1,389 research outputs found
Non-equilibrium phase behavior of confined molecular films at low shear rates
In a recent publication [MaÄkowiak et al., J. Chem. Phys. 145, 164704 (2016)] the results of Non-Equilibrium Molecular Dynamics (NEMD) simulations of confined sheared Lennard-Jones molecular films have been presented. The present work builds on that study by focusing on the low wall speed (shear rate) regime. Maps are given of the steady-state structures and corresponding friction coefficients in the region where a transition from static to kinetic friction is observed. The boundary between static and kinetic friction regions is determined as a function of wall speed and applied pressure, which is located for wall speeds up to about 0.8âmâsâ1. It was found that stick-slip behavior extends to pressures as high as 1000âMPa. The NEMD equations of motion are shown to be consistent with the PrandtlâTomlinson model in the âsoft springâ limit, which leads to a new expression for the friction coefficient. This study provides new details and insights into the nature of anomalous friction behavior in the so-called Plug-Slip part of the nonquilibrium phase diagram regime
Why are Prices Sticky? Evidence from Business Survey Data
This paper offers new insights on the price setting behaviour of German retail firms using a novel dataset that
consists of a large panel of monthly business surveys from 1991-2006. The firm-level data allows matching changes
in firms' prices to several other firm-characteristics. Moreover, information on price expectations allow analyzing
the determinants of price updating. Using univariate and bivariate ordered probit specifications, empirical menu
cost models are estimated relating the probability of price adjustment and price updating, respectively, to both
time- and state- dependent variables. First, results suggest an important role for state-dependence; changes in
the macroeconomic and institutional environment as well as firm-specific factors are significantly related to the
timing of price adjustment. These findings imply that price setting models should endogenize the timing of price
adjustment in order to generate realistic predictions concerning the transmission of monetary policy. Second, an
analysis of price expectations yields similar results providing evidence in favour of state-dependent sticky plan
models. Third, intermediate input cost changes are among the most important determinants of price adjustment
suggesting that pricing models should explicitly incorporate price setting at different production stages. However, the results show that adjustment to input cost changes takes time indicating "additional stickiness" at the last stage of processing
Approaches toward Sustainable Forage-Livestock Systems: Strip-Planting a Legume into a Warm-Season Perennial Grass Pasture
Despite the demonstrated potential of rhizoma peanut (Arachis glabrata Benth.; RP) for grazing in the southeastern USA (Ortega-S. et al. 1992), high establishment cost and removal of land from production during establishment have limited its use to primarily hay production systems. The premise of this experiment is that strip-planting RP in existing bahiagrass (Paspalum notatum FlĂŒgge) pastures offers the opportunity to use grass forage during the legume establishment phase so that land need not be totally removed from grazing, while allowing successful establishment of the legume
Breeding Small Grains as a Forage, Silage and Cover Crop for the Southern Coastal Plain (USA) in a Changing Climatic Environment
Forage breeding of small grains in the southern Coastal Plains region of the U.S. mimic many other countries experiencing climate changes and breeding strategies should be similar for improving small grains grown for forage, silage or as cover crops. Significant focus on improvements in stress-adaptation has encouraged members of the SunGrains cooperative to cross, evaluate and develop experimental lines with inherent adaptation to climatic conditions including heat stress, drought tolerance, short-day and long-day forage production periods, and flooded conditions for events with storm-related, short-term durations. Many new cultivars, grown throughout the southeastern U.S. have resulted from breeding selection under abiotic and biotic stresses, adapted to climate change and related concerns, such as disease and insect pests
ExpressĂŁo e distribuição da conexina 32 em fĂgados de ratos com fibrose induzida experimentalmente
