Sistema de gerenciamento dos Bancos Ativos de Germoplasma da Embrapa Trigo.

bitstream/CNPT-2010/40598/1/p-co233.pd

Development and preliminary data on the use of a mobile app specifically designed to increase community awareness of invasive pneumococcal disease and its prevention

PublishedGiven the growing use and great potential of mobile apps, this project aimed to develop and implement a user-friendly app to increase laypeople's knowledge and awareness of invasive pneumococcal disease (IPD). Despite the heavy burden of IPD, the documented low awareness of IPD among both laypeople and healthcare professionals and far from optimal pneumococcal vaccination coverage, no app specifically targeting IPD has been developed so far. The app was designed to be maximally functional and conceived in accordance with user-centered design. Its content, layout and usability were discussed and formally tested during several workshops that involved the principal stakeholders, including experts in IPD and information technology and potential end-users. Following several workshops, it was decided that, in order to make the app more interactive, its core should be a personal “checker” of the risk of contracting IPD and a user-friendly risk-communication strategy. The checker was populated with risk factors identified through both Italian and international official guidelines. Formal evaluation of the app revealed its good readability and usability properties. A sister web site with the same content was created to achieve higher population exposure. Seven months after being launched in a price- and registration-free modality, the app, named “Pneumo Rischio,” averaged 20.9 new users/day and 1.3 sessions/user. The first in-field results suggest that “Pneumo Rischio” is a promising tool for increasing the population's awareness of IPD and its prevention through a user-friendly risk checker.The development of the app is a part of the project on increasing the population's awareness of invasive pneumococcal disease and has been supported by sponsorship from Pfizer S.r.l. The sponsor had no role in the app design and development. The authors thank Progetti di Impresa Srl for creating the app and website

Sustainable brand communications about value-related scandals

Brands (un)knowingly highlight inequalities for their benefit through their marketing efforts that may face unpredictable consumer attitudes. This unethical communication is often a cause of brand scandal. Brand communication mistakes, with related stories and customers’ reactions, leave a digital footprint that can last online for many years. Thus, this study primarily focuses on understanding the phenomenon of ethical brand scandals and uncover corporate actions to reduce inequalities. The article applies multiple case study analysis methodology using archival research design. The findings of the study highlight multiple case themes, sustainable corporate strategies, and the importance of consumer’s pre-scandal attitude about the brand. This study captured the digital presence of brand scandal stories, that showcase the mistakes that should be avoided by managers in the future, hopefully inspiring future researchers to explore the triadic relationship between consumers, brands, and channel members

Financing decisions following negative shocks in the product market: A matrix-completion study of the U.S. pharmaceutical industry

We investigate whether firms adjust their financing policies in response to a negative shock affecting their product market. Focusing on the pharmaceutical industry, we leverage the U.S. Inflation Reduction Act (IRA) of 2022 as an exogenous shock, marking the government's inaugural authority to negotiate drug prices. Using a matrix completion approach, a supervised machine-learning methodology that allows to compare treatment outcomes against predicted counterfactual values in absence of the treatment, our analysis reveals that pharmaceutical firms react to this regulatory intervention by issuing more equity. This finding suggests that firms raise fresh capital to mitigate the adverse impact of IRA on the product market

Cross-resistance to elvitegravir and dolutegravir in 502 patients failing on raltegravir: a French national study of raltegravir-experienced HIV-1-infected patients

OBJECTIVES: The objectives of this study were to determine the prevalence and patterns of resistance to integrase strand transfer inhibitors (INSTIs) in patients experiencing virological failure on raltegravir-based ART and the impact on susceptibility to INSTIs (raltegravir, elvitegravir and dolutegravir). PATIENTS AND METHODS: Data were collected from 502 treatment-experienced patients failing a raltegravir-containing regimen in a multicentre study. Reverse transcriptase, protease and integrase were sequenced at failure for each patient. INSTI resistance-associated mutations investigated were those included in the last ANRS genotypic algorithm (v23). RESULTS: Among the 502 patients, at failure, median baseline HIV-1 RNA (viral load) was 2.9 log10 copies/mL. Patients had been previously exposed to a median of five NRTIs, one NNRTI and three PIs. Seventy-one percent harboured HIV-1 subtype B and the most frequent non-B subtype was CRF02_AG (13.3%). The most frequent mutations observed were N155H/S (19.1%), Q148G/H/K/R (15.4%) and Y143C/G/H/R/S (6.7%). At failure, viruses were considered as fully susceptible to all INSTIs in 61.0% of cases, whilst 38.6% were considered as resistant to raltegravir, 34.9% to elvitegravir and 13.9% to dolutegravir. In the case of resistance to raltegravir, viruses were considered as susceptible to elvitegravir in 11% and to dolutegravir in 64% of cases. High HIV-1 viral load at failure (P < 0.001) and low genotypic sensitivity score of the associated treatment with raltegravir (P < 0.001) were associated with the presence of raltegravir-associated mutations at failure. Q148 mutations were selected more frequently in B subtypes versus non-B subtypes (P = 0.004). CONCLUSIONS: This study shows that a high proportion of viruses remain susceptible to dolutegravir in the case of failure on a raltegravir-containing regimen

Hadronization dynamics from the spectral representation of the gauge invariant quark propagator

Using the spectral representation of the quark propagator we study the Dirac decomposition of the gauge invariant quark propagator, whose imaginary part describes the hadronization of a quark as this interacts with the vacuum. We then demonstrate the formal gauge invariance of the so-called jet mass, that is of the coefficient of the chiral-odd part of the gauge invariant propagator, that can be expressed in any gauge as the first moment of the chiral-odd quark spectral function. This is therefore revealed to be a \textit{bona fide} QCD observable encoding aspects of the dynamical mass generation in the QCD vacuum, and is furthermore experimentally measurable in specific twist-3 longitudinal-transverse asymmetries in DIS and in semi-inclusive electron-positron collisions. In light-like axial gauges, we also obtain a new sum rule for the spectral function associated with the gauge fixing vector. We finally present a gauge-dependent formula that connects the second moment of the chiral-even coefficient of the quark spectral function to invariant mass generation and final state rescattering in the hadronization of a quark. Finding twist-4 experimental observables sensitive to this quantity is left for future work.Comment: Contribution to DIS2023: XXX International Workshop on Deep-Inelastic Scattering and Related Subjects, Michigan State University, USA, 27-31 March 202