Validation of the face-name pairs task in major depression: impaired recall but not recognition

Major depression can be associated with neurocognitive deficits which are believed in part to be related to medial temporal lobe pathology. The purpose of this study was to investigate this impairment using a hippocampal-dependent neuropsychological task. The face-name pairs task was used to assess associative memory functioning in 19 patients with major depression. When compared to age-sex-and-education matched controls, patients with depression showed impaired learning, delayed cued-recall, and delayed free-recall. However, they also showed preserved recognition of the verbal and nonverbal components of this task. Results indicate that the face-name pairs task is sensitive to neurocognitive deficits in major depression.Thisresearchwasfundedbya4-yearHealthResearch Board grant

Automated tutoring for a database skills training environment

Universities are increasingly offering courses online. Feedback, assessment, and guidance are important features of this online courseware. Together, in the absence of a human tutor, they aid the student in the learning process. We present a programming training environment for a database course. It aims to offer a substitute for classroom based learning by providing synchronous automated feedback to the student, along with guidance based on a personalized assessment. The automated tutoring system should promote procedural knowledge acquisition and skills training. An automated tutoring feature is an integral part of this tutoring system

Emission characteristics and dynamics of the stagnation layer in colliding laser produced plasmas

The expansion dynamics of ion and neutral species in laterally colliding laser produced aluminum plasmas have been investigated using time and space resolved optical emission spectroscopies and spectrally and angularly resolved fast imaging. The emission results highlight a difference in neutral atom and ion distributions in the stagnation layer where, at a time delay of 80 ns, the neutral atoms are localized in the vicinity of the target surface 1 mm from the target surface while singly and doubly charged ions lie predominantly at larger distances, 1.5 and 2 mm, respectively. The imaging results show that the ions were found to form a well defined, but compressed, stagnation layer at the collision front between the two seed plasmas at early times (Dt ~ 80 ns). On the other hand, the excited neutrals were observed to form a V-shaped emission feature at the outer regions of the collision front with enhanced neutral emission in the less dense, cooler regions of the stagnation layer

Serious Games in Cultural Heritage

Although the widespread use of gaming for leisure purposes has been well documented, the use of games to support cultural heritage purposes, such as historical teaching and learning, or for enhancing museum visits, has been less well considered. The state-of-the-art in serious game technology is identical to that of the state-of-the-art in entertainment games technology. As a result the field of serious heritage games concerns itself with recent advances in computer games, real-time computer graphics, virtual and augmented reality and artificial intelligence. On the other hand, the main strengths of serious gaming applications may be generalised as being in the areas of communication, visual expression of information, collaboration mechanisms, interactivity and entertainment. In this report, we will focus on the state-of-the-art with respect to the theories, methods and technologies used in serious heritage games. We provide an overview of existing literature of relevance to the domain, discuss the strengths and weaknesses of the described methods and point out unsolved problems and challenges. In addition, several case studies illustrating the application of methods and technologies used in cultural heritage are presented

Simple manipulation of a microwave dressed-state ion qubit

Many schemes for implementing quantum information processing require that the atomic states used have a non-zero magnetic moment, however such magnetically sensitive states of an atom are vulnerable to decoherence due to fluctuating magnetic fields. Dressing an atom with an external field is a powerful method of reducing such decoherence [N. Timoney et al., Nature 476, 185], even if the states being dressed are strongly coupled to the environment. We introduce an experimentally simpler method of manipulating such a dressed-state qubit, which allows the implementation of general rotations of the qubit, and demonstrate this method using a trapped ytterbium ion

EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes.

Cognitive or executive control is a critical mental ability, an important marker of mental illness, and among the most heritable of neurocognitive traits. Two candidate genes, catechol-O-methyltransferase (COMT) and DRD4, which both have a roles in the regulation of cortical dopamine, have been consistently associated with cognitive control. Here, we predicted that individuals with the COMT Met/Met allele would show improved response execution and inhibition as indexed by event-related potentials in a Go/NoGo task, while individuals with the DRD4 7-repeat allele would show impaired brain activity. We used independent component analysis (ICA) to separate brain source processes contributing to high-density EEG scalp signals recorded during the task. As expected, individuals with the DRD4 7-repeat polymorphism had reduced parietal P3 source and scalp responses to response (Go) compared to those without the 7-repeat. Contrary to our expectation, the COMT homozygous Met allele was associated with a smaller frontal P3 source and scalp response to response-inhibition (NoGo) stimuli, suggesting that while more dopamine in frontal cortical areas has advantages in some tasks, it may also compromise response inhibition function. An interaction effect emerged for P3 source responses to Go stimuli. These were reduced in those with both the 7-repeat DRD4 allele and either the COMT Val/Val or the Met/Met homozygous polymorphisms but not in those with the heterozygous Val/Met polymorphism. This epistatic interaction between DRD4 and COMT replicates findings that too little or too much dopamine impairs cognitive control. The anatomic and functional separated maximally independent cortical EEG sources proved more informative than scalp channel measures for genetic studies of brain function and thus better elucidate the complex mechanisms in psychiatric illness

Relational Operant Skills Training Increases Standardized Matrices Scores in Adolescents: A Stratified Active-Controlled Trial

In recent years, small-scale studies have suggested that we may be able to substantially strengthen children's general cognitive abilities and intelligence quotient (IQ) scores using a relational operant skills training program (SMART). Only one of these studies to date has included an active Control Condition, and that study reported the smallest mean IQ rise. The present study is a larger stratified active-controlled trial to independently test the utility of SMART training for raising Non-verbal IQ (NVIQ) and processing speed. We measured personality traits, NVIQs, and processing speeds of a cohort of school pupils (aged 12–15). Participants were allocated to either a SMART intervention group or a Scratch computer coding control group, for a period of 3 months. We reassessed pupils’ NVIQs and processing speeds after the 3-month intervention. We observed a significant mean increase in the SMART training group’s (final nexp = 43) NVIQs of 5.98 points, while there was a nonsignificant increase of 1.85 points in the Scratch active-control group (final ncont = 27). We also observed an increase in processing speed across both conditions (final nexp = 70; ncont = 55) over Time. Our results suggest that relational skills training may be useful for improving performance on matrices tasks, and perhaps in future, accelerating children’s progression toward developmental milestones

Constructing streak surfaces for 3D unsteady vector fields

Visualization of 3D, unsteady flow (4D) is very difficult due to both perceptual challenges and the large size of 4D vector field data. One approach to this challenge is to use integral surfaces to visualize the 4D properties of the field. However the construction of streak surfaces has remained elusive due to problems stemming from expensive computation and complex meshing schemes. We present a novel streak surface construction algorithm that generates the surface using a quadrangular mesh. In contrast to previous approaches the algorithm offers a combination of speed for exploration of 3D unsteady flow, high precision, and places less restriction on data or mesh size due to its CPU-based implementation compared to a GPU-based method. The algorithm can be applied to large data sets because it is based on local operations performed on the quad primitives. We demonstrate the technique on a variety of 3D, unsteady simulation data sets to show its speed and robustness. We also present both a detailed implementation and a performance evaluation. We show that a technique based on quad meshes handles large data sets and can achieve interactive frame rates