The connexin 32 (Cx32) is a protein that forms the channels that promote the gap junction intercellular communication (GJIC) in the liver, allowing the diffusion of small molecules through cytosol from cell-to-cell. Hepatic fibrosis is characterized by a disruption of normal tissue architeture by cellular lesions, and may alter the GJIC. This work aimed to study the expression and distribution of Cx32 in liver fibrosis induced by the oral administration of dimethylnitrosamine in female Wistar rats. The necropsy of the rats was carried out after five weeks of drug administration. They presented a hepatic fibrosis state. Sections from livers with fibrosis and from control livers were submitted to immunohistochemical, Real Time-PCR and Western-Blot analysis to Cx32. In fibrotic livers the Cxs were diffusely scattered in the cytoplasm, contrasting with the control livers, where the Cx32 formed junction plaques at the cell membrane. Also it was found a decrease in the gene expression of Cx32 without reduction in the protein quantity when compared with controls. These results suggest that there the mechanism of intercellular communication between hepatocytes was reduced by the fibrotic process, which may predispose to the occurrence of a neoplastic process, taken in account that connexins are considered tumor suppressing genes.A conexina 32 (Cx32) Ă© uma proteĂna que constitui os canais que promovem as comunicaçÔes intercelulares via junçÔes comunicantes (CIJC) no fĂgado, permitindo difusĂŁo de pequenas molĂ©culas citoplasmĂĄticas de uma cĂ©lula Ă outra. A fibrose hepĂĄtica caracteriza-se pela alteração da arquitetura normal do fĂgado e podem alterar as CIJCs. O objetivo deste trabalho foi estudar a expressĂŁo e distribuição de Cx32 na fibrose hepĂĄtica. O objetivo do presente trabalho foi estudar a expressĂŁo e distribuição da Cx32 em fĂgados com fibrose induzida pela administração oral de dimetilnitrosamina em fĂȘmeas de ratos Wistar. A necropsia foi realizada apĂłs cinco semanas da Ășltima administração da droga e observou-se um quadro de fibrose hepĂĄtica. Amostras dos fĂgados com fibrose e de animais controle foram submetidas Ă anĂĄlise imunoistoquĂmica, por Real Time-PCR e por Western-Blot verificando-se a presença de Cx32 difusa e dispersa no citoplasma dos fĂgados com fibrose. No grupo controle a Cx32 localizou-se na membrana citoplasmĂĄtica com a formação de placas juncionais. O fĂgado com fibrose tambĂ©m revelou diminuição da expressĂŁo gĂȘnica de Cx32, embora sem a redução da quantidade do produto protĂ©ico, quando comparado ao grupo controle. Estes resultados sugerem que o mecanismo de comunicação intercelular entre os hepatĂłcitos reduziu-se durante o processo fibrĂłtico, o que pode predispor a ocorrĂȘncia de processos neoplĂĄsicos, uma vez que as conexinas sĂŁo consideradas genes supressores de tumores.FAPESPCNP
Pricing in inflationary times: The penny drops
How does the frequency and magnitude of micro-price rises and falls relate to macroeconomic crisis, as well as moderation? Weekly micropricing behaviour in British groceries was investigated across three leading retailers over the moderation period 2004â7 and the crisis period 2008â10. We find significant price flexibility sharply distinguished from behaviour observed in most previous works. Downward price flexibility increased markedly in 2008. Overall basket prices rise, but significantly more individual prices fall than rise in the latter period. Tests of obfuscation in price setting suggested that large numbers of small price falls were used to disguise the basket price rises
The Ultimate Fate of Supercooled Liquids
In recent years it has become widely accepted that a dynamical length scale
{\xi}_{\alpha} plays an important role in supercooled liquids near the glass
transition. We examine the implications of the interplay between the growing
{\xi}_{\alpha} and the size of the crystal nucleus, {\xi}_M, which shrinks on
cooling. We argue that at low temperatures where {\xi}_{\alpha} > {\xi}_M a new
crystallization mechanism emerges enabling rapid development of a large scale
web of sparsely connected crystallinity. Though we predict this web percolates
the system at too low a temperature to be easily seen in the laboratory, there
are noticeable residual effects near the glass transition that can account for
several previously observed unexplained phenomena of deeply supercooled liquids
including Fischer clusters, and anomalous crystal growth near T_g
Cognitive impairment after lacunar stroke: systematic review and meta-analysis of incidence, prevalence and comparison with other stroke subtypes
Funding SDJM is supported by a Wellcome Trust Project Grant (WT088134/Z/09/A). JMW is supported by the Scottish Funding Council through the Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Initiative (http://www. sinapse.ac.uk). The study was independent of the funders.Peer reviewedPublisher PD
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