Rigidity results for complete spacelike submanifolds in plane fronted waves

New rigidity results for complete non-compact spacelike submanifolds of arbitrary codimension in plane fronted waves are obtained. Under appropriate assumptions, we prove that a complete spacelike submanifold in these spacetimes is contained in a characteristic lightlike hypersurface. Moreover, for a complete codimension two extremal submanifold in a plane fronted wave we show sufficient conditions to guarantee that it is a (totally geodesic) wavefront.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Funding for open access charge: Universidad de Málaga / CBU

Episodic Vestibulocerebellar Ataxia Associated with a CACNA1G Missense Variant

Episodic vestibulocerebellar ataxias are rare diseases, frequently linked to mutations in different ion channels. Our objective in this work was to describe a kindred with episodic vestibular dysfunction and ataxia, associated with a novel CACNA1G variant. Two individuals from successive generations developed episodes of transient dizziness, gait unsteadiness, a sensation of fall triggered by head movements, headache, and cheek numbness. These were suppressed by carbamazepine (CBZ) administration in the proband, although acetazolamide and topiramate worsened instability, and amitriptyline and flunarizine did not prevent headache spells. On examination, the horizontal head impulse test (HIT) yielded saccadic responses bilaterally and was accompanied by cerebellar signs. Two additional family members were asymptomatic, with normal neurological examinations. Reduced vestibulo-ocular reflex gain values, overt and covert saccades were shown by video-assisted HIT in affected subjects. Hearing acuity was normal. Whole-exome sequencing demonstrated the heterozygous CACNA1G missense variant c.6958G>T (p.Gly2320Cys) in symptomatic individuals. It was absent in 1 unaffected member (not tested in the other asymptomatic individual) and should be considered likely pathogenic. CACNA1G encodes for the pore-forming, a1G subunit of the T-type voltage-gated calcium channel (VGCC), in which currents are transient owing to fast inactivation, and tiny, due to small conductance. Mutations in CACNA1G cause generalized absence epilepsy and adult-onset, dominantly inherited, spinocerebellar ataxia type 42. In this kindred, the aforementioned CACNA1G variant segregated with disease, which was consistent with episodic vestibulocerebellar ataxia. CBZ proved successful in bout prevention and provided symptomatic benefit in the proband, probably as a result of interaction of this drug with VGCC. Further studies are needed to fully determine the vestibular and neurological manifestations of this form of episodic vestibulocerebellar ataxia. This novel disease variant could be designated episodic vestibulocerebellar ataxia type 10. © 2021 The Author(s). Published by S. Karger AG, Basel

Non-singular radiation cosmological models

In this paper we analyse the possibility of constructing singularity-free inhomogeneous cosmological models with a pure radiation field as matter content. It is shown that the conditions for regularity are very easy to implement and therefore there is a huge number of such spacetimes.Comment: 13 pages, LaTex, ws-mpla, to appear in Modern Physics Letters

Preanalytical errors: the professionals’ perspective

This study was aimed at understanding the perspective on preanalytical errors from the point of view of the professionals involved in the preanalytical process. A significant contribution of their specialized knowledge and experience in day-to-day practice for identifying these kinds of mistakes, and their most frequent causes, was expected.It seems evident that weaknesses and threats are closely related to institutional organization aspects and the same is true for positive elements (strengths and opportunities). There is also an important appreciation of the staff’s implication. Staff´s opinions should be taken into account by institution managers, as they offer an approach that is different and complementary to the one traditionally applied, which is purely managerial and therefore not sufficient. The results should be complemented with more updated information. Multidisciplinary cooperation must involve not only professionals from different fields but also with different roles, i.e., managers, in order to obtain results that can be used to improve healthcare, save costs and to guarantee patient’s safety. We will continue with this research line investigating the same questions among primary care staff, in order to assess “the other side of the coin” of this problem.This study was partially supported by project Fondo de Investigaciones Sanitarias (FIS) grant PIFIS 1099/12 from “Instituto de Salud Carlos III” Ministerio de Sanidad y Política Social. Gobierno de España. (Health Ministry, Spanish Government).Yes2015-04-0

Phenotypic heterogeneity in Pseudomonas syringae

The notion of isogenic bacterial populations displaying phenotypic differences is widely accepted today. A particular case of phenotypic heterogeneity is bistability. Bistability occurs when bacterial population splits into two subpopulations showing distinct phenotypes. Phenotypic heterogeneity can allow some individuals to survive sudden environmental changes (risk-spreading) and can also lead to the cooperation (division of labour) between individuals. The relevance of this process has been highlighted in some animal pathogens, nevertheless, little is known about the occurrence or impact of these processes in the adaptation of bacteria to non-animal hosts. Pseudomonas syringae is a plant-pathogenic bacterium whose virulence depend of the T3SS expression. We have reported that T3SS expression is bistable in hrp-induction medium. This bistability generates two subpopulations, that show differences in virulence. Flagella is also an important virulence determinant for Pseudomonas syringae colonization. Here, we show how flagella expression also displays markedly phenotypic heterogeneity during growth within the plant. Although subpopulations displaying flagONT3SSON and flagOFFT3SSOFF can be identified within the plant, we provide evidence of cross regulation between T3SS and flagella expression at the individual cell level and propose phenotypic heterogeneity as an adaptative value for Pseudomonas adaptation to the plant host.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Length-weight relationships of soft-bottom demersal fishes from Jalisco and Colima states, Mexico

The parameters a and b of the length-weight relationship of the form W=aL super(b) were estimated for 24 species of soft bottom demersal fishes caught on the continental shelf off Jalisco and Colima states, Mexico. The estimates of b ranged from 2.74 to 3.33. The mean of the b values is 3.02 with a standard deviation of 0.15

Relativistic effects on the nuclear magnetic shielding tensor

A new approach for calculating relativistic corrections to the nuclear magnetic shieldings is presented. Starting from a full relativistic second order perturbation theory expression a two-component formalism is constructed by transforming matrix elements using the elimination of small component scheme and separating out the contributions from the no-virtual pair and the virtual pair part of the second order corrections to the energy. In this way we avoid a strong simplification used previously in the literature. We arrive at final expressions for the relativistic corrections which are equivalent to those of Fukui et al. J. Chem Phys. 105, 3175 (1996) and at some other additional terms correcting both the paramagnetic and the diamagnetic part of the nuclear magnetic shielding. Results for some relativistic corrections to the shieldings of the heavy and light nuclei in HX and CHȝX (X=Br,I) at both random phase and second order polarization propagator approach levels are given.Fil: Melo, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Ruiz de Azua, Martín César. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Giribet, Claudia Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Aucar, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura. Departamento de Física; ArgentinaFil: Romero, Rodolfo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura. Departamento de Física; Argentin