Estructura factorial y consistencia interna de la Escala de Severidad de Fatiga en población colombiana con enfermedades crónicas

El presente estudio de corte psicométrico, tuvo como objetivo analizar la estructura factorial y la consistencia interna versión en español del cuestionario Fatigue Severity Scale (FSS) en población colombiana de enfermos crónicos. Para ello se aplicó el cuestionario a 52 enfermos crónicos de la ciudad de Villavicencio. El análisis factorial denota tres factores: el factor 1 denominado como afectación física, el factor 2 denominado afectación social y finalmente el factor 3 denominado afectación motivacional de la fatiga, que explican el 76,324% de la varianza total acumulada, y un alfa de Cronbach de 870. Los resultados muestran una alta confiabilidad y concordancia en la estructura factorial con la versión original, lo que implica adecuada validez de la prueba en población colombiana de enfermos crónicos.The present study has a psychometric design, with the objective of analyzing the factorial structure and the internal consistency for the Spanish version of the Fatigue Severity Scale (FSS) Questionnaire for Colombian population with chronic disease. Was applied the questionnaire to 52 people with chronic disease in Villavicencio city. The factorial Analysis indicates three factors: Factor 1 named physical affectation, Factor 2 named social affectation and Factor 3 named motivational affectation of the fatigue, where they explain the 76.324% of the total cumulative variance with .870 of Cronbach's Alpha. The results present a high reliability and concordance for the factorial structure with the original version which indicates an adequate validity of the test for Colombian population with chronic disease. © Servicio de Publicaciones - Universidad de Murcia

Imatinib mesylate in the treatment of newly diagnosed or refractory/resistant c-KIT positive acute myeloid leukemia. Results of an Italian Multicentric Phase II Study

We evaluated safety and efficacy of imatinib (600 mg) in 36 c-KIT+ acute myeloid leukemia patients not amenable to receive conventional chemotherapy. No patient achieved complete remission. One patient obtained a hematologic improvement (platelet increase with transfusion independence). Median overall survival was 3 months (0.5-44+). Non-hematologic toxicity was overall mild

Imatinib mesylate in the treatment of newly diagnosed or refractory/resistant c-KIT positive acute myeloid leukemia. Results of an Italian Multicentric Phase II Study

We evaluated safety and efficacy of imatinib (600 mg) in 36 c-KIT+ acute myeloid leukemia patients not amenable to receive conventional chemotherapy. No patient achieved complete remission. One patient obtained a hematologic improvement (platelet increase with transfusion independence). Median overall survival was 3 months (0.5-44+). Non-hematologic toxicity was overall mild

Evaluación de la calidad de vida y su relación con la cognición hacia la enfermedad en pacientes colostomizados con diagnóstico de cáncer colorectal

El objetivo de la siguiente investigación fue evaluar la calidad de vida y s relación con la cognición a la enfermedad, en pacientes colostomizados con diagnostico de cáncer colorectal. Para esto se trabajo con 65 pacientes, de ambos géneros, a partir de 6 meses posteriores del tratamiento médico quirúrgico. Como instrumentos de medida para la calidad de vida se utilizo el SF36 versión española de Alonso y Cols. 1998 y el cuestionario de cognición a la enfermedad ICQ, versión Holandesa de Evers, 2001. Los resultados fueron analizados con el paquete SPSS, encontrándose diferencias significativas entre las medias españolas del SF 36 y las medias en nuestra población de pacientes colostomizados en las dimensiones de función físico, dolor corporal, función social, rol emocional y salud mental. Con respecto al ICQ los niveles de desesperanza y aceptación a la enfermedad fueron más elevados en nuestras medias que en las muestras originales de pacientes con Artritis reumatoide y Esclerosis múltiple (Evers, 2001)

Exploiting external reflection FTIR spectroscopy for the in-situ identification of pigments and binders in illuminated manuscripts : brochantite and posnjakite as a case study

