Influence of rotational force fields on the determination of the work done on a driven Brownian particle

For a Brownian system the evolution of thermodynamic quantities is a stochastic process. In particular, the work performed on a driven colloidal particle held in an optical trap changes for each realization of the experimental manipulation, even though the manipulation protocol remains unchanged. Nevertheless, the work distribution is governed by established laws. Here, we show how the measurement of the work distribution is influenced by the presence of rotational, i.e. nonconservative, radiation forces. Experiments on particles of different materials show that the rotational radiation forces, and therefore their effect on the work distributions, increase with the particle refractive index.Comment: 12 pages, 4 figure

Effects of organic herbicides on phototrophic microbial communities in freshwater ecosystems

Over the past 15 years, significant research efforts have been channelled into assessing the effects of organic herbicides on freshwater phototrophic microbial communities. The results of this research are reviewed herein. Main conclusions could be summarized into 5 points: - Most relevant assessments of this sort have dealt with the effects of triazine and phenylurea herbicides. Herbicides from these chemical classes are often considered to be model compounds when photosystem-II inhibitors are studied. - Until the early 2000s, the vast majority of investigations conducted to evaluate herbicide effects on phototropic microbes were performed in micro- or meso-cosms. In such studies, herbicides were usually applied alone, and often at concentrations much higher than those detected in the environment. More recently, the trend has been towards more realistic and relevant studies, in which lower herbicide concentrations were considered, and compound mixtures or successive treatments were tested. Increasingly, in situ studies are being designed to directly evaluate microbial community responses, following chemical exposures in contaminated aquatic environments. - Several biological endpoints are used to evaluate how organisms in the phototrophic microbial community respond to herbicide exposure. These endpoints allow the detection of quantitative changes, such as chl a concentrations, total cell counts or periphytic biomass, qualitative changes such as community structure to algal diversity, or functional changes such as photosynthesis, respiration, etc. They could give different and complementary information concerning the responses of microbial communities. - In addition, PICT approaches, which have generally combined functional and structural measurements, may prove to be valuable for assessing both an immediate impact, and for factoring in the contamination history of an ecosystem at the community level. - A relevant assessment of pesticides effects should include details on environmental characterization, such as abiotic parameters (light, flow speed, nutrients content) or biotic parameters (diversity and structure of biofilms), as they control the bioavailability of pesticides and the exposure of microbial communities. To improve the value of ecotoxicological risk assessments, future research is needed in two key areas: first, the effects of pollutants at the community level must be detailed (new tools and new end points), and second, more effort must be directed to reinforcing the ecological relevance of toxicological investigations

mtDNA and mitochondrial stress signaling in human diseases: A special issue

: The completion of the Special Issue dedicated to "mtDNA and mitochondrial stress signaling in human diseases" requests a final overall look to highlight the most valuable findings among the many presented data [...]

Merging of globular clusters within inner galactic regions. II. The Nuclear Star Cluster formation

In this paper we present the results of two detailed N-body simulations of the interaction of a sample of four massive globular clusters in the inner region of a triaxial galaxy. A full merging of the clusters takes place, leading to a slowly evolving cluster which is quite similar to observed Nuclear Clusters. Actually, both the density and the velocity dispersion profiles match qualitatively, and quantitatively after scaling, with observed features of many nucleated galaxies. In the case of dense initial clusters, the merger remnant shows a density profile more concentrated than that of the progenitors, with a central density higher than the sum of the central progenitors central densities. These findings support the idea that a massive Nuclear Cluster may have formed in early phases of the mother galaxy evolution and lead to the formation of a nucleus, which, in many galaxies, has indeed a luminosity profile similar to that of an extended King model. A correlation with galactic nuclear activity is suggested.Comment: 18 pages, 10 figures, 3 tables. Submitted to ApJ, main journa

Closure statistics in interferometric data

Interferometric visibilities, reflecting the complex correlations between signals recorded at antennas in an interferometric array, carry information about the angular structure of a distant source. While unknown antenna gains in both amplitude and phase can prevent direct interpretation of these measurements, certain combinations of visibilities called closure phases and closure amplitudes are independent of antenna gains and provide a convenient set of robust observables. However, these closure quantities have subtle noise properties and are generally both linearly and statistically dependent. These complications have obstructed the proper use of closure quantities in interferometric analysis, and they have obscured the relationship between analysis with closure quantities and other analysis techniques such as self calibration. We review the statistics of closure quantities, noting common pitfalls that arise when approaching low signal-to-noise due to the nonlinear propagation of statistical errors. We then develop a strategy for isolating and fitting to the independent degrees of freedom captured by the closure quantities through explicit construction of linearly independent sets of quantities along with their noise covariance in the Gaussian limit, valid for moderate signal-to-noise, and we demonstrate that model fits have biased posteriors when this covariance is ignored. Finally, we introduce a unified procedure for fitting to both closure information and partially calibrated visibilities, and we demonstrate both analytically and numerically the direct equivalence of inference based on closure quantities to that based on self calibration of complex visibilities with unconstrained antenna gains.Comment: 31 pages, 17 figure

Major depression with ischemic heart disease: Effects of paroxetine and nortriptyline on long-term heart rate variability measures

