PC4CAST: A tool for DSN load forecasting and capacity planning

Effectively planning the use and evolution of the Deep Space Network (DSN) is a complex problem involving many parameters. The tool that models many of these complexities, yet requires simple structured inputs and provides concise easy-to-understand metrics to aid in the planning process is discussed. The tool, PC4CAST, is used for both load forecasting (predicting how well planned that DSN resources meet expected demand) and as a decision support tool in the capacity-planning process (determining the relative benefits of capacity expansion options). It is now in use in the TDA Planning Office, has been used in numerous studies, and is also being used by the JPL Multimission Operations System Office (MOSO) as an integral part of Resource Allocation Team activities. Experience using the tool has helped to identify additional requirements that will further improve the planning process, which can be met by future PC4CAST versions

ATP-dependent chromatosome remodeling

Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime. One important principle that endows chromatin with flexibility involves ATP-dependent `remodeling' factors, which alter DNA-histone interactions to form, disrupt or move nucleosomes. Remodeling is well documented at the nucleosomal level, but little is known about the action of remodeling factors in a more physiological chromatin environment. Recent findings suggest that some remodeling machines can reorganize even folded chromatin fibers containing the linker histone H1, extending the potential scope of remodeling reactions to the bulk of euchromatin

Telemedicine Volunteering Experience as a Medical Student During the COVID-19 Pandemic in Brazil

The coronavirus disease 2019 (COVID-19) pandemic has strongly affected Brazil and many universities canceled in-person classes for an indefinite period. Many Brazilian medical students enrolled themselves as volunteers in telemedicine services across the country. This text will share the authors’ experience in telemedicine and their insights into the topic as volunteer medical students in Brazil

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state

Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte nucleus. How viral cccDNA gene expression is regulated by its chromatin structure; more importantly, how the modulation of this structure impacts on viral gene expression remains elusive. Here, we found that the enzyme SetDB1 contributes to setting up a repressed cccDNA chromatin state. This repressive state is activated by the histone lysine demethylase-1 (LSD1). Consistently, inhibiting or reducing LSD1 levels led to repression of viral gene expression. This correlates with the transcriptionally repressive mark H3K9 methylation and reduction on the activating marks H3 acetylation and H3K4 methylation on viral promoters. Investigating the importance of viral proteins we found that LSD1 recruitment to viral promoters was dependent on the viral transactivator protein HBx. Moreover, the histone methyltransferase Set1A and HBx are simultaneously bound to the core promoter, and Set1A expression correlates with cccDNA H3K4 methylation. Our results shed light on the mechanisms of HBV regulation mediated by the cccDNA chromatin structure, offering new therapeutic targets to develop drugs for the treatment of chronically infected HBV patients.http://www.nature.com/articles/srep2590

Global priorities for conservation across multiple dimensions of mammalian diversity

Conservation priorities that are based on species distribution, endemism, and vulnerability may underrepresent biologically unique species as well as their functional roles and evolutionary histories. To ensure that priorities are biologically comprehensive, multiple dimensions of diversity must be considered. Further, understanding how the different dimensions relate to one another spatially is important for conservation prioritization, but the relationship remains poorly understood. Here, we use spatial conservation planning to (i) identify and compare priority regions for global mammal conservation across three key dimensions of biodiversity-taxonomic, phylogenetic, and traits-and (ii) determine the overlap of these regions with the locations of threatened species and existing protected areas. We show that priority areas for mammal conservation exhibit low overlap across the three dimensions, highlighting the need for an integrative approach for biodiversity conservation. Additionally, currently protected areas poorly represent the three dimensions of mammalian biodiversity. We identify areas of high conservation priority among and across the dimensions that should receive special attention for expanding the global protected area network. These high-priority areas, combined with areas of high priority for other taxonomic groups and with social, economic, and political considerations, provide a biological foundation for future conservation planning efforts