In the present work, the use of portable instrumentation allowing in-situ reflection FTIR analyses is exploited to identify the coloring matters of northern-Italian illuminations dating to the XVI century. In order to build a database of spectra, reference paint samples were prepared spreading the pigments on parchment with two different binders, i.e. gum arabic and egg white, used in antiquity. Pigments for the database were chosen considering their use in the Middle Ages and in the Renaissance and their response in the mid- and near-IR region. The reflection FTIR spectra obtained resulted to be dominated by the specular reflection component, allowing the use of the Kramers\u2013Kronig transform to convert them to the more conventional absorbance FTIR spectra. Several pigments could thus be identified in ancient illuminations, even if some green details showed a spectral pattern different with respect to the most common commercial green pigments of the database. Therefore, in addition, basic copper sulfates brochantite and posnjakite were synthesized and characterized. In three green details, posnjakite was identified, both as a pure compound and together with malachite

Exploiting reflectance FTIR spectroscopy for the in situ identification of pigments in illuminated manuscripts

The non-destructive identification of pigments used in pictorial works is of great interest in the field of the study of cultural heritage, in particular when it is applied in situ and thus in the place of conservation of the artefacts, avoiding the costs and risks related to the transport to the laboratory. As far as the in situ identification of inorganic pigments is concerned, the techniques mostly established are, undoubtedly, X-ray fluorescence (XRF), which however provides only the elemental composition of the pigment; visible-NIR reflectance spectroscopy, not always specific due to the bandwidth; and micro-Raman spectroscopy, highly specific but sometimes of difficult application for those compounds that are only weak scatterers. Therefore the recent development of portable instrumentation for reflectance FTIR spectroscopy is very appealing, allowing the application in the field of a technique highly specific for the identification of compounds. Indeed, several studies have been reported in the literature concerning the use of this technique for the study of cultural heritage.1-2 In the present work a very compact portable FTIR spectrometer which is provided with a reflectance module for contactless measurements and a DTGS detector was used. This kind of instrumentation works at room temperature and exhibits a linear response on the spectral range between 7500 and 375 cm-1, thus allowing to record also overtone and combination bands at higher wavenumbers. In this way, the reflectance FTIR spectra of several inorganic pigments spread on parchment with different binders (arabic gum and egg white) were recorded in order to build a spectral database and moreover to evaluate the influence of the binders on the spectroscopic patterns. Exploiting the specular reflection arising from the samples, the reflectance FTIR spectra acquired could be converted to the more conventional absorbance FTIR spectra applying the Kramers-Kronig transformation. Finally, reflectance FTIR spectra were acquired from some northern-Italian illuminations dating to the XVI century, and then were compared to the reference FTIR spectra, in order to identify the coloring matter. Lapis lazuli, azurite, malachite, lead tin yellow and yellow ochre were recognized in the illuminated details analyzed. In some cases, it was also possible to identify the organic matters used in the illuminations as binders. Basic copper sulfates brochantite and posnjakite as a case study As it has been recently discussed in the literature,3 among all the pigments commonly employed in the ancient paintings, those which provide the green colour are the most elusive from the point of view of identification. Even neglecting the not uncommon cases in which the green hue was obtained by a mixture of blues and yellows, indeed, most of green pigments are based on copper compounds (for example malachite CuCO3\u387Cu(OH)2 and verdigris Cu(CH3COO)2\u3872H2O) and thus they result to be indistinguishable by means of techniques such as XRF, able to identify only copper, or vis-NIR reflectance, being the chromophore the same ion Cu2+, and also hardly identifiable by means of Raman spectroscopy, being all of them rather weak scatterers. Moreover, in several pictorial works and in particular in illuminations, besides the most common and already mentioned malachite and verdigris, also basic copper sulphates were discovered, in more detail posnjakite CuSO4\u3873Cu(OH)2\u387H2O and brochantite CuSO4\u3873Cu(OH)2 in northern-European and Italian illuminations dating from XII to XVII century4-7. When these pigments were recognized in other contexts, such as mural paintings8 and ancient wallpapers9, their formation was supposed to be the result of the degradation of the most common copper pigments, also because recipes for the production of such basic copper sulphates were not known before the XVII century and these compounds, although present in nature as minerals, are not widespread. Nevertheless, especially in the case of illuminations, often perfectly preserved, scientists have more often hypothesized that such pigments, of natural origin or artificial origin, were used on purpose6. In the present work, as a case study, pure brochantite and posnjakite were synthesized and characterized. Then reflectance FTIR spectra of these compounds spread on parchment were used for the identification of green pigments of northern-Italian illuminations, recognizing mainly posnjakite. Notably, the reflectance FTIR spectra of the basic copper sulphates mentioned above are reported here for the first time