Background: Studies have linked depression to sudden death and serious cardiovascular events in patients with preexisting cardiac illness. Recent studies have shown decreased vagal function in cardiac patients with depression and depressed patients without cardiac illness. Methods: We compared 20-hour, sleeping, and awake heart period variability measures using spectral analysis, fractal dimension, and symbolic dynamics in two patient groups with major depression and ischemic heart disease (mean age 59-60 years) before and after 6 weeks of paroxetine or nortriptyline treatment. Results: Spectral measures showed decreases in awake and sleeping total power (TP: 0.0-0.5 Hz), ultra low frequency power (ULF: 0-0.0033 Hz), very low frequency power (VLF: 0.0033-0.04 Hz), and low-frequency power (LF: 0.04-0.15 Hz) for nortriptyline condition and a decrease in high-frequency power (HF: 0.15-0.5 Hz) for the awake condition in patients who received nortriptyline. A measure of nonlinear complexity, WC-100, significantly increased after paroxetine during the awake condition. Conclusions: These findings suggest that nortriptyline has stronger vagolytic effects on cardiac autonomic function compared with paroxetine, which is in agreement with previous clinical and preclinical reports. Paroxetine may have some cardio-protective effects, especially in cardiac patients

Direct UV observations of the circumstellar envelope of alpha Orionis

Observations were made in the IUE LWP camera, low dispersion mode, with alpha Ori being offset various distances from the center of the Long Wavelength Large Aperture along its major axis. Signal was acquired at all offset positions and is comprised of unequal components of background/dark counts, telescope-scattered light, and scattered light emanating from the extended circumstellar shell. The star is known from optical and infrared observations to possess an extended, arc-minute sized, shell of cool material. Attempts to observe this shell with the IUE are described, although the deconvolution of the stellar signal from the telescope scattered light requires further calibration effort

Formation and evolution of clumpy tidal tails around globular clusters

We present some results of numerical simulations of a globular cluster orbiting in the central region of a triaxial galaxy on a set of 'loop' orbits. Tails start forming after about a quarter of the globular cluster orbital period and develop, in most cases, along the cluster orbit, showing clumpy substructures as observed, for example, in Palomar 5. If completely detectable, clumps can contain about 7,000 solar masses each, i.e. about 10% of the cluster mass at that epoch. The morphology of tails and clumps and the kinematical properties of stars in the tails are studied and compared with available observational data. Our finding is that the stellar velocity dispersion tends to level off at large radii, in agreement to that found for M15 and Omega Centauri.Comment: LaTeX 2e, uses AASTeX v5.x, 40 pages with 18 figures. Submitted to The Astronomical Journa

Major depression with ischemic heart disease: Effects of paroxetine and nortriptyline on measures of nonlinearity and chaos of heart rate

Depression is associated with increased cardiovascular mortality in patients with preexisting cardiac illness. A decrease in cardiac vagal function as suggested by a decrease in heart rate variability (HRV) or heart period variability has been linked to sudden death in patients with cardiac disease as well as in normal controls. Recent studies have shown decreased vagal function in cardiac patients with depression as well as in depressed patients without cardiac illness. In this study, we compared 20 h awake and sleep heart period nonlinear measures using quantification of nonlinearity and chaos in two groups of patients with major depression and ischemic heart disease (mean age 59-60 years) before and after 6 weeks of treatment with paroxetine or nortriptyline. Patients received paroxetine, 20-30 mg/day or nortriptyline targeted to 190-570 nmol/l for 6 weeks. For HRV analysis, 24 patients were included in the paroxetine treatment study and 20 patients in the nortriptyline study who had at least 20,000 s of awake data. The ages of these groups were 60.4 +/- 10.5 years for paroxetine and 60.8 +/- 13.4 years for nortriptyline. There was a significant decrease in the largest Lyapunov exponent (LLE) after treatment with nortriptyline but not paroxetine. There were also significant decreases in nonlinearity scores on S-netPR and S-netGS after nortriptyline, which may be due to a decrease in cardiac vagal modulation of HRV. S-netGS and awake LLE were the most significant variables that contributed to the discrimination of postparoxetine and postnortriptyline groups even with the inclusion of time and frequency domain measures. These findings suggest that nortriptyline decreases the measures of chaos probably through its stronger vagolytic effects on cardiac autonomic function compared with paroxetine, which is in agreement with previous clinical and preclinical reports. Nortriptyline was also associated with a significant decrease in nonlinearity scores, which may be due to anticholinergic and/or sympatholytic effects. As depression is associated with a strong risk factor for cardiovascular mortality, one should be careful about using any drug that adversely affects cardiac vagal function. Copyright (C) 2002 S. Karger AG, Basel

Stratonovich-to-Ito transition in noisy systems with multiplicative feedback

Cataloged from PDF version of article.Intrinsically noisy mechanisms drive most physical, biological and economic phenomena. Frequently, the system's state influences the driving noise intensity (multiplicative feedback). These phenomena are often modelled using stochastic differential equations, which can be interpreted according to various conventions (for example, Ito calculus and Stratonovich calculus), leading to qualitatively different solutions. Thus, a stochastic differential equation-convention pair must be determined from the available experimental data before being able to predict the system's behaviour under new conditions. Here we experimentally demonstrate that the convention for a given system may vary with the operational conditions: we show that a noisy electric circuit shifts from obeying Stratonovich calculus to obeying Ito calculus. We track such a transition to the underlying dynamics of the system and, in particular, to the ratio between the driving noise correlation time and the feedback delay time. We discuss possible implications of our conclusions, supported by numerics, for biology and economics