint excursions and angular impulses during single-leg jumps. Results: PFPS subjects produced less hip-abduction, hip external-rotation, and trunk lateral- flexion force than the control group. The PFPS group also demonstrated greater hipadduction excursion and hip-abduction impulses. The association between the strength measurements and LE mechanics was low. Conclusions: Women with PFPS demonstrate specific weaknesses and altered LE mechanics. Weakness is not, however, highly correlated with observed differences in mechanics. ABSTRACT FROM AUTHO

Attractants for Synanthropic Flies. 2. Response Patterns of House Flies to Attractive Baits on Poultry Ranches

A proteinaceous attractant, prepared by freeze-drying fermented whole egg solids, was found to attract Musca domestica L. and other synanthropic Diptera. In field experiments, a mixture of 2 g of the attractant and 2 g of dichlorvos sugar-bait increased fly collection two-fold on manure substrate in trays set on the ground and three-fold in suspended bait units over the sugar-toxicant bait alone. This increase was due primarily to the increased response of nulliparous and parous females in which vitellogenesis was about to occur. Attractancy of the bait declined sharply after 48 hours of field exposure. The location of bait stations significantly affected the number, sex ratio, and female age structure of the flies collected. Stations collecting the greatest number of flies were generally situated at the ends of the cage rows in sunlight-shade border areas. Fly collections from areas of greatest fly activity were characterized by a high proportion of hoth nulliparous and parous protein-searching females, and the sex ratio in these high-activity zones approached 1. East-west and north-south preferences of certain female age groups were manifested in the collection

Bait Units for Collection of House Flies

Lurtox™4 is a proteinaceous attractant for Musca domestica L. and other synanthropic Diptera (Mulla et al. 1973: Willson and Mulla 1973a) and is easily mixed with commercial poison sugar baits. The mixture of Lurtox and dichlorvos sugar bait (50:50 by wt) can be administered in measurable quantities into compact bait units where dead flies can be easily recovered for counting and for other studies. While developing Lurtox for control of Hippelates eye gnats, Mulla et al. (1973) found that moisture was essential for the emanation of the volatile attractants contained in the bait. Therefore, if the prevalent humidity level is not sufficient to activate the attractant, the bait unit designed for use with the bait mixture should include a moisture sourc

Modeling Solar Lyman Alpha Irradiance

Solar Lyman alpha irradiance is estimated from various solar indices using linear regression analyses. Models developed with multiple linear regression analysis, including daily values and 81-day running means of solar indices, predict reasonably well both the short- and long-term variations observed in Lyman alpha. It is shown that the full disk equivalent width of the He line at 1083 nm offers the best proxy for Lyman alpha, and that the total irradiance corrected for sunspot effect also has a high correlation with Lyman alpha

ACRIM-gap and total solar irradiance revisited: Is there a secular trend between 1986 and 1996?

A gap in the total solar irradiance (TSI) measurements between ACRIM-1 and ACRIM-2 led to the ongoing debate on the presence or not of a secular trend between the minima preceding cycles 22 (in 1986) and 23 (1996). It was recently proposed to use the SATIRE model of solar irradiance variations to bridge this gap. When doing this, it is important to use the appropriate SATIRE-based reconstruction, which we do here, employing a reconstruction based on magnetograms. The accuracy of this model on months to years timescales is significantly higher than that of a model developed for long-term reconstructions used by the ACRIM team for such an analysis. The constructed `mixed' ACRIM - SATIRE composite shows no increase in the TSI from 1986 to 1996, in contrast to the ACRIM TSI composite.Comment: 4 figure

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors

We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), several analogues were identified with micromolar activity through targeted displacement of bound water molecules in the active site. Since the TDZ analogues showed reduced promiscuity compared to their 2,4-dianilinopyrimidine counter parts, they represent starting points for development of highly selective kinase inhibitors

Combined analysis of solar neutrino and solar irradiance data: further evidence for variability of the solar neutrino flux and its implications concerning the solar core

A search for any particular feature in any single solar neutrino dataset is unlikely to establish variability of the solar neutrino flux since the count rates are very low. It helps to combine datasets, and in this article we examine data from both the Homestake and GALLEX experiments. These show evidence of modulation with a frequency of 11.85 yr-1, which could be indicative of rotational modulation originating in the solar core. We find that precisely the same frequency is prominent in power spectrum analyses of the ACRIM irradiance data for both the Homestake and GALLEX time intervals. These results suggest that the solar core is inhomogeneous and rotates with sidereal frequency 12.85 yr-1. We find, by Monte Carlo calculations, that the probability that the neutrino data would by chance match the irradiance data in this way is only 2 parts in 10,000. This rotation rate is significantly lower than that of the inner radiative zone (13.97 yr-1) as recently inferred from analysis of Super-Kamiokande data, suggesting that there may be a second, inner tachocline separating the core from the radiative zone. This opens up the possibility that there may be an inner dynamo that could produce a strong internal magnetic field and a second solar cycle.Comment: 22 pages, 9 tables, 10 figure