Validez de constructo y confiabilidad de la versión en español del Spirituality Index of Well-Being (SIWB) en población colombiana con enfermedad pulmonar crónica

Introduction: Chronic obstructive pulmonary disease (COPD) is a public health problem that is increasing in Colombia, with high social and economic costs, without instruments to measure their conditions directly. Objective:To study the construct validity and reliability of the Spanish version of the questionnaire Spirituality Index of Well-Being (SIWB) in a Colombian sample of patients diagnosed with chronic lung disease. Methodology: Cross-sectional study, descriptive scope and instrument type, where applied the questionnaire to 71 adult patients diagnosed with chronic obstructive pulmonary disease in Bogota. Factor analyzes were performed by extraction method of principal components with Varimax rotation and analysis of consistency by Cronbach’s alpha for the overall scale and each factor obtained inter-item correlations and statistical full-element. Results: Factor analysis indicates two factors: self-efficacy (38.884% of explained variance) and life patterns (37.557% of explained variance), factors explaining 76,440% of the total cumulative variance and consistent with the theoretical proposal of the scales, as well as a general Cronbach, 943 and positive correlations between all reagents. Conclusions: The scale shows high reliability, appropriate internal consistency between the reactants, concordance between elements-all corrected, and agreement on the factorial structure with the original version, suggesting adequate construct validity of the test, with appropriate reliability and consistency Colombian population of chronically ill.Introducción: La enfermedad pulmonar obstructiva crónica (EPOC) es un problema de salud pública que está aumentando en Colombia, con altos costos sociales y económicos, sin contar con instrumentos para medir sus condiciones directamente. Objetivo: Estudiar la validez de constructo y la confiabilidad de la versión en español del cuestionario Spirituality Index of Well-Being (SIWB) en una muestra colombiana de pacientes con diagnóstico de enfermedad crónica pulmonar. Metodología: Estudio de corte transversal, de alcance descriptivo y de tipo instrumental, donde se aplicó el cuestionario a 71 pacientes adultos con diagnóstico de enfermedad pulmonar obstructiva crónica de la ciudad de Bogotá. Se realizaron análisis factoriales por método de extracción de componentes principales, con rotación Varimax, así como análisis de consistencia por alfa de Cronbach para la escala general y cada factor obtenido, correlaciones inter-elemento y estadísticos total-elemento. Resultados: El análisis factorial denota dos factores: autoeficacia (38,884% de varianza explicada) y esquemas vitales (37,557% de varianza explicada), factores que explican el 76,440 % de la varianza total acumulada y que concuerdan con la propuesta teórica de las escalas, así como un alfa de Cronbach general de 943 y correlaciones positivas entre todos los reactivos. Conclusiones: La escala muestra una alta confiabilidad, apropiada consistencia interna entre los reactivos, concordancia entre elementos-total corregida, y concordancia en la estructura factorial con la versión original, lo que sugiere una adecuada validez de constructo de la prueba, con apropiada confiabilidad y consistencia en población colombiana de enfermos crónicos

Inventario de sistema de creencias (SBI-15 R) en Colombia: estructura factorial y confiabilidad en población universitaria y en pacientes crónicos

El presente estudio de corte psicométrico, tuvo como objetivo analizar la estructura factorial y la consistencia interna del Inventario de Sistema de Creencias (SBI-15 R) en universitarios y enfermos crónicos colombianos. Para ello se aplicó el cuestionario SBI-15R a 265 estudiantes universitarios adultos y 52 enfermos crónicos. El análisis factorial denota dos factores: el factor 1 denominado convicción religiosa y el factor 2 denominado soporte social religioso, sin hallar diferencias en la estructura para cada muestra, y un alfa de Cronbach total de 0,926. Los resultados encontrados después de la eliminación de un ítem muestran una alta confiabilidad y concordancia en la estructura factorial del Inventario de Sistema de Creencias (SBI-14-Col) con la versión original mexicana, lo que implica adecuada validez de la prueba en población colombiana