How Claudian changed epic to praise Stilicho

Claudian, whose surviving works in Latin date from 394 to 404, wrote a variety of poems, including the first traditional epic for three hundred years, De Raptu Proserpinae. His most substantive works other than that are the ten political poems, known as the Carmina maiora, that describe current events; one other poem is relevant, the Epithalamium, composed to celebrate the wedding of Honorius and Maria, daughter of Stilicho, in early 398. The political poems fall into three types: panegyrics especially of Stilicho, the effective ruler under the child-emperor Honorius; vituperations of their opponents, Rufinus and Eutropius; and two short mini-epics. These poems are the subject of my thesis. It has been argued, notably by Cameron in 1970, that Claudian should be viewed primarily as a propagandist for Stilicho. More recently there has been a concentration on the poet’s role as heir of the epic tradition. Claudian is a politically engaged poet rather than a propagandist; his success in this role was rewarded by a statue awarded by the decree of the Senate and the two emperors; only the base has survived where the inscription declares him to be the equal of Homer and Virgil. As a poet writing within the epic tradition, he was remarkably innovative. I begin with an examination of his epic heritage and then his new creation (chapters 2-3). The poet shows a detailed knowledge of the different types of epic, which he adapts to create a new type, panegyrical epic. Next, I move to analyse various elements of his poetics, in terms of structural changes such as his use of verse prefaces (chapter 4), and his use of similes (chapter 5), both those adapted from his predecessors and his own inventions. I then examine his creation of the goddess Roma (chapter 6), and his treatment of heroes and villains (chapter 7): Roma is his most enduring creation and it is clear that the goddess had a special meaning for the poet. His characters, both good and evil, lack the moral complexity of the creations of his epic predecessors. I conclude with a separate analysis, to allow an evaluation of Claudian as an historical source; here I suggest that neither Claudian nor his audience were especially interested in accuracy. Throughout the thesis I show that the effectiveness of his adaptations to epic is shown by his influence on his successors

Daratumumab and venetoclax in combination with chemotherapy provide sustained molecular remission in relapsed/refractory CD19, CD20, and CD22 negative acute B lymphoblastic leukemia with KMT2A-AFF1 transcript.

Relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) has a very poor prognosis with a median overall survival of four to nine months. Achieving a complete molecular response is most often required to obtain a sustained leukemia-free survival after allogeneic hematopoietic stem cell transplantation. Immunotherapies targeting CD19, CD20, or CD22 are very efficient in achieving this goal. However, in the absence of the expression of these immunotherapeutic targets by lymphoblasts, treatment options are extremely scarce. We report the successful treatment of a 26-year-old man who suffered R/R, CD19, CD20, and CD22 negative B-ALL targeting Bcl-2 and CD38 by combining venetoclax and daratumumab with chemotherapy

Design and Analysis of an X-Ray Mirror Assembly Using the Meta-Shell Approach

Lightweight and high resolution optics are needed for future space-based x-ray telescopes to achieve advances in high-energy astrophysics. Past missions such as Chandra and XMM-Newton have achieved excellent angular resolution using a full shell mirror approach. Other missions such as Suzaku and NuSTAR have achieved lightweight mirrors using a segmented approach. This paper describes a new approach, called meta-shells, which combines the fabrication advantages of segmented optics with the alignment advantages of full shell optics. Meta-shells are built by layering overlapping mirror segments onto a central structural shell. The resulting optic has the stiffness and rotational symmetry of a full shell, but with an order of magnitude greater collecting area. Several meta-shells so constructed can be integrated into a large x-ray mirror assembly by proven methods used for Chandra and XMM-Newton. The mirror segments are mounted to the meta-shell using a novel four point semi-kinematic mount. The four point mount deterministically locates the segment in its most performance sensitive degrees of freedom. Extensive analysis has been performed to demonstrate the feasibility of the four point mount and meta-shell approach. A mathematical model of a meta-shell constructed with mirror segments bonded at four points and subject to launch loads has been developed to determine the optimal design parameters, namely bond size, mirror segment span, and number of layers per meta-shell. The parameters of an example 1.3 m diameter mirror assembly are given including the predicted effective area. To verify the mathematical model and support opto-mechanical analysis, a detailed finite element model of a meta-shell was created. Finite element analysis predicts low gravity distortion and low sensitivity to thermal gradients