MODELAGEM DA TEMPERATURA E OTIMIZAÇÃO DO ÍNDICE DE DESPLACAMENTO DE PAINÉIS DE MDF ENVERNIZADOS EM FORNOS UV

A cura de verniz em painéis de MDF envernizados em escala industrial normalmente é realizada com uso de fornos UV. A falha nos ajustes destes fornos, pode levar ao superaquecimento do filme, provocando a degradação do verniz. Na prática, essa degradação é reconhecida como desplacamento e compromete a qualidade do filme. Neste contexto, esta pesquisa tem como objetivo, avaliar o efeito da radiação, convecção e velocidade de transporte dos painéis sobre a temperatura de cura e o ID(índice de desplacamento). A metodologia empregada foi experimental em escala industrial, além de abordagem matemática. Diante dos resultados e com base no que a literatura reporta, o efeito do fenômeno de radiação sobre a temperatura é cinco vezes mais importante em relação aos demais fatores. Os resultados revelaram que o efeito da convecção e de velocidade de transporte, são inversamente proporcionais para o aumento da temperatura do filme e desplacamento. Já os resultados do modelo de transporte de calor a parâmetros concentrados, mostraram boa aderência aos dados de temperaturas experimentais. As condições operacionais ótimas (temperatura de 53⁰C, ID até 26% e padrão de qualidade ISO 3/ ASTM 2B) aceitáveis para a prática de cura UV podem ser alcançadas com ajuste da potência em 190W/cm², velocidade de transporte em 18 m/min e velocidade de ventilação em 24 m/s. Palavras-chave: Temperatura de cura; Desplacamento de verniz; Abordagem experimental

Banking Efficiency in Chile: a Profit Frontier Approach

This paper characterizes the evolution of the efficiency X in the Chilean banking industry over 1987 to 2007, based on a profit frontier approach. Our results suggest that over this period the Chilean banking sector has attained just a 15% over its maximum profits. This inefficiency basically arises from a technical source rather than an assignative one, and mainly affects domestic and small banks. Nevertheless, the level of efficiency X of the industry as a whole has dramatically improved since the late 1990’s, which is consistent with important economic, technological and regulatory transformations.

Neural network interpolation of the magnetic field for the LISA Pathfinder Diagnostics Subsystem

LISA Pathfinder is a science and technology demonstrator of the European Space Agency within the framework of its LISA mission, which aims to be the first space-borne gravitational wave observatory. The payload of LISA Pathfinder is the so-called LISA Technology Package, which is designed to measure relative accelerations between two test masses in nominal free fall. Its disturbances are monitored and dealt by the diagnostics subsystem. This subsystem consists of several modules, and one of these is the magnetic diagnostics system, which includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions of the test masses. However, since the magnetometers are located far from the positions of the test masses, the magnetic field at their positions must be interpolated. It has been recently shown that because there are not enough magnetic channels, classical interpolation methods fail to derive reliable measurements at the positions of the test masses, while neural network interpolation can provide the required measurements at the desired accuracy. In this paper we expand these studies and we assess the reliability and robustness of the neural network interpolation scheme for variations of the locations and possible offsets of the magnetometers, as well as for changes in environmental conditions. We find that neural networks are robust enough to derive accurate measurements of the magnetic field at the positions of the test masses in most circumstances

Penggunaan archival footage dalam pengerjaan film dokumenter “jalan pulang”

Archival footage adalah rekaman yang tidak dapat diulang baik dalam lokasi, waktu, pelaku, dan kejadian. Archival footage berperan banyak dalam pembuatan film dokumenter. Dalam pengerjaan film dokumenter, Archival footage dapat dijadikan alat penyalur struktur cerita untuk mendapatkan pemahaman baru tentang sebuah peristiwa. Hal ini terjadi karena adanya perbedaan waktu, lokasi dan kejadian saat perekaman kejadian dan dipresentasikan kembali dengan sudut pandang yang baru. Film dokumenter Jalan Pulang bercerita tentang ritual pembersihan bala (Ke’o Rado) akibat kematian tidak wajar (Mata Golo). Proses pembuatannya memakai Archival footage dan Real footage. Paduan keduanya dilandasi oleh pandangan agar Mata Golo dan ritual Ke’o Rado dalam budaya Bajawa – Flores dapat diterima secara terbuka sebagai bagian dari budayanya

Informe DRIS (Diagnosis and Recommendation Integrated System)

Obtención de normas para el análisis foliar del olivo en Jaén según “Diagnosis and Recommendation Integrated System” (DRIS) partiendo de la base de datos de FERTIBERIA. El DRIS es un ventajoso sistema de diagnostico del estado nutricional de las plantas y si se corrobora la eficacia de desarrollar este sistema para el olivo, a partir de la base de datos de FERTIBERIA, podría ser aplicado a otros cultivos en sus respectivas zonas. Con los resultados obtenidos en el desarrollo del DRIS para el olivar en Jaén se puede valorar esta utilidad de la base de datos