A study on the effects of cognitive overloading and distractions on human movement during robot-assisted dressing

For robots that can provide physical assistance, maintaining synchronicity of the robot and human movement is a precursor for interaction safety. Existing research on collaborative HRI does not consider how synchronicity can be affected if humans are subjected to cognitive overloading and distractions during close physical interaction. Cognitive neuroscience has shown that unexpected events during interactions not only affect action cognition but also human motor control Gentsch et al. (Cognition, 2016, 146, 81–89). If the robot is to safely adapt its trajectory to distracted human motion, quantitative changes in the human movement should be evaluated. The main contribution of this study is the analysis and quantification of disrupted human movement during a physical collaborative task that involves robot-assisted dressing. Quantifying disrupted movement is the first step in maintaining the synchronicity of the human-robot interaction. The human movement data collected from a series of experiments where participants are subjected to cognitive loading and distractions during the human-robot interaction, are projected in a 2-D latent space that efficiently represents the high-dimensionality and non-linearity of the data. The quantitative data analysis is supported by a qualitative study of user experience, using the NASA Task Load Index to measure perceived workload, and the PeRDITA questionnaire to represent the human psychological state during these interactions. In addition, we present an experimental methodology to collect interaction data in this type of human-robot collaboration that provides realism, experimental rigour and high fidelity of the human-robot interaction in the scenarios

Reviewing the Carbonation Resistance of Concrete

The paper reviews the studies on one of the important durability properties of concrete i.e. Carbonation. One of the main causes of deterioration of concrete is carbonation, which occurs when carbon dioxide (CO2) penetrates the concrete’s porous system to create an environment with lower pH around the reinforcement in which corrosion can proceed. Carbonation is a major cause of degradation of concrete structures leading to expensive maintenance and conservation operations. Herein, the importance, process and effect of various parameters such as water/cement ratio, water/binder ratio, curing conditions, concrete cover, super plasticizers, type of aggregates, grade of concrete, porosity, contaminants, compaction, gas permeability, supplementary cementitious materials (SCMs)/ admixtures on the carbonation of concrete has been reviewed. Various methods for estimating the carbonation depth are also reported briefl

The STAR-X X-Ray Telescope Assembly (XTA)

The Survey and Time-domain Astrophysical Research eXplorer (STAR-X) science goals are to discover what powers the most violent explosions in the Universe, understand how black holes grow across cosmic time and mass scale, and measure how structure formation heats the majority of baryons in the Universe. To achieve these goals, STAR-X requires a powerful X-ray telescope with a large field of view, large collecting area, and excellent point spread function. The STAR-X instrument, the X-Ray Telescope Assembly (XTA), meets these requirements using a powerful X-ray mirror technology based on precision-polished single crystal silicon and a mature CCD detector technology. The XTA is composed of three major subsystems: an X-ray Mirror Assembly (MA) of high resolution, lightweight mirror segments fabricated out of single crystal silicon; a Focal Plane Assembly (FPA) made of back-illuminated CCD's capable of detecting X-rays with excellent quantum efficiency; and a composite Telescope Tube that structurally links the MA and FPA. The MA consists of 5,972 silicon mirror segments mounted into five subassemblies called meta-shells. A meta-shell is constructed from an annular central structural shell covered with interlocking layers of mirror segments. This paper describes the requirements, design, and analysis of the XTA subsystems with particular focus on the MA

Whole-soil warming decreases abundance and modifies the community structure of microorganisms in the subsoil but not in surface soil

The microbial community composition in subsoils remains understudied, and it is largely unknown whether subsoil microorganisms show a similar response to global warming as microorganisms at the soil surface do. Since microorganisms are the key drivers of soil organic carbon decomposition, this knowledge gap causes uncertainty in the predictions of future carbon cycling in the subsoil carbon pool (> 50 % of the soil organic carbon stocks are below 30 cm soil depth). In the Blodgett Forest field warming experiment (California, USA) we investigated how +4 ∘C warming in the whole-soil profile to 100 cm soil depth for 4.5 years has affected the abundance and community structure of microorganisms. We used proxies for bulk microbial biomass carbon (MBC) and functional microbial groups based on lipid biomarkers, such as phospholipid fatty acids (PLFAs) and branched glycerol dialkyl glycerol tetraethers (brGDGTs). With depth, the microbial biomass decreased and the community composition changed. Our results show that the concentration of PLFAs decreased with warming in the subsoil (below 30 cm) by 28 % but was not affected in the topsoil. Phospholipid fatty acid concentrations changed in concert with soil organic carbon. The microbial community response to warming was depth dependent. The relative abundance of Actinobacteria increased in warmed subsoil, and Gram+ bacteria in subsoils adapted their cell membrane structure to warming-induced stress, as indicated by the ratio of anteiso to iso branched PLFAs. Our results show for the first time that subsoil microorganisms can be more affected by warming compared to topsoil microorganisms. These microbial responses could be explained by the observed decrease in subsoil organic carbon concentrations in the warmed plots. A decrease in microbial abundance in warmed subsoils might reduce the magnitude of the respiration response over time. The shift in the subsoil microbial community towards more Actinobacteria might disproportionately enhance the degradation of previously stable subsoil carbon, as this group is able to metabolize complex carbon sources

A new perspective on robot ethics through investigating human–robot interactions with older adults

This work explored the use of human–robot interaction research to investigate robot ethics. A longitudinal human–robot interaction study was conducted with self-reported healthy older adults to determine whether expression of artificial emotions by a social robot could result in emotional deception and emotional attachment. The findings from this study have highlighted that currently there appears to be no adequate tools, or the means, to determine the ethical impact and concerns ensuing from long-term interactions between social robots and older adults. This raises the question whether we should continue the fundamental development of social robots if we cannot determine their potential negative impact and whether we should shift our focus to the development of human–robot interaction assessment tools that provide more objective measures of ethical impact

Which factors impact on quality of life for adults with blepharospasm and hemifacial spasm?

Purpose: Benign essential blepharospasm (BEB) and hemifacial spasm (HFS) are debilitating conditions causing spasms to the eyes and/or face and can significantly impact on quality of life (QoL). Initial research has highlighted potential factors impacting on QoL in BEB, but there remains a wealth of demographic, clinical, and psychosocial factors that may contribute to QoL but have not received attention. Methods: Cross-sectional baseline data were collected before a single-masked randomised controlled trial from 130 adults with BEB and HFS recruited from botulinum toxin clinics at Moorfields Eye Hospital, London. QoL was measured using the 24-item Craniocervical Dystonia Questionnaire (CDQ24), which provides a total score and five subscale scores relating to Stigma, Emotional state, Pain, Activities of daily living (ADL), and Social/family life. Treating clinicians provided clinical data. Hierarchical multiple regressions were performed on this baseline data to identify significant predictors of QoL. Results: ADL and Stigma were the areas most impacted upon whilst patients experienced better adjustment in relation to Pain, Social/family life, and Emotional state. CDQ24 Total scores were explained by the model (80% variance) and were significantly associated with appearance concerns, emotional representations, perceived negative consequences of the condition, mood, and dose of botulinum toxin. Conclusions: Patients with BEB and HFS report a detrimental impact on ADL and perceived stigma in relation to their condition. Predominantly, individual perceptions and mood are associated with QoL in this population, rather than demographic and clinical factors, signifying areas to target in the design of future healthcare services or